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Protein

Granzyme K

Gene

GZMK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Charge relay system1
Active sitei116Charge relay system1
Active sitei214Charge relay system1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B4 2681

Protein family/group databases

MEROPSiS01.146

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme K (EC:3.4.21.-)
Alternative name(s):
Fragmentin-3
Granzyme-3
NK-tryptase-2
Short name:
NK-Tryp-2
Gene namesi
Name:GZMK
Synonyms:TRYP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113088.5
HGNCiHGNC:4711 GZMK
MIMi600784 gene
neXtProtiNX_P49863

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3003
OpenTargetsiENSG00000113088
PharmGKBiPA29089

Chemistry databases

ChEMBLiCHEMBL4930

Polymorphism and mutation databases

BioMutaiGZMK
DMDMi1708035

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000002741525 – 26Activation peptide2 Publications2
ChainiPRO_000002741627 – 264Granzyme KAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 68
Disulfide bondi149 ↔ 220
Disulfide bondi181 ↔ 199
Disulfide bondi210 ↔ 234

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP49863
PeptideAtlasiP49863
PRIDEiP49863
ProteomicsDBi56162
TopDownProteomicsiP49863

PTM databases

iPTMnetiP49863
PhosphoSitePlusiP49863

Expressioni

Tissue specificityi

Expressed in lung, spleen, thymus and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000113088 Expressed in 136 organ(s), highest expression level in lymph node
CleanExiHS_GZMK
GenevisibleiP49863 HS

Organism-specific databases

HPAiHPA063181

Interactioni

Protein-protein interaction databases

BioGridi109258, 12 interactors
IntActiP49863, 3 interactors
STRINGi9606.ENSP00000231009

Chemistry databases

BindingDBiP49863

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49863
SMRiP49863
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49863

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 259Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP49863
KOiK08663
OMAiNMEIIGG
OrthoDBiEOG091G0AH5
PhylomeDBiP49863
TreeFamiTF333630

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49863-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKFSSFSLF FLIVGAYMTH VCFNMEIIGG KEVSPHSRPF MASIQYGGHH
60 70 80 90 100
VCGGVLIDPQ WVLTAAHCQY RFTKGQSPTV VLGAHSLSKN EASKQTLEIK
110 120 130 140 150
KFIPFSRVTS DPQSNDIMLV KLQTAAKLNK HVKMLHIRSK TSLRSGTKCK
160 170 180 190 200
VTGWGATDPD SLRPSDTLRE VTVTVLSRKL CNSQSYYNGD PFITKDMVCA
210 220 230 240 250
GDAKGQKDSC KGDSGGPLIC KGVFHAIVSG GHECGVATKP GIYTLLTKKY
260
QTWIKSNLVP PHTN
Length:264
Mass (Da):28,882
Last modified:October 1, 1996 - v1
Checksum:i2A93FDBAF9286CC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34S → Q AA sequence (PubMed:1460416).Curated1
Sequence conflicti43S → A AA sequence (PubMed:1460416).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35237 mRNA Translation: AAA79063.1
U26174 mRNA Translation: AAA74578.1
AK312074 mRNA Translation: BAG35010.1
CH471123 Genomic DNA Translation: EAW54899.1
BC035802 mRNA Translation: AAH35802.1
CCDSiCCDS3964.1
PIRiS65663
RefSeqiNP_002095.1, NM_002104.2
UniGeneiHs.277937

Genome annotation databases

EnsembliENST00000231009; ENSP00000231009; ENSG00000113088
GeneIDi3003
KEGGihsa:3003
UCSCiuc003jpl.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35237 mRNA Translation: AAA79063.1
U26174 mRNA Translation: AAA74578.1
AK312074 mRNA Translation: BAG35010.1
CH471123 Genomic DNA Translation: EAW54899.1
BC035802 mRNA Translation: AAH35802.1
CCDSiCCDS3964.1
PIRiS65663
RefSeqiNP_002095.1, NM_002104.2
UniGeneiHs.277937

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MZAX-ray2.23A25-264[»]
1MZDX-ray2.90A25-264[»]
ProteinModelPortaliP49863
SMRiP49863
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109258, 12 interactors
IntActiP49863, 3 interactors
STRINGi9606.ENSP00000231009

Chemistry databases

BindingDBiP49863
ChEMBLiCHEMBL4930

Protein family/group databases

MEROPSiS01.146

PTM databases

iPTMnetiP49863
PhosphoSitePlusiP49863

Polymorphism and mutation databases

BioMutaiGZMK
DMDMi1708035

Proteomic databases

PaxDbiP49863
PeptideAtlasiP49863
PRIDEiP49863
ProteomicsDBi56162
TopDownProteomicsiP49863

Protocols and materials databases

DNASUi3003
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231009; ENSP00000231009; ENSG00000113088
GeneIDi3003
KEGGihsa:3003
UCSCiuc003jpl.2 human

Organism-specific databases

CTDi3003
DisGeNETi3003
EuPathDBiHostDB:ENSG00000113088.5
GeneCardsiGZMK
HGNCiHGNC:4711 GZMK
HPAiHPA063181
MIMi600784 gene
neXtProtiNX_P49863
OpenTargetsiENSG00000113088
PharmGKBiPA29089
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP49863
KOiK08663
OMAiNMEIIGG
OrthoDBiEOG091G0AH5
PhylomeDBiP49863
TreeFamiTF333630

Enzyme and pathway databases

BRENDAi3.4.21.B4 2681

Miscellaneous databases

EvolutionaryTraceiP49863
GeneWikiiGZMK
GenomeRNAii3003
PROiPR:P49863
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113088 Expressed in 136 organ(s), highest expression level in lymph node
CleanExiHS_GZMK
GenevisibleiP49863 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRAK_HUMAN
AccessioniPrimary (citable) accession number: P49863
Secondary accession number(s): B2R563
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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