Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caveolin-1

Gene

Cav1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-203615 eNOS activation
R-MMU-203641 NOSTRIN mediated eNOS trafficking
R-MMU-210991 Basigin interactions
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-5218920 VEGFR2 mediated vascular permeability

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:102709 Cav1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 104CytoplasmicSequence analysisAdd BLAST103
Intramembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 178CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000047662 – 178Caveolin-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineBy similarity1
Modified residuei5N6-acetyllysine; alternateCombined sources1
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei14Phosphotyrosine; by ABL1 and INSRCombined sources2 Publications1
Modified residuei25PhosphotyrosineBy similarity1
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Lipidationi133S-palmitoyl cysteineBy similarity1
Lipidationi143S-palmitoyl cysteineBy similarity1
Lipidationi156S-palmitoyl cysteineBy similarity1

Post-translational modificationi

The N-terminus of both isoforms are blocked.
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.2 Publications
Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP49817
PaxDbiP49817
PeptideAtlasiP49817
PRIDEiP49817

PTM databases

iPTMnetiP49817
PhosphoSitePlusiP49817
SwissPalmiP49817

Expressioni

Tissue specificityi

Adipose tissue, lung, heart, skeletal muscle, stomach, small bowel, kidney, spleen and testis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000007655 Expressed in 264 organ(s), highest expression level in adipose tissue
CleanExiMM_CAV1
ExpressionAtlasiP49817 baseline and differential
GenevisibleiP49817 MM

Interactioni

Subunit structurei

Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1 (By similarity). Interacts with PACSIN2 (PubMed:21610094). Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Interacts with CAVIN1 (PubMed:19546242). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198514, 10 interactors
DIPiDIP-35140N
IntActiP49817, 19 interactors
MINTiP49817
STRINGi10090.ENSMUSP00000007799

Structurei

3D structure databases

SMRiP49817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 94Required for homooligomerizationBy similarityAdd BLAST93
Regioni82 – 94Interaction with CAVIN3By similarityAdd BLAST13

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IV7A Eukaryota
ENOG4111HJR LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP49817
KOiK06278
OMAiIYVHTFC
OrthoDBiEOG091G0M1R
PhylomeDBiP49817
TreeFamiTF315736

Family and domain databases

InterProiView protein in InterPro
IPR015504 CAV-1
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF18 PTHR10844:SF18, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49817-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPLF EAIGKIFSNI RISTQKEI
Length:178
Mass (Da):20,539
Last modified:October 1, 1996 - v1
Checksum:iCF88FE9B1D3D67AE
GO
Isoform 2 (identifier: P49817-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:147
Mass (Da):17,090
Checksum:iF1D1A06351AF6C3C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z148D3Z148_MOUSE
Caveolin
Cav1
115Annotation score:
D3Z0J2D3Z0J2_MOUSE
Caveolin
Cav1
47Annotation score:
H3BKG0H3BKG0_MOUSE
Caveolin-1
Cav1
93Annotation score:
H3BLQ4H3BLQ4_MOUSE
Caveolin-1
Cav1
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170I → F in BAC29118 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186931 – 31Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07645 mRNA Translation: AAA85784.1
AB029929 mRNA Translation: BAA89461.1
AB029930 mRNA Translation: BAA89462.1
AB029931 Genomic DNA Translation: BAA89463.1
AY439333 mRNA Translation: AAR99702.1
AK003489 mRNA Translation: BAB22817.1
AK028738 mRNA Translation: BAC26091.1
AK035592 mRNA Translation: BAC29118.1
AK090074 mRNA Translation: BAC41079.1
BC038280 mRNA Translation: AAH38280.1
BC052859 mRNA Translation: AAH52859.1
CCDSiCCDS19924.1 [P49817-1]
CCDS57410.1 [P49817-2]
PIRiI48976
RefSeqiNP_001229993.1, NM_001243064.1 [P49817-2]
NP_031642.1, NM_007616.4 [P49817-1]
XP_006505037.1, XM_006504974.1 [P49817-1]
XP_006505038.1, XM_006504975.1 [P49817-2]
XP_006505039.1, XM_006504976.1 [P49817-2]
UniGeneiMm.28278

Genome annotation databases

EnsembliENSMUST00000007799; ENSMUSP00000007799; ENSMUSG00000007655 [P49817-1]
ENSMUST00000115453; ENSMUSP00000111113; ENSMUSG00000007655 [P49817-2]
ENSMUST00000115454; ENSMUSP00000111114; ENSMUSG00000007655 [P49817-2]
ENSMUST00000115456; ENSMUSP00000111116; ENSMUSG00000007655 [P49817-1]
GeneIDi12389
KEGGimmu:12389
UCSCiuc009azo.2 mouse [P49817-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07645 mRNA Translation: AAA85784.1
AB029929 mRNA Translation: BAA89461.1
AB029930 mRNA Translation: BAA89462.1
AB029931 Genomic DNA Translation: BAA89463.1
AY439333 mRNA Translation: AAR99702.1
AK003489 mRNA Translation: BAB22817.1
AK028738 mRNA Translation: BAC26091.1
AK035592 mRNA Translation: BAC29118.1
AK090074 mRNA Translation: BAC41079.1
BC038280 mRNA Translation: AAH38280.1
BC052859 mRNA Translation: AAH52859.1
CCDSiCCDS19924.1 [P49817-1]
CCDS57410.1 [P49817-2]
PIRiI48976
RefSeqiNP_001229993.1, NM_001243064.1 [P49817-2]
NP_031642.1, NM_007616.4 [P49817-1]
XP_006505037.1, XM_006504974.1 [P49817-1]
XP_006505038.1, XM_006504975.1 [P49817-2]
XP_006505039.1, XM_006504976.1 [P49817-2]
UniGeneiMm.28278

3D structure databases

SMRiP49817
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198514, 10 interactors
DIPiDIP-35140N
IntActiP49817, 19 interactors
MINTiP49817
STRINGi10090.ENSMUSP00000007799

PTM databases

iPTMnetiP49817
PhosphoSitePlusiP49817
SwissPalmiP49817

Proteomic databases

MaxQBiP49817
PaxDbiP49817
PeptideAtlasiP49817
PRIDEiP49817

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007799; ENSMUSP00000007799; ENSMUSG00000007655 [P49817-1]
ENSMUST00000115453; ENSMUSP00000111113; ENSMUSG00000007655 [P49817-2]
ENSMUST00000115454; ENSMUSP00000111114; ENSMUSG00000007655 [P49817-2]
ENSMUST00000115456; ENSMUSP00000111116; ENSMUSG00000007655 [P49817-1]
GeneIDi12389
KEGGimmu:12389
UCSCiuc009azo.2 mouse [P49817-1]

Organism-specific databases

CTDi857
MGIiMGI:102709 Cav1

Phylogenomic databases

eggNOGiENOG410IV7A Eukaryota
ENOG4111HJR LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP49817
KOiK06278
OMAiIYVHTFC
OrthoDBiEOG091G0M1R
PhylomeDBiP49817
TreeFamiTF315736

Enzyme and pathway databases

ReactomeiR-MMU-203615 eNOS activation
R-MMU-203641 NOSTRIN mediated eNOS trafficking
R-MMU-210991 Basigin interactions
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-5218920 VEGFR2 mediated vascular permeability

Miscellaneous databases

PROiPR:P49817
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007655 Expressed in 264 organ(s), highest expression level in adipose tissue
CleanExiMM_CAV1
ExpressionAtlasiP49817 baseline and differential
GenevisibleiP49817 MM

Family and domain databases

InterProiView protein in InterPro
IPR015504 CAV-1
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF18 PTHR10844:SF18, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAV1_MOUSE
AccessioniPrimary (citable) accession number: P49817
Secondary accession number(s): Q8C1X7
, Q8CBP4, Q9QYH3, Q9QYH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 195 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again