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Protein

DNA ligase 3

Gene

LIG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).2 Publications

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.PROSITE-ProRule annotation2 Publications

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei506ATPCombined sourcesCurated1
Active sitei508N6-AMP-lysine intermediatePROSITE-ProRule annotation1 Publication1
Binding sitei513ATPCombined sourcesCurated1
Binding sitei528ATPBy similarity1
Metal bindingi560Magnesium 1By similarity1
Metal bindingi655Magnesium 2By similarity1
Binding sitei660ATPCombined sourcesCurated1
Binding sitei671ATPBy similarity1
Binding sitei675ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 185PARP-typePROSITE-ProRule annotation1 PublicationAdd BLAST93

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: InterPro
  • DNA ligase (ATP) activity Source: BHF-UCL
  • DNA ligase activity Source: BHF-UCL
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi6.5.1.1 2681
ReactomeiR-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
SIGNORiP49916

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 3 (EC:6.5.1.12 Publications)
Alternative name(s):
DNA ligase III
Polydeoxyribonucleotide synthase [ATP] 3
Gene namesi
Name:LIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000005156.11
HGNCiHGNC:6600 LIG3
MIMi600940 gene
neXtProtiNX_P49916

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi410K → E: Nearly abolishes ligase activity with blunt-ended DNA, but not with nicked DNA. 1 Publication1
Mutagenesisi414R → E: Abolishes ligase activity with blunt-ended DNA, but not with nicked DNA. 1 Publication1

Organism-specific databases

DisGeNETi3980
OpenTargetsiENSG00000005156
PharmGKBiPA30374

Chemistry databases

DrugBankiDB00290 Bleomycin

Polymorphism and mutation databases

BioMutaiLIG3
DMDMi251757259

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionSequence analysisAdd BLAST42
ChainiPRO_000005957443 – 1009DNA ligase 3Add BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei913PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49916
MaxQBiP49916
PaxDbiP49916
PeptideAtlasiP49916
PRIDEiP49916
ProteomicsDBi56181
56182 [P49916-2]

PTM databases

iPTMnetiP49916
PhosphoSitePlusiP49916

Expressioni

Tissue specificityi

Testis, thymus, prostate and heart.

Gene expression databases

BgeeiENSG00000005156 Expressed in 207 organ(s), highest expression level in brain
CleanExiHS_LIG3
ExpressionAtlasiP49916 baseline and differential
GenevisibleiP49916 HS

Organism-specific databases

HPAiHPA006723

Interactioni

Subunit structurei

Isoform 3 interacts (via BRCT domain) with the nuclear DNA-repair protein XRCC1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAXP612442EBI-1753381,EBI-751711

Protein-protein interaction databases

BioGridi110168, 68 interactors
CORUMiP49916
IntActiP49916, 33 interactors
MINTiP49916
STRINGi9606.ENSP00000367787

Structurei

Secondary structure

11009
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49916
SMRiP49916
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49916

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini933 – 1009BRCTPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 280Interaction with DNA1 Publication4
Regioni318 – 323Interaction with DNA1 Publication6
Regioni388 – 391Interaction with DNA1 Publication4
Regioni421 – 427Interaction with DNA1 Publication7

Domaini

The PARP-type zinc finger is required for DNA ligase activity.1 Publication

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 185PARP-typePROSITE-ProRule annotation1 PublicationAdd BLAST93

Keywords - Domaini

Transit peptide, Zinc-finger

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00860000133792
HOGENOMiHOG000007653
HOVERGENiHBG005515
InParanoidiP49916
KOiK10776
OMAiMPVWEIT
OrthoDBiEOG091G0XBU
PhylomeDBiP49916
TreeFamiTF316220

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49916-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF
60 70 80 90 100
LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR
110 120 130 140 150
GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA
160 170 180 190 200
RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA
210 220 230 240 250
KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS
260 270 280 290 300
SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH
310 320 330 340 350
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV
360 370 380 390 400
SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI
410 420 430 440 450
ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV
460 470 480 490 500
VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP
510 520 530 540 550
NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP
560 570 580 590 600
GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF
610 620 630 640 650
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI
660 670 680 690 700
QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG
710 720 730 740 750
QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI
760 770 780 790 800
SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI
810 820 830 840 850
SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT
860 870 880 890 900
GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS
910 920 930 940 950
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP
960 970 980 990 1000
DFSRLRRYFV AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI

RKRRLVAPC
Note: Produced by alternative splicing.
Length:1,009
Mass (Da):112,907
Last modified:July 7, 2009 - v2
Checksum:i0E4057E33C3F19A6
GO
Isoform 2 (identifier: P49916-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     933-1009: VLLDIFTGVR...IRKRRLVAPC → RRPASEQRGRTVPAGRR

Note: Produced by alternative splicing.
Show »
Length:949
Mass (Da):106,018
Checksum:i0C10E40E0686DB77
GO
Isoform 3 (identifier: P49916-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: Produced by alternative initiation of isoform 1.
Show »
Length:922
Mass (Da):102,691
Checksum:iFC3C60F988868808
GO
Isoform 4 (identifier: P49916-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     933-1009: VLLDIFTGVR...IRKRRLVAPC → RRPASEQRGRTVPAGRR

Note: Produced by alternative initiation of isoform 2.
Show »
Length:862
Mass (Da):95,802
Checksum:iF6A3C6B1422FD895
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERZ5K7ERZ5_HUMAN
DNA ligase 3
LIG3
545Annotation score:
K7EQB6K7EQB6_HUMAN
DNA ligase 3
LIG3
185Annotation score:
K7ENR9K7ENR9_HUMAN
DNA ligase 3
LIG3
207Annotation score:
K7ELY6K7ELY6_HUMAN
DNA ligase 3
LIG3
38Annotation score:
K7EJR4K7EJR4_HUMAN
DNA ligase 3
LIG3
36Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020196224R → W. Corresponds to variant dbSNP:rs3744356Ensembl.1
Natural variantiVAR_036513717D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs757797167Ensembl.1
Natural variantiVAR_072387768Y → H1 PublicationCorresponds to variant dbSNP:rs200981995Ensembl.1
Natural variantiVAR_018807867R → H1 PublicationCorresponds to variant dbSNP:rs3136025Ensembl.1
Natural variantiVAR_021938898K → T. Corresponds to variant dbSNP:rs4986974Ensembl.1
Natural variantiVAR_020197986P → S. Corresponds to variant dbSNP:rs4986973Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574641 – 87Missing in isoform 3 and isoform 4. CuratedAdd BLAST87
Alternative sequenceiVSP_001302933 – 1009VLLDI…LVAPC → RRPASEQRGRTVPAGRR in isoform 2 and isoform 4. 1 PublicationCuratedAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84740 mRNA Translation: CAA59230.1
U40671 mRNA Translation: AAA85022.1
HQ204826 Genomic DNA Translation: ADP89974.1
HQ204826 Genomic DNA Translation: ADP89975.1
HQ204827 Genomic DNA Translation: ADP89976.1
HQ204827 Genomic DNA Translation: ADP89977.1
HQ204828 Genomic DNA Translation: ADP89978.1
HQ204828 Genomic DNA Translation: ADP89979.1
HQ204829 Genomic DNA Translation: ADP89980.1
HQ204829 Genomic DNA Translation: ADP89981.1
HQ204830 Genomic DNA Translation: ADP89982.1
HQ204830 Genomic DNA Translation: ADP89983.1
HQ204831 Genomic DNA Translation: ADP89984.1
HQ204831 Genomic DNA Translation: ADP89985.1
HQ204832 Genomic DNA Translation: ADP89986.1
HQ204832 Genomic DNA Translation: ADP89987.1
HQ204833 Genomic DNA Translation: ADP89988.1
HQ204833 Genomic DNA Translation: ADP89989.1
HQ204834 Genomic DNA Translation: ADP89990.1
HQ204834 Genomic DNA Translation: ADP89991.1
HQ204835 Genomic DNA Translation: ADP89992.1
HQ204835 Genomic DNA Translation: ADP89993.1
HQ204836 Genomic DNA Translation: ADP89994.1
HQ204836 Genomic DNA Translation: ADP89995.1
HQ204837 Genomic DNA Translation: ADP89996.1
HQ204837 Genomic DNA Translation: ADP89997.1
HQ204838 Genomic DNA Translation: ADP89998.1
HQ204838 Genomic DNA Translation: ADP89999.1
HQ204839 Genomic DNA Translation: ADP90000.1
HQ204839 Genomic DNA Translation: ADP90001.1
HQ204840 Genomic DNA Translation: ADP90002.1
HQ204840 Genomic DNA Translation: ADP90003.1
HQ204841 Genomic DNA Translation: ADP90004.1
HQ204841 Genomic DNA Translation: ADP90005.1
HQ204842 Genomic DNA Translation: ADP90006.1
HQ204842 Genomic DNA Translation: ADP90007.1
HQ204843 Genomic DNA Translation: ADP90008.1
HQ204843 Genomic DNA Translation: ADP90009.1
HQ204844 Genomic DNA Translation: ADP90010.1
HQ204844 Genomic DNA Translation: ADP90011.1
HQ204845 Genomic DNA Translation: ADP90012.1
HQ204845 Genomic DNA Translation: ADP90013.1
HQ204846 Genomic DNA Translation: ADP90014.1
HQ204846 Genomic DNA Translation: ADP90015.1
HQ204847 Genomic DNA Translation: ADP90016.1
HQ204847 Genomic DNA Translation: ADP90017.1
HQ204848 Genomic DNA Translation: ADP90018.1
HQ204848 Genomic DNA Translation: ADP90019.1
HQ204849 Genomic DNA Translation: ADP90020.1
HQ204849 Genomic DNA Translation: ADP90021.1
HQ204850 Genomic DNA Translation: ADP90022.1
HQ204850 Genomic DNA Translation: ADP90023.1
HQ204851 Genomic DNA Translation: ADP90024.1
HQ204851 Genomic DNA Translation: ADP90025.1
HQ204852 Genomic DNA Translation: ADP90026.1
HQ204852 Genomic DNA Translation: ADP90027.1
HQ204853 Genomic DNA Translation: ADP90028.1
HQ204853 Genomic DNA Translation: ADP90029.1
HQ204854 Genomic DNA Translation: ADP90030.1
HQ204854 Genomic DNA Translation: ADP90031.1
HQ204855 Genomic DNA Translation: ADP90032.1
HQ204855 Genomic DNA Translation: ADP90033.1
HQ204856 Genomic DNA Translation: ADP90034.1
HQ204856 Genomic DNA Translation: ADP90035.1
HQ204857 Genomic DNA Translation: ADP90036.1
HQ204857 Genomic DNA Translation: ADP90037.1
HQ204858 Genomic DNA Translation: ADP90038.1
HQ204858 Genomic DNA Translation: ADP90039.1
HQ204859 Genomic DNA Translation: ADP90040.1
HQ204859 Genomic DNA Translation: ADP90041.1
HQ204860 Genomic DNA Translation: ADP90042.1
HQ204860 Genomic DNA Translation: ADP90043.1
HQ204861 Genomic DNA Translation: ADP90044.1
HQ204861 Genomic DNA Translation: ADP90045.1
HQ204862 Genomic DNA Translation: ADP90046.1
HQ204862 Genomic DNA Translation: ADP90047.1
HQ204863 Genomic DNA Translation: ADP90048.1
HQ204863 Genomic DNA Translation: ADP90049.1
HQ204864 Genomic DNA Translation: ADP90050.1
HQ204864 Genomic DNA Translation: ADP90051.1
HQ204865 Genomic DNA Translation: ADP90052.1
HQ204865 Genomic DNA Translation: ADP90053.1
AF491645 Genomic DNA Translation: AAL91592.1
AC004223 Genomic DNA No translation available.
AC022903 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80197.1
CH471147 Genomic DNA Translation: EAW80199.1
BC068005 mRNA Translation: AAH68005.1
CCDSiCCDS11284.2 [P49916-1]
CCDS11285.2 [P49916-2]
PIRiI37292
RefSeqiNP_002302.2, NM_002311.4 [P49916-2]
NP_039269.2, NM_013975.3 [P49916-1]
XP_016880113.1, XM_017024624.1 [P49916-1]
UniGeneiHs.100299
Hs.556108

Genome annotation databases

EnsembliENST00000262327; ENSP00000262327; ENSG00000005156 [P49916-2]
ENST00000378526; ENSP00000367787; ENSG00000005156 [P49916-1]
GeneIDi3980
KEGGihsa:3980
UCSCiuc002hij.4 human [P49916-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

DNA ligase entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84740 mRNA Translation: CAA59230.1
U40671 mRNA Translation: AAA85022.1
HQ204826 Genomic DNA Translation: ADP89974.1
HQ204826 Genomic DNA Translation: ADP89975.1
HQ204827 Genomic DNA Translation: ADP89976.1
HQ204827 Genomic DNA Translation: ADP89977.1
HQ204828 Genomic DNA Translation: ADP89978.1
HQ204828 Genomic DNA Translation: ADP89979.1
HQ204829 Genomic DNA Translation: ADP89980.1
HQ204829 Genomic DNA Translation: ADP89981.1
HQ204830 Genomic DNA Translation: ADP89982.1
HQ204830 Genomic DNA Translation: ADP89983.1
HQ204831 Genomic DNA Translation: ADP89984.1
HQ204831 Genomic DNA Translation: ADP89985.1
HQ204832 Genomic DNA Translation: ADP89986.1
HQ204832 Genomic DNA Translation: ADP89987.1
HQ204833 Genomic DNA Translation: ADP89988.1
HQ204833 Genomic DNA Translation: ADP89989.1
HQ204834 Genomic DNA Translation: ADP89990.1
HQ204834 Genomic DNA Translation: ADP89991.1
HQ204835 Genomic DNA Translation: ADP89992.1
HQ204835 Genomic DNA Translation: ADP89993.1
HQ204836 Genomic DNA Translation: ADP89994.1
HQ204836 Genomic DNA Translation: ADP89995.1
HQ204837 Genomic DNA Translation: ADP89996.1
HQ204837 Genomic DNA Translation: ADP89997.1
HQ204838 Genomic DNA Translation: ADP89998.1
HQ204838 Genomic DNA Translation: ADP89999.1
HQ204839 Genomic DNA Translation: ADP90000.1
HQ204839 Genomic DNA Translation: ADP90001.1
HQ204840 Genomic DNA Translation: ADP90002.1
HQ204840 Genomic DNA Translation: ADP90003.1
HQ204841 Genomic DNA Translation: ADP90004.1
HQ204841 Genomic DNA Translation: ADP90005.1
HQ204842 Genomic DNA Translation: ADP90006.1
HQ204842 Genomic DNA Translation: ADP90007.1
HQ204843 Genomic DNA Translation: ADP90008.1
HQ204843 Genomic DNA Translation: ADP90009.1
HQ204844 Genomic DNA Translation: ADP90010.1
HQ204844 Genomic DNA Translation: ADP90011.1
HQ204845 Genomic DNA Translation: ADP90012.1
HQ204845 Genomic DNA Translation: ADP90013.1
HQ204846 Genomic DNA Translation: ADP90014.1
HQ204846 Genomic DNA Translation: ADP90015.1
HQ204847 Genomic DNA Translation: ADP90016.1
HQ204847 Genomic DNA Translation: ADP90017.1
HQ204848 Genomic DNA Translation: ADP90018.1
HQ204848 Genomic DNA Translation: ADP90019.1
HQ204849 Genomic DNA Translation: ADP90020.1
HQ204849 Genomic DNA Translation: ADP90021.1
HQ204850 Genomic DNA Translation: ADP90022.1
HQ204850 Genomic DNA Translation: ADP90023.1
HQ204851 Genomic DNA Translation: ADP90024.1
HQ204851 Genomic DNA Translation: ADP90025.1
HQ204852 Genomic DNA Translation: ADP90026.1
HQ204852 Genomic DNA Translation: ADP90027.1
HQ204853 Genomic DNA Translation: ADP90028.1
HQ204853 Genomic DNA Translation: ADP90029.1
HQ204854 Genomic DNA Translation: ADP90030.1
HQ204854 Genomic DNA Translation: ADP90031.1
HQ204855 Genomic DNA Translation: ADP90032.1
HQ204855 Genomic DNA Translation: ADP90033.1
HQ204856 Genomic DNA Translation: ADP90034.1
HQ204856 Genomic DNA Translation: ADP90035.1
HQ204857 Genomic DNA Translation: ADP90036.1
HQ204857 Genomic DNA Translation: ADP90037.1
HQ204858 Genomic DNA Translation: ADP90038.1
HQ204858 Genomic DNA Translation: ADP90039.1
HQ204859 Genomic DNA Translation: ADP90040.1
HQ204859 Genomic DNA Translation: ADP90041.1
HQ204860 Genomic DNA Translation: ADP90042.1
HQ204860 Genomic DNA Translation: ADP90043.1
HQ204861 Genomic DNA Translation: ADP90044.1
HQ204861 Genomic DNA Translation: ADP90045.1
HQ204862 Genomic DNA Translation: ADP90046.1
HQ204862 Genomic DNA Translation: ADP90047.1
HQ204863 Genomic DNA Translation: ADP90048.1
HQ204863 Genomic DNA Translation: ADP90049.1
HQ204864 Genomic DNA Translation: ADP90050.1
HQ204864 Genomic DNA Translation: ADP90051.1
HQ204865 Genomic DNA Translation: ADP90052.1
HQ204865 Genomic DNA Translation: ADP90053.1
AF491645 Genomic DNA Translation: AAL91592.1
AC004223 Genomic DNA No translation available.
AC022903 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80197.1
CH471147 Genomic DNA Translation: EAW80199.1
BC068005 mRNA Translation: AAH68005.1
CCDSiCCDS11284.2 [P49916-1]
CCDS11285.2 [P49916-2]
PIRiI37292
RefSeqiNP_002302.2, NM_002311.4 [P49916-2]
NP_039269.2, NM_013975.3 [P49916-1]
XP_016880113.1, XM_017024624.1 [P49916-1]
UniGeneiHs.100299
Hs.556108

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IMONMR-A924-1009[»]
1IN1NMR-A924-1009[»]
1UW0NMR-A88-204[»]
3L2PX-ray3.00A257-833[»]
3PC7X-ray1.65A/B924-1009[»]
3PC8X-ray2.31C/D924-1008[»]
3QVGX-ray2.26A/C924-1008[»]
ProteinModelPortaliP49916
SMRiP49916
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110168, 68 interactors
CORUMiP49916
IntActiP49916, 33 interactors
MINTiP49916
STRINGi9606.ENSP00000367787

Chemistry databases

DrugBankiDB00290 Bleomycin

PTM databases

iPTMnetiP49916
PhosphoSitePlusiP49916

Polymorphism and mutation databases

BioMutaiLIG3
DMDMi251757259

Proteomic databases

EPDiP49916
MaxQBiP49916
PaxDbiP49916
PeptideAtlasiP49916
PRIDEiP49916
ProteomicsDBi56181
56182 [P49916-2]

Protocols and materials databases

DNASUi3980
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262327; ENSP00000262327; ENSG00000005156 [P49916-2]
ENST00000378526; ENSP00000367787; ENSG00000005156 [P49916-1]
GeneIDi3980
KEGGihsa:3980
UCSCiuc002hij.4 human [P49916-1]

Organism-specific databases

CTDi3980
DisGeNETi3980
EuPathDBiHostDB:ENSG00000005156.11
GeneCardsiLIG3
HGNCiHGNC:6600 LIG3
HPAiHPA006723
MIMi600940 gene
neXtProtiNX_P49916
OpenTargetsiENSG00000005156
PharmGKBiPA30374
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00860000133792
HOGENOMiHOG000007653
HOVERGENiHBG005515
InParanoidiP49916
KOiK10776
OMAiMPVWEIT
OrthoDBiEOG091G0XBU
PhylomeDBiP49916
TreeFamiTF316220

Enzyme and pathway databases

BRENDAi6.5.1.1 2681
ReactomeiR-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
SIGNORiP49916

Miscellaneous databases

ChiTaRSiLIG3 human
EvolutionaryTraceiP49916
GeneWikiiLIG3
GenomeRNAii3980
PROiPR:P49916
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000005156 Expressed in 207 organ(s), highest expression level in brain
CleanExiHS_LIG3
ExpressionAtlasiP49916 baseline and differential
GenevisibleiP49916 HS

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNLI3_HUMAN
AccessioniPrimary (citable) accession number: P49916
Secondary accession number(s): E5KLB5
, E5KLB6, Q16714, Q6NVK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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