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Protein

Cathelicidin antimicrobial peptide

Gene

CAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.2 Publications

Caution

PubMed:11238224 sequence was incorrectly assigned to originate from M.mulatta.Curated

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antifungal humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • chronic inflammatory response Source: UniProtKB
  • cytolysis by host of symbiont cells Source: UniProtKB
  • defense response to bacterium Source: MGI
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
  • killing by host of symbiont cells Source: MGI
  • modification of morphology or physiology of other organism Source: UniProtKB
  • negative regulation of growth of symbiont on or near host surface Source: MGI
  • neutrophil degranulation Source: Reactome
  • positive regulation of interleukin-8 secretion Source: UniProtKB
  • response to yeast Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides
SIGNORiP49913

Protein family/group databases

TCDBi1.C.33.1.10 the cathelicidin (cathelicidin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin antimicrobial peptideImported
Alternative name(s):
18 kDa cationic antimicrobial protein1 Publication
Short name:
CAP-181 Publication
Short name:
hCAP-181 Publication
Cleaved into the following 2 chains:
Antibacterial peptide FALL-391 Publication
Alternative name(s):
FALL-39 peptide antibiotic1 Publication
Antibacterial peptide LL-371 Publication
Gene namesi
Name:CAMPImported
Synonyms:CAP181 Publication, FALL391 Publication
ORF Names:HSD26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:1472 CAMP
MIMi600474 gene
neXtProtiNX_P49913

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi820
PharmGKBiPA26054

Chemistry databases

DrugBankiDB02345 Selenocysteine

Polymorphism and mutation databases

BioMutaiCAMP
DMDMi1706745

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000000472231 – 1311 PublicationAdd BLAST101
PeptideiPRO_0000004723132 – 170Antibacterial peptide FALL-391 PublicationAdd BLAST39
PeptideiPRO_0000004724134 – 170Antibacterial peptide LL-371 PublicationAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi86 ↔ 97By similarity
Disulfide bondi108 ↔ 125By similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP49913
PeptideAtlasiP49913
PRIDEiP49913
ProteomicsDBi56178

PTM databases

iPTMnetiP49913
PhosphoSitePlusiP49913

Miscellaneous databases

PMAP-CutDBiP49913

Expressioni

Tissue specificityi

Expressed in bone marrow and testis and neutrophils.

Gene expression databases

CleanExiHS_CAMP

Organism-specific databases

HPAiHPA029874

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IGF1RP080693EBI-6378485,EBI-475981

Protein-protein interaction databases

BioGridi107270, 2 interactors
IntActiP49913, 2 interactors
STRINGi9606.ENSP00000458149

Structurei

Secondary structure

1170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 49Combined sources15
Beta strandi53 – 61Combined sources9
Beta strandi75 – 87Combined sources13
Helixi94 – 96Combined sources3
Beta strandi105 – 112Combined sources8
Beta strandi122 – 126Combined sources5
Helixi135 – 163Combined sources29

3D structure databases

DisProtiDP00004
ProteinModelPortaliP49913
SMRiP49913
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49913

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R Eukaryota
ENOG41119S0 LUCA
HOGENOMiHOG000093184
HOVERGENiHBG006116
InParanoidiP49913
KOiK13916
PhylomeDBiP49913
TreeFamiTF338457

Family and domain databases

InterProiView protein in InterPro
IPR001894 Cathelicidin
IPR018216 Cathelicidin_CS
IPR022746 Cathlecidin_C
PANTHERiPTHR10206 PTHR10206, 1 hit
PfamiView protein in Pfam
PF12153 CAP18_C, 1 hit
PROSITEiView protein in PROSITE
PS00946 CATHELICIDINS_1, 1 hit
PS00947 CATHELICIDINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQRDGHSL GRWSLVLLLL GLVMPLAIIA QVLSYKEAVL RAIDGINQRS
60 70 80 90 100
SDANLYRLLD LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK
110 120 130 140 150
KDGLVKRCMG TVTLNQARGS FDISCDKDNK RFALLGDFFR KSKEKIGKEF
160 170
KRIVQRIKDF LRNLVPRTES
Length:170
Mass (Da):19,301
Last modified:October 1, 1996 - v1
Checksum:i055B07DCA95A7D16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6D → N (PubMed:7529412).Curated1
Sequence conflicti6D → N (Ref. 6) Curated1
Sequence conflicti6D → N (Ref. 7) Curated1
Sequence conflicti6D → N in CAG46759 (Ref. 9) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38026 mRNA Translation: CAA86115.1
X89658 mRNA Translation: CAA61805.1
U19970 mRNA Translation: AAA74084.1
U48795 Genomic DNA Translation: AAC02634.1
X96735 Genomic DNA No translation available.
AY162210 mRNA Translation: AAN78318.1
AY251531 mRNA Translation: AAP20054.1
AF288284 mRNA Translation: AAG40802.1
CR457083 mRNA Translation: CAG33364.1
CR541961 mRNA Translation: CAG46759.1
BC055089 mRNA Translation: AAH55089.1
PIRiI38932
S74248
RefSeqiNP_004336.3, NM_004345.4
UniGeneiHs.51120

Genome annotation databases

EnsembliENST00000576243; ENSP00000458149; ENSG00000164047
GeneIDi820
KEGGihsa:820

Similar proteinsi

Entry informationi

Entry nameiCAMP_HUMAN
AccessioniPrimary (citable) accession number: P49913
Secondary accession number(s): Q71SN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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