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Protein

Sperm mitochondrial-associated cysteine-rich protein

Gene

SMCP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).By similarity

Caution

Was originally thought to be a selenoprotein and was known as sperm mitochondrial capsule selenoprotein.1 Publication

GO - Biological processi

Keywordsi

Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm mitochondrial-associated cysteine-rich protein
Gene namesi
Name:SMCP
Synonyms:MCS, MCSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163206.5
HGNCiHGNC:6962 SMCP
MIMi601148 gene
neXtProtiNX_P49901

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi4184
OpenTargetsiENSG00000163206
PharmGKBiPA30710

Polymorphism and mutation databases

BioMutaiSMCP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963071 – 116Sperm mitochondrial-associated cysteine-rich proteinAdd BLAST116

Proteomic databases

PaxDbiP49901
PeptideAtlasiP49901
PRIDEiP49901
ProteomicsDBi56173

PTM databases

PhosphoSitePlusiP49901

Expressioni

Tissue specificityi

Testis. Is selectively expressed in the spermatids of seminiferous tubules.1 Publication

Developmental stagei

Expressed in postmeiotic cells.1 Publication

Gene expression databases

BgeeiENSG00000163206 Expressed in 73 organ(s), highest expression level in right testis
CleanExiHS_SMCP
ExpressionAtlasiP49901 baseline and differential
GenevisibleiP49901 HS

Organism-specific databases

HPAiHPA035105

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110350, 20 interactors
IntActiP49901, 69 interactors
STRINGi9606.ENSP00000357754

Structurei

3D structure databases

ProteinModelPortaliP49901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 1318
Repeati14 – 2128
Repeati30 – 3738
Repeati38 – 4548
Repeati46 – 5358
Repeati54 – 6168
Repeati62 – 6877

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 687 X 7 (OR 8) AA approximate repeatsAdd BLAST63

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KI9M Eukaryota
ENOG4110QG7 LUCA
GeneTreeiENSGT00440000039991
HOGENOMiHOG000113504
HOVERGENiHBG057842
InParanoidiP49901
OMAiGNQCCPP
OrthoDBiEOG091G12JZ
PhylomeDBiP49901

Family and domain databases

InterProiView protein in InterPro
IPR039347 SMCP
IPR039364 SMCP_C-term
PANTHERiPTHR35820 PTHR35820, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026527 PD026527, 1 hit

Sequencei

Sequence statusi: Complete.

P49901-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC
60 70 80 90 100
CPPKHNHCCQ PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ
110
TQQQPHSPQN ESRPSK
Length:116
Mass (Da):12,767
Last modified:January 31, 2002 - v2
Checksum:i242191C60AEE03B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63P → A in CAA62000 (PubMed:8833144).Curated1
Sequence conflicti63P → A in CAD56487 (PubMed:8833144).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89960 mRNA Translation: CAA62000.1
X89961 Genomic DNA Translation: CAD56487.1
BC014593 mRNA Translation: AAH14593.1
BC016744 mRNA Translation: AAH16744.1
CCDSiCCDS1029.1
RefSeqiNP_109588.2, NM_030663.2
UniGeneiHs.111850

Genome annotation databases

EnsembliENST00000368765; ENSP00000357754; ENSG00000163206
GeneIDi4184
KEGGihsa:4184

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89960 mRNA Translation: CAA62000.1
X89961 Genomic DNA Translation: CAD56487.1
BC014593 mRNA Translation: AAH14593.1
BC016744 mRNA Translation: AAH16744.1
CCDSiCCDS1029.1
RefSeqiNP_109588.2, NM_030663.2
UniGeneiHs.111850

3D structure databases

ProteinModelPortaliP49901
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110350, 20 interactors
IntActiP49901, 69 interactors
STRINGi9606.ENSP00000357754

PTM databases

PhosphoSitePlusiP49901

Polymorphism and mutation databases

BioMutaiSMCP

Proteomic databases

PaxDbiP49901
PeptideAtlasiP49901
PRIDEiP49901
ProteomicsDBi56173

Protocols and materials databases

DNASUi4184
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368765; ENSP00000357754; ENSG00000163206
GeneIDi4184
KEGGihsa:4184

Organism-specific databases

CTDi4184
DisGeNETi4184
EuPathDBiHostDB:ENSG00000163206.5
GeneCardsiSMCP
HGNCiHGNC:6962 SMCP
HPAiHPA035105
MIMi601148 gene
neXtProtiNX_P49901
OpenTargetsiENSG00000163206
PharmGKBiPA30710
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KI9M Eukaryota
ENOG4110QG7 LUCA
GeneTreeiENSGT00440000039991
HOGENOMiHOG000113504
HOVERGENiHBG057842
InParanoidiP49901
OMAiGNQCCPP
OrthoDBiEOG091G12JZ
PhylomeDBiP49901

Miscellaneous databases

ChiTaRSiSMCP human
GeneWikiiSMCP
GenomeRNAii4184
PROiPR:P49901
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163206 Expressed in 73 organ(s), highest expression level in right testis
CleanExiHS_SMCP
ExpressionAtlasiP49901 baseline and differential
GenevisibleiP49901 HS

Family and domain databases

InterProiView protein in InterPro
IPR039347 SMCP
IPR039364 SMCP_C-term
PANTHERiPTHR35820 PTHR35820, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026527 PD026527, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMCSP_HUMAN
AccessioniPrimary (citable) accession number: P49901
Secondary accession number(s): Q96A42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 31, 2002
Last modified: September 12, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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