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Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

GO - Molecular functioni

  • calmodulin binding Source: ProtInc
  • G-protein alpha-subunit binding Source: Ensembl
  • GTPase activator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGP4
Short name:
RGS4
Gene namesi
Name:RGS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117152.13
HGNCiHGNC:10000 RGS4
MIMi602516 gene
neXtProtiNX_P49798

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Schizophrenia (SCZD)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
See also OMIM:181500

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNETi5999
MIMi181500 phenotype
OpenTargetsiENSG00000117152
Orphaneti3140 Schizophrenia
PharmGKBiPA34375

Chemistry databases

ChEMBLiCHEMBL1795091
GuidetoPHARMACOLOGYi2811

Polymorphism and mutation databases

BioMutaiRGS4
DMDMi1710146

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041851 – 205Regulator of G-protein signaling 4Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2S-palmitoyl cysteine1 Publication1
Lipidationi12S-palmitoyl cysteine1 Publication1
Lipidationi95S-palmitoyl cysteine1 Publication1

Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12.1 Publication
Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP49798
PRIDEiP49798
ProteomicsDBi56129
56130 [P49798-2]
56131 [P49798-3]
56132 [P49798-4]
56133 [P49798-5]

PTM databases

iPTMnetiP49798
PhosphoSitePlusiP49798
SwissPalmiP49798

Expressioni

Tissue specificityi

Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.1 Publication

Gene expression databases

BgeeiENSG00000117152 Expressed in 185 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_RGS4
ExpressionAtlasiP49798 baseline and differential
GenevisibleiP49798 HS

Organism-specific databases

HPAiHPA030802

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111931, 16 interactors
DIPiDIP-59092N
IntActiP49798, 3 interactors
STRINGi9606.ENSP00000397181

Chemistry databases

BindingDBiP49798

Structurei

3D structure databases

ProteinModelPortaliP49798
SMRiP49798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 178RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000049106
HOVERGENiHBG013233
InParanoidiP49798
KOiK16449
OMAiNIDFWVS
OrthoDBiEOG091G0BDG
PhylomeDBiP49798
TreeFamiTF315837

Family and domain databases

CDDicd08714 RGS_RGS4, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034952 RGS4
IPR034953 RGS_RGS4
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF184 PTHR10845:SF184, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: May be produced by alternative promoter usage.

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P49798-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR
60 70 80 90 100
VSQEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
110 120 130 140 150
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD
160 170 180 190 200
EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP SSCGAEKQKG AKSSADCASL

VPQCA
Length:205
Mass (Da):23,256
Last modified:October 1, 1996 - v1
Checksum:i7713F1F7496A698B
GO
Isoform 2 (identifier: P49798-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: F → S

Show »
Length:205
Mass (Da):23,196
Checksum:i6AA52A87496A698B
GO
Isoform 3 (identifier: P49798-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MYNMMLLIQK...LANSKLLNKM

Show »
Length:302
Mass (Da):33,919
Checksum:i1D058A564C79BB58
GO
Isoform 4 (identifier: P49798-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-205: GLAAFKAFLK...DCASLVPQCA → EPGFLHQGRDKPEHARAYNNLL

Show »
Length:93
Mass (Da):10,556
Checksum:i52F755864B24E3FA
GO
Isoform 5 (identifier: P49798-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:187
Mass (Da):21,452
Checksum:i33A39E66A6333B5C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS05E9PS05_HUMAN
Regulator of G-protein-signaling 4
RGS4
143Annotation score:
E9PR32E9PR32_HUMAN
Regulator of G-protein-signaling 4
RGS4
113Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051795195A → S. Corresponds to variant dbSNP:rs14665Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0438541 – 18Missing in isoform 5. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0438531M → MYNMMLLIQKRKGIGSQLLR AGEAEGDRGAGTAERSSDWL DGRSWAIKETPTGLAGRRSE DSDNIFTGEEAKYAQSRSHS SSCRISFLLANSKLLNKM in isoform 3. 2 Publications1
Alternative sequenceiVSP_04385572 – 205GLAAF…VPQCA → EPGFLHQGRDKPEHARAYNN LL in isoform 4. CuratedAdd BLAST134
Alternative sequenceiVSP_043856173F → S in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27768 mRNA Translation: AAC50395.1
DQ346662 mRNA Translation: ABC94590.1
DQ346663 mRNA Translation: ABC94591.1
DQ346664 mRNA Translation: ABC94592.1
EF054877 mRNA Translation: ABL74968.1
AK093959 mRNA No translation available.
AK295540 mRNA Translation: BAG58449.1
AK296240 mRNA Translation: BAG58958.1
AK312250 mRNA Translation: BAG35182.1
AF493928 mRNA Translation: AAM12642.1
BT007025 mRNA Translation: AAP35671.1
AL583850 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90727.1
CH471067 Genomic DNA Translation: EAW90728.1
BC000737 mRNA Translation: AAH00737.1
BC051869 mRNA Translation: AAH51869.1
CCDSiCCDS1243.1 [P49798-1]
CCDS44270.1 [P49798-3]
CCDS44271.1 [P49798-4]
CCDS44272.1 [P49798-5]
PIRiS78221
RefSeqiNP_001095915.1, NM_001102445.2 [P49798-3]
NP_001106851.1, NM_001113380.1 [P49798-5]
NP_001106852.1, NM_001113381.1 [P49798-4]
NP_005604.1, NM_005613.5 [P49798-1]
UniGeneiHs.386726

Genome annotation databases

EnsembliENST00000367906; ENSP00000356882; ENSG00000117152 [P49798-5]
ENST00000367908; ENSP00000356884; ENSG00000117152 [P49798-4]
ENST00000367909; ENSP00000356885; ENSG00000117152 [P49798-1]
ENST00000421743; ENSP00000397181; ENSG00000117152 [P49798-3]
ENST00000527809; ENSP00000433261; ENSG00000117152 [P49798-5]
GeneIDi5999
KEGGihsa:5999
UCSCiuc001gcl.5 human [P49798-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRGS4_HUMAN
AccessioniPrimary (citable) accession number: P49798
Secondary accession number(s): A7XA56
, A7XA58, A7XA59, A7YVV7, B1APZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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