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Entry version 204 (08 May 2019)
Sequence version 2 (07 Jul 2009)
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Protein

DNA ligase 3

Gene

LIG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei506ATPCombined sourcesCurated1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei508N6-AMP-lysine intermediatePROSITE-ProRule annotation1 Publication1
Binding sitei513ATPCombined sourcesCurated1
Binding sitei528ATPBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi560Magnesium 1By similarity1
Metal bindingi655Magnesium 2By similarity1
Binding sitei660ATPCombined sourcesCurated1
Binding sitei671ATPBy similarity1
Binding sitei675ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri93 – 185PARP-typePROSITE-ProRule annotation1 PublicationAdd BLAST93

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.5.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49916

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA ligase 3 (EC:6.5.1.12 Publications)
Alternative name(s):
DNA ligase III
Polydeoxyribonucleotide synthase [ATP] 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6600 LIG3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600940 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49916

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi410K → E: Nearly abolishes ligase activity with blunt-ended DNA, but not with nicked DNA. 1 Publication1
Mutagenesisi414R → E: Abolishes ligase activity with blunt-ended DNA, but not with nicked DNA. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3980

Open Targets

More...
OpenTargetsi
ENSG00000005156

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30374

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00290 Bleomycin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIG3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
251757259

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 42MitochondrionSequence analysisAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005957443 – 1009DNA ligase 3Add BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei210PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei913PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49916

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49916

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49916

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49916

PeptideAtlas

More...
PeptideAtlasi
P49916

PRoteomics IDEntifications database

More...
PRIDEi
P49916

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56181
56182 [P49916-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49916

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49916

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis, thymus, prostate and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005156 Expressed in 207 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49916 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49916 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006723

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 3 interacts (via BRCT domain) with the nuclear DNA-repair protein XRCC1.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MAXP612442EBI-1753381,EBI-751711

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110168, 77 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P49916

Protein interaction database and analysis system

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IntActi
P49916, 39 interactors

Molecular INTeraction database

More...
MINTi
P49916

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367787

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11009
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IMONMR-A924-1009[»]
1IN1NMR-A924-1009[»]
1UW0NMR-A88-204[»]
3L2PX-ray3.00A257-833[»]
3PC7X-ray1.65A/B924-1009[»]
3PC8X-ray2.31C/D924-1008[»]
3QVGX-ray2.26A/C924-1008[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49916

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49916

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini933 – 1009BRCTPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni277 – 280Interaction with DNA1 Publication4
Regioni318 – 323Interaction with DNA1 Publication6
Regioni388 – 391Interaction with DNA1 Publication4
Regioni421 – 427Interaction with DNA1 Publication7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PARP-type zinc finger is required for DNA ligase activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 185PARP-typePROSITE-ProRule annotation1 PublicationAdd BLAST93

Keywords - Domaini

Transit peptide, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4437 Eukaryota
COG1793 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007653

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49916

KEGG Orthology (KO)

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KOi
K10776

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPVWEIT

Database of Orthologous Groups

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OrthoDBi
274264at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49916

TreeFam database of animal gene trees

More...
TreeFami
TF316220

Family and domain databases

Conserved Domains Database

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CDDi
cd00027 BRCT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 1 hit
SM01336 zf-PARP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00574 dnl1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49916-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF
60 70 80 90 100
LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR
110 120 130 140 150
GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA
160 170 180 190 200
RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA
210 220 230 240 250
KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS
260 270 280 290 300
SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH
310 320 330 340 350
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV
360 370 380 390 400
SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI
410 420 430 440 450
ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV
460 470 480 490 500
VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP
510 520 530 540 550
NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP
560 570 580 590 600
GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF
610 620 630 640 650
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI
660 670 680 690 700
QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG
710 720 730 740 750
QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI
760 770 780 790 800
SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI
810 820 830 840 850
SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT
860 870 880 890 900
GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS
910 920 930 940 950
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP
960 970 980 990 1000
DFSRLRRYFV AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI

RKRRLVAPC
Note: Produced by alternative splicing.
Length:1,009
Mass (Da):112,907
Last modified:July 7, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E4057E33C3F19A6
GO
Isoform 2 (identifier: P49916-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     933-1009: VLLDIFTGVR...IRKRRLVAPC → RRPASEQRGRTVPAGRR

Note: Produced by alternative splicing.
Show »
Length:949
Mass (Da):106,018
Checksum:i0C10E40E0686DB77
GO
Isoform 3 (identifier: P49916-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: Produced by alternative initiation of isoform 1.
Show »
Length:922
Mass (Da):102,691
Checksum:iFC3C60F988868808
GO
Isoform 4 (identifier: P49916-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     933-1009: VLLDIFTGVR...IRKRRLVAPC → RRPASEQRGRTVPAGRR

Note: Produced by alternative initiation of isoform 2.
Show »
Length:862
Mass (Da):95,802
Checksum:iF6A3C6B1422FD895
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERZ5K7ERZ5_HUMAN
DNA ligase 3
LIG3
545Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQB6K7EQB6_HUMAN
DNA ligase 3
LIG3
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENR9K7ENR9_HUMAN
DNA ligase 3
LIG3
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELY6K7ELY6_HUMAN
DNA ligase 3
LIG3
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJR4K7EJR4_HUMAN
DNA ligase 3
LIG3
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020196224R → W. Corresponds to variant dbSNP:rs3744356Ensembl.1
Natural variantiVAR_036513717D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs757797167Ensembl.1
Natural variantiVAR_072387768Y → H1 PublicationCorresponds to variant dbSNP:rs200981995Ensembl.1
Natural variantiVAR_018807867R → H1 PublicationCorresponds to variant dbSNP:rs3136025Ensembl.1
Natural variantiVAR_021938898K → T. Corresponds to variant dbSNP:rs4986974Ensembl.1
Natural variantiVAR_020197986P → S. Corresponds to variant dbSNP:rs4986973Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0574641 – 87Missing in isoform 3 and isoform 4. CuratedAdd BLAST87
Alternative sequenceiVSP_001302933 – 1009VLLDI…LVAPC → RRPASEQRGRTVPAGRR in isoform 2 and isoform 4. 1 PublicationCuratedAdd BLAST77

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X84740 mRNA Translation: CAA59230.1
U40671 mRNA Translation: AAA85022.1
HQ204826 Genomic DNA Translation: ADP89974.1
HQ204826 Genomic DNA Translation: ADP89975.1
HQ204827 Genomic DNA Translation: ADP89976.1
HQ204827 Genomic DNA Translation: ADP89977.1
HQ204828 Genomic DNA Translation: ADP89978.1
HQ204828 Genomic DNA Translation: ADP89979.1
HQ204829 Genomic DNA Translation: ADP89980.1
HQ204829 Genomic DNA Translation: ADP89981.1
HQ204830 Genomic DNA Translation: ADP89982.1
HQ204830 Genomic DNA Translation: ADP89983.1
HQ204831 Genomic DNA Translation: ADP89984.1
HQ204831 Genomic DNA Translation: ADP89985.1
HQ204832 Genomic DNA Translation: ADP89986.1
HQ204832 Genomic DNA Translation: ADP89987.1
HQ204833 Genomic DNA Translation: ADP89988.1
HQ204833 Genomic DNA Translation: ADP89989.1
HQ204834 Genomic DNA Translation: ADP89990.1
HQ204834 Genomic DNA Translation: ADP89991.1
HQ204835 Genomic DNA Translation: ADP89992.1
HQ204835 Genomic DNA Translation: ADP89993.1
HQ204836 Genomic DNA Translation: ADP89994.1
HQ204836 Genomic DNA Translation: ADP89995.1
HQ204837 Genomic DNA Translation: ADP89996.1
HQ204837 Genomic DNA Translation: ADP89997.1
HQ204838 Genomic DNA Translation: ADP89998.1
HQ204838 Genomic DNA Translation: ADP89999.1
HQ204839 Genomic DNA Translation: ADP90000.1
HQ204839 Genomic DNA Translation: ADP90001.1
HQ204840 Genomic DNA Translation: ADP90002.1
HQ204840 Genomic DNA Translation: ADP90003.1
HQ204841 Genomic DNA Translation: ADP90004.1
HQ204841 Genomic DNA Translation: ADP90005.1
HQ204842 Genomic DNA Translation: ADP90006.1
HQ204842 Genomic DNA Translation: ADP90007.1
HQ204843 Genomic DNA Translation: ADP90008.1
HQ204843 Genomic DNA Translation: ADP90009.1
HQ204844 Genomic DNA Translation: ADP90010.1
HQ204844 Genomic DNA Translation: ADP90011.1
HQ204845 Genomic DNA Translation: ADP90012.1
HQ204845 Genomic DNA Translation: ADP90013.1
HQ204846 Genomic DNA Translation: ADP90014.1
HQ204846 Genomic DNA Translation: ADP90015.1
HQ204847 Genomic DNA Translation: ADP90016.1
HQ204847 Genomic DNA Translation: ADP90017.1
HQ204848 Genomic DNA Translation: ADP90018.1
HQ204848 Genomic DNA Translation: ADP90019.1
HQ204849 Genomic DNA Translation: ADP90020.1
HQ204849 Genomic DNA Translation: ADP90021.1
HQ204850 Genomic DNA Translation: ADP90022.1
HQ204850 Genomic DNA Translation: ADP90023.1
HQ204851 Genomic DNA Translation: ADP90024.1
HQ204851 Genomic DNA Translation: ADP90025.1
HQ204852 Genomic DNA Translation: ADP90026.1
HQ204852 Genomic DNA Translation: ADP90027.1
HQ204853 Genomic DNA Translation: ADP90028.1
HQ204853 Genomic DNA Translation: ADP90029.1
HQ204854 Genomic DNA Translation: ADP90030.1
HQ204854 Genomic DNA Translation: ADP90031.1
HQ204855 Genomic DNA Translation: ADP90032.1
HQ204855 Genomic DNA Translation: ADP90033.1
HQ204856 Genomic DNA Translation: ADP90034.1
HQ204856 Genomic DNA Translation: ADP90035.1
HQ204857 Genomic DNA Translation: ADP90036.1
HQ204857 Genomic DNA Translation: ADP90037.1
HQ204858 Genomic DNA Translation: ADP90038.1
HQ204858 Genomic DNA Translation: ADP90039.1
HQ204859 Genomic DNA Translation: ADP90040.1
HQ204859 Genomic DNA Translation: ADP90041.1
HQ204860 Genomic DNA Translation: ADP90042.1
HQ204860 Genomic DNA Translation: ADP90043.1
HQ204861 Genomic DNA Translation: ADP90044.1
HQ204861 Genomic DNA Translation: ADP90045.1
HQ204862 Genomic DNA Translation: ADP90046.1
HQ204862 Genomic DNA Translation: ADP90047.1
HQ204863 Genomic DNA Translation: ADP90048.1
HQ204863 Genomic DNA Translation: ADP90049.1
HQ204864 Genomic DNA Translation: ADP90050.1
HQ204864 Genomic DNA Translation: ADP90051.1
HQ204865 Genomic DNA Translation: ADP90052.1
HQ204865 Genomic DNA Translation: ADP90053.1
AF491645 Genomic DNA Translation: AAL91592.1
AC004223 Genomic DNA No translation available.
AC022903 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80197.1
CH471147 Genomic DNA Translation: EAW80199.1
BC068005 mRNA Translation: AAH68005.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11284.2 [P49916-1]
CCDS11285.2 [P49916-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I37292

NCBI Reference Sequences

More...
RefSeqi
NP_002302.2, NM_002311.4 [P49916-2]
NP_039269.2, NM_013975.3 [P49916-1]
XP_016880113.1, XM_017024624.1 [P49916-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262327; ENSP00000262327; ENSG00000005156 [P49916-2]
ENST00000378526; ENSP00000367787; ENSG00000005156 [P49916-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3980

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3980

UCSC genome browser

More...
UCSCi
uc002hij.4 human [P49916-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

DNA ligase entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84740 mRNA Translation: CAA59230.1
U40671 mRNA Translation: AAA85022.1
HQ204826 Genomic DNA Translation: ADP89974.1
HQ204826 Genomic DNA Translation: ADP89975.1
HQ204827 Genomic DNA Translation: ADP89976.1
HQ204827 Genomic DNA Translation: ADP89977.1
HQ204828 Genomic DNA Translation: ADP89978.1
HQ204828 Genomic DNA Translation: ADP89979.1
HQ204829 Genomic DNA Translation: ADP89980.1
HQ204829 Genomic DNA Translation: ADP89981.1
HQ204830 Genomic DNA Translation: ADP89982.1
HQ204830 Genomic DNA Translation: ADP89983.1
HQ204831 Genomic DNA Translation: ADP89984.1
HQ204831 Genomic DNA Translation: ADP89985.1
HQ204832 Genomic DNA Translation: ADP89986.1
HQ204832 Genomic DNA Translation: ADP89987.1
HQ204833 Genomic DNA Translation: ADP89988.1
HQ204833 Genomic DNA Translation: ADP89989.1
HQ204834 Genomic DNA Translation: ADP89990.1
HQ204834 Genomic DNA Translation: ADP89991.1
HQ204835 Genomic DNA Translation: ADP89992.1
HQ204835 Genomic DNA Translation: ADP89993.1
HQ204836 Genomic DNA Translation: ADP89994.1
HQ204836 Genomic DNA Translation: ADP89995.1
HQ204837 Genomic DNA Translation: ADP89996.1
HQ204837 Genomic DNA Translation: ADP89997.1
HQ204838 Genomic DNA Translation: ADP89998.1
HQ204838 Genomic DNA Translation: ADP89999.1
HQ204839 Genomic DNA Translation: ADP90000.1
HQ204839 Genomic DNA Translation: ADP90001.1
HQ204840 Genomic DNA Translation: ADP90002.1
HQ204840 Genomic DNA Translation: ADP90003.1
HQ204841 Genomic DNA Translation: ADP90004.1
HQ204841 Genomic DNA Translation: ADP90005.1
HQ204842 Genomic DNA Translation: ADP90006.1
HQ204842 Genomic DNA Translation: ADP90007.1
HQ204843 Genomic DNA Translation: ADP90008.1
HQ204843 Genomic DNA Translation: ADP90009.1
HQ204844 Genomic DNA Translation: ADP90010.1
HQ204844 Genomic DNA Translation: ADP90011.1
HQ204845 Genomic DNA Translation: ADP90012.1
HQ204845 Genomic DNA Translation: ADP90013.1
HQ204846 Genomic DNA Translation: ADP90014.1
HQ204846 Genomic DNA Translation: ADP90015.1
HQ204847 Genomic DNA Translation: ADP90016.1
HQ204847 Genomic DNA Translation: ADP90017.1
HQ204848 Genomic DNA Translation: ADP90018.1
HQ204848 Genomic DNA Translation: ADP90019.1
HQ204849 Genomic DNA Translation: ADP90020.1
HQ204849 Genomic DNA Translation: ADP90021.1
HQ204850 Genomic DNA Translation: ADP90022.1
HQ204850 Genomic DNA Translation: ADP90023.1
HQ204851 Genomic DNA Translation: ADP90024.1
HQ204851 Genomic DNA Translation: ADP90025.1
HQ204852 Genomic DNA Translation: ADP90026.1
HQ204852 Genomic DNA Translation: ADP90027.1
HQ204853 Genomic DNA Translation: ADP90028.1
HQ204853 Genomic DNA Translation: ADP90029.1
HQ204854 Genomic DNA Translation: ADP90030.1
HQ204854 Genomic DNA Translation: ADP90031.1
HQ204855 Genomic DNA Translation: ADP90032.1
HQ204855 Genomic DNA Translation: ADP90033.1
HQ204856 Genomic DNA Translation: ADP90034.1
HQ204856 Genomic DNA Translation: ADP90035.1
HQ204857 Genomic DNA Translation: ADP90036.1
HQ204857 Genomic DNA Translation: ADP90037.1
HQ204858 Genomic DNA Translation: ADP90038.1
HQ204858 Genomic DNA Translation: ADP90039.1
HQ204859 Genomic DNA Translation: ADP90040.1
HQ204859 Genomic DNA Translation: ADP90041.1
HQ204860 Genomic DNA Translation: ADP90042.1
HQ204860 Genomic DNA Translation: ADP90043.1
HQ204861 Genomic DNA Translation: ADP90044.1
HQ204861 Genomic DNA Translation: ADP90045.1
HQ204862 Genomic DNA Translation: ADP90046.1
HQ204862 Genomic DNA Translation: ADP90047.1
HQ204863 Genomic DNA Translation: ADP90048.1
HQ204863 Genomic DNA Translation: ADP90049.1
HQ204864 Genomic DNA Translation: ADP90050.1
HQ204864 Genomic DNA Translation: ADP90051.1
HQ204865 Genomic DNA Translation: ADP90052.1
HQ204865 Genomic DNA Translation: ADP90053.1
AF491645 Genomic DNA Translation: AAL91592.1
AC004223 Genomic DNA No translation available.
AC022903 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80197.1
CH471147 Genomic DNA Translation: EAW80199.1
BC068005 mRNA Translation: AAH68005.1
CCDSiCCDS11284.2 [P49916-1]
CCDS11285.2 [P49916-2]
PIRiI37292
RefSeqiNP_002302.2, NM_002311.4 [P49916-2]
NP_039269.2, NM_013975.3 [P49916-1]
XP_016880113.1, XM_017024624.1 [P49916-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IMONMR-A924-1009[»]
1IN1NMR-A924-1009[»]
1UW0NMR-A88-204[»]
3L2PX-ray3.00A257-833[»]
3PC7X-ray1.65A/B924-1009[»]
3PC8X-ray2.31C/D924-1008[»]
3QVGX-ray2.26A/C924-1008[»]
SMRiP49916
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110168, 77 interactors
CORUMiP49916
IntActiP49916, 39 interactors
MINTiP49916
STRINGi9606.ENSP00000367787

Chemistry databases

DrugBankiDB00290 Bleomycin

PTM databases

iPTMnetiP49916
PhosphoSitePlusiP49916

Polymorphism and mutation databases

BioMutaiLIG3
DMDMi251757259

Proteomic databases

EPDiP49916
jPOSTiP49916
MaxQBiP49916
PaxDbiP49916
PeptideAtlasiP49916
PRIDEiP49916
ProteomicsDBi56181
56182 [P49916-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3980
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262327; ENSP00000262327; ENSG00000005156 [P49916-2]
ENST00000378526; ENSP00000367787; ENSG00000005156 [P49916-1]
GeneIDi3980
KEGGihsa:3980
UCSCiuc002hij.4 human [P49916-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3980
DisGeNETi3980

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LIG3
HGNCiHGNC:6600 LIG3
HPAiHPA006723
MIMi600940 gene
neXtProtiNX_P49916
OpenTargetsiENSG00000005156
PharmGKBiPA30374

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00940000156492
HOGENOMiHOG000007653
InParanoidiP49916
KOiK10776
OMAiMPVWEIT
OrthoDBi274264at2759
PhylomeDBiP49916
TreeFamiTF316220

Enzyme and pathway databases

BRENDAi6.5.1.1 2681
ReactomeiR-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
SIGNORiP49916

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LIG3 human
EvolutionaryTraceiP49916

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LIG3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3980

Protein Ontology

More...
PROi
PR:P49916

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000005156 Expressed in 207 organ(s), highest expression level in brain
ExpressionAtlasiP49916 baseline and differential
GenevisibleiP49916 HS

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNLI3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49916
Secondary accession number(s): E5KLB5
, E5KLB6, Q16714, Q6NVK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: May 8, 2019
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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