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UniProtKB - P49847 (TAF6_DROME)
Protein
Transcription initiation factor TFIID subunit 6
Gene
Taf6
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
1 PublicationGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
- RNA polymerase II general transcription initiation factor activity Source: InterPro
- transcription coactivator activity Source: GO_Central
GO - Biological processi
- RNA polymerase II preinitiation complex assembly Source: GO_Central
- transcription by RNA polymerase II Source: FlyBase
- transcription initiation from RNA polymerase II promoter Source: FlyBase
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-674695, RNA Polymerase II Pre-transcription Events R-DME-6804756, Regulation of TP53 Activity through Phosphorylation R-DME-6807505, RNA polymerase II transcribes snRNA genes R-DME-73776, RNA Polymerase II Promoter Escape R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-75953, RNA Polymerase II Transcription Initiation R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SignaLinki | P49847 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 6Alternative name(s): TAFII-60 TAFII-62 Transcription initiation factor TFIID 62 kDa subunit Short name: p62 |
Gene namesi | Name:Taf6 Synonyms:Taf60 ORF Names:CG32211 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010417, Taf6 |
VEuPathDBi | VectorBase:FBgn0010417 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: FlyBase
- SAGA complex Source: InterPro
- SLIK (SAGA-like) complex Source: InterPro
- transcription factor TFIID complex Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118877 | 1 – 606 | Transcription initiation factor TFIID subunit 6Add BLAST | 606 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 546 | Phosphoserine1 Publication | 1 | |
Modified residuei | 547 | Phosphoserine1 Publication | 1 | |
Modified residuei | 550 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P49847 |
PRIDEi | P49847 |
PTM databases
iPTMneti | P49847 |
Expressioni
Gene expression databases
Bgeei | FBgn0010417, Expressed in embryo and 36 other tissues |
ExpressionAtlasi | P49847, baseline and differential |
Genevisiblei | P49847, DM |
Interactioni
Subunit structurei
Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). E(y)1 and Taf6 exist as a heterotetramer.
Interacts with Taf1.
2 PublicationsBinary interactionsi
P49847
With | #Exp. | IntAct |
---|---|---|
e(y)1 [Q27272] | 2 | EBI-136204,EBI-174260 |
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 65404, 33 interactors |
DIPi | DIP-778N |
IntActi | P49847, 7 interactors |
STRINGi | 7227.FBpp0074709 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P49847 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P49847 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TAF6 family.Curated
Phylogenomic databases
eggNOGi | KOG2549, Eukaryota |
GeneTreei | ENSGT00640000091486 |
InParanoidi | P49847 |
OMAi | MQKYIVV |
OrthoDBi | 384329at2759 |
PhylomeDBi | P49847 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR009072, Histone-fold IPR037796, TAF6 IPR011442, TAF6_C IPR004823, TAF_TATA-bd |
PANTHERi | PTHR10221, PTHR10221, 1 hit |
Pfami | View protein in Pfam PF02969, TAF, 1 hit PF07571, TAF6_C, 1 hit |
SMARTi | View protein in SMART SM00803, TAF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P49847-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGKPSKPSS PSSSMLYGSS ISAESMKVIA ESIGVGSLSD DAAKELAEDV
60 70 80 90 100
SIKLKRIVQD AAKFMNHAKR QKLSVRDIDM SLKVRNVEPQ YGFVAKDFIP
110 120 130 140 150
FRFASGGGRE LHFTEDKEID LGEITSTNSV KIPLDLTLRS HWFVVEGVQP
160 170 180 190 200
TVPENPPPLS KDSQLLDSVN PVIKMDQGLN KDAAGKPTTG KIHKLKNVET
210 220 230 240 250
IHVKQLATHE LSVEQQLYYK EITEACVGSD EPRRGEALQS LGSDPGLHEM
260 270 280 290 300
LPRMCTFIAE GVKVNVVQNN LALLIYLMRM VRALLDNPSL FLEKYLHELI
310 320 330 340 350
PSVMTCIVSK QLCMRPELDN HWALRDFASR LMAQICKNFN TLTNNLQTRV
360 370 380 390 400
TRIFSKALQN DKTHLSSLYG SIAGLSELGG EVIKVFIIPR LKFISERIEP
410 420 430 440 450
HLLGTSISNT DKTAAGHIRA MLQKCCPPIL RQMRSAPDTA EDYKNDFGFL
460 470 480 490 500
GPSLCQAVVK VRNAPASSIV TLSSNTINTA PITSAAQTAT TIGRVSMPTT
510 520 530 540 550
QRQGSPGVSS LPQIRAIQAN QPAQKFVIVT QNSPQQGQAK VVRRGSSPHS
560 570 580 590 600
VVLSAASNAA SASNSNSSSS GSLLAAAQRS SDNVCVIAGS EAPAVDGITV
QSFRAS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9PG32 | M9PG32_DROME | TBP-associated factor 6, isoform B | Taf6 62, CG9348, d60, dme-TAFII60, Dmel\CG32211 | 605 | Annotation score: |
Sequence cautioni
The sequence AAA16536 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC46480 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | G → K AA sequence (PubMed:7545910).Curated | 1 | |
Sequence conflicti | 101 | F → L in AAA16536 (PubMed:8262073).Curated | 1 | |
Sequence conflicti | 582 | D → E in AAC46480 (PubMed:7545910).Curated | 1 | |
Sequence conflicti | 582 | D → E in AAA16536 (PubMed:8262073).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49139.2 AY051702 mRNA Translation: AAK93126.1 U06459 mRNA Translation: AAC46480.1 Different initiation. L25443 mRNA Translation: AAA16536.1 Different initiation. |
RefSeqi | NP_524161.2, NM_079437.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0074941; FBpp0074709; FBgn0010417 |
GeneIDi | 40134 |
KEGGi | dme:Dmel_CG32211 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49139.2 AY051702 mRNA Translation: AAK93126.1 U06459 mRNA Translation: AAC46480.1 Different initiation. L25443 mRNA Translation: AAA16536.1 Different initiation. |
RefSeqi | NP_524161.2, NM_079437.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1TAF | X-ray | 2.00 | B | 15-84 | [»] | |
SMRi | P49847 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 65404, 33 interactors |
DIPi | DIP-778N |
IntActi | P49847, 7 interactors |
STRINGi | 7227.FBpp0074709 |
PTM databases
iPTMneti | P49847 |
Proteomic databases
PaxDbi | P49847 |
PRIDEi | P49847 |
Genome annotation databases
EnsemblMetazoai | FBtr0074941; FBpp0074709; FBgn0010417 |
GeneIDi | 40134 |
KEGGi | dme:Dmel_CG32211 |
Organism-specific databases
CTDi | 6878 |
FlyBasei | FBgn0010417, Taf6 |
VEuPathDBi | VectorBase:FBgn0010417 |
Phylogenomic databases
eggNOGi | KOG2549, Eukaryota |
GeneTreei | ENSGT00640000091486 |
InParanoidi | P49847 |
OMAi | MQKYIVV |
OrthoDBi | 384329at2759 |
PhylomeDBi | P49847 |
Enzyme and pathway databases
Reactomei | R-DME-674695, RNA Polymerase II Pre-transcription Events R-DME-6804756, Regulation of TP53 Activity through Phosphorylation R-DME-6807505, RNA polymerase II transcribes snRNA genes R-DME-73776, RNA Polymerase II Promoter Escape R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-75953, RNA Polymerase II Transcription Initiation R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SignaLinki | P49847 |
Miscellaneous databases
BioGRID-ORCSi | 40134, 1 hit in 1 CRISPR screen |
EvolutionaryTracei | P49847 |
GenomeRNAii | 40134 |
PROi | PR:P49847 |
Gene expression databases
Bgeei | FBgn0010417, Expressed in embryo and 36 other tissues |
ExpressionAtlasi | P49847, baseline and differential |
Genevisiblei | P49847, DM |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR009072, Histone-fold IPR037796, TAF6 IPR011442, TAF6_C IPR004823, TAF_TATA-bd |
PANTHERi | PTHR10221, PTHR10221, 1 hit |
Pfami | View protein in Pfam PF02969, TAF, 1 hit PF07571, TAF6_C, 1 hit |
SMARTi | View protein in SMART SM00803, TAF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF6_DROME | |
Accessioni | P49847Primary (citable) accession number: P49847 Secondary accession number(s): Q961B6, Q9VW16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 27, 2003 | |
Last modified: | February 23, 2022 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families