UniProtKB - P49922 (GNRHR_PIG)
Protein
Gonadotropin-releasing hormone receptor
Gene
GNRHR
Organism
Sus scrofa (Pig)
Status
Functioni
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- gonadotropin-releasing hormone receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Gonadotropin-releasing hormone receptorShort name: GnRH receptor Short name: GnRH-R Alternative name(s): Luteinizing hormone-releasing hormone receptor Short name: LHRH |
Gene namesi | Name:GNRHR |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 58 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 59 – 77 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 78 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 98 – 115 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 116 – 137 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 138 – 164 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 165 – 184 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 185 – 212 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 213 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 233 – 281 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 282 – 300 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 301 – 306 | ExtracellularSequence analysis | 6 | |
Transmembranei | 307 – 326 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 327 – 328 | CytoplasmicSequence analysis | 2 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069490 | 1 – 328 | Gonadotropin-releasing hormone receptorAdd BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 196 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P49922 |
PRIDEi | P49922 |
Expressioni
Tissue specificityi
Pituitary gland.
Gene expression databases
Bgeei | ENSSSCG00000008925, Expressed in pituitary gland and 24 other tissues |
Genevisiblei | P49922, SS |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
HOGENOMi | CLU_009579_15_2_1 |
InParanoidi | P49922 |
OrthoDBi | 858238at2759 |
TreeFami | TF106499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001658, GphnRH_fam_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00529, GNADOTRPHINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P49922-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANSASPEQN QNHCSAINSS ILLTQGNLPT LTLSGKIRVT VTFFLFLLST
60 70 80 90 100
AFNASFLLKL QKWTQRKEKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG EFLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITRPLAVK
160 170 180 190 200
SNSRLGRFMI GLAWLLSSIF AGPQLYIFRM IHLADSSGQT EGFSQCVTHG
210 220 230 240 250
SFPQWWHQAF YNFFTFSCLF IIPLLIMLIC NAKIMFTLTR VLQQDPHNLQ
260 270 280 290 300
LNQSKNNIPR ARLRTLKMTV AFAASFIVCW TPYYVLGIWY WFDPEMVNRV
310 320
SDPVNHFFFL FAFLNPCFDP LIYGYFSL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 – 36 | GK → PN in AAA31067 (PubMed:7928774).Curated | 2 | |
Sequence conflicti | 212 | N → D in AAA31067 (PubMed:7928774).Curated | 1 | |
Sequence conflicti | 284 | Y → L in AAA31067 (PubMed:7928774).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29342 mRNA Translation: AAA31067.1 AF227686, AF227685 Genomic DNA Translation: AAF33402.1 |
RefSeqi | NP_999438.1, NM_214273.1 |
Genome annotation databases
Ensembli | ENSSSCT00070017085; ENSSSCP00070014138; ENSSSCG00070008818 |
GeneIDi | 397515 |
KEGGi | ssc:397515 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29342 mRNA Translation: AAA31067.1 AF227686, AF227685 Genomic DNA Translation: AAF33402.1 |
RefSeqi | NP_999438.1, NM_214273.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000009521 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | P49922 |
PRIDEi | P49922 |
Genome annotation databases
Ensembli | ENSSSCT00070017085; ENSSSCP00070014138; ENSSSCG00070008818 |
GeneIDi | 397515 |
KEGGi | ssc:397515 |
Organism-specific databases
CTDi | 2798 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
HOGENOMi | CLU_009579_15_2_1 |
InParanoidi | P49922 |
OrthoDBi | 858238at2759 |
TreeFami | TF106499 |
Gene expression databases
Bgeei | ENSSSCG00000008925, Expressed in pituitary gland and 24 other tissues |
Genevisiblei | P49922, SS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001658, GphnRH_fam_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00529, GNADOTRPHINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNRHR_PIG | |
Accessioni | P49922Primary (citable) accession number: P49922 Secondary accession number(s): Q9N142 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 12, 2003 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families