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UniProtKB - P49888 (ST1E1_HUMAN)

Entry version 182 (25 May 2022)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Sulfotransferase 1E1

Gene

SULT1E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110).

Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875).

Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).

May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by estradiol.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 55 min(-1) with (24S)-hydroxycholesterol.1 Publication
  1. KM=0.3 µM for 17beta-estradiol1 Publication
  2. KM=0.2 µM for estrone1 Publication
  3. KM=0.2 µM for DHEA1 Publication
  4. KM=32220 µM for dopamine1 Publication
  5. KM=76.6 µM for p-nitrophenol1 Publication
  6. KM=0.9 µM for (24S)-hydroxycholesterol1 Publication
  7. KM=0.66 µM for PAPS1 Publication
  8. KM=0.46 µM for PAPS1 Publication
  1. Vmax=37.2 nmol/min/mg enzyme with 17beta-estradiol1 Publication
  2. Vmax=16.3 nmol/min/mg enzyme with estrone1 Publication
  3. Vmax=5.5 nmol/min/mg enzyme with DHEA1 Publication
  4. Vmax=13.3 nmol/min/mg enzyme with dopaminne
  5. Vmax=135.9 nmol/min/mg enzyme with p-nitrophenol1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei107Proton acceptor1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei129PAPSBy similarity1
Binding sitei137PAPS1 Publication1
Binding sitei192PAPSBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi47 – 52PAPSBy similarity6
Nucleotide bindingi226 – 231PAPSBy similarity6
Nucleotide bindingi256 – 258PAPSBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processLipid metabolism
LigandLipid-binding, Steroid-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.8.2.4, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49888

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156584, Cytosolic sulfonation of small molecules

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P49888

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49888

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49888

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001693

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfotransferase 1E1 (EC:2.8.2.42 Publications)
Short name:
ST1E1
Alternative name(s):
EST-11 Publication
Estrogen sulfotransferase1 Publication
Sulfotransferase, estrogen-preferring
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SULT1E1
Synonyms:STE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11377, SULT1E1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600043, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49888

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000109193

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi85K → A: Does not have decreased sulfonation activity towards the estrogens and DHEA. 1 Publication1
Mutagenesisi107H → A: Complete loss of sulfonation activity towards all substrates tested. 1 Publication1
Mutagenesisi137S → A: Decreased gradually the sulfotransferase activity. 1 Publication1
Mutagenesisi137S → C: Decreased gradually the sulfotransferase activity. 1 Publication1
Mutagenesisi145V → E: Substrate specificity constants for estradiol and estrone are reduced. Dramatic 400-fold increase in the ability to sulfonate dopamine. 1 Publication1
Mutagenesisi269V → E: Does not prevent the formation of homodimer. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6783

Open Targets

More...OpenTargetsi		ENSG00000109193

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA340

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49888, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2346

Drug and drug target database

More...DrugBanki		DB02902, 3'-phospho-5'-adenylyl sulfate
DB03346, 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol
DB01812, Adenosine 3',5'-diphosphate
DB00714, Apomorphine
DB14635, Curcumin sulfate
DB01176, Cyclizine
DB00977, Ethinylestradiol
DB09288, Propacetamol
DB00675, Tamoxifen
DB09100, Thyroid, porcine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SULT1E1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1711604

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000851531 – 294Sulfotransferase 1E1Add BLAST294

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49888

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49888

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49888

PeptideAtlas

More...PeptideAtlasi		P49888

PRoteomics IDEntifications database

More...PRIDEi		P49888

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56163

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49888

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49888

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, intestine and at lower level in the kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000109193, Expressed in kidney and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49888, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49888, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000109193, Tissue enhanced (intestine, liver, skin, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112660, 14 interactors

Protein interaction database and analysis system

More...IntActi		P49888, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000226444

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P49888

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49888, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P49888

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49888

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P49888

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 107Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1584, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162261

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027239_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49888

Identification of Orthologs from Complete Genome Data

More...OMAi		VIKVIQF

Database of Orthologous Groups

More...OrthoDBi		780670at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49888

TreeFam database of animal gene trees

More...TreeFami		TF321745

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00685, Sulfotransfer_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49888-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSELDYYEK FEEVHGILMY KDFVKYWDNV EAFQARPDDL VIATYPKSGT 
        60         70         80         90        100
TWVSEIVYMI YKEGDVEKCK EDVIFNRIPF LECRKENLMN GVKQLDEMNS 
       110        120        130        140        150
PRIVKTHLPP ELLPASFWEK DCKIIYLCRN AKDVAVSFYY FFLMVAGHPN 
       160        170        180        190        200
PGSFPEFVEK FMQGQVPYGS WYKHVKSWWE KGKSPRVLFL FYEDLKEDIR 
       210        220        230        240        250
KEVIKLIHFL ERKPSEELVD RIIHHTSFQE MKNNPSTNYT TLPDEIMNQK 
       260        270        280        290 
LSPFMRKGIT GDWKNHFTVA LNEKFDKHYE QQMKESTLKF RTEI
Length:294
Mass (Da):35,126
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EC8923D20757D57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154F → L in AAH27956 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01890722D → Y1 PublicationCorresponds to variant dbSNP:rs11569705Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U08098 mRNA Translation: AAA82125.1
U20521 U20520 Genomic DNA Translation: AAC50286.1
S77383 mRNA Translation: AAB34601.1
Y11195 mRNA Translation: CAA72079.1
AY436634 Genomic DNA Translation: AAQ97179.1
BC027956 mRNA Translation: AAH27956.1
U55764 mRNA Translation: AAB51658.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3531.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC2229

NCBI Reference Sequences

More...RefSeqi		NP_005411.1, NM_005420.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000226444.4; ENSP00000226444.3; ENSG00000109193.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6783

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000226444.4; ENSP00000226444.3; NM_005420.3; NP_005411.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08098 mRNA Translation: AAA82125.1
U20521 U20520 Genomic DNA Translation: AAC50286.1
S77383 mRNA Translation: AAB34601.1
Y11195 mRNA Translation: CAA72079.1
AY436634 Genomic DNA Translation: AAQ97179.1
BC027956 mRNA Translation: AAH27956.1
U55764 mRNA Translation: AAB51658.1
CCDSiCCDS3531.1
PIRiJC2229
RefSeqiNP_005411.1, NM_005420.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G3MX-ray1.70A/B1-294[»]
1HY3X-ray1.80A/B1-294[»]
4JVLX-ray1.94A/B1-294[»]
4JVMX-ray1.99A/B1-294[»]
4JVNX-ray2.05A/B1-294[»]
AlphaFoldDBiP49888
SMRiP49888
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112660, 14 interactors
IntActiP49888, 12 interactors
STRINGi9606.ENSP00000226444

Chemistry databases

BindingDBiP49888
ChEMBLiCHEMBL2346
DrugBankiDB02902, 3'-phospho-5'-adenylyl sulfate
DB03346, 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol
DB01812, Adenosine 3',5'-diphosphate
DB00714, Apomorphine
DB14635, Curcumin sulfate
DB01176, Cyclizine
DB00977, Ethinylestradiol
DB09288, Propacetamol
DB00675, Tamoxifen
DB09100, Thyroid, porcine
SwissLipidsiSLP:000001693

PTM databases

iPTMnetiP49888
PhosphoSitePlusiP49888

Genetic variation databases

BioMutaiSULT1E1
DMDMi1711604

Proteomic databases

EPDiP49888
MassIVEiP49888
PaxDbiP49888
PeptideAtlasiP49888
PRIDEiP49888
ProteomicsDBi56163

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24249, 293 antibodies from 34 providers

The CPTC Antibody Portal

More...CPTCi		P49888, 3 antibodies

The DNASU plasmid repository

More...DNASUi		6783

Genome annotation databases

EnsembliENST00000226444.4; ENSP00000226444.3; ENSG00000109193.12
GeneIDi6783
KEGGihsa:6783
MANE-SelectiENST00000226444.4; ENSP00000226444.3; NM_005420.3; NP_005411.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6783
DisGeNETi6783

GeneCards: human genes, protein and diseases

More...GeneCardsi		SULT1E1
HGNCiHGNC:11377, SULT1E1
HPAiENSG00000109193, Tissue enhanced (intestine, liver, skin, vagina)
MIMi600043, gene
neXtProtiNX_P49888
OpenTargetsiENSG00000109193
PharmGKBiPA340
VEuPathDBiHostDB:ENSG00000109193

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1584, Eukaryota
GeneTreeiENSGT00940000162261
HOGENOMiCLU_027239_1_2_1
InParanoidiP49888
OMAiVIKVIQF
OrthoDBi780670at2759
PhylomeDBiP49888
TreeFamiTF321745

Enzyme and pathway databases

BRENDAi2.8.2.4, 2681
PathwayCommonsiP49888
ReactomeiR-HSA-156584, Cytosolic sulfonation of small molecules
SABIO-RKiP49888
SignaLinkiP49888
SIGNORiP49888

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6783, 76 hits in 1076 CRISPR screens
EvolutionaryTraceiP49888

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SULT1E1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6783
PharosiP49888, Tchem

Protein Ontology

More...PROi		PR:P49888
RNActiP49888, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000109193, Expressed in kidney and 122 other tissues
ExpressionAtlasiP49888, baseline and differential
GenevisibleiP49888, HS

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom
PfamiView protein in Pfam
PF00685, Sulfotransfer_1, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiST1E1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49888
Secondary accession number(s): Q8N6X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 25, 2022
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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