UniProtKB - P49910 (ZN165_HUMAN)
Protein
Zinc finger protein 165
Gene
ZNF165
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 290 – 314 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 344 – 366 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P49910 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 165Alternative name(s): Cancer/testis antigen 53 Short name: CT53 LD65 Zinc finger and SCAN domain-containing protein 7 |
Gene namesi | Name:ZNF165 Synonyms:ZPF165, ZSCAN7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12953, ZNF165 |
MIMi | 600834, gene |
neXtProti | NX_P49910 |
VEuPathDBi | HostDB:ENSG00000197279.3 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7718 |
OpenTargetsi | ENSG00000197279 |
PharmGKBi | PA37535 |
Miscellaneous databases
Pharosi | P49910, Tbio |
Genetic variation databases
BioMutai | ZNF165 |
DMDMi | 1731420 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047436 | 1 – 485 | Zinc finger protein 165Add BLAST | 485 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 23 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 162 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 195 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | P49910 |
MassIVEi | P49910 |
PaxDbi | P49910 |
PeptideAtlasi | P49910 |
PRIDEi | P49910 |
ProteomicsDBi | 56177 |
PTM databases
iPTMneti | P49910 |
PhosphoSitePlusi | P49910 |
Expressioni
Tissue specificityi
Expressed specifically in testis.
Gene expression databases
Bgeei | ENSG00000197279, Expressed in epithelium of mammary gland and 154 other tissues |
ExpressionAtlasi | P49910, baseline and differential |
Genevisiblei | P49910, HS |
Organism-specific databases
HPAi | ENSG00000197279, Tissue enhanced (testis) |
Interactioni
Binary interactionsi
Hide detailsP49910
Protein-protein interaction databases
BioGRIDi | 113511, 48 interactors |
IntActi | P49910, 42 interactors |
MINTi | P49910 |
STRINGi | 9606.ENSP00000366542 |
Miscellaneous databases
RNActi | P49910, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 127 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 290 – 314 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 344 – 366 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163388 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | P49910 |
OMAi | VKRQWEK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P49910 |
TreeFami | TF338304 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
i Sequence
Sequence statusi: Complete.
P49910-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ
60 70 80 90 100
LFRQFCYQDS PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI
110 120 130 140 150
LPGDLQAWVH EHYPESGEEA VTILEDLERG TDEAVLQVQA HEHGQEIFQK
160 170 180 190 200
KVSPPGPALN VKLQPVETKA HFDSSEPQLL WDCDNESENS RSMPKLEIFE
210 220 230 240 250
KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE SGESQRLSSA
260 270 280 290 300
QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS
310 320 330 340 350
FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG
360 370 380 390 400
KAFRHSSKLA RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF
410 420 430 440 450
GCKECGRAFN LNSHLIRHQR IHTREKPYEC SECGKTFRVS SHLIRHFRIH
460 470 480
TGEKPYECSE CGRAFSQSSN LSQHQRIHMR ENLLM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84801 mRNA Translation: CAA59268.1 U78722 mRNA Translation: AAC51658.1 U88086, U88084, U88085 Genomic DNA Translation: AAD04755.1 AL121944 Genomic DNA No translation available. BC026092 mRNA Translation: AAH26092.1 |
CCDSi | CCDS4643.1 |
PIRi | S52411 |
RefSeqi | NP_003438.1, NM_003447.3 XP_016866747.1, XM_017011258.1 XP_016866748.1, XM_017011259.1 XP_016866749.1, XM_017011260.1 |
Genome annotation databases
Ensembli | ENST00000377325; ENSP00000366542; ENSG00000197279 |
GeneIDi | 7718 |
KEGGi | hsa:7718 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84801 mRNA Translation: CAA59268.1 U78722 mRNA Translation: AAC51658.1 U88086, U88084, U88085 Genomic DNA Translation: AAD04755.1 AL121944 Genomic DNA No translation available. BC026092 mRNA Translation: AAH26092.1 |
CCDSi | CCDS4643.1 |
PIRi | S52411 |
RefSeqi | NP_003438.1, NM_003447.3 XP_016866747.1, XM_017011258.1 XP_016866748.1, XM_017011259.1 XP_016866749.1, XM_017011260.1 |
3D structure databases
SMRi | P49910 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113511, 48 interactors |
IntActi | P49910, 42 interactors |
MINTi | P49910 |
STRINGi | 9606.ENSP00000366542 |
PTM databases
iPTMneti | P49910 |
PhosphoSitePlusi | P49910 |
Genetic variation databases
BioMutai | ZNF165 |
DMDMi | 1731420 |
Proteomic databases
jPOSTi | P49910 |
MassIVEi | P49910 |
PaxDbi | P49910 |
PeptideAtlasi | P49910 |
PRIDEi | P49910 |
ProteomicsDBi | 56177 |
Protocols and materials databases
ABCDi | P49910, 9 sequenced antibodies |
Antibodypediai | 25827, 196 antibodies |
DNASUi | 7718 |
Genome annotation databases
Ensembli | ENST00000377325; ENSP00000366542; ENSG00000197279 |
GeneIDi | 7718 |
KEGGi | hsa:7718 |
Organism-specific databases
CTDi | 7718 |
DisGeNETi | 7718 |
GeneCardsi | ZNF165 |
HGNCi | HGNC:12953, ZNF165 |
HPAi | ENSG00000197279, Tissue enhanced (testis) |
MIMi | 600834, gene |
neXtProti | NX_P49910 |
OpenTargetsi | ENSG00000197279 |
PharmGKBi | PA37535 |
VEuPathDBi | HostDB:ENSG00000197279.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163388 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | P49910 |
OMAi | VKRQWEK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P49910 |
TreeFami | TF338304 |
Enzyme and pathway databases
PathwayCommonsi | P49910 |
Miscellaneous databases
BioGRID-ORCSi | 7718, 6 hits in 1012 CRISPR screens |
ChiTaRSi | ZNF165, human |
GeneWikii | Zinc_finger_protein_165 |
GenomeRNAii | 7718 |
Pharosi | P49910, Tbio |
PROi | PR:P49910 |
RNActi | P49910, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197279, Expressed in epithelium of mammary gland and 154 other tissues |
ExpressionAtlasi | P49910, baseline and differential |
Genevisiblei | P49910, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN165_HUMAN | |
Accessioni | P49910Primary (citable) accession number: P49910 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families