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Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-417973 Adenosine P1 receptors
R-GGA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 324CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2114

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689951 – 324Adenosine receptor A1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP49892

Expressioni

Gene expression databases

BgeeiENSGALG00000000168 Expressed in 5 organ(s), highest expression level in cerebellum

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000223

Chemistry databases

BindingDBiP49892

Structurei

3D structure databases

ProteinModelPortaliP49892
SMRiP49892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP49892
KOiK04265
OMAiVYAFRIH
OrthoDBiEOG091G0I3U
PhylomeDBiP49892
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49892-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSVTAFQA AYISIEVLIA LVSVPGNILV IWAVKMNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAIIIN IGPQTEFYSC LMMACPVLIL TESSILALLA
110 120 130 140 150
IAVDRYLRVK IPVRYKSVVT PRRAAVAIAC CWIVSFLVGL TPMFGWNNLN
160 170 180 190 200
KVLGTRDLNV SHSEFVIKCQ FETVISMEYM VYFNFFVWVL PPLLLMLLIY
210 220 230 240 250
LEVFNLIRTQ LNKKVSSSSN DPQKYYGKEL KIAKSLALVL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PSCKTPHILT YIAIFLTHGN SAMNPIVYAF RIKKFRTAFL
310 320
QIWNQYFCCK TNKSSSSSTA ETVN
Length:324
Mass (Da):36,323
Last modified:October 1, 1996 - v1
Checksum:i6FCAD801A5D3DD13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28380 mRNA Translation: AAA68977.1
U28381 Genomic DNA Translation: AAA68978.1
S78192 mRNA Translation: AAB34234.1
S78199 Genomic DNA Translation: AAB34235.1
PIRiS55231 S55302
RefSeqiNP_989647.3, NM_204316.3
UniGeneiGga.4980

Genome annotation databases

EnsembliENSGALT00000000224; ENSGALP00000000223; ENSGALG00000000168
ENSGALT00000083570; ENSGALP00000062155; ENSGALG00000000168
GeneIDi374212
KEGGigga:374212

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28380 mRNA Translation: AAA68977.1
U28381 Genomic DNA Translation: AAA68978.1
S78192 mRNA Translation: AAB34234.1
S78199 Genomic DNA Translation: AAB34235.1
PIRiS55231 S55302
RefSeqiNP_989647.3, NM_204316.3
UniGeneiGga.4980

3D structure databases

ProteinModelPortaliP49892
SMRiP49892
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000223

Chemistry databases

BindingDBiP49892
ChEMBLiCHEMBL2114

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP49892

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000224; ENSGALP00000000223; ENSGALG00000000168
ENSGALT00000083570; ENSGALP00000062155; ENSGALG00000000168
GeneIDi374212
KEGGigga:374212

Organism-specific databases

CTDi134

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP49892
KOiK04265
OMAiVYAFRIH
OrthoDBiEOG091G0I3U
PhylomeDBiP49892
TreeFamiTF325296

Enzyme and pathway databases

ReactomeiR-GGA-417973 Adenosine P1 receptors
R-GGA-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P49892

Gene expression databases

BgeeiENSGALG00000000168 Expressed in 5 organ(s), highest expression level in cerebellum

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAA1R_CHICK
AccessioniPrimary (citable) accession number: P49892
Secondary accession number(s): P87469
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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