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Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calmodulin binding Source: ProtInc
  • G-protein alpha-subunit binding Source: Ensembl
  • GTPase activator activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGP4
Short name:
RGS4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000117152.13

Human Gene Nomenclature Database

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HGNCi
HGNC:10000 RGS4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602516 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P49798

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Schizophrenia (SCZD)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
See also OMIM:181500

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNET

More...
DisGeNETi
5999
MIMi181500 phenotype

Open Targets

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OpenTargetsi
ENSG00000117152

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34375

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1795091

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2811

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RGS4

Domain mapping of disease mutations (DMDM)

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DMDMi
1710146

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041851 – 205Regulator of G-protein signaling 4Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2S-palmitoyl cysteine1 Publication1
Lipidationi12S-palmitoyl cysteine1 Publication1
Lipidationi95S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12.1 Publication
Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P49798

PRoteomics IDEntifications database

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PRIDEi
P49798

ProteomicsDB human proteome resource

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ProteomicsDBi
56129
56130 [P49798-2]
56131 [P49798-3]
56132 [P49798-4]
56133 [P49798-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49798

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P49798

SwissPalm database of S-palmitoylation events

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SwissPalmi
P49798

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000117152 Expressed in 185 organ(s), highest expression level in middle temporal gyrus

CleanEx database of gene expression profiles

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CleanExi
HS_RGS4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49798 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49798 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA030802

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111931, 16 interactors

Database of interacting proteins

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DIPi
DIP-59092N

Protein interaction database and analysis system

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IntActi
P49798, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000397181

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P49798

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P49798

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49798

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 178RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159036

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233512

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG013233

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49798

KEGG Orthology (KO)

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KOi
K16449

Identification of Orthologs from Complete Genome Data

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OMAi
NIDFWVS

Database of Orthologous Groups

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OrthoDBi
282791at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P49798

TreeFam database of animal gene trees

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TreeFami
TF315837

Family and domain databases

Conserved Domains Database

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CDDi
cd08714 RGS_RGS4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.196.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016137 RGS
IPR034952 RGS4
IPR034953 RGS_RGS4
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3

The PANTHER Classification System

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PANTHERi
PTHR10845:SF184 PTHR10845:SF184, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48097 SSF48097, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: May be produced by alternative promoter usage.

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49798-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR
60 70 80 90 100
VSQEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
110 120 130 140 150
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD
160 170 180 190 200
EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP SSCGAEKQKG AKSSADCASL

VPQCA
Length:205
Mass (Da):23,256
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7713F1F7496A698B
GO
Isoform 2 (identifier: P49798-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: F → S

Show »
Length:205
Mass (Da):23,196
Checksum:i6AA52A87496A698B
GO
Isoform 3 (identifier: P49798-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MYNMMLLIQK...LANSKLLNKM

Show »
Length:302
Mass (Da):33,919
Checksum:i1D058A564C79BB58
GO
Isoform 4 (identifier: P49798-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-205: GLAAFKAFLK...DCASLVPQCA → EPGFLHQGRDKPEHARAYNNLL

Show »
Length:93
Mass (Da):10,556
Checksum:i52F755864B24E3FA
GO
Isoform 5 (identifier: P49798-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:187
Mass (Da):21,452
Checksum:i33A39E66A6333B5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS05E9PS05_HUMAN
Regulator of G-protein-signaling 4
RGS4
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR32E9PR32_HUMAN
Regulator of G-protein-signaling 4
RGS4
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051795195A → S. Corresponds to variant dbSNP:rs14665Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0438541 – 18Missing in isoform 5. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0438531M → MYNMMLLIQKRKGIGSQLLR AGEAEGDRGAGTAERSSDWL DGRSWAIKETPTGLAGRRSE DSDNIFTGEEAKYAQSRSHS SSCRISFLLANSKLLNKM in isoform 3. 2 Publications1
Alternative sequenceiVSP_04385572 – 205GLAAF…VPQCA → EPGFLHQGRDKPEHARAYNN LL in isoform 4. CuratedAdd BLAST134
Alternative sequenceiVSP_043856173F → S in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U27768 mRNA Translation: AAC50395.1
DQ346662 mRNA Translation: ABC94590.1
DQ346663 mRNA Translation: ABC94591.1
DQ346664 mRNA Translation: ABC94592.1
EF054877 mRNA Translation: ABL74968.1
AK093959 mRNA No translation available.
AK295540 mRNA Translation: BAG58449.1
AK296240 mRNA Translation: BAG58958.1
AK312250 mRNA Translation: BAG35182.1
AF493928 mRNA Translation: AAM12642.1
BT007025 mRNA Translation: AAP35671.1
AL583850 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90727.1
CH471067 Genomic DNA Translation: EAW90728.1
BC000737 mRNA Translation: AAH00737.1
BC051869 mRNA Translation: AAH51869.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1243.1 [P49798-1]
CCDS44270.1 [P49798-3]
CCDS44271.1 [P49798-4]
CCDS44272.1 [P49798-5]

Protein sequence database of the Protein Information Resource

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PIRi
S78221

NCBI Reference Sequences

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RefSeqi
NP_001095915.1, NM_001102445.2 [P49798-3]
NP_001106851.1, NM_001113380.1 [P49798-5]
NP_001106852.1, NM_001113381.1 [P49798-4]
NP_005604.1, NM_005613.5 [P49798-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.386726

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000367906; ENSP00000356882; ENSG00000117152 [P49798-5]
ENST00000367908; ENSP00000356884; ENSG00000117152 [P49798-4]
ENST00000367909; ENSP00000356885; ENSG00000117152 [P49798-1]
ENST00000421743; ENSP00000397181; ENSG00000117152 [P49798-3]
ENST00000527809; ENSP00000433261; ENSG00000117152 [P49798-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5999

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5999

UCSC genome browser

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UCSCi
uc001gcl.5 human [P49798-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27768 mRNA Translation: AAC50395.1
DQ346662 mRNA Translation: ABC94590.1
DQ346663 mRNA Translation: ABC94591.1
DQ346664 mRNA Translation: ABC94592.1
EF054877 mRNA Translation: ABL74968.1
AK093959 mRNA No translation available.
AK295540 mRNA Translation: BAG58449.1
AK296240 mRNA Translation: BAG58958.1
AK312250 mRNA Translation: BAG35182.1
AF493928 mRNA Translation: AAM12642.1
BT007025 mRNA Translation: AAP35671.1
AL583850 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90727.1
CH471067 Genomic DNA Translation: EAW90728.1
BC000737 mRNA Translation: AAH00737.1
BC051869 mRNA Translation: AAH51869.1
CCDSiCCDS1243.1 [P49798-1]
CCDS44270.1 [P49798-3]
CCDS44271.1 [P49798-4]
CCDS44272.1 [P49798-5]
PIRiS78221
RefSeqiNP_001095915.1, NM_001102445.2 [P49798-3]
NP_001106851.1, NM_001113380.1 [P49798-5]
NP_001106852.1, NM_001113381.1 [P49798-4]
NP_005604.1, NM_005613.5 [P49798-1]
UniGeneiHs.386726

3D structure databases

ProteinModelPortaliP49798
SMRiP49798
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111931, 16 interactors
DIPiDIP-59092N
IntActiP49798, 3 interactors
STRINGi9606.ENSP00000397181

Chemistry databases

BindingDBiP49798
ChEMBLiCHEMBL1795091
GuidetoPHARMACOLOGYi2811

PTM databases

iPTMnetiP49798
PhosphoSitePlusiP49798
SwissPalmiP49798

Polymorphism and mutation databases

BioMutaiRGS4
DMDMi1710146

Proteomic databases

PaxDbiP49798
PRIDEiP49798
ProteomicsDBi56129
56130 [P49798-2]
56131 [P49798-3]
56132 [P49798-4]
56133 [P49798-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5999
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367906; ENSP00000356882; ENSG00000117152 [P49798-5]
ENST00000367908; ENSP00000356884; ENSG00000117152 [P49798-4]
ENST00000367909; ENSP00000356885; ENSG00000117152 [P49798-1]
ENST00000421743; ENSP00000397181; ENSG00000117152 [P49798-3]
ENST00000527809; ENSP00000433261; ENSG00000117152 [P49798-5]
GeneIDi5999
KEGGihsa:5999
UCSCiuc001gcl.5 human [P49798-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5999
DisGeNETi5999
EuPathDBiHostDB:ENSG00000117152.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RGS4
HGNCiHGNC:10000 RGS4
HPAiHPA030802
MIMi181500 phenotype
602516 gene
neXtProtiNX_P49798
OpenTargetsiENSG00000117152
PharmGKBiPA34375

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000159036
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiP49798
KOiK16449
OMAiNIDFWVS
OrthoDBi282791at2759
PhylomeDBiP49798
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RGS4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RGS4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5999

Protein Ontology

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PROi
PR:P49798

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117152 Expressed in 185 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_RGS4
ExpressionAtlasiP49798 baseline and differential
GenevisibleiP49798 HS

Family and domain databases

CDDicd08714 RGS_RGS4, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034952 RGS4
IPR034953 RGS_RGS4
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF184 PTHR10845:SF184, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49798
Secondary accession number(s): A7XA56
, A7XA58, A7XA59, A7YVV7, B1APZ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 16, 2019
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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