SMCP

Functionⁱ

Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).By similarity

Caution

Was originally thought to be a selenoprotein and was known as sperm mitochondrial capsule selenoprotein.1 Publication

GO - Biological processⁱ

flagellated sperm motility Source: UniProtKB
penetration of zona pellucida Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Fertilization

Biological process

Fertilization

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sperm mitochondrial-associated cysteine-rich protein
Gene namesⁱ	Name:SMCP Synonyms:MCS, MCSP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163206.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6962 SMCP
MIMⁱ	601148 gene
neXtProtⁱ	NX_P49901

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4184
Open Targets More...OpenTargetsⁱ	ENSG00000163206
PharmGKBⁱ	PA30710

Polymorphism and mutation databases

BioMutaⁱ	SMCP

BioMutaⁱ

SMCP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096307	1 – 116	Sperm mitochondrial-associated cysteine-rich proteinAdd BLAST		116

Proteomic databases

PaxDbⁱ	P49901
PeptideAtlas More...PeptideAtlasⁱ	P49901
PRIDEⁱ	P49901
ProteomicsDBⁱ	56173

PTM databases

PhosphoSitePlusⁱ	P49901

PhosphoSitePlusⁱ

P49901

Expressionⁱ

Tissue specificityⁱ

Testis. Is selectively expressed in the spermatids of seminiferous tubules.1 Publication

Developmental stageⁱ

Expressed in postmeiotic cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163206 Expressed in 73 organ(s), highest expression level in right testis
CleanExⁱ	HS_SMCP
ExpressionAtlasⁱ	P49901 baseline and differential
Genevisibleⁱ	P49901 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035105

HPAⁱ

HPA035105

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CALCOCO2	Q13137	3	EBI-750494,EBI-739580
CYSRT1	A8MQ03	4	EBI-750494,EBI-3867333
DYNLL1	P63167	4	EBI-750494,EBI-349105
GOLGA2	Q08379	3	EBI-750494,EBI-618309
KRT31	Q15323	5	EBI-750494,EBI-948001
KRTAP10-5	P60370	3	EBI-750494,EBI-10172150
KRTAP10-7	P60409	3	EBI-750494,EBI-10172290
KRTAP10-8	P60410	7	EBI-750494,EBI-10171774
KRTAP10-9	P60411	7	EBI-750494,EBI-10172052
KRTAP4-11	Q9BYQ6	5	EBI-750494,EBI-10302392
KRTAP4-12	Q9BQ66	9	EBI-750494,EBI-739863
KRTAP4-4	Q9BYR3	4	EBI-750494,EBI-11958132
KRTAP4-7	Q9BYR0	3	EBI-750494,EBI-10302547
KRTAP5-2	Q701N4	4	EBI-750494,EBI-11958178
KRTAP5-6	Q6L8G9	5	EBI-750494,EBI-10250562
KRTAP5-9	P26371	9	EBI-750494,EBI-3958099
KRTAP9-2	Q9BYQ4	7	EBI-750494,EBI-1044640
KRTAP9-3	Q9BYQ3	4	EBI-750494,EBI-1043191
KRTAP9-4	Q9BYQ2	3	EBI-750494,EBI-10185730
KRTAP9-8	Q9BYQ0	4	EBI-750494,EBI-11958364
LCE4A	Q5TA78	5	EBI-750494,EBI-10246358
NOTCH2NL	Q7Z3S9	5	EBI-750494,EBI-945833
RGS17	Q9UGC6	3	EBI-750494,EBI-3918154
TCF4	P15884	3	EBI-750494,EBI-533224

Protein-protein interaction databases

BioGridⁱ	110350, 20 interactors
IntActⁱ	P49901, 69 interactors
STRINGⁱ	9606.ENSP00000357754

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P49901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	6 – 13	1	8
Repeatⁱ	14 – 21	2	8
Repeatⁱ	30 – 37	3	8
Repeatⁱ	38 – 45	4	8
Repeatⁱ	46 – 53	5	8
Repeatⁱ	54 – 61	6	8
Repeatⁱ	62 – 68	7	7

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	6 – 68	7 X 7 (OR 8) AA approximate repeatsAdd BLAST		63

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410KI9M Eukaryota ENOG4110QG7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039991
HOGENOMⁱ	HOG000113504
HOVERGENⁱ	HBG057842
InParanoidⁱ	P49901
OMAⁱ	GNQCCPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G12JZ
PhylomeDBⁱ	P49901

Family and domain databases

InterProⁱ	View protein in InterPro IPR039347 SMCP IPR039364 SMCP_C-term
PANTHERⁱ	PTHR35820 PTHR35820, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD026527 PD026527, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P49901-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC 
        60         70         80         90        100
CPPKHNHCCQ PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ 
       110 
TQQQPHSPQN ESRPSK

Length:116

Mass (Da):12,767

Last modified:January 31, 2002 - v2

Checksum:ⁱ242191C60AEE03B2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	63	P → A in CAA62000 (PubMed:8833144).Curated		1
Sequence conflictⁱ	63	P → A in CAD56487 (PubMed:8833144).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X89960 mRNA Translation: CAA62000.1 X89961 Genomic DNA Translation: CAD56487.1 BC014593 mRNA Translation: AAH14593.1 BC016744 mRNA Translation: AAH16744.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1029.1
NCBI Reference Sequences More...RefSeqⁱ	NP_109588.2, NM_030663.2
UniGeneⁱ	Hs.111850

Genome annotation databases

Ensemblⁱ	ENST00000368765; ENSP00000357754; ENSG00000163206
GeneIDⁱ	4184
KEGGⁱ	hsa:4184

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49901	Sperm mitochondria-associated cysteine-rich protein		HUMAN		116	UniRef100_P49901

Protein	Similar proteins		Species	Score	Length	Source
P49901	Sperm mitochondria-associated cysteine-rich protein		HUMAN		116	UniRef90_P49901
SMCP isoform 1		PANTR		116
Uncharacterized protein		PANPA		116
UPI0001FA2D35		GORGO		116
UPI00020AB14B		NOMLE		116

Protein	Similar proteins		Species	Score	Length	Source
P49901	Sperm mitochondria-associated cysteine-rich protein		HUMAN		116	UniRef50_P49901
SMCP isoform 1		PANTR		116
Uncharacterized protein		PANPA		116
Sperm mitochondria associated cysteine rich protein		CALJA		122
Uncharacterized protein		FELCA		111
+33

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X89960 mRNA Translation: CAA62000.1 X89961 Genomic DNA Translation: CAD56487.1 BC014593 mRNA Translation: AAH14593.1 BC016744 mRNA Translation: AAH16744.1
CCDSⁱ	CCDS1029.1
RefSeqⁱ	NP_109588.2, NM_030663.2
UniGeneⁱ	Hs.111850

3D structure databases

ProteinModelPortalⁱ	P49901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110350, 20 interactors
IntActⁱ	P49901, 69 interactors
STRINGⁱ	9606.ENSP00000357754

PTM databases

PhosphoSitePlusⁱ	P49901

PhosphoSitePlusⁱ

P49901

Polymorphism and mutation databases

BioMutaⁱ	SMCP

BioMutaⁱ

SMCP

Proteomic databases

PaxDbⁱ	P49901
PeptideAtlasⁱ	P49901
PRIDEⁱ	P49901
ProteomicsDBⁱ	56173

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4184
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368765; ENSP00000357754; ENSG00000163206
GeneIDⁱ	4184
KEGGⁱ	hsa:4184

Organism-specific databases

CTDⁱ	4184
DisGeNETⁱ	4184
EuPathDBⁱ	HostDB:ENSG00000163206.5
GeneCardsⁱ	SMCP
HGNCⁱ	HGNC:6962 SMCP
HPAⁱ	HPA035105
MIMⁱ	601148 gene
neXtProtⁱ	NX_P49901
OpenTargetsⁱ	ENSG00000163206
PharmGKBⁱ	PA30710
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KI9M Eukaryota ENOG4110QG7 LUCA
GeneTreeⁱ	ENSGT00440000039991
HOGENOMⁱ	HOG000113504
HOVERGENⁱ	HBG057842
InParanoidⁱ	P49901
OMAⁱ	GNQCCPP
OrthoDBⁱ	EOG091G12JZ
PhylomeDBⁱ	P49901

Miscellaneous databases

ChiTaRSⁱ	SMCP human
GeneWikiⁱ	SMCP
GenomeRNAiⁱ	4184
Protein Ontology More...PROⁱ	PR:P49901
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163206 Expressed in 73 organ(s), highest expression level in right testis
CleanExⁱ	HS_SMCP
ExpressionAtlasⁱ	P49901 baseline and differential
Genevisibleⁱ	P49901 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039347 SMCP IPR039364 SMCP_C-term
PANTHERⁱ	PTHR35820 PTHR35820, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD026527 PD026527, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MCSP_HUMAN
Accessionⁱ	P49901Primary (citable) accession number: P49901 Secondary accession number(s): Q96A42
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	January 31, 2002
	Last modified:	September 12, 2018
	This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P49901 (MCSP_HUMAN)

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Sperm mitochondrial-associated cysteine-rich protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Other locations

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ