Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 167 (22 Apr 2020)
Sequence version 2 (18 Oct 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Serine/threonine-protein kinase 19

Gene

STK19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 PublicationNote: Divalent metal cations. Has a preference for Mn2+.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Specifically inhibited by ZT-12-037-01 (1a) (N2-cyclopropyl-N4-(1-isopropylpiperidin-4-yl)- 6,7-dimethoxyquinazoline-2,4-diamine) (PubMed:30712867). Inhibition by ZT-12-037-01 (1a) blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth (PubMed:30712867).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Manganese, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase 19Curated (EC:2.7.11.11 Publication)
Alternative name(s):
Protein G111 Publication
Protein RP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STK191 PublicationImported
Synonyms:G111 Publication, RP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11398 STK19

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604977 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49842

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Gain-of-function variants in STK19 are involved in NRAS-driven melanomagenesis (PubMed:30712867). Melanoma are malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites (PubMed:30712867). Conditional knockin mice overexpressing Asn-89 variant exhibit hyperpigmentation of the skin, ears, and tail, and the melanin content in skin was significantly increased after tamoxifen induction (PubMed:30712867). Moreover, knockin mice overexpressing Asn-89 variant promote NRAS 'Arg-61'-driven melanomagenesis (PubMed:30712867).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi134V → Y: Prevents inhition by ZT-12-037-01 (1a) without affecting much the serine/threonine-protein kinase activity. 1 Publication1
Mutagenesisi139L → V: Prevents inhition by ZT-12-037-01 (1a) without affecting much the serine/threonine-protein kinase activity. 1 Publication1
Mutagenesisi300K → P: Partial loss of activity. 1 Publication1
Mutagenesisi315K → P: Partial loss of activity. 1 Publication1
Mutagenesisi317K → P: Complete loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8859

Open Targets

More...
OpenTargetsi
ENSG00000204344

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36206

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49842 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STK19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
19860281

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722751 – 368Serine/threonine-protein kinase 19Add BLAST368

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49842

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49842

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49842

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49842

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49842

PeptideAtlas

More...
PeptideAtlasi
P49842

PRoteomics IDEntifications database

More...
PRIDEi
P49842

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56153 [P49842-1]
56154 [P49842-2]
56155 [P49842-3]
56156 [P49842-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49842

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49842

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204344 Expressed in left adrenal gland and 102 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49842 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49842 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204344 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with BAG1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114383, 9 interactors

Protein interaction database and analysis system

More...
IntActi
P49842, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364482

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P49842 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STK19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEVV Eukaryota
ENOG410YGZ8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018295

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_064399_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49842

KEGG Orthology (KO)

More...
KOi
K08880

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDPEITH

Database of Orthologous Groups

More...
OrthoDBi
1329271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49842

TreeFam database of animal gene trees

More...
TreeFami
TF105332

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018865 Ser/Thr_kinase_19

The PANTHER Classification System

More...
PANTHERi
PTHR15243 PTHR15243, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10494 Stk19, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49842-1) [UniParc]FASTAAdd to basket
Also known as: G11-Z

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKWFSAFDD AIIQRQWRAN PSRGGGGVSF TKEVDTNVAT GAPPRRQRVP
60 70 80 90 100
GRACPWREPI RGRRGARPGG GDAGGTPGET VRHCSAPEDP IFRFSSLHSY
110 120 130 140 150
PFPGTIKSRD MSWKRHHLIP ETFGVKRRRK RGPVESDPLR GEPGSARAAV
160 170 180 190 200
SELMQLFPRG LFEDALPPIV LRSQVYSLVP DRTVADRQLK ELQEQGEIRI
210 220 230 240 250
VQLGFDLDAH GIIFTEDYRT RVCDCVLKAC DGRPYAGAVQ KFLASVLPAC
260 270 280 290 300
GDLSFQQDQM TQTFGFRDSE ITHLVNAGVL TVRDAGSWWL AVPGAGRFIK
310 320 330 340 350
YFVKGRQAVL SMVRKAKYRE LLLSELLGRR APVVVRLGLT YHVHDLIGAQ
360
LVDCISTTSG TLLRLPET
Length:368
Mass (Da):40,916
Last modified:October 18, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA05AC847081DE8F8
GO
Isoform 2 (identifier: P49842-2) [UniParc]FASTAAdd to basket
Also known as: G11-Z-short

The sequence of this isoform differs from the canonical sequence as follows:
     222-225: Missing.

Show »
Length:364
Mass (Da):40,495
Checksum:iB904F6999B7C533E
GO
Isoform 3 (identifier: P49842-3) [UniParc]FASTAAdd to basket
Also known as: G11-Y1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:258
Mass (Da):28,885
Checksum:iBE79A520BA211E22
GO
Isoform 4 (identifier: P49842-4) [UniParc]FASTAAdd to basket
Also known as: G11-Y-short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     222-225: Missing.

Show »
Length:254
Mass (Da):28,465
Checksum:i1B3800438D9DD5A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAS4H0YAS4_HUMAN
Serine/threonine-protein kinase 19
STK19
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLL1A0A0G2JLL1_HUMAN
Serine/threonine-protein kinase 19
STK19
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6S8C9J6S8_HUMAN
Serine/threonine-protein kinase 19
STK19
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZLI8B7ZLI8_HUMAN
Serine/threonine kinase 19
STK19
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8X5A0A140T8X5_HUMAN
STK19
STK19
364Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA37A0A140TA37_HUMAN
Serine/threonine-protein kinase 19
STK19
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195 – 197QGE → GQR in AAA99716 (PubMed:8575831).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05138739A → D. Corresponds to variant dbSNP:rs34843142Ensembl.1
Natural variantiVAR_04236189D → N Recurrent gain-of-function variant found in metastatic melanoma; promotes NRAS signaling; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs267600971EnsemblClinVar.1
Natural variantiVAR_042362311S → G2 PublicationsCorresponds to variant dbSNP:rs616634Ensembl.1
Natural variantiVAR_042363331A → V1 PublicationCorresponds to variant dbSNP:rs7743647Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0044321 – 110Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_004433222 – 225Missing in isoform 2 and isoform 4. 2 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X77474 X77491 Genomic DNA Translation: CAA54622.1
X77474 X77491 Genomic DNA Translation: CAA54623.1
X77386 mRNA Translation: CAA54565.1
L26261 Genomic DNA Translation: AAA20120.1
L26260 mRNA Translation: AAA20122.1
AF019413 Genomic DNA Translation: AAB67976.1
AL049547 Genomic DNA Translation: CAB89303.1
AL049547 Genomic DNA Translation: CAB89304.1
AL645922 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX679671 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03566.1
CH471081 Genomic DNA Translation: EAX03567.1
U24578 Genomic DNA Translation: AAA99716.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34417.1 [P49842-2]
CCDS4733.1 [P49842-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
B53439 A53439

NCBI Reference Sequences

More...
RefSeqi
NP_004188.1, NM_004197.1 [P49842-2]
NP_115830.1, NM_032454.1 [P49842-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375331; ENSP00000364480; ENSG00000204344 [P49842-2]
ENST00000375333; ENSP00000364482; ENSG00000204344 [P49842-1]
ENST00000383327; ENSP00000372817; ENSG00000206342
ENST00000424104; ENSP00000393272; ENSG00000236250 [P49842-2]
ENST00000425138; ENSP00000395028; ENSG00000234947 [P49842-2]
ENST00000426802; ENSP00000389352; ENSG00000226257 [P49842-2]
ENST00000431383; ENSP00000403479; ENSG00000226033 [P49842-1]
ENST00000433397; ENSP00000395864; ENSG00000234947 [P49842-1]
ENST00000438256; ENSP00000391798; ENSG00000236250 [P49842-1]
ENST00000444147; ENSP00000399915; ENSG00000226033 [P49842-2]
ENST00000452688; ENSP00000413766; ENSG00000226257 [P49842-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8859

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8859

UCSC genome browser

More...
UCSCi
uc003nyv.4 human [P49842-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77474 X77491 Genomic DNA Translation: CAA54622.1
X77474 X77491 Genomic DNA Translation: CAA54623.1
X77386 mRNA Translation: CAA54565.1
L26261 Genomic DNA Translation: AAA20120.1
L26260 mRNA Translation: AAA20122.1
AF019413 Genomic DNA Translation: AAB67976.1
AL049547 Genomic DNA Translation: CAB89303.1
AL049547 Genomic DNA Translation: CAB89304.1
AL645922 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX679671 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03566.1
CH471081 Genomic DNA Translation: EAX03567.1
U24578 Genomic DNA Translation: AAA99716.1
CCDSiCCDS34417.1 [P49842-2]
CCDS4733.1 [P49842-1]
PIRiB53439 A53439
RefSeqiNP_004188.1, NM_004197.1 [P49842-2]
NP_115830.1, NM_032454.1 [P49842-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi114383, 9 interactors
IntActiP49842, 7 interactors
STRINGi9606.ENSP00000364482

PTM databases

iPTMnetiP49842
PhosphoSitePlusiP49842

Polymorphism and mutation databases

BioMutaiSTK19
DMDMi19860281

Proteomic databases

EPDiP49842
jPOSTiP49842
MassIVEiP49842
MaxQBiP49842
PaxDbiP49842
PeptideAtlasiP49842
PRIDEiP49842
ProteomicsDBi56153 [P49842-1]
56154 [P49842-2]
56155 [P49842-3]
56156 [P49842-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28162 188 antibodies

The DNASU plasmid repository

More...
DNASUi
8859

Genome annotation databases

EnsembliENST00000375331; ENSP00000364480; ENSG00000204344 [P49842-2]
ENST00000375333; ENSP00000364482; ENSG00000204344 [P49842-1]
ENST00000383327; ENSP00000372817; ENSG00000206342
ENST00000424104; ENSP00000393272; ENSG00000236250 [P49842-2]
ENST00000425138; ENSP00000395028; ENSG00000234947 [P49842-2]
ENST00000426802; ENSP00000389352; ENSG00000226257 [P49842-2]
ENST00000431383; ENSP00000403479; ENSG00000226033 [P49842-1]
ENST00000433397; ENSP00000395864; ENSG00000234947 [P49842-1]
ENST00000438256; ENSP00000391798; ENSG00000236250 [P49842-1]
ENST00000444147; ENSP00000399915; ENSG00000226033 [P49842-2]
ENST00000452688; ENSP00000413766; ENSG00000226257 [P49842-1]
GeneIDi8859
KEGGihsa:8859
UCSCiuc003nyv.4 human [P49842-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8859
DisGeNETi8859

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STK19
HGNCiHGNC:11398 STK19
HPAiENSG00000204344 Low tissue specificity
MIMi604977 gene
neXtProtiNX_P49842
OpenTargetsiENSG00000204344
PharmGKBiPA36206

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEVV Eukaryota
ENOG410YGZ8 LUCA
GeneTreeiENSGT00390000018295
HOGENOMiCLU_064399_0_0_1
InParanoidiP49842
KOiK08880
OMAiRDPEITH
OrthoDBi1329271at2759
PhylomeDBiP49842
TreeFamiTF105332

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
STK19 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
STK19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8859
PharosiP49842 Tbio

Protein Ontology

More...
PROi
PR:P49842
RNActiP49842 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204344 Expressed in left adrenal gland and 102 other tissues
ExpressionAtlasiP49842 baseline and differential
GenevisibleiP49842 HS

Family and domain databases

InterProiView protein in InterPro
IPR018865 Ser/Thr_kinase_19
PANTHERiPTHR15243 PTHR15243, 1 hit
PfamiView protein in Pfam
PF10494 Stk19, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTK19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49842
Secondary accession number(s): A6NF95
, A6NFW8, B0QZR5, Q13159, Q31617, Q5JP77, Q5ST72, Q5ST75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 18, 2001
Last modified: April 22, 2020
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again