Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P49796 (RGS3_HUMAN)

Entry version 210 (02 Dec 2020)
Sequence version 2 (07 Jun 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Regulator of G-protein signaling 3

Gene

RGS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49796

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 3
Short name:
RGP3
Short name:
RGS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000138835.22

Human Gene Nomenclature Database

More...HGNCi		HGNC:9999, RGS3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602189, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49796

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5998

Open Targets

More...OpenTargetsi		ENSG00000138835

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34374

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49796, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RGS3

Domain mapping of disease mutations (DMDM)

More...DMDMi		67477383

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041821 – 1198Regulator of G-protein signaling 3Add BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei448Omega-N-methylarginineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Modified residuei946PhosphoserineBy similarity1
Modified residuei978PhosphoserineBy similarity1
Modified residuei1007PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by cyclic GMP-dependent protein kinase.By similarity
ISGylated.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49796

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49796

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49796

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49796

PeptideAtlas

More...PeptideAtlasi		P49796

PRoteomics IDEntifications database

More...PRIDEi		P49796

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3705
56123 [P49796-3]
56124 [P49796-1]
56125 [P49796-2]
56126 [P49796-4]
56127 [P49796-5]
56128 [P49796-6]
65662

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49796

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49796

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P49796

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138835, Expressed in left coronary artery and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49796, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49796, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138835, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111930, 54 interactors

Protein interaction database and analysis system

More...IntActi		P49796, 53 interactors

Molecular INTeraction database

More...MINTi		P49796

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49796, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P49796

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49796

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P49796

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini137 – 256C2PROSITE-ProRule annotationAdd BLAST120
Domaini299 – 376PDZPROSITE-ProRule annotationAdd BLAST78
Domaini1073 – 1198RGSPROSITE-ProRule annotationAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi705 – 819Pro-richAdd BLAST115

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3589, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154416

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005574_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49796

Identification of Orthologs from Complete Genome Data

More...OMAi		EGTASTW

Database of Orthologous Groups

More...OrthoDBi		201302at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49796

TreeFam database of animal gene trees

More...TreeFami		TF351952

Family and domain databases

Conserved Domains Database

More...CDDi		cd08713, RGS_RGS3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.196.10, 2 hits
2.30.29.30, 1 hit
2.30.42.10, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR016137, RGS
IPR034951, RGS_RGS3
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF00595, PDZ, 1 hit
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00228, PDZ, 1 hit
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS50106, PDZ, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P49796-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVIPALWEV EMGRSQGQEI ETILANRSHS DSTPLPNFLS GSHRPECCTC 
        60         70         80         90        100
RLLTASGAQD SLPFGRRLYS GPWRSCEEVC HVSVLSVLST SCGLSLSLPI 
       110        120        130        140        150
FPGWMEWLSP DIALPRRDEW TQTSPARKRI THAKVQGAGQ LRLSIDAQDR 
       160        170        180        190        200
VLLLHIIEGK GLISKQPGTC DPYVKISLIP EDSRLRHQKT QTVPDCRDPA 
       210        220        230        240        250
FHEHFFFPVQ EEDDQKRLLV TVWNRASQSR QSGLIGCMSF GVKSLLTPDK 
       260        270        280        290        300
EISGWYYLLG EHLGRTKHLK VARRRLRPLR DPLLRMPGGG DTENGKKLKI 
       310        320        330        340        350
TIPRGKDGFG FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE 
       360        370        380        390        400
HWKCVELAHE IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ 
       410        420        430        440        450
SPPNKREKNC THGVQARPEQ RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG 
       460        470        480        490        500
QHTLPALSRA TAPTDPNYII LAPLNPGSQL LRPVYQEDTI PEESGSPSKG 
       510        520        530        540        550
KSYTGLGKKS RLMKTVQTMK GHGNYQNCPV VRPHATHSSY GTYVTLAPKV 
       560        570        580        590        600
LVFPVFVQPL DLCNPARTLL LSEELLLYEG RNKAAEVTLF AYSDLLLFTK 
       610        620        630        640        650
EDEPGRCDVL RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS 
       660        670        680        690        700
QEQKKRVCWC LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG 
       710        720        730        740        750
AEDSPPSKEP SPGQELPPGQ DLPPNKDSPS GQEPAPSQEP LSSKDSATSE 
       760        770        780        790        800
GSPPGPDAPP SKDVPPCQEP PPAQDLSPCQ DLPAGQEPLP HQDPLLTKDL 
       810        820        830        840        850
PAIQESPTRD LPPCQDLPPS QVSLPAKALT EDTMSSGDLL AATGDPPAAP 
       860        870        880        890        900
RPAFVIPEVR LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE GEEGEEDEDE 
       910        920        930        940        950
DTSDDNYGER SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE 
       960        970        980        990       1000
PRGPCFASDT TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF 
      1010       1020       1030       1040       1050
TGHRKMSGAD TVGDDDEASR KRKSKNLAKD MKNKLGIFRR RNESPGAPPA 
      1060       1070       1080       1090       1100
GKADKMMKSF KPTSEEALKW GESLEKLLVH KYGLAVFQAF LRTEFSEENL 
      1110       1120       1130       1140       1150
EFWLACEDFK KVKSQSKMAS KAKKIFAEYI AIQACKEVNL DSYTREHTKD 
      1160       1170       1180       1190 
NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL
Length:1,198
Mass (Da):132,336
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE615DA49022EFFE4
GO
Isoform 1 (identifier: P49796-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-679: Missing.

Show »
Length:519
Mass (Da):56,602
Checksum:iF1CFE3F27D4673A0
GO
Isoform 2 (identifier: P49796-2) [UniParc]FASTAAdd to basket
Also known as: RGS3T

The sequence of this isoform differs from the canonical sequence as follows:
     1-992: Missing.

Note: Nuclear.1 Publication
Show »
Length:206
Mass (Da):23,725
Checksum:iE24047B4952692D4
GO
Isoform 4 (identifier: P49796-4) [UniParc]FASTAAdd to basket
Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
     282-299: PLLRMPGGGDTENGKKLK → MNRFNGLCKVCSERRYRQ

Show »
Length:917
Mass (Da):100,948
Checksum:i17D77BE23D0A1C52
GO
Isoform 5 (identifier: P49796-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-138: ALPRRDEWTQTSPARKRITHAKVQGA → MERSLHRVSLGSRRAHPDLSFYLTTF
     680-714: MFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQ → KLHPFGSLQQEMGPVNSTNATQDRSFTSPGQTLIG
     715-1198: Missing.

Show »
Length:602
Mass (Da):67,282
Checksum:i1976A77C3FC3933F
GO
Isoform 6 (identifier: P49796-6) [UniParc]FASTAAdd to basket
Also known as: C2PA-RGS3

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:1,094
Mass (Da):121,008
Checksum:i9465608DAA6F95B6
GO
Isoform 7 (identifier: P49796-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1027: MPVIPALWEV...ASRKRKSKNL → MVTRRPVTNS...NLQRRHTMKE

Show »
Length:311
Mass (Da):35,108
Checksum:i6886A35CF3ADF13E
GO
Isoform 8 (identifier: P49796-8) [UniParc]FASTAAdd to basket
Also known as: RGS3S

The sequence of this isoform differs from the canonical sequence as follows:
     1-1027: MPVIPALWEV...ASRKRKSKNL → MVTRRPVTNS...NLQRRHTMKE
     1198-1198: L → LDYKDDDDK

Show »
Length:319
Mass (Da):36,103
Checksum:iB667E606719743CF
GO
Isoform 9 (identifier: P49796-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
     282-299: PLLRMPGGGDTENGKKLK → MNRFNGLCKVCSERRYRQ
     679-1004: Missing.

Show »
Length:591
Mass (Da):66,478
Checksum:i379E2AA9DB27D837
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VXC0Q5VXC0_HUMAN
Regulator of G-protein-signaling 3
RGS3
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C539H7C539_HUMAN
Regulator of G-protein-signaling 3
RGS3
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J582C9J582_HUMAN
Regulator of G-protein-signaling 3
RGS3
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6G2C9J6G2_HUMAN
Regulator of G-protein-signaling 3
RGS3
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXY1H7BXY1_HUMAN
Regulator of G-protein signalling 3...
RGS3 hCG_29191
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUY2A0A087WUY2_HUMAN
Regulator of G-protein-signaling 3
RGS3
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti170C → W in AAM33254 (PubMed:12036301).Curated1
Sequence conflicti206F → S in BAC11328 (PubMed:14702039).Curated1
Sequence conflicti266T → A in AAM33254 (PubMed:12036301).Curated1
Sequence conflicti462A → V in AAL68829 (Ref. 4) Curated1
Sequence conflicti585A → V in AAM33255 (PubMed:12036301).Curated1
Sequence conflicti632C → R in BAC11328 (PubMed:14702039).Curated1
Sequence conflicti705Missing in AAM33254 (PubMed:12036301).Curated1
Sequence conflicti725N → S in AAH42555 (PubMed:15489334).Curated1
Sequence conflicti873Q → H in AAM33254 (PubMed:12036301).Curated1
Sequence conflicti883 – 884EE → KQ in AAM33254 (PubMed:12036301).Curated2
Sequence conflicti984K → R in AAM12641 (Ref. 5) Curated1
Sequence conflicti1127A → V in AAM33253 (PubMed:12036301).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051794129R → K. Corresponds to variant dbSNP:rs16933949Ensembl.1
Natural variantiVAR_061769809R → Q. Corresponds to variant dbSNP:rs41305473Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470291 – 1027MPVIP…KSKNL → MVTRRPVTNSWDWLPAGAAP EAVPCRHMPLSRLPLRVGQK EFFFPLPLLVPPISWLLLSE SQPRLVPGSPVIRPGFQRAC VAAACTVAARCPGRGVGDRS QSGASYRPICGPKVGGPTEM LRGMYLTRNGNLQRRHTMKE in isoform 7 and isoform 8. 1 PublicationAdd BLAST1027
Alternative sequenceiVSP_0056621 – 992Missing in isoform 2. 1 PublicationAdd BLAST992
Alternative sequenceiVSP_0139581 – 679Missing in isoform 1. 4 PublicationsAdd BLAST679
Alternative sequenceiVSP_0139591 – 281Missing in isoform 4 and isoform 9. 5 PublicationsAdd BLAST281
Alternative sequenceiVSP_0139611 – 112Missing in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_0139601 – 104Missing in isoform 6. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_013962113 – 138ALPRR…KVQGA → MERSLHRVSLGSRRAHPDLS FYLTTF in isoform 5. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_013963282 – 299PLLRM…GKKLK → MNRFNGLCKVCSERRYRQ in isoform 4 and isoform 9. 5 PublicationsAdd BLAST18
Alternative sequenceiVSP_054690679 – 1004Missing in isoform 9. 1 PublicationAdd BLAST326
Alternative sequenceiVSP_013964680 – 714MFETE…PSPGQ → KLHPFGSLQQEMGPVNSTNA TQDRSFTSPGQTLIG in isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_013965715 – 1198Missing in isoform 5. 1 PublicationAdd BLAST484
Alternative sequenceiVSP_0535331198L → LDYKDDDDK in isoform 8. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U27655 mRNA Translation: AAC50394.1
AF490838 mRNA Translation: AAM33253.1
AF490839 mRNA Translation: AAM33254.1
AF490840 mRNA Translation: AAM33255.1
AK074977 mRNA Translation: BAC11328.1
AK096840 mRNA Translation: BAG53374.1
AK128127 mRNA Translation: BAC87285.1
AK289666 mRNA Translation: BAF82355.1
AF493927 mRNA Translation: AAM12641.1
AF493941 mRNA Translation: AAM12655.1
AY585192 mRNA Translation: AAT79495.1
AF463495 Genomic DNA Translation: AAL68829.1
AL137066 Genomic DNA No translation available.
AL162727 Genomic DNA No translation available.
AL359455 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87388.1
CH471090 Genomic DNA Translation: EAW87391.1
CH471090 Genomic DNA Translation: EAW87393.1
BC019039 mRNA Translation: AAH19039.3
BC042555 mRNA Translation: AAH42555.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35113.1 [P49796-5]
CCDS35114.1 [P49796-7]
CCDS43869.1 [P49796-3]
CCDS65111.1 [P49796-9]
CCDS6797.1 [P49796-4]
CCDS6798.1 [P49796-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S78089

NCBI Reference Sequences

More...RefSeqi		NP_001263189.1, NM_001276260.1 [P49796-1]
NP_001263190.1, NM_001276261.1 [P49796-9]
NP_001263191.1, NM_001276262.1
NP_001269851.1, NM_001282922.1 [P49796-1]
NP_001269852.1, NM_001282923.1
NP_060260.3, NM_017790.4 [P49796-5]
NP_570613.2, NM_130795.3 [P49796-4]
NP_602299.1, NM_134427.2
NP_652759.3, NM_144488.5 [P49796-3]
NP_652760.2, NM_144489.3 [P49796-7]
XP_006717282.1, XM_006717219.2
XP_006717289.1, XM_006717226.2
XP_006717293.1, XM_006717230.3
XP_011517198.1, XM_011518896.1
XP_011517199.1, XM_011518897.2
XP_011517200.1, XM_011518898.1
XP_011517202.1, XM_011518900.1
XP_011517203.1, XM_011518901.1
XP_016870494.1, XM_017015005.1
XP_016870495.1, XM_017015006.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317613; ENSP00000312844; ENSG00000138835 [P49796-5]
ENST00000343817; ENSP00000340284; ENSG00000138835 [P49796-4]
ENST00000350696; ENSP00000259406; ENSG00000138835 [P49796-3]
ENST00000374134; ENSP00000363249; ENSG00000138835 [P49796-1]
ENST00000374140; ENSP00000363255; ENSG00000138835 [P49796-3]
ENST00000394646; ENSP00000378141; ENSG00000138835 [P49796-9]
ENST00000462143; ENSP00000420356; ENSG00000138835 [P49796-1]
ENST00000462403; ENSP00000436168; ENSG00000138835 [P49796-7]
ENST00000613049; ENSP00000482612; ENSG00000138835 [P49796-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5998

UCSC genome browser

More...UCSCi		uc004bhq.5, human [P49796-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27655 mRNA Translation: AAC50394.1
AF490838 mRNA Translation: AAM33253.1
AF490839 mRNA Translation: AAM33254.1
AF490840 mRNA Translation: AAM33255.1
AK074977 mRNA Translation: BAC11328.1
AK096840 mRNA Translation: BAG53374.1
AK128127 mRNA Translation: BAC87285.1
AK289666 mRNA Translation: BAF82355.1
AF493927 mRNA Translation: AAM12641.1
AF493941 mRNA Translation: AAM12655.1
AY585192 mRNA Translation: AAT79495.1
AF463495 Genomic DNA Translation: AAL68829.1
AL137066 Genomic DNA No translation available.
AL162727 Genomic DNA No translation available.
AL359455 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87388.1
CH471090 Genomic DNA Translation: EAW87391.1
CH471090 Genomic DNA Translation: EAW87393.1
BC019039 mRNA Translation: AAH19039.3
BC042555 mRNA Translation: AAH42555.1
CCDSiCCDS35113.1 [P49796-5]
CCDS35114.1 [P49796-7]
CCDS43869.1 [P49796-3]
CCDS65111.1 [P49796-9]
CCDS6797.1 [P49796-4]
CCDS6798.1 [P49796-1]
PIRiS78089
RefSeqiNP_001263189.1, NM_001276260.1 [P49796-1]
NP_001263190.1, NM_001276261.1 [P49796-9]
NP_001263191.1, NM_001276262.1
NP_001269851.1, NM_001282922.1 [P49796-1]
NP_001269852.1, NM_001282923.1
NP_060260.3, NM_017790.4 [P49796-5]
NP_570613.2, NM_130795.3 [P49796-4]
NP_602299.1, NM_134427.2
NP_652759.3, NM_144488.5 [P49796-3]
NP_652760.2, NM_144489.3 [P49796-7]
XP_006717282.1, XM_006717219.2
XP_006717289.1, XM_006717226.2
XP_006717293.1, XM_006717230.3
XP_011517198.1, XM_011518896.1
XP_011517199.1, XM_011518897.2
XP_011517200.1, XM_011518898.1
XP_011517202.1, XM_011518900.1
XP_011517203.1, XM_011518901.1
XP_016870494.1, XM_017015005.1
XP_016870495.1, XM_017015006.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F5YX-ray2.39A/B300-384[»]
2OJ4X-ray2.30A1064-1190[»]
3FBKX-ray2.00A/B134-276[»]
BMRBiP49796
SMRiP49796
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111930, 54 interactors
IntActiP49796, 53 interactors
MINTiP49796
STRINGi9606.ENSP00000363255

PTM databases

iPTMnetiP49796
PhosphoSitePlusiP49796
SwissPalmiP49796

Polymorphism and mutation databases

BioMutaiRGS3
DMDMi67477383

Proteomic databases

EPDiP49796
jPOSTiP49796
MassIVEiP49796
PaxDbiP49796
PeptideAtlasiP49796
PRIDEiP49796
ProteomicsDBi3705
56123 [P49796-3]
56124 [P49796-1]
56125 [P49796-2]
56126 [P49796-4]
56127 [P49796-5]
56128 [P49796-6]
65662

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15339, 168 antibodies

Genome annotation databases

EnsembliENST00000317613; ENSP00000312844; ENSG00000138835 [P49796-5]
ENST00000343817; ENSP00000340284; ENSG00000138835 [P49796-4]
ENST00000350696; ENSP00000259406; ENSG00000138835 [P49796-3]
ENST00000374134; ENSP00000363249; ENSG00000138835 [P49796-1]
ENST00000374140; ENSP00000363255; ENSG00000138835 [P49796-3]
ENST00000394646; ENSP00000378141; ENSG00000138835 [P49796-9]
ENST00000462143; ENSP00000420356; ENSG00000138835 [P49796-1]
ENST00000462403; ENSP00000436168; ENSG00000138835 [P49796-7]
ENST00000613049; ENSP00000482612; ENSG00000138835 [P49796-7]
GeneIDi5998
KEGGihsa:5998
UCSCiuc004bhq.5, human [P49796-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5998
DisGeNETi5998
EuPathDBiHostDB:ENSG00000138835.22

GeneCards: human genes, protein and diseases

More...GeneCardsi		RGS3
HGNCiHGNC:9999, RGS3
HPAiENSG00000138835, Low tissue specificity
MIMi602189, gene
neXtProtiNX_P49796
OpenTargetsiENSG00000138835
PharmGKBiPA34374

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3589, Eukaryota
GeneTreeiENSGT00940000154416
HOGENOMiCLU_005574_0_0_1
InParanoidiP49796
OMAiEGTASTW
OrthoDBi201302at2759
PhylomeDBiP49796
TreeFamiTF351952

Enzyme and pathway databases

PathwayCommonsiP49796
ReactomeiR-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5998, 9 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RGS3, human
EvolutionaryTraceiP49796

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RGS3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5998
PharosiP49796, Tbio

Protein Ontology

More...PROi		PR:P49796
RNActiP49796, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138835, Expressed in left coronary artery and 238 other tissues
ExpressionAtlasiP49796, baseline and differential
GenevisibleiP49796, HS

Family and domain databases

CDDicd08713, RGS_RGS3, 1 hit
Gene3Di1.10.196.10, 2 hits
2.30.29.30, 1 hit
2.30.42.10, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR016137, RGS
IPR034951, RGS_RGS3
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00595, PDZ, 1 hit
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00228, PDZ, 1 hit
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50106, PDZ, 1 hit
PS50132, RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49796
Secondary accession number(s): A6NHA0
, A8K0V1, B3KUB2, Q5VXB8, Q5VXC1, Q5VZ05, Q5VZ06, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8NFN6, Q8TD59, Q8TD68, Q8WV02, Q8WXA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 7, 2005
Last modified: December 2, 2020
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again