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Protein

Cyclin-dependent kinase inhibitor 1C

Gene

Cdkn1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor
Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-69231 Cyclin D associated events in G1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 1C
Alternative name(s):
Cyclin-dependent kinase inhibitor p57
p57Kip2
Gene namesi
Name:Cdkn1c
Synonyms:Kip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104564 Cdkn1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900881 – 348Cyclin-dependent kinase inhibitor 1CAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP49919
PaxDbiP49919
PeptideAtlasiP49919
PRIDEiP49919

PTM databases

iPTMnetiP49919
PhosphoSitePlusiP49919

Expressioni

Tissue specificityi

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.

Gene expression databases

BgeeiENSMUSG00000037664 Expressed in 312 organ(s), highest expression level in dorsal pancreas
CleanExiMM_CDKN1C
ExpressionAtlasiP49919 baseline and differential
GenevisibleiP49919 MM

Interactioni

Subunit structurei

Interacts with PCNA.By similarity

Protein-protein interaction databases

BioGridi198653, 2 interactors
ELMiP49919
IntActiP49919, 1 interactor
MINTiP49919
STRINGi10090.ENSMUSP00000128828

Structurei

3D structure databases

ProteinModelPortaliP49919
SMRiP49919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi309 – 312Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 189Pro-richAdd BLAST82
Compositional biasi178 – 284Asp/Glu-rich (acidic)Add BLAST107

Sequence similaritiesi

Belongs to the CDI family.Curated

Phylogenomic databases

eggNOGiKOG4743 Eukaryota
ENOG410XXN5 LUCA
GeneTreeiENSGT00530000063588
HOGENOMiHOG000294081
HOVERGENiHBG107407
InParanoidiP49919
KOiK09993
OMAiQWTEVDS
OrthoDBiEOG091G19PZ
TreeFamiTF101111

Family and domain databases

InterProiView protein in InterPro
IPR003175 CDI
IPR029842 CDKN1C
PANTHERiPTHR10265 PTHR10265, 1 hit
PTHR10265:SF7 PTHR10265:SF7, 1 hit
PfamiView protein in Pfam
PF02234 CDI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform KIP2a (identifier: P49919-1) [UniParc]FASTAAdd to basket
Also known as: p57a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGMSDVYLRS RTAMERLASS DTFPVIARSS ACRSLFGPVD HEELGRELRM
60 70 80 90 100
RLAELNAEDQ NRWDFNFQQD VPLRGPGRLQ WMEVDSESVP AFYRETVQVG
110 120 130 140 150
RCRLQLGPRP PPVAVAVIPR SGPPAGEAPD GLEEAPEQPP SAPASAVVAE
160 170 180 190 200
PTPPATPAPA SDLTSDPIPE VTLVATSDPT PDPIPDANPD VATRDGEEQV
210 220 230 240 250
PEQVSEQGEE SGAEPGDELG TEPVSEQGEE QGAEPVEEKD EEPEEEQGAE
260 270 280 290 300
PVEEQGAEPV EEQNGEPVEE QDENQEQRGQ ELKDQPLSGI PGRPAPGTAA
310 320 330 340
ANANDFFAKR KRTAQENKAS NDVPPGCPSP NVAPGVGAVE QTPRKRLR
Length:348
Mass (Da):37,372
Last modified:October 3, 2012 - v2
Checksum:i100032B2F76BEC92
GO
Isoform KIP2b (identifier: P49919-2) [UniParc]FASTAAdd to basket
Also known as: p57b

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:335
Mass (Da):35,903
Checksum:iE5C40675287FEB3F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LJ83A0A140LJ83_MOUSE
Cyclin-dependent kinase inhibitor 1...
Cdkn1c
179Annotation score:
A0A140LJA8A0A140LJA8_MOUSE
Cyclin-dependent kinase inhibitor 1...
Cdkn1c
146Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150 – 151EP → DA in AAC52186 (PubMed:7729683).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0008681 – 13Missing in isoform KIP2b. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20553 mRNA Translation: AAC52186.1
AC023248 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL18208.1
U22399 mRNA Translation: AAA85096.1
CCDSiCCDS22040.1 [P49919-2]
CCDS52463.1 [P49919-1]
PIRiI49262
RefSeqiNP_001155096.1, NM_001161624.1 [P49919-1]
NP_034006.3, NM_009876.4 [P49919-2]
XP_006508534.1, XM_006508471.3
UniGeneiMm.168789

Genome annotation databases

EnsembliENSMUST00000037287; ENSMUSP00000037302; ENSMUSG00000037664 [P49919-2]
ENSMUST00000167912; ENSMUSP00000128828; ENSMUSG00000037664 [P49919-1]
GeneIDi12577
KEGGimmu:12577
UCSCiuc009kpd.2 mouse [P49919-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20553 mRNA Translation: AAC52186.1
AC023248 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL18208.1
U22399 mRNA Translation: AAA85096.1
CCDSiCCDS22040.1 [P49919-2]
CCDS52463.1 [P49919-1]
PIRiI49262
RefSeqiNP_001155096.1, NM_001161624.1 [P49919-1]
NP_034006.3, NM_009876.4 [P49919-2]
XP_006508534.1, XM_006508471.3
UniGeneiMm.168789

3D structure databases

ProteinModelPortaliP49919
SMRiP49919
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198653, 2 interactors
ELMiP49919
IntActiP49919, 1 interactor
MINTiP49919
STRINGi10090.ENSMUSP00000128828

PTM databases

iPTMnetiP49919
PhosphoSitePlusiP49919

Proteomic databases

MaxQBiP49919
PaxDbiP49919
PeptideAtlasiP49919
PRIDEiP49919

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037287; ENSMUSP00000037302; ENSMUSG00000037664 [P49919-2]
ENSMUST00000167912; ENSMUSP00000128828; ENSMUSG00000037664 [P49919-1]
GeneIDi12577
KEGGimmu:12577
UCSCiuc009kpd.2 mouse [P49919-1]

Organism-specific databases

CTDi1028
MGIiMGI:104564 Cdkn1c

Phylogenomic databases

eggNOGiKOG4743 Eukaryota
ENOG410XXN5 LUCA
GeneTreeiENSGT00530000063588
HOGENOMiHOG000294081
HOVERGENiHBG107407
InParanoidiP49919
KOiK09993
OMAiQWTEVDS
OrthoDBiEOG091G19PZ
TreeFamiTF101111

Enzyme and pathway databases

ReactomeiR-MMU-69231 Cyclin D associated events in G1

Miscellaneous databases

ChiTaRSiCdkn1c mouse
PROiPR:P49919
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037664 Expressed in 312 organ(s), highest expression level in dorsal pancreas
CleanExiMM_CDKN1C
ExpressionAtlasiP49919 baseline and differential
GenevisibleiP49919 MM

Family and domain databases

InterProiView protein in InterPro
IPR003175 CDI
IPR029842 CDKN1C
PANTHERiPTHR10265 PTHR10265, 1 hit
PTHR10265:SF7 PTHR10265:SF7, 1 hit
PfamiView protein in Pfam
PF02234 CDI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDN1C_MOUSE
AccessioniPrimary (citable) accession number: P49919
Secondary accession number(s): G3UW61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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