UniProtKB - P49796 (RGS3_HUMAN)
Regulator of G-protein signaling 3
RGS3
Functioni
GO - Molecular functioni
- GTPase activator activity Source: ProtInc
- GTPase activity Source: Reactome
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- inactivation of MAPK activity Source: ProtInc
- regulation of G protein-coupled receptor signaling pathway Source: ProtInc
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Signal transduction inhibitor |
Enzyme and pathway databases
PathwayCommonsi | P49796 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 3Short name: RGP3 Short name: RGS3 |
Gene namesi | Name:RGS3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138835.22 |
HGNCi | HGNC:9999, RGS3 |
MIMi | 602189, gene |
neXtProti | NX_P49796 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).
Cytosol
- cytosol Source: ProtInc
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5998 |
OpenTargetsi | ENSG00000138835 |
PharmGKBi | PA34374 |
Miscellaneous databases
Pharosi | P49796, Tbio |
Polymorphism and mutation databases
BioMutai | RGS3 |
DMDMi | 67477383 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204182 | 1 – 1198 | Regulator of G-protein signaling 3Add BLAST | 1198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 448 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 674 | PhosphoserineCombined sources | 1 | |
Modified residuei | 943 | PhosphoserineCombined sources | 1 | |
Modified residuei | 946 | PhosphoserineBy similarity | 1 | |
Modified residuei | 978 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1007 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P49796 |
jPOSTi | P49796 |
MassIVEi | P49796 |
PaxDbi | P49796 |
PeptideAtlasi | P49796 |
PRIDEi | P49796 |
ProteomicsDBi | 3705 56123 [P49796-3] 56124 [P49796-1] 56125 [P49796-2] 56126 [P49796-4] 56127 [P49796-5] 56128 [P49796-6] 65662 |
PTM databases
iPTMneti | P49796 |
PhosphoSitePlusi | P49796 |
SwissPalmi | P49796 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138835, Expressed in left coronary artery and 238 other tissues |
ExpressionAtlasi | P49796, baseline and differential |
Genevisiblei | P49796, HS |
Organism-specific databases
HPAi | ENSG00000138835, Low tissue specificity |
Interactioni
Subunit structurei
Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.
By similarityBinary interactionsi
Hide detailsP49796
With | #Exp. | IntAct |
---|---|---|
ACD [Q96AP0] | 2 | EBI-2107809,EBI-717666 |
PLSCR1 [O15162] | 3 | EBI-2107809,EBI-740019 |
Isoform 4 [P49796-4]
With | #Exp. | IntAct |
---|---|---|
CYSRT1 [A8MQ03] | 3 | EBI-12006708,EBI-3867333 |
Isoform 8 [P49796-8]
With | #Exp. | IntAct |
---|---|---|
GORASP2 [Q9H8Y8] | 3 | EBI-10211517,EBI-739467 |
Protein-protein interaction databases
BioGRIDi | 111930, 54 interactors |
IntActi | P49796, 53 interactors |
MINTi | P49796 |
STRINGi | 9606.ENSP00000363255 |
Miscellaneous databases
RNActi | P49796, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P49796 |
SMRi | P49796 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P49796 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 137 – 256 | C2PROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 299 – 376 | PDZPROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 1073 – 1198 | RGSPROSITE-ProRule annotationAdd BLAST | 126 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 705 – 819 | Pro-richAdd BLAST | 115 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000154416 |
HOGENOMi | CLU_005574_0_0_1 |
InParanoidi | P49796 |
OMAi | EGTASTW |
OrthoDBi | 201302at2759 |
PhylomeDBi | P49796 |
TreeFami | TF351952 |
Family and domain databases
CDDi | cd08713, RGS_RGS3, 1 hit |
Gene3Di | 1.10.196.10, 2 hits 2.30.29.30, 1 hit 2.30.42.10, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR016137, RGS IPR034951, RGS_RGS3 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00595, PDZ, 1 hit PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00228, PDZ, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50106, PDZ, 1 hit PS50132, RGS, 1 hit |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVIPALWEV EMGRSQGQEI ETILANRSHS DSTPLPNFLS GSHRPECCTC
60 70 80 90 100
RLLTASGAQD SLPFGRRLYS GPWRSCEEVC HVSVLSVLST SCGLSLSLPI
110 120 130 140 150
FPGWMEWLSP DIALPRRDEW TQTSPARKRI THAKVQGAGQ LRLSIDAQDR
160 170 180 190 200
VLLLHIIEGK GLISKQPGTC DPYVKISLIP EDSRLRHQKT QTVPDCRDPA
210 220 230 240 250
FHEHFFFPVQ EEDDQKRLLV TVWNRASQSR QSGLIGCMSF GVKSLLTPDK
260 270 280 290 300
EISGWYYLLG EHLGRTKHLK VARRRLRPLR DPLLRMPGGG DTENGKKLKI
310 320 330 340 350
TIPRGKDGFG FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE
360 370 380 390 400
HWKCVELAHE IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ
410 420 430 440 450
SPPNKREKNC THGVQARPEQ RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG
460 470 480 490 500
QHTLPALSRA TAPTDPNYII LAPLNPGSQL LRPVYQEDTI PEESGSPSKG
510 520 530 540 550
KSYTGLGKKS RLMKTVQTMK GHGNYQNCPV VRPHATHSSY GTYVTLAPKV
560 570 580 590 600
LVFPVFVQPL DLCNPARTLL LSEELLLYEG RNKAAEVTLF AYSDLLLFTK
610 620 630 640 650
EDEPGRCDVL RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS
660 670 680 690 700
QEQKKRVCWC LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG
710 720 730 740 750
AEDSPPSKEP SPGQELPPGQ DLPPNKDSPS GQEPAPSQEP LSSKDSATSE
760 770 780 790 800
GSPPGPDAPP SKDVPPCQEP PPAQDLSPCQ DLPAGQEPLP HQDPLLTKDL
810 820 830 840 850
PAIQESPTRD LPPCQDLPPS QVSLPAKALT EDTMSSGDLL AATGDPPAAP
860 870 880 890 900
RPAFVIPEVR LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE GEEGEEDEDE
910 920 930 940 950
DTSDDNYGER SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE
960 970 980 990 1000
PRGPCFASDT TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF
1010 1020 1030 1040 1050
TGHRKMSGAD TVGDDDEASR KRKSKNLAKD MKNKLGIFRR RNESPGAPPA
1060 1070 1080 1090 1100
GKADKMMKSF KPTSEEALKW GESLEKLLVH KYGLAVFQAF LRTEFSEENL
1110 1120 1130 1140 1150
EFWLACEDFK KVKSQSKMAS KAKKIFAEYI AIQACKEVNL DSYTREHTKD
1160 1170 1180 1190
NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL
The sequence of this isoform differs from the canonical sequence as follows:
1-112: Missing.
113-138: ALPRRDEWTQTSPARKRITHAKVQGA → MERSLHRVSLGSRRAHPDLSFYLTTF
680-714: MFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQ → KLHPFGSLQQEMGPVNSTNATQDRSFTSPGQTLIG
715-1198: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5VXC0 | Q5VXC0_HUMAN | Regulator of G-protein-signaling 3 | RGS3 | 340 | Annotation score: | ||
H7C539 | H7C539_HUMAN | Regulator of G-protein-signaling 3 | RGS3 | 214 | Annotation score: | ||
C9J582 | C9J582_HUMAN | Regulator of G-protein-signaling 3 | RGS3 | 247 | Annotation score: | ||
C9J6G2 | C9J6G2_HUMAN | Regulator of G-protein-signaling 3 | RGS3 | 74 | Annotation score: | ||
H7BXY1 | H7BXY1_HUMAN | Regulator of G-protein signalling 3... | RGS3 hCG_29191 | 168 | Annotation score: | ||
A0A087WUY2 | A0A087WUY2_HUMAN | Regulator of G-protein-signaling 3 | RGS3 | 192 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | C → W in AAM33254 (PubMed:12036301).Curated | 1 | |
Sequence conflicti | 206 | F → S in BAC11328 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 266 | T → A in AAM33254 (PubMed:12036301).Curated | 1 | |
Sequence conflicti | 462 | A → V in AAL68829 (Ref. 4) Curated | 1 | |
Sequence conflicti | 585 | A → V in AAM33255 (PubMed:12036301).Curated | 1 | |
Sequence conflicti | 632 | C → R in BAC11328 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 705 | Missing in AAM33254 (PubMed:12036301).Curated | 1 | |
Sequence conflicti | 725 | N → S in AAH42555 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 873 | Q → H in AAM33254 (PubMed:12036301).Curated | 1 | |
Sequence conflicti | 883 – 884 | EE → KQ in AAM33254 (PubMed:12036301).Curated | 2 | |
Sequence conflicti | 984 | K → R in AAM12641 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1127 | A → V in AAM33253 (PubMed:12036301).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051794 | 129 | R → K. Corresponds to variant dbSNP:rs16933949Ensembl. | 1 | |
Natural variantiVAR_061769 | 809 | R → Q. Corresponds to variant dbSNP:rs41305473Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047029 | 1 – 1027 | MPVIP…KSKNL → MVTRRPVTNSWDWLPAGAAP EAVPCRHMPLSRLPLRVGQK EFFFPLPLLVPPISWLLLSE SQPRLVPGSPVIRPGFQRAC VAAACTVAARCPGRGVGDRS QSGASYRPICGPKVGGPTEM LRGMYLTRNGNLQRRHTMKE in isoform 7 and isoform 8. 1 PublicationAdd BLAST | 1027 | |
Alternative sequenceiVSP_005662 | 1 – 992 | Missing in isoform 2. 1 PublicationAdd BLAST | 992 | |
Alternative sequenceiVSP_013958 | 1 – 679 | Missing in isoform 1. 4 PublicationsAdd BLAST | 679 | |
Alternative sequenceiVSP_013959 | 1 – 281 | Missing in isoform 4 and isoform 9. 5 PublicationsAdd BLAST | 281 | |
Alternative sequenceiVSP_013961 | 1 – 112 | Missing in isoform 5. 1 PublicationAdd BLAST | 112 | |
Alternative sequenceiVSP_013960 | 1 – 104 | Missing in isoform 6. 1 PublicationAdd BLAST | 104 | |
Alternative sequenceiVSP_013962 | 113 – 138 | ALPRR…KVQGA → MERSLHRVSLGSRRAHPDLS FYLTTF in isoform 5. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_013963 | 282 – 299 | PLLRM…GKKLK → MNRFNGLCKVCSERRYRQ in isoform 4 and isoform 9. 5 PublicationsAdd BLAST | 18 | |
Alternative sequenceiVSP_054690 | 679 – 1004 | Missing in isoform 9. 1 PublicationAdd BLAST | 326 | |
Alternative sequenceiVSP_013964 | 680 – 714 | MFETE…PSPGQ → KLHPFGSLQQEMGPVNSTNA TQDRSFTSPGQTLIG in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_013965 | 715 – 1198 | Missing in isoform 5. 1 PublicationAdd BLAST | 484 | |
Alternative sequenceiVSP_053533 | 1198 | L → LDYKDDDDK in isoform 8. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2F5Y | X-ray | 2.39 | A/B | 300-384 | [»] | |
2OJ4 | X-ray | 2.30 | A | 1064-1190 | [»] | |
3FBK | X-ray | 2.00 | A/B | 134-276 | [»] | |
BMRBi | P49796 | |||||
SMRi | P49796 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111930, 54 interactors |
IntActi | P49796, 53 interactors |
MINTi | P49796 |
STRINGi | 9606.ENSP00000363255 |
PTM databases
iPTMneti | P49796 |
PhosphoSitePlusi | P49796 |
SwissPalmi | P49796 |
Polymorphism and mutation databases
BioMutai | RGS3 |
DMDMi | 67477383 |
Proteomic databases
EPDi | P49796 |
jPOSTi | P49796 |
MassIVEi | P49796 |
PaxDbi | P49796 |
PeptideAtlasi | P49796 |
PRIDEi | P49796 |
ProteomicsDBi | 3705 56123 [P49796-3] 56124 [P49796-1] 56125 [P49796-2] 56126 [P49796-4] 56127 [P49796-5] 56128 [P49796-6] 65662 |
Protocols and materials databases
Antibodypediai | 15339, 168 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 5998 |
DisGeNETi | 5998 |
EuPathDBi | HostDB:ENSG00000138835.22 |
GeneCardsi | RGS3 |
HGNCi | HGNC:9999, RGS3 |
HPAi | ENSG00000138835, Low tissue specificity |
MIMi | 602189, gene |
neXtProti | NX_P49796 |
OpenTargetsi | ENSG00000138835 |
PharmGKBi | PA34374 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000154416 |
HOGENOMi | CLU_005574_0_0_1 |
InParanoidi | P49796 |
OMAi | EGTASTW |
OrthoDBi | 201302at2759 |
PhylomeDBi | P49796 |
TreeFami | TF351952 |
Enzyme and pathway databases
PathwayCommonsi | P49796 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 5998, 9 hits in 847 CRISPR screens |
ChiTaRSi | RGS3, human |
EvolutionaryTracei | P49796 |
GeneWikii | RGS3 |
GenomeRNAii | 5998 |
Pharosi | P49796, Tbio |
PROi | PR:P49796 |
RNActi | P49796, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138835, Expressed in left coronary artery and 238 other tissues |
ExpressionAtlasi | P49796, baseline and differential |
Genevisiblei | P49796, HS |
Family and domain databases
CDDi | cd08713, RGS_RGS3, 1 hit |
Gene3Di | 1.10.196.10, 2 hits 2.30.29.30, 1 hit 2.30.42.10, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR016137, RGS IPR034951, RGS_RGS3 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00595, PDZ, 1 hit PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00228, PDZ, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50106, PDZ, 1 hit PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS3_HUMAN | |
Accessioni | P49796Primary (citable) accession number: P49796 Secondary accession number(s): A6NHA0 Q8WXA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | June 7, 2005 | |
Last modified: | December 2, 2020 | |
This is version 210 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations