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Protein

Tropomodulin-1

Gene

Tmod1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: InterPro
  • tropomyosin binding Source: MGI

GO - Biological processi

  • actin filament organization Source: GO_Central
  • adult locomotory behavior Source: MGI
  • lens fiber cell development Source: CACAO
  • muscle contraction Source: MGI
  • myofibril assembly Source: MGI
  • pointed-end actin filament capping Source: InterPro

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-1
Alternative name(s):
Erythrocyte tropomodulin
Short name:
E-Tmod
Gene namesi
Name:Tmod1
Synonyms:Tmod
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98775 Tmod1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861291 – 359Tropomodulin-1Add BLAST359

Proteomic databases

MaxQBiP49813
PaxDbiP49813
PeptideAtlasiP49813
PRIDEiP49813
TopDownProteomicsiP49813

PTM databases

iPTMnetiP49813
PhosphoSitePlusiP49813

Expressioni

Tissue specificityi

Highly expressed in the erythrocyte, heart and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000028328
CleanExiMM_TMOD1
ExpressionAtlasiP49813 baseline and differential
GenevisibleiP49813 MM

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: InterPro
  • tropomyosin binding Source: MGI

Protein-protein interaction databases

BioGridi204233, 1 interactor
IntActiP49813, 2 interactors
MINTiP49813
STRINGi10090.ENSMUSP00000103402

Structurei

3D structure databases

ProteinModelPortaliP49813
SMRiP49813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 138Tropomyosin-bindingSequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00760000119226
HOGENOMiHOG000261624
HOVERGENiHBG056172
InParanoidiP49813
KOiK10370
OMAiSTIVNKQ
OrthoDBiEOG091G0C3H
TreeFamiTF315841

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR030135 TMOD1
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF8 PTHR10901:SF8, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit

Sequencei

Sequence statusi: Complete.

P49813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ
60 70 80 90 100
KDQTTKAPTG PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ
110 120 130 140 150
KPMDPVLESV TLEPELEEAL ANASDAELCD IAAILGMHTL MSNQQYYQAL
160 170 180 190 200
GSSSIVNKEG LNSVIKPTQY KPVPDEEPNS TDVEETLERI KNNDPELEEV
210 220 230 240 250
NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV AFALAEMLKV
260 270 280 290 300
NKVLKTLNVE SNFISGAGIL RLVEALPHNT SLVELKIDNQ SQPLGNKVEM
310 320 330 340 350
EIVNMLEKNT TLLKFGYHFT QQGPRLRASN AMMSNNDLVR KRRLADLTGP

IIPKCRSGV
Length:359
Mass (Da):40,466
Last modified:July 27, 2011 - v2
Checksum:iEAE340B83048823B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352I → M in AAB33388 (PubMed:7851652).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76831 mRNA Translation: AAB33388.1
AF287746
, AF287738, AF287739, AF287740, AF287741, AF287742, AF287743, AF287744, AF287745 Genomic DNA Translation: AAF91487.1
AL732615 Genomic DNA Translation: CAM17028.1
CH466565 Genomic DNA Translation: EDL02383.1
BC106849 mRNA Translation: AAI06850.1
BC106850 mRNA Translation: AAI06851.1
CCDSiCCDS18143.1
RefSeqiNP_068683.1, NM_021883.2
UniGeneiMm.249594
Mm.331588

Genome annotation databases

EnsembliENSMUST00000107773; ENSMUSP00000103402; ENSMUSG00000028328
GeneIDi21916
KEGGimmu:21916
UCSCiuc008ste.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTMOD1_MOUSE
AccessioniPrimary (citable) accession number: P49813
Secondary accession number(s): Q3KP84, Q9ERR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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