UniProtKB - P49806 (RGS10_RAT)
Protein
Regulator of G-protein signaling 10
Gene
Rgs10
Organism
Rattus norvegicus (Rat)
Status
Functioni
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.By similarity
GO - Molecular functioni
- G-protein alpha-subunit binding Source: RGD
- GTPase activator activity Source: UniProtKB
GO - Biological processi
- G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
- negative regulation of signal transduction Source: UniProtKB-KW
- positive regulation of GTPase activity Source: UniProtKB
- regulation of G protein-coupled receptor signaling pathway Source: RGD
- response to amphetamine Source: RGD
Keywordsi
Molecular function | GTPase activation, Signal transduction inhibitor |
Enzyme and pathway databases
Reactomei | R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 10Short name: RGS10 |
Gene namesi | Name:Rgs10 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3562, Rgs10 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: RGD
Other locations
- axon terminus Source: RGD
- dendritic spine Source: RGD
- neuronal cell body Source: RGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204209 | 1 – 181 | Regulator of G-protein signaling 10Add BLAST | 181 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphoserineBy similarity | 1 | |
Modified residuei | 41 | PhosphoserineBy similarity | 1 | |
Lipidationi | 74 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 176 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P49806 |
PRIDEi | P49806 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000042592, Expressed in thymus and 21 other tissues |
Interactioni
Subunit structurei
Interacts with GNAZ, GNAI1 and GNAI3. Associates specifically with the activated, GTP-bound forms of GNAZ and GNAI3.
By similarityGO - Molecular functioni
- G-protein alpha-subunit binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027375 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 156 | RGSPROSITE-ProRule annotationAdd BLAST | 116 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000161426 |
InParanoidi | P49806 |
OMAi | DPPDTQT |
TreeFami | TF315837 |
Family and domain databases
CDDi | cd08741, RGS_RGS10, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR037879, RGS10_RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
i Sequence
Sequence statusi: Complete.
P49806-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFTRAVSRLS RKRPPSDIHD GDGSSSSGHQ SLKSTAKWAS SLENLLEDPE
60 70 80 90 100
GVKRFREFLK KEFSEENVLF WLACEDFKKT EDKKQMQEKA KKIYMTFLSN
110 120 130 140 150
KASSQVNVEG QSRLTEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD
160 170 180
LFLKHRRTEE EEEDPPDAQT AAKRASRIYN T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07005782 Genomic DNA No translation available. AABR07005783 Genomic DNA No translation available. AABR07071989 Genomic DNA No translation available. CH473956 Genomic DNA Translation: EDM17179.1 U32437 mRNA Translation: AAC52374.1 |
Genome annotation databases
Ensembli | ENSRNOT00000027375; ENSRNOP00000027375; ENSRNOG00000042592 |
UCSCi | RGD:3562, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07005782 Genomic DNA No translation available. AABR07005783 Genomic DNA No translation available. AABR07071989 Genomic DNA No translation available. CH473956 Genomic DNA Translation: EDM17179.1 U32437 mRNA Translation: AAC52374.1 |
3D structure databases
SMRi | P49806 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027375 |
Proteomic databases
PaxDbi | P49806 |
PRIDEi | P49806 |
Genome annotation databases
Ensembli | ENSRNOT00000027375; ENSRNOP00000027375; ENSRNOG00000042592 |
UCSCi | RGD:3562, rat |
Organism-specific databases
RGDi | 3562, Rgs10 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000161426 |
InParanoidi | P49806 |
OMAi | DPPDTQT |
TreeFami | TF315837 |
Enzyme and pathway databases
Reactomei | R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P49806 |
Gene expression databases
Bgeei | ENSRNOG00000042592, Expressed in thymus and 21 other tissues |
Family and domain databases
CDDi | cd08741, RGS_RGS10, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR037879, RGS10_RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS10_RAT | |
Accessioni | P49806Primary (citable) accession number: P49806 Secondary accession number(s): G3V8Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 17, 2016 | |
Last modified: | August 12, 2020 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |