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Protein

Transcription initiation factor TFIID subunit 6

Gene

TAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: CAFA
  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity Source: UniProtKB
  • protein heterodimerization activity Source: InterPro
  • RNA polymerase II activating transcription factor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 6
Alternative name(s):
RNA polymerase II TBP-associated factor subunit E
Transcription initiation factor TFIID 70 kDa subunit
Short name:
TAF(II)70
Short name:
TAFII-70
Short name:
TAFII70
Transcription initiation factor TFIID 80 kDa subunit
Short name:
TAF(II)80
Short name:
TAFII-80
Short name:
TAFII80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF6
Synonyms:TAF2E, TAFII70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106290.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11540 TAF6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602955 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49848

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Alazami-Yuan syndrome (ALYUS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome reminiscent of Cornelia de Lange syndrome and characterized by delayed psychomotor development with intellectual disability, hypotonia, microcephaly, short stature, poor speech, and dysmorphic features.
See also OMIM:617126
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07784046R → C in ALYUS; decreased interaction with TAF1 and TBP shown by functional expression studies in a Drosophila cell line. 1 PublicationCorresponds to variant dbSNP:rs727503778EnsemblClinVar.1
Natural variantiVAR_07784171I → T in ALYUS; decreased interaction with TAF1, TAF9 and TBP shown by functional expression studies in a Drosophila cell line. 2 PublicationsCorresponds to variant dbSNP:rs374993554EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6878

MalaCards human disease database

More...
MalaCardsi
TAF6
MIMi617126 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000106290

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36315

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAF6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1729810

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188731 – 677Transcription initiation factor TFIID subunit 6Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphothreonineBy similarity1
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei524Omega-N-methylarginineCombined sources1
Modified residuei626PhosphoserineBy similarity1
Modified residuei634PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei660PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 4: In cells undergoing apoptosis, cleaved in a caspase-dependent manner to produce a 40 kDa product.1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P49848

MaxQB - The MaxQuant DataBase

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MaxQBi
P49848

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P49848

PeptideAtlas

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PeptideAtlasi
P49848

PRoteomics IDEntifications database

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PRIDEi
P49848

ProteomicsDB human proteome resource

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ProteomicsDBi
56157
56158 [P49848-2]
56159 [P49848-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49848

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P49848

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 4: Induced in cells undergoing apoptosis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106290 Expressed in 230 organ(s), highest expression level in right frontal lobe

CleanEx database of gene expression profiles

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CleanExi
HS_TAF6

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49848 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49848 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006566

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex. Isoform 1: Interacts with TP53/p53 (PubMed:20096117). Isoform 4: Part of a TFIID-like complex which lacks TAF9 (PubMed:11583621). Isoform 4: Not part of the TFTC (PubMed:11583621). Isoform 4: Interacts with TP53/p53 (PubMed:20096117).7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PB1Q1K9H52EBI-1560206,EBI-6050669From Influenza A virus (strain A/Wilson-Smith/1933 H1N1).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112741, 66 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-903 TFTC histone acetylation complex
CPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P49848

Database of interacting proteins

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DIPi
DIP-773N

Protein interaction database and analysis system

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IntActi
P49848, 26 interactors

Molecular INTeraction database

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MINTi
P49848

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000399982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P49848

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49848

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2549 Eukaryota
COG5095 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00640000091486

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000253001

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG012489

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49848

KEGG Orthology (KO)

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KOi
K03131

Database for complete collections of gene phylogenies

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PhylomeDBi
P49848

TreeFam database of animal gene trees

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TreeFami
TF313632

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR009072 Histone-fold
IPR037796 TAF6
IPR011442 TAF6_C
IPR004823 TAF_TATA-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10221 PTHR10221, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02969 TAF, 1 hit
PF07571 TAF6_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00803 TAF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49848-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI
60 70 80 90 100
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG
110 120 130 140 150
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP
160 170 180 190 200
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGATTADG KGKEKKAPPL
210 220 230 240 250
LEGAPLRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP
260 270 280 290 300
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY
310 320 330 340 350
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN
360 370 380 390 400
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG
410 420 430 440 450
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRA
460 470 480 490 500
EFGSLGPLLC SQVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG
510 520 530 540 550
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSAPST
560 570 580 590 600
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPSGP
610 620 630 640 650
GSVQKYIVVS LPPTGEGKGG PTSHPSPVPP PASSPSPLSG SALCGGKQEA
660 670
GDSPPPAPGT PKANGSQPNS GSPQPAP
Length:677
Mass (Da):72,668
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06C6BFA563580823
GO
Isoform 2 (identifier: P49848-2) [UniParc]FASTAAdd to basket
Also known as: Gamma1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     477-486: Missing.

Show »
Length:667
Mass (Da):71,540
Checksum:i85488E83976800FC
GO
Isoform 3 (identifier: P49848-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTKRRLQTITACLQLREGSPSLHRGLHPSREEKRDSRM

Note: No experimental confirmation available.
Show »
Length:714
Mass (Da):76,995
Checksum:i1A1E41AB1BC47388
GO
Isoform 4 (identifier: P49848-4) [UniParc]FASTAAdd to basket
Also known as: Delta2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     43-52: Missing.

Show »
Length:667
Mass (Da):71,480
Checksum:i7913E23A05CFA39C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KR72J3KR72_HUMAN
Transcription initiation factor TFI...
TAF6
734Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTY6C9JTY6_HUMAN
Transcription initiation factor TFI...
TAF6
255Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFL8C9JFL8_HUMAN
Transcription initiation factor TFI...
TAF6
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEJ7F8WEJ7_HUMAN
Transcription initiation factor TFI...
TAF6
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7C4C9J7C4_HUMAN
Transcription initiation factor TFI...
TAF6
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIS2C9JIS2_HUMAN
Transcription initiation factor TFI...
TAF6
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J088C9J088_HUMAN
Transcription initiation factor TFI...
TAF6
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHQ8C9JHQ8_HUMAN
Transcription initiation factor TFI...
TAF6
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHA1E5RHA1_HUMAN
Transcription initiation factor TFI...
TAF6
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RKA5E5RKA5_HUMAN
Transcription initiation factor TFI...
TAF6
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti196K → E in CAH10485 (PubMed:17974005).Curated1
Sequence conflicti417R → W in CAH10485 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01434936C → S1 PublicationCorresponds to variant dbSNP:rs4134897Ensembl.1
Natural variantiVAR_07784046R → C in ALYUS; decreased interaction with TAF1 and TBP shown by functional expression studies in a Drosophila cell line. 1 PublicationCorresponds to variant dbSNP:rs727503778EnsemblClinVar.1
Natural variantiVAR_07784171I → T in ALYUS; decreased interaction with TAF1, TAF9 and TBP shown by functional expression studies in a Drosophila cell line. 2 PublicationsCorresponds to variant dbSNP:rs374993554EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437091M → MTKRRLQTITACLQLREGSP SLHRGLHPSREEKRDSRM in isoform 3. 1 Publication1
Alternative sequenceiVSP_05985143 – 52Missing in isoform 4. 1 Publication10
Alternative sequenceiVSP_037476477 – 486Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L25444 mRNA Translation: AAA63643.1
U31659 mRNA Translation: AAA84390.1
AK300005 mRNA Translation: BAG61823.1
CR627390 mRNA Translation: CAH10485.1
AY149894 Genomic DNA Translation: AAN10295.1
CH236956 Genomic DNA Translation: EAL23851.1
CH236956 Genomic DNA Translation: EAL23852.1
CH471091 Genomic DNA Translation: EAW76589.1
CH471091 Genomic DNA Translation: EAW76591.1
CH471091 Genomic DNA Translation: EAW76592.1
BC018115 mRNA Translation: AAH18115.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55135.1 [P49848-3]
CCDS5686.1 [P49848-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001177344.1, NM_001190415.1 [P49848-3]
NP_005632.1, NM_005641.3 [P49848-1]
NP_647476.1, NM_139315.2 [P49848-1]
XP_006716163.1, XM_006716100.2 [P49848-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.489309

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344095; ENSP00000344537; ENSG00000106290 [P49848-1]
ENST00000437822; ENSP00000399982; ENSG00000106290 [P49848-3]
ENST00000452041; ENSP00000416396; ENSG00000106290 [P49848-1]
ENST00000453269; ENSP00000389575; ENSG00000106290 [P49848-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6878

UCSC genome browser

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UCSCi
uc003uti.4 human [P49848-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25444 mRNA Translation: AAA63643.1
U31659 mRNA Translation: AAA84390.1
AK300005 mRNA Translation: BAG61823.1
CR627390 mRNA Translation: CAH10485.1
AY149894 Genomic DNA Translation: AAN10295.1
CH236956 Genomic DNA Translation: EAL23851.1
CH236956 Genomic DNA Translation: EAL23852.1
CH471091 Genomic DNA Translation: EAW76589.1
CH471091 Genomic DNA Translation: EAW76591.1
CH471091 Genomic DNA Translation: EAW76592.1
BC018115 mRNA Translation: AAH18115.1
CCDSiCCDS55135.1 [P49848-3]
CCDS5686.1 [P49848-1]
RefSeqiNP_001177344.1, NM_001190415.1 [P49848-3]
NP_005632.1, NM_005641.3 [P49848-1]
NP_647476.1, NM_139315.2 [P49848-1]
XP_006716163.1, XM_006716100.2 [P49848-1]
UniGeneiHs.489309

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FURelectron microscopy8.50J/K1-677[»]
ProteinModelPortaliP49848
SMRiP49848
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112741, 66 interactors
ComplexPortaliCPX-903 TFTC histone acetylation complex
CPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant
CORUMiP49848
DIPiDIP-773N
IntActiP49848, 26 interactors
MINTiP49848
STRINGi9606.ENSP00000399982

PTM databases

iPTMnetiP49848
PhosphoSitePlusiP49848

Polymorphism and mutation databases

BioMutaiTAF6
DMDMi1729810

Proteomic databases

EPDiP49848
MaxQBiP49848
PaxDbiP49848
PeptideAtlasiP49848
PRIDEiP49848
ProteomicsDBi56157
56158 [P49848-2]
56159 [P49848-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6878
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344095; ENSP00000344537; ENSG00000106290 [P49848-1]
ENST00000437822; ENSP00000399982; ENSG00000106290 [P49848-3]
ENST00000452041; ENSP00000416396; ENSG00000106290 [P49848-1]
ENST00000453269; ENSP00000389575; ENSG00000106290 [P49848-1]
GeneIDi6878
KEGGihsa:6878
UCSCiuc003uti.4 human [P49848-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6878
DisGeNETi6878
EuPathDBiHostDB:ENSG00000106290.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAF6
HGNCiHGNC:11540 TAF6
HPAiHPA006566
MalaCardsiTAF6
MIMi602955 gene
617126 phenotype
neXtProtiNX_P49848
OpenTargetsiENSG00000106290
PharmGKBiPA36315

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2549 Eukaryota
COG5095 LUCA
GeneTreeiENSGT00640000091486
HOGENOMiHOG000253001
HOVERGENiHBG012489
InParanoidiP49848
KOiK03131
PhylomeDBiP49848
TreeFamiTF313632

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TAF6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAF6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6878

Protein Ontology

More...
PROi
PR:P49848

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106290 Expressed in 230 organ(s), highest expression level in right frontal lobe
CleanExiHS_TAF6
ExpressionAtlasiP49848 baseline and differential
GenevisibleiP49848 HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009072 Histone-fold
IPR037796 TAF6
IPR011442 TAF6_C
IPR004823 TAF_TATA-bd
PANTHERiPTHR10221 PTHR10221, 1 hit
PfamiView protein in Pfam
PF02969 TAF, 1 hit
PF07571 TAF6_C, 1 hit
SMARTiView protein in SMART
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49848
Secondary accession number(s): A4D2B2
, A4D2B3, B4DT11, D6W5U2, Q6AI29
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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