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Protein

Bacterioferritin

Gene

bfr

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.By similarity
  • Fe cationBy similarityNote: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Iron 1PROSITE-ProRule annotation1
Metal bindingi51Iron 1PROSITE-ProRule annotation1
Metal bindingi51Iron 2PROSITE-ProRule annotation1
Metal bindingi52Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi54Iron 1PROSITE-ProRule annotation1
Metal bindingi94Iron 2PROSITE-ProRule annotation1
Metal bindingi127Iron 1PROSITE-ProRule annotation1
Metal bindingi127Iron 2PROSITE-ProRule annotation1
Metal bindingi130Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBMEL224914:G1FZL-2931-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Gene namesi
Name:bfr
Ordered Locus Names:BMEII0704
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001925891 – 161BacterioferritinAdd BLAST161

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

Protein-protein interaction databases

STRINGi224914.BAWG_1871

Structurei

3D structure databases

ProteinModelPortaliP49944
SMRiP49944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 145Ferritin-like diironPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated

Phylogenomic databases

eggNOGiENOG4108UQY Bacteria
COG2193 LUCA
HOGENOMiHOG000262383
KOiK03594
OMAiFLHAKMQ

Family and domain databases

CDDicd00907 Bacterioferritin, 1 hit
Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR002024 Bacterioferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
PIRSFiPIRSF002560 Bacterioferritin, 1 hit
PRINTSiPR00601 BACFERRITIN
SUPFAMiSSF47240 SSF47240, 1 hit
TIGRFAMsiTIGR00754 bfr, 1 hit
PROSITEiView protein in PROSITE
PS00549 BACTERIOFERRITIN, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P49944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGEPKVIER LNDALFLELG AVNQYWLHYR LLNDWGYTRL AKKEREESIE
60 70 80 90 100
EMHHADKLIN RIIFFEGFPN LQTVSPLRIG QNVKEVLEAD LKGEYDARAS
110 120 130 140 150
YKESREICDK LGDYVSKQLF DELLADEEGH IDFLETQLDL LAKIGEERYG
160
QLNAAPADEA E
Length:161
Mass (Da):18,659
Last modified:October 1, 1996 - v1
Checksum:i5A92C1759B68BD1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19760 Genomic DNA Translation: AAC43322.1
AE008918 Genomic DNA Translation: AAL53946.1
PIRiAG3597
S68771
RefSeqiWP_004686876.1, NZ_GG703779.1

Genome annotation databases

EnsemblBacteriaiAAL53946; AAL53946; BMEII0704
GeneIDi29595661
KEGGibme:BMEII0704
bmel:DK63_2538
PATRICifig|224914.52.peg.2660

Similar proteinsi

Entry informationi

Entry nameiBFR_BRUME
AccessioniPrimary (citable) accession number: P49944
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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