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Protein

Serine/threonine-protein kinase 19

Gene

STK19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+Note: Divalent metal cations. Has a preference for Mn2+.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 19 (EC:2.7.11.1)
Alternative name(s):
Protein G11
Protein RP1
Gene namesi
Name:STK19
Synonyms:G11, RP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204344.14
HGNCiHGNC:11398 STK19
MIMi604977 gene
neXtProtiNX_P49842

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi300K → P: Partial loss of activity. 1
Mutagenesisi315K → P: Partial loss of activity. 1
Mutagenesisi317K → P: Complete loss of activity. 1

Organism-specific databases

DisGeNETi8859
OpenTargetsiENSG00000204344
PharmGKBiPA36206

Polymorphism and mutation databases

BioMutaiSTK19
DMDMi19860281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722751 – 368Serine/threonine-protein kinase 19Add BLAST368

Proteomic databases

EPDiP49842
MaxQBiP49842
PaxDbiP49842
PeptideAtlasiP49842
PRIDEiP49842
ProteomicsDBi56153
56154 [P49842-2]
56155 [P49842-3]
56156 [P49842-4]

PTM databases

iPTMnetiP49842
PhosphoSitePlusiP49842

Expressioni

Tissue specificityi

Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.

Gene expression databases

BgeeiENSG00000204344 Expressed in 103 organ(s), highest expression level in left adrenal gland
CleanExiHS_RP1
HS_STK19
ExpressionAtlasiP49842 baseline and differential
GenevisibleiP49842 HS

Organism-specific databases

HPAiHPA031510
HPA031511
HPA068559

Interactioni

Subunit structurei

The N-terminus interacts with BAG1.1 Publication

Protein-protein interaction databases

BioGridi114383, 8 interactors
IntActiP49842, 6 interactors
STRINGi9606.ENSP00000364482

Structurei

3D structure databases

ProteinModelPortaliP49842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STK19 family.Curated

Phylogenomic databases

eggNOGiENOG410IEVV Eukaryota
ENOG410YGZ8 LUCA
GeneTreeiENSGT00390000018295
HOVERGENiHBG056144
InParanoidiP49842
KOiK08880
OMAiREPVRHC
OrthoDBiEOG093706AL
PhylomeDBiP49842
TreeFamiTF105332

Family and domain databases

InterProiView protein in InterPro
IPR018865 Ser/Thr_kinase_19
PANTHERiPTHR15243 PTHR15243, 1 hit
PfamiView protein in Pfam
PF10494 Stk19, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49842-1) [UniParc]FASTAAdd to basket
Also known as: G11-Z

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKWFSAFDD AIIQRQWRAN PSRGGGGVSF TKEVDTNVAT GAPPRRQRVP
60 70 80 90 100
GRACPWREPI RGRRGARPGG GDAGGTPGET VRHCSAPEDP IFRFSSLHSY
110 120 130 140 150
PFPGTIKSRD MSWKRHHLIP ETFGVKRRRK RGPVESDPLR GEPGSARAAV
160 170 180 190 200
SELMQLFPRG LFEDALPPIV LRSQVYSLVP DRTVADRQLK ELQEQGEIRI
210 220 230 240 250
VQLGFDLDAH GIIFTEDYRT RVCDCVLKAC DGRPYAGAVQ KFLASVLPAC
260 270 280 290 300
GDLSFQQDQM TQTFGFRDSE ITHLVNAGVL TVRDAGSWWL AVPGAGRFIK
310 320 330 340 350
YFVKGRQAVL SMVRKAKYRE LLLSELLGRR APVVVRLGLT YHVHDLIGAQ
360
LVDCISTTSG TLLRLPET
Length:368
Mass (Da):40,916
Last modified:October 18, 2001 - v2
Checksum:iA05AC847081DE8F8
GO
Isoform 2 (identifier: P49842-2) [UniParc]FASTAAdd to basket
Also known as: G11-Z-short

The sequence of this isoform differs from the canonical sequence as follows:
     222-225: Missing.

Show »
Length:364
Mass (Da):40,495
Checksum:iB904F6999B7C533E
GO
Isoform 3 (identifier: P49842-3) [UniParc]FASTAAdd to basket
Also known as: G11-Y

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:258
Mass (Da):28,885
Checksum:iBE79A520BA211E22
GO
Isoform 4 (identifier: P49842-4) [UniParc]FASTAAdd to basket
Also known as: G11-Y-short

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     222-225: Missing.

Show »
Length:254
Mass (Da):28,465
Checksum:i1B3800438D9DD5A9
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZLI8B7ZLI8_HUMAN
Serine/threonine kinase 19
STK19
321Annotation score:
C9J6S8C9J6S8_HUMAN
Serine/threonine-protein kinase 19
STK19
112Annotation score:
H0YAS4H0YAS4_HUMAN
Serine/threonine-protein kinase 19
STK19
70Annotation score:
A0A140T8X5A0A140T8X5_HUMAN
STK19
STK19
364Annotation score:
A0A140TA37A0A140TA37_HUMAN
Serine/threonine-protein kinase 19
STK19
321Annotation score:
A0A0G2JLL1A0A0G2JLL1_HUMAN
Serine/threonine-protein kinase 19
STK19
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195 – 197QGE → GQR in AAA99716 (PubMed:8575831).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05138739A → D. Corresponds to variant dbSNP:rs34843142Ensembl.1
Natural variantiVAR_04236189D → N in a metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267600971EnsemblClinVar.1
Natural variantiVAR_042362311S → G2 PublicationsCorresponds to variant dbSNP:rs616634Ensembl.1
Natural variantiVAR_042363331A → V1 PublicationCorresponds to variant dbSNP:rs7743647Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0044321 – 110Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_004433222 – 225Missing in isoform 2 and isoform 4. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77474
, X77489, X77490, X77491 Genomic DNA Translation: CAA54622.1
X77474
, X77489, X77490, X77491 Genomic DNA Translation: CAA54623.1
X77386 mRNA Translation: CAA54565.1
L26261 Genomic DNA Translation: AAA20120.1
L26260 mRNA Translation: AAA20122.1
AF019413 Genomic DNA Translation: AAB67976.1
AL049547 Genomic DNA Translation: CAB89303.1
AL049547 Genomic DNA Translation: CAB89304.1
AL645922 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX679671 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03566.1
CH471081 Genomic DNA Translation: EAX03567.1
U24578 Genomic DNA Translation: AAA99716.1
CCDSiCCDS34417.1 [P49842-2]
CCDS4733.1 [P49842-1]
PIRiB53439 A53439
RefSeqiNP_004188.1, NM_004197.1 [P49842-2]
NP_115830.1, NM_032454.1 [P49842-1]
UniGeneiHs.654371

Genome annotation databases

EnsembliENST00000375331; ENSP00000364480; ENSG00000204344 [P49842-2]
ENST00000375333; ENSP00000364482; ENSG00000204344 [P49842-1]
ENST00000383327; ENSP00000372817; ENSG00000206342
ENST00000424104; ENSP00000393272; ENSG00000236250 [P49842-2]
ENST00000425138; ENSP00000395028; ENSG00000234947 [P49842-2]
ENST00000426802; ENSP00000389352; ENSG00000226257 [P49842-2]
ENST00000431383; ENSP00000403479; ENSG00000226033 [P49842-1]
ENST00000433397; ENSP00000395864; ENSG00000234947 [P49842-1]
ENST00000438256; ENSP00000391798; ENSG00000236250 [P49842-1]
ENST00000444147; ENSP00000399915; ENSG00000226033 [P49842-2]
ENST00000452688; ENSP00000413766; ENSG00000226257 [P49842-1]
GeneIDi8859
KEGGihsa:8859
UCSCiuc003nyv.4 human [P49842-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77474
, X77489, X77490, X77491 Genomic DNA Translation: CAA54622.1
X77474
, X77489, X77490, X77491 Genomic DNA Translation: CAA54623.1
X77386 mRNA Translation: CAA54565.1
L26261 Genomic DNA Translation: AAA20120.1
L26260 mRNA Translation: AAA20122.1
AF019413 Genomic DNA Translation: AAB67976.1
AL049547 Genomic DNA Translation: CAB89303.1
AL049547 Genomic DNA Translation: CAB89304.1
AL645922 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX679671 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03566.1
CH471081 Genomic DNA Translation: EAX03567.1
U24578 Genomic DNA Translation: AAA99716.1
CCDSiCCDS34417.1 [P49842-2]
CCDS4733.1 [P49842-1]
PIRiB53439 A53439
RefSeqiNP_004188.1, NM_004197.1 [P49842-2]
NP_115830.1, NM_032454.1 [P49842-1]
UniGeneiHs.654371

3D structure databases

ProteinModelPortaliP49842
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114383, 8 interactors
IntActiP49842, 6 interactors
STRINGi9606.ENSP00000364482

PTM databases

iPTMnetiP49842
PhosphoSitePlusiP49842

Polymorphism and mutation databases

BioMutaiSTK19
DMDMi19860281

Proteomic databases

EPDiP49842
MaxQBiP49842
PaxDbiP49842
PeptideAtlasiP49842
PRIDEiP49842
ProteomicsDBi56153
56154 [P49842-2]
56155 [P49842-3]
56156 [P49842-4]

Protocols and materials databases

DNASUi8859
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375331; ENSP00000364480; ENSG00000204344 [P49842-2]
ENST00000375333; ENSP00000364482; ENSG00000204344 [P49842-1]
ENST00000383327; ENSP00000372817; ENSG00000206342
ENST00000424104; ENSP00000393272; ENSG00000236250 [P49842-2]
ENST00000425138; ENSP00000395028; ENSG00000234947 [P49842-2]
ENST00000426802; ENSP00000389352; ENSG00000226257 [P49842-2]
ENST00000431383; ENSP00000403479; ENSG00000226033 [P49842-1]
ENST00000433397; ENSP00000395864; ENSG00000234947 [P49842-1]
ENST00000438256; ENSP00000391798; ENSG00000236250 [P49842-1]
ENST00000444147; ENSP00000399915; ENSG00000226033 [P49842-2]
ENST00000452688; ENSP00000413766; ENSG00000226257 [P49842-1]
GeneIDi8859
KEGGihsa:8859
UCSCiuc003nyv.4 human [P49842-1]

Organism-specific databases

CTDi8859
DisGeNETi8859
EuPathDBiHostDB:ENSG00000204344.14
GeneCardsiSTK19
H-InvDBiHIX0058171
HGNCiHGNC:11398 STK19
HPAiHPA031510
HPA031511
HPA068559
MIMi604977 gene
neXtProtiNX_P49842
OpenTargetsiENSG00000204344
PharmGKBiPA36206
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEVV Eukaryota
ENOG410YGZ8 LUCA
GeneTreeiENSGT00390000018295
HOVERGENiHBG056144
InParanoidiP49842
KOiK08880
OMAiREPVRHC
OrthoDBiEOG093706AL
PhylomeDBiP49842
TreeFamiTF105332

Miscellaneous databases

ChiTaRSiSTK19 human
GeneWikiiSTK19
GenomeRNAii8859
PROiPR:P49842
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204344 Expressed in 103 organ(s), highest expression level in left adrenal gland
CleanExiHS_RP1
HS_STK19
ExpressionAtlasiP49842 baseline and differential
GenevisibleiP49842 HS

Family and domain databases

InterProiView protein in InterPro
IPR018865 Ser/Thr_kinase_19
PANTHERiPTHR15243 PTHR15243, 1 hit
PfamiView protein in Pfam
PF10494 Stk19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTK19_HUMAN
AccessioniPrimary (citable) accession number: P49842
Secondary accession number(s): A6NF95
, A6NFW8, B0QZR5, Q13159, Q31617, Q5JP77, Q5ST72, Q5ST75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 18, 2001
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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