UniProtKB - P49841 (GSK3B_HUMAN)
Glycogen synthase kinase-3 beta
GSK3B
Functioni
Miscellaneous
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 85 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 181 | Proton acceptor | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 62 – 70 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- beta-catenin binding Source: BHF-UCL
- dynactin binding Source: ARUK-UCL
- kinase activity Source: UniProtKB
- NF-kappaB binding Source: UniProtKB
- p53 binding Source: MGI
- protease binding Source: ParkinsonsUK-UCL
- protein kinase A catalytic subunit binding Source: BHF-UCL
- protein kinase activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
- RNA polymerase II transcription factor binding Source: UniProtKB
- tau protein binding Source: ARUK-UCL
- tau-protein kinase activity Source: UniProtKB
- ubiquitin protein ligase binding Source: BHF-UCL
GO - Biological processi
- beta-catenin destruction complex assembly Source: Reactome
- beta-catenin destruction complex disassembly Source: Reactome
- cellular response to amyloid-beta Source: ARUK-UCL
- cellular response to interleukin-3 Source: UniProtKB
- circadian rhythm Source: UniProtKB
- dopamine receptor signaling pathway Source: ParkinsonsUK-UCL
- epithelial to mesenchymal transition Source: UniProtKB
- ER overload response Source: MGI
- establishment of cell polarity Source: ARUK-UCL
- excitatory postsynaptic potential Source: ParkinsonsUK-UCL
- extrinsic apoptotic signaling pathway Source: ARUK-UCL
- extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
- glycogen metabolic process Source: BHF-UCL
- hippocampus development Source: BHF-UCL
- insulin receptor signaling pathway Source: GO_Central
- intracellular signal transduction Source: MGI
- maintenance of cell polarity Source: ARUK-UCL
- negative regulation of apoptotic process Source: MGI
- negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- negative regulation of dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
- negative regulation of glycogen (starch) synthase activity Source: UniProtKB
- negative regulation of glycogen biosynthetic process Source: UniProtKB
- negative regulation of neuron death Source: UniProtKB
- negative regulation of phosphoprotein phosphatase activity Source: ARUK-UCL
- negative regulation of protein acetylation Source: ARUK-UCL
- negative regulation of protein binding Source: BHF-UCL
- negative regulation of protein-containing complex assembly Source: BHF-UCL
- negative regulation of protein localization to nucleus Source: BHF-UCL
- negative regulation of type B pancreatic cell development Source: UniProtKB
- neuron projection development Source: UniProtKB
- neuron projection organization Source: ARUK-UCL
- peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of autophagy Source: UniProtKB
- positive regulation of cell-matrix adhesion Source: BHF-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of GTPase activity Source: BHF-UCL
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
- positive regulation of mitochondrion organization Source: ParkinsonsUK-UCL
- positive regulation of neuron death Source: ParkinsonsUK-UCL
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
- positive regulation of protein binding Source: UniProtKB
- positive regulation of protein catabolic process Source: BHF-UCL
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- positive regulation of protein export from nucleus Source: MGI
- positive regulation of protein localization to centrosome Source: ARUK-UCL
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of axon extension Source: ARUK-UCL
- regulation of axonogenesis Source: ARUK-UCL
- regulation of cellular response to heat Source: Reactome
- regulation of circadian rhythm Source: UniProtKB
- regulation of dendrite morphogenesis Source: ARUK-UCL
- regulation of long-term synaptic potentiation Source: UniProtKB
- regulation of microtubule anchoring at centrosome Source: ARUK-UCL
- regulation of microtubule-based process Source: UniProtKB
- regulation of microtubule cytoskeleton organization Source: ARUK-UCL
- regulation of neuron projection development Source: GO_Central
- regulation of synaptic vesicle exocytosis Source: SynGO
- signal transduction Source: GO_Central
- superior temporal gyrus development Source: BHF-UCL
- Wnt signaling pathway Source: Reactome
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase |
Biological process | Biological rhythms, Carbohydrate metabolism, Differentiation, Glycogen metabolism, Neurogenesis, Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.26, 2681 |
PathwayCommonsi | P49841 |
Reactomei | R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-196299, Beta-catenin phosphorylation cascade R-HSA-198323, AKT phosphorylates targets in the cytosol R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-399956, CRMPs in Sema3A signaling R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated R-HSA-5467337, APC truncation mutants have impaired AXIN binding R-HSA-5467340, AXIN missense mutants destabilize the destruction complex R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-9682706, Replication of the SARS-CoV-1 genome R-HSA-9683610, Maturation of nucleoprotein R-HSA-9694631, Maturation of nucleoprotein R-HSA-9694686, Replication of the SARS-CoV-2 genome |
SignaLinki | P49841 |
SIGNORi | P49841 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GSK3B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4617, GSK3B |
MIMi | 605004, gene |
neXtProti | NX_P49841 |
VEuPathDBi | HostDB:ENSG00000082701.14 |
Subcellular locationi
Plasma membrane
Nucleus
Other locations
- Cytoplasm 1 Publication
Note: The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- axon Source: ARUK-UCL
- beta-catenin destruction complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- dendrite Source: ARUK-UCL
- glutamatergic synapse Source: SynGO
- postsynapse Source: GOC
- Wnt signalosome Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 9 | S → A: Loss of phosphorylation; No inhibition of activity and constitutively active. 1 Publication | 1 | |
Mutagenesisi | 96 | R → A: Prevents the phosphorylation of phosphate-primed glycogen synthase. 1 Publication | 1 | |
Mutagenesisi | 128 | L → A: Abolishes activity toward AXIN1. 1 Publication | 1 |
Keywords - Diseasei
Alzheimer disease, Diabetes mellitusOrganism-specific databases
DisGeNETi | 2932 |
OpenTargetsi | ENSG00000082701 |
PharmGKBi | PA29009 |
Miscellaneous databases
Pharosi | P49841, Tclin |
Chemistry databases
ChEMBLi | CHEMBL262 |
DrugBanki | DB08073, (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE DB07149, (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one DB07014, 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole DB07676, 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one DB01772, 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione DB07859, 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE DB07585, 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine DB07058, 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione DB03444, 6-bromoindirubin-3'-oxime DB04014, Alsterpaullone DB01950, AR-AO-14418 DB12010, Fostamatinib DB02052, Indirubin-3'-monoxime DB07947, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE DB14509, Lithium carbonate DB01356, Lithium cation DB14507, Lithium citrate DB14508, Lithium succinate DB07812, N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide DB07584, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine DB04395, Phosphoaminophosphonic Acid-Adenylate Ester DB01793, SB-409513 DB02010, Staurosporine DB12129, Tideglusib |
DrugCentrali | P49841 |
GuidetoPHARMACOLOGYi | 2030 |
Genetic variation databases
BioMutai | GSK3B |
DMDMi | 20455502 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085980 | 1 – 420 | Glycogen synthase kinase-3 betaAdd BLAST | 420 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK36 Publications | 1 | |
Modified residuei | 216 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 389 | PhosphoserineBy similarity | 1 | |
Modified residuei | 390 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 402 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
ADP-ribosylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-804 |
EPDi | P49841 |
jPOSTi | P49841 |
MassIVEi | P49841 |
PaxDbi | P49841 |
PeptideAtlasi | P49841 |
PRIDEi | P49841 |
ProteomicsDBi | 56151 [P49841-1] 56152 [P49841-2] |
PTM databases
iPTMneti | P49841 |
PhosphoSitePlusi | P49841 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000082701, Expressed in forebrain and 241 other tissues |
ExpressionAtlasi | P49841, baseline and differential |
Genevisiblei | P49841, HS |
Organism-specific databases
HPAi | ENSG00000082701, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
Interacts with ARRB2, DISC1 and ZBED3 (By similarity).
Interacts with CABYR, MMP2, MUC1, NIN and PRUNE1.
Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction.
Interacts with and phosphorylates SNAI1.
Interacts with DNM1L (via a C-terminal domain).
Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity).
Interacts with SGK3.
Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation.
Interacts (via C2 domain) with PPP2CA.
Interacts with the CLOCK-ARNTL/BMAL1 heterodimer (PubMed:19946213).
Interacts with the ARNTL/BMAL1 (PubMed:28903391).
Interacts with CTNND2 (PubMed:19706605).
Interacts with NCYM (PubMed:24391509). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (PubMed:25169422).
Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (PubMed:27484798, PubMed:20007971, PubMed:25920809).
Interacts with GSKIP (PubMed:16981698).
Interacts with GID8 (PubMed:28829046).
Interacts with PIWIL2 (By similarity).
Interacts with LMBR1L (PubMed:31073040).
Interacts with DDX3X (PubMed:18846110).
Interacts with BIRC2 (PubMed:18846110).
Interacts with TNFRSF10B; TNFRSF10B stimulation inhibits GSK3B kinase activity (PubMed:18846110).
By similarity24 PublicationsBinary interactionsi
Hide detailsP49841
Isoform 2 [P49841-2]
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-15870655,EBI-77613 |
FUS [P35637] | 3 | EBI-15870655,EBI-400434 |
MYC [P01106] | 3 | EBI-15870655,EBI-447544 |
Dzip1 - isoform 1 [Q8BMD2-1] from Mus musculus. | 3 | EBI-15870655,EBI-16153101 |
GO - Molecular functioni
- beta-catenin binding Source: BHF-UCL
- dynactin binding Source: ARUK-UCL
- NF-kappaB binding Source: UniProtKB
- p53 binding Source: MGI
- protease binding Source: ParkinsonsUK-UCL
- protein kinase A catalytic subunit binding Source: BHF-UCL
- protein kinase binding Source: UniProtKB
- RNA polymerase II transcription factor binding Source: UniProtKB
- tau protein binding Source: ARUK-UCL
- ubiquitin protein ligase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109187, 555 interactors |
ComplexPortali | CPX-109, Beta-catenin destruction core complex, variant 1 CPX-439, Beta-catenin destruction core complex, variant 3 CPX-440, Beta-catenin destruction core complex, variant 4 CPX-459, Nuclear export complex FRAT1-GSK3B CPX-462, Nuclear export complex FRAT2-GSK3B CPX-99, Beta-catenin destruction core complex, variant 2 |
CORUMi | P49841 |
DIPi | DIP-878N |
ELMi | P49841 |
IntActi | P49841, 310 interactors |
MINTi | P49841 |
STRINGi | 9606.ENSP00000324806 |
Chemistry databases
BindingDBi | P49841 |
Miscellaneous databases
RNActi | P49841, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P49841 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P49841 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 340 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 285 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
GeneTreei | ENSGT00520000055635 |
HOGENOMi | CLU_000288_181_20_1 |
InParanoidi | P49841 |
OMAi | MQYTQCK |
OrthoDBi | 990896at2759 |
PhylomeDBi | P49841 |
TreeFami | TF101104 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
DisProti | DP00385 |
IDEALi | IID00052 |
InterProi | View protein in InterPro IPR033573, GSK3B IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
PANTHERi | PTHR24057:SF8, PTHR24057:SF8, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL
360 370 380 390 400
PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA
410 420
NTGDRGQTNN AASASASNST
The sequence of this isoform differs from the canonical sequence as follows:
303-303: K → KDSSGTGHFTSGVR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITW1 | A0A3B3ITW1_HUMAN | Glycogen synthase kinase-3 beta | GSK3B | 470 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | V → G in AAD48517 (PubMed:10486203).Curated | 1 | |
Sequence conflicti | 350 | L → H in AAA66475 (PubMed:7980435).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004790 | 303 | K → KDSSGTGHFTSGVR in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L33801 mRNA Translation: AAA66475.1 CH471052 Genomic DNA Translation: EAW79533.1 CH471052 Genomic DNA Translation: EAW79536.1 BC000251 mRNA Translation: AAH00251.1 BC012760 mRNA Translation: AAH12760.1 AF074333 Genomic DNA Translation: AAD48517.1 AF098789 Genomic DNA Translation: AAC69340.1 |
CCDSi | CCDS2996.1 [P49841-2] CCDS54628.1 [P49841-1] |
PIRi | S53324 |
RefSeqi | NP_001139628.1, NM_001146156.1 [P49841-1] NP_002084.2, NM_002093.3 [P49841-2] |
Genome annotation databases
Ensembli | ENST00000264235; ENSP00000264235; ENSG00000082701 [P49841-1] ENST00000316626; ENSP00000324806; ENSG00000082701 [P49841-2] |
GeneIDi | 2932 |
KEGGi | hsa:2932 |
UCSCi | uc003edn.4, human [P49841-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L33801 mRNA Translation: AAA66475.1 CH471052 Genomic DNA Translation: EAW79533.1 CH471052 Genomic DNA Translation: EAW79536.1 BC000251 mRNA Translation: AAH00251.1 BC012760 mRNA Translation: AAH12760.1 AF074333 Genomic DNA Translation: AAD48517.1 AF098789 Genomic DNA Translation: AAC69340.1 |
CCDSi | CCDS2996.1 [P49841-2] CCDS54628.1 [P49841-1] |
PIRi | S53324 |
RefSeqi | NP_001139628.1, NM_001146156.1 [P49841-1] NP_002084.2, NM_002093.3 [P49841-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GNG | X-ray | 2.60 | A/B | 27-393 | [»] | |
1H8F | X-ray | 2.80 | A/B | 35-386 | [»] | |
1I09 | X-ray | 2.70 | A/B | 1-420 | [»] | |
1J1B | X-ray | 1.80 | A/B | 1-420 | [»] | |
1J1C | X-ray | 2.10 | A/B | 1-420 | [»] | |
1O6K | X-ray | 1.70 | C | 3-12 | [»] | |
1O6L | X-ray | 1.60 | C | 3-12 | [»] | |
1O9U | X-ray | 2.40 | A | 35-384 | [»] | |
1PYX | X-ray | 2.40 | A/B | 1-420 | [»] | |
1Q3D | X-ray | 2.20 | A/B | 2-420 | [»] | |
1Q3W | X-ray | 2.30 | A/B | 2-420 | [»] | |
1Q41 | X-ray | 2.10 | A/B | 2-420 | [»] | |
1Q4L | X-ray | 2.77 | A/B | 2-420 | [»] | |
1Q5K | X-ray | 1.94 | A/B | 7-420 | [»] | |
1R0E | X-ray | 2.25 | A/B | 35-420 | [»] | |
1UV5 | X-ray | 2.80 | A | 35-384 | [»] | |
2JDO | X-ray | 1.80 | C | 3-12 | [»] | |
2JDR | X-ray | 2.30 | C | 3-12 | [»] | |
2JLD | X-ray | 2.35 | A/B | 1-420 | [»] | |
2O5K | X-ray | 3.20 | A | 29-393 | [»] | |
2OW3 | X-ray | 2.80 | A/B | 35-386 | [»] | |
2UW9 | X-ray | 2.10 | C | 3-12 | [»] | |
2X39 | X-ray | 1.93 | C | 3-12 | [»] | |
2XH5 | X-ray | 2.72 | C | 3-12 | [»] | |
3CQU | X-ray | 2.20 | C | 3-12 | [»] | |
3CQW | X-ray | 2.00 | C | 3-12 | [»] | |
3DU8 | X-ray | 2.20 | A/B | 1-420 | [»] | |
3E87 | X-ray | 2.30 | C/D | 3-12 | [»] | |
3E88 | X-ray | 2.50 | C/D | 3-12 | [»] | |
3E8D | X-ray | 2.70 | C/D | 3-12 | [»] | |
3F7Z | X-ray | 2.40 | A/B | 35-383 | [»] | |
3F88 | X-ray | 2.60 | A/B | 35-383 | [»] | |
3GB2 | X-ray | 2.40 | A | 34-383 | [»] | |
3I4B | X-ray | 2.30 | A/B | 7-420 | [»] | |
3L1S | X-ray | 2.90 | A/B | 7-420 | [»] | |
3M1S | X-ray | 3.13 | A/B | 1-420 | [»] | |
3MV5 | X-ray | 2.47 | C | 3-12 | [»] | |
3OW4 | X-ray | 2.60 | C/D | 3-12 | [»] | |
3PUP | X-ray | 2.99 | A/B | 1-420 | [»] | |
3Q3B | X-ray | 2.70 | A/B | 2-420 | [»] | |
3QKK | X-ray | 2.30 | C | 3-12 | [»] | |
3SAY | X-ray | 2.23 | A/B | 1-420 | [»] | |
3SD0 | X-ray | 2.70 | A/B | 35-384 | [»] | |
3ZDI | X-ray | 2.64 | A | 35-384 | [»] | |
3ZRK | X-ray | 2.37 | A/B | 23-393 | [»] | |
3ZRL | X-ray | 2.48 | A/B | 23-393 | [»] | |
3ZRM | X-ray | 2.49 | A/B | 23-393 | [»] | |
4ACC | X-ray | 2.21 | A/B | 1-420 | [»] | |
4ACD | X-ray | 2.60 | A/B | 1-420 | [»] | |
4ACG | X-ray | 2.60 | A/B | 1-420 | [»] | |
4ACH | X-ray | 2.60 | A/B | 1-420 | [»] | |
4AFJ | X-ray | 1.98 | A/B | 27-393 | [»] | |
4B7T | X-ray | 2.77 | A | 35-384 | [»] | |
4DIT | X-ray | 2.60 | A | 27-393 | [»] | |
4EKK | X-ray | 2.80 | C/D | 3-12 | [»] | |
4IQ6 | X-ray | 3.12 | A/B | 1-420 | [»] | |
4J1R | X-ray | 2.70 | A/B/C/D | 1-420 | [»] | |
4J71 | X-ray | 2.31 | A/B | 1-420 | [»] | |
4NM0 | X-ray | 2.50 | A | 1-383 | [»] | |
4NM3 | X-ray | 2.10 | A | 1-383 | [»] | |
4NM5 | X-ray | 2.30 | A | 13-383 | [»] | |
4NM7 | X-ray | 2.30 | A | 13-383 | [»] | |
4PTC | X-ray | 2.71 | A/B | 1-420 | [»] | |
4PTE | X-ray | 2.03 | A/B | 1-420 | [»] | |
4PTG | X-ray | 2.36 | A/B | 1-420 | [»] | |
5F94 | X-ray | 2.51 | A/B | 36-385 | [»] | |
5F95 | X-ray | 2.52 | A/B | 36-385 | [»] | |
5HLN | X-ray | 3.10 | A/B | 1-420 | [»] | |
5HLP | X-ray | 2.45 | A/B | 1-420 | [»] | |
5K5N | X-ray | 2.20 | A/B | 28-384 | [»] | |
5KPK | X-ray | 2.40 | A/B | 1-420 | [»] | |
5KPL | X-ray | 2.60 | A/B | 1-420 | [»] | |
5KPM | X-ray | 2.69 | A/B | 1-420 | [»] | |
5OY4 | X-ray | 3.20 | A/B | 1-420 | [»] | |
5T31 | X-ray | 2.85 | A/B | 1-420 | [»] | |
6B8J | X-ray | 2.60 | A | 1-420 | [»] | |
6BUU | X-ray | 2.40 | F/G | 3-12 | [»] | |
6GJO | X-ray | 2.91 | A/B | 7-420 | [»] | |
6GN1 | X-ray | 2.60 | A/B | 27-393 | [»] | |
6H0U | X-ray | 2.30 | A/B | 1-420 | [»] | |
6HK3 | X-ray | 2.35 | A/B | 35-384 | [»] | |
6HK4 | X-ray | 2.50 | A/B | 35-384 | [»] | |
6HK7 | X-ray | 3.20 | A | 36-382 | [»] | |
6NPZ | X-ray | 2.12 | F/G | 3-12 | [»] | |
6TCU | X-ray | 2.14 | A | 35-386 | [»] | |
6V6L | X-ray | 2.19 | A | 1-420 | [»] | |
6Y9R | X-ray | 2.08 | A | 35-384 | [»] | |
6Y9S | X-ray | 2.03 | A/B | 35-384 | [»] | |
SMRi | P49841 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109187, 555 interactors |
ComplexPortali | CPX-109, Beta-catenin destruction core complex, variant 1 CPX-439, Beta-catenin destruction core complex, variant 3 CPX-440, Beta-catenin destruction core complex, variant 4 CPX-459, Nuclear export complex FRAT1-GSK3B CPX-462, Nuclear export complex FRAT2-GSK3B CPX-99, Beta-catenin destruction core complex, variant 2 |
CORUMi | P49841 |
DIPi | DIP-878N |
ELMi | P49841 |
IntActi | P49841, 310 interactors |
MINTi | P49841 |
STRINGi | 9606.ENSP00000324806 |
Chemistry databases
BindingDBi | P49841 |
ChEMBLi | CHEMBL262 |
DrugBanki | DB08073, (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE DB07149, (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one DB07014, 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole DB07676, 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one DB01772, 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione DB07859, 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE DB07585, 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine DB07058, 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione DB03444, 6-bromoindirubin-3'-oxime DB04014, Alsterpaullone DB01950, AR-AO-14418 DB12010, Fostamatinib DB02052, Indirubin-3'-monoxime DB07947, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE DB14509, Lithium carbonate DB01356, Lithium cation DB14507, Lithium citrate DB14508, Lithium succinate DB07812, N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide DB07584, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine DB04395, Phosphoaminophosphonic Acid-Adenylate Ester DB01793, SB-409513 DB02010, Staurosporine DB12129, Tideglusib |
DrugCentrali | P49841 |
GuidetoPHARMACOLOGYi | 2030 |
PTM databases
iPTMneti | P49841 |
PhosphoSitePlusi | P49841 |
Genetic variation databases
BioMutai | GSK3B |
DMDMi | 20455502 |
Proteomic databases
CPTACi | CPTAC-804 |
EPDi | P49841 |
jPOSTi | P49841 |
MassIVEi | P49841 |
PaxDbi | P49841 |
PeptideAtlasi | P49841 |
PRIDEi | P49841 |
ProteomicsDBi | 56151 [P49841-1] 56152 [P49841-2] |
Protocols and materials databases
Antibodypediai | 4266, 1238 antibodies |
CPTCi | P49841, 10 antibodies |
DNASUi | 2932 |
Genome annotation databases
Ensembli | ENST00000264235; ENSP00000264235; ENSG00000082701 [P49841-1] ENST00000316626; ENSP00000324806; ENSG00000082701 [P49841-2] |
GeneIDi | 2932 |
KEGGi | hsa:2932 |
UCSCi | uc003edn.4, human [P49841-1] |
Organism-specific databases
CTDi | 2932 |
DisGeNETi | 2932 |
GeneCardsi | GSK3B |
HGNCi | HGNC:4617, GSK3B |
HPAi | ENSG00000082701, Low tissue specificity |
MIMi | 605004, gene |
neXtProti | NX_P49841 |
OpenTargetsi | ENSG00000082701 |
PharmGKBi | PA29009 |
VEuPathDBi | HostDB:ENSG00000082701.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
GeneTreei | ENSGT00520000055635 |
HOGENOMi | CLU_000288_181_20_1 |
InParanoidi | P49841 |
OMAi | MQYTQCK |
OrthoDBi | 990896at2759 |
PhylomeDBi | P49841 |
TreeFami | TF101104 |
Enzyme and pathway databases
BRENDAi | 2.7.11.26, 2681 |
PathwayCommonsi | P49841 |
Reactomei | R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-196299, Beta-catenin phosphorylation cascade R-HSA-198323, AKT phosphorylates targets in the cytosol R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-399956, CRMPs in Sema3A signaling R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated R-HSA-5467337, APC truncation mutants have impaired AXIN binding R-HSA-5467340, AXIN missense mutants destabilize the destruction complex R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-9682706, Replication of the SARS-CoV-1 genome R-HSA-9683610, Maturation of nucleoprotein R-HSA-9694631, Maturation of nucleoprotein R-HSA-9694686, Replication of the SARS-CoV-2 genome |
SignaLinki | P49841 |
SIGNORi | P49841 |
Miscellaneous databases
BioGRID-ORCSi | 2932, 53 hits in 918 CRISPR screens |
ChiTaRSi | GSK3B, human |
EvolutionaryTracei | P49841 |
GeneWikii | GSK3B |
GenomeRNAii | 2932 |
Pharosi | P49841, Tclin |
PROi | PR:P49841 |
RNActi | P49841, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000082701, Expressed in forebrain and 241 other tissues |
ExpressionAtlasi | P49841, baseline and differential |
Genevisiblei | P49841, HS |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
DisProti | DP00385 |
IDEALi | IID00052 |
InterProi | View protein in InterPro IPR033573, GSK3B IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
PANTHERi | PTHR24057:SF8, PTHR24057:SF8, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GSK3B_HUMAN | |
Accessioni | P49841Primary (citable) accession number: P49841 Secondary accession number(s): D3DN89, Q9BWH3, Q9UL47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 2, 2002 | |
Last modified: | February 10, 2021 | |
This is version 250 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families