UniProtKB - P49800 (RGS5_RAT)
Protein
Regulator of G-protein signaling 5
Gene
Rgs5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).By similarity
GO - Biological processi
- negative regulation of signal transduction Source: UniProtKB-KW
- negative regulation of vascular associated smooth muscle cell proliferation Source: RGD
- signal transduction Source: RGD
Keywordsi
Molecular function | Signal transduction inhibitor |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 5Short name: RGS5 |
Gene namesi | Name:Rgs5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3568, Rgs5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204191 | 1 – 181 | Regulator of G-protein signaling 5Add BLAST | 181 |
Proteomic databases
PaxDbi | P49800 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 180 | RGSPROSITE-ProRule annotationAdd BLAST | 117 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
InParanoidi | P49800 |
OrthoDBi | 1416350at2759 |
PhylomeDBi | P49800 |
Family and domain databases
CDDi | cd08717, RGS_RGS5, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR034955, RGS5 IPR034956, RGS_RGS5 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF42, PTHR10845:SF42, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P49800-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA
60 70 80 90 100
HKPSLEEVLQ WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY
110 120 130 140 150
KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPHS
160 170 180
FDLAQKRIYA LMEKDSLPRF VRSEFYKELI N
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JVF3 | A0A0G2JVF3_RAT | Regulator of G-protein signaling 5 | Rgs5 | 180 | Annotation score: | ||
F1LP00 | F1LP00_RAT | Regulator of G-protein signaling 5 | Rgs5 | 167 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF241259 mRNA Translation: AAF73424.1 U32435 mRNA Translation: AAC52372.1 |
RefSeqi | NP_062214.1, NM_019341.1 |
Genome annotation databases
GeneIDi | 54294 |
KEGGi | rno:54294 |
UCSCi | RGD:3568, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF241259 mRNA Translation: AAF73424.1 U32435 mRNA Translation: AAC52372.1 |
RefSeqi | NP_062214.1, NM_019341.1 |
3D structure databases
SMRi | P49800 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003705 |
Proteomic databases
PaxDbi | P49800 |
Genome annotation databases
GeneIDi | 54294 |
KEGGi | rno:54294 |
UCSCi | RGD:3568, rat |
Organism-specific databases
CTDi | 8490 |
RGDi | 3568, Rgs5 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
InParanoidi | P49800 |
OrthoDBi | 1416350at2759 |
PhylomeDBi | P49800 |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P49800 |
Family and domain databases
CDDi | cd08717, RGS_RGS5, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR034955, RGS5 IPR034956, RGS_RGS5 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF42, PTHR10845:SF42, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS5_RAT | |
Accessioni | P49800Primary (citable) accession number: P49800 Secondary accession number(s): Q9JKD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 21, 2001 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |