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UniProtKB - P49901 (MCSP_HUMAN)
Protein
Sperm mitochondrial-associated cysteine-rich protein
Gene
SMCP
Organism
Homo sapiens (Human)
Status
Functioni
Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).
By similarityCaution
Was originally thought to be a selenoprotein and was known as sperm mitochondrial capsule selenoprotein.1 Publication
GO - Biological processi
- flagellated sperm motility Source: UniProtKB
- penetration of zona pellucida Source: UniProtKB
Keywordsi
Biological process | Fertilization |
Enzyme and pathway databases
PathwayCommonsi | P49901 |
SignaLinki | P49901 |
Names & Taxonomyi
Protein namesi | Recommended name: Sperm mitochondrial-associated cysteine-rich protein |
Gene namesi | Name:SMCP Synonyms:MCS, MCSP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6962, SMCP |
MIMi | 601148, gene |
neXtProti | NX_P49901 |
VEuPathDBi | HostDB:ENSG00000163206 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
Cytoplasm and Cytosol
Note: Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis.By similarity
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 4184 |
OpenTargetsi | ENSG00000163206 |
PharmGKBi | PA30710 |
Miscellaneous databases
Pharosi | P49901, Tbio |
Genetic variation databases
BioMutai | SMCP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096307 | 1 – 116 | Sperm mitochondrial-associated cysteine-rich proteinAdd BLAST | 116 |
Proteomic databases
MassIVEi | P49901 |
PaxDbi | P49901 |
PeptideAtlasi | P49901 |
PRIDEi | P49901 |
ProteomicsDBi | 56173 |
PTM databases
PhosphoSitePlusi | P49901 |
Expressioni
Tissue specificityi
Testis. Is selectively expressed in the spermatids of seminiferous tubules.1 Publication
Developmental stagei
Expressed in postmeiotic cells.1 Publication
Gene expression databases
Bgeei | ENSG00000163206, Expressed in right testis and 99 other tissues |
ExpressionAtlasi | P49901, baseline and differential |
Genevisiblei | P49901, HS |
Organism-specific databases
HPAi | ENSG00000163206, Tissue enriched (testis) |
Interactioni
Binary interactionsi
P49901
Protein-protein interaction databases
BioGRIDi | 110350, 75 interactors |
IntActi | P49901, 69 interactors |
STRINGi | 9606.ENSP00000357754 |
Miscellaneous databases
RNActi | P49901, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 13 | 1 | 8 | |
Repeati | 14 – 21 | 2 | 8 | |
Repeati | 30 – 37 | 3 | 8 | |
Repeati | 38 – 45 | 4 | 8 | |
Repeati | 46 – 53 | 5 | 8 | |
Repeati | 54 – 61 | 6 | 8 | |
Repeati | 62 – 68 | 7 | 7 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 6 – 68 | 7 X 7 (OR 8) AA approximate repeatsAdd BLAST | 63 | |
Regioni | 80 – 116 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 83 – 116 | Polar residuesSequence analysisAdd BLAST | 34 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502TDSM, Eukaryota |
GeneTreei | ENSGT00440000039991 |
HOGENOMi | CLU_169086_0_0_1 |
InParanoidi | P49901 |
OMAi | CCPSKCN |
OrthoDBi | 1548594at2759 |
PhylomeDBi | P49901 |
Family and domain databases
InterProi | View protein in InterPro IPR039347, SMCP |
PANTHERi | PTHR35820, PTHR35820, 1 hit |
i Sequence
Sequence statusi: Complete.
P49901-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC
60 70 80 90 100
CPPKHNHCCQ PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ
110
TQQQPHSPQN ESRPSK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | P → A in CAA62000 (PubMed:8833144).Curated | 1 | |
Sequence conflicti | 63 | P → A in CAD56487 (PubMed:8833144).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89960 mRNA Translation: CAA62000.1 X89961 Genomic DNA Translation: CAD56487.1 BC014593 mRNA Translation: AAH14593.1 BC016744 mRNA Translation: AAH16744.1 |
CCDSi | CCDS1029.1 |
RefSeqi | NP_109588.2, NM_030663.2 |
Genome annotation databases
Ensembli | ENST00000368765; ENSP00000357754; ENSG00000163206 |
GeneIDi | 4184 |
KEGGi | hsa:4184 |
MANE-Selecti | ENST00000368765.4; ENSP00000357754.3; NM_030663.3; NP_109588.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89960 mRNA Translation: CAA62000.1 X89961 Genomic DNA Translation: CAD56487.1 BC014593 mRNA Translation: AAH14593.1 BC016744 mRNA Translation: AAH16744.1 |
CCDSi | CCDS1029.1 |
RefSeqi | NP_109588.2, NM_030663.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110350, 75 interactors |
IntActi | P49901, 69 interactors |
STRINGi | 9606.ENSP00000357754 |
PTM databases
PhosphoSitePlusi | P49901 |
Genetic variation databases
BioMutai | SMCP |
Proteomic databases
MassIVEi | P49901 |
PaxDbi | P49901 |
PeptideAtlasi | P49901 |
PRIDEi | P49901 |
ProteomicsDBi | 56173 |
Protocols and materials databases
Antibodypediai | 34107, 209 antibodies from 21 providers |
DNASUi | 4184 |
Genome annotation databases
Ensembli | ENST00000368765; ENSP00000357754; ENSG00000163206 |
GeneIDi | 4184 |
KEGGi | hsa:4184 |
MANE-Selecti | ENST00000368765.4; ENSP00000357754.3; NM_030663.3; NP_109588.2 |
Organism-specific databases
CTDi | 4184 |
DisGeNETi | 4184 |
GeneCardsi | SMCP |
HGNCi | HGNC:6962, SMCP |
HPAi | ENSG00000163206, Tissue enriched (testis) |
MIMi | 601148, gene |
neXtProti | NX_P49901 |
OpenTargetsi | ENSG00000163206 |
PharmGKBi | PA30710 |
VEuPathDBi | HostDB:ENSG00000163206 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDSM, Eukaryota |
GeneTreei | ENSGT00440000039991 |
HOGENOMi | CLU_169086_0_0_1 |
InParanoidi | P49901 |
OMAi | CCPSKCN |
OrthoDBi | 1548594at2759 |
PhylomeDBi | P49901 |
Enzyme and pathway databases
PathwayCommonsi | P49901 |
SignaLinki | P49901 |
Miscellaneous databases
BioGRID-ORCSi | 4184, 6 hits in 1037 CRISPR screens |
ChiTaRSi | SMCP, human |
GeneWikii | SMCP |
GenomeRNAii | 4184 |
Pharosi | P49901, Tbio |
PROi | PR:P49901 |
RNActi | P49901, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163206, Expressed in right testis and 99 other tissues |
ExpressionAtlasi | P49901, baseline and differential |
Genevisiblei | P49901, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039347, SMCP |
PANTHERi | PTHR35820, PTHR35820, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MCSP_HUMAN | |
Accessioni | P49901Primary (citable) accession number: P49901 Secondary accession number(s): Q96A42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 31, 2002 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot