RGS3

Functionⁱ

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

4 Publications

GO - Molecular functionⁱ

GTPase activator activity
Source: ProtInc
Traceable author statementⁱ
- Ref.9
  "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11."
  Dulin N.O., Sorokin A., Reed E., Elliott S., Kehrl J.H., Dunn M.J.
  Mol. Cell. Biol. 19:714-723(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH GNA11 AND GNA13, SUBCELLULAR LOCATION.
GTPase activity Source: Reactome

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor

Molecular function

Signal transduction inhibitor

Enzyme and pathway databases

PathwayCommonsⁱ	P49796
Reactomeⁱ	R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 3 Short name: RGP3 Short name: RGS3
Gene namesⁱ	Name:RGS3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9999, RGS3
MIMⁱ	602189, gene
neXtProtⁱ	NX_P49796
VEuPathDBⁱ	HostDB:ENSG00000138835

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5998
Open Targets More...OpenTargetsⁱ	ENSG00000138835
PharmGKBⁱ	PA34374

Miscellaneous databases

Pharosⁱ	P49796, Tbio

Pharosⁱ

P49796, Tbio

Genetic variation databases

BioMutaⁱ	RGS3
DMDMⁱ	67477383

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204182	1 – 1198	Regulator of G-protein signaling 3Add BLAST		1198

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	448	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	674	PhosphoserineCombined sources	1
Modified residueⁱ	943	PhosphoserineCombined sources	1
Modified residueⁱ	946	PhosphoserineBy similarity	1
Modified residueⁱ	978	PhosphoserineBy similarity	1
Modified residueⁱ	1007	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

ISGylated.1 Publication

Keywords - PTMⁱ

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P49796
jPOSTⁱ	P49796
MassIVEⁱ	P49796
PaxDbⁱ	P49796
PeptideAtlas More...PeptideAtlasⁱ	P49796
PRIDEⁱ	P49796
ProteomicsDBⁱ	3705 56123 [P49796-3] 56124 [P49796-1] 56125 [P49796-2] 56126 [P49796-4] 56127 [P49796-5] 56128 [P49796-6] 65662

PTM databases

iPTMnetⁱ	P49796
PhosphoSitePlusⁱ	P49796
SwissPalmⁱ	P49796

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000138835, Expressed in left coronary artery and 239 other tissues
ExpressionAtlasⁱ	P49796, baseline and differential
Genevisibleⁱ	P49796, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000138835, Low tissue specificity

HPAⁱ

ENSG00000138835, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.

By similarity

Binary interactionsⁱ

Hide details

P49796

With	#Exp.	IntAct
ACD [Q96AP0]	2	EBI-2107809,EBI-717666
PLSCR1 [O15162]	3	EBI-2107809,EBI-740019

Isoform 4 [P49796-4]

With	#Exp.	IntAct
CYSRT1 [A8MQ03]	3	EBI-12006708,EBI-3867333

Isoform 8 [P49796-8]

With	#Exp.	IntAct
GORASP2 [Q9H8Y8]	3	EBI-10211517,EBI-739467

Protein-protein interaction databases

BioGRIDⁱ	111930, 59 interactors
IntActⁱ	P49796, 53 interactors
STRINGⁱ	9606.ENSP00000363255

Miscellaneous databases

RNActⁱ	P49796, protein

RNActⁱ

P49796, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	140 – 161	Combined sources	22
Beta strandⁱ	166 – 168	Combined sources	3
Beta strandⁱ	172 – 180	Combined sources	9
Beta strandⁱ	200 – 208	Combined sources	9
Helixⁱ	211 – 213	Combined sources	3
Beta strandⁱ	216 – 224	Combined sources	9
Helixⁱ	229 – 231	Combined sources	3
Beta strandⁱ	233 – 241	Combined sources	9
Helixⁱ	242 – 245	Combined sources	4
Beta strandⁱ	252 – 257	Combined sources	6
Helixⁱ	263 – 265	Combined sources	3
Beta strandⁱ	299 – 303	Combined sources	5
Beta strandⁱ	310 – 314	Combined sources	5
Beta strandⁱ	316 – 318	Combined sources	3
Beta strandⁱ	320 – 324	Combined sources	5
Helixⁱ	329 – 333	Combined sources	5
Beta strandⁱ	340 – 344	Combined sources	5
Helixⁱ	354 – 362	Combined sources	9
Beta strandⁱ	365 – 374	Combined sources	10
Helixⁱ	1066 – 1070	Combined sources	5
Helixⁱ	1074 – 1078	Combined sources	5
Helixⁱ	1081 – 1093	Combined sources	13
Helixⁱ	1097 – 1109	Combined sources	13
Helixⁱ	1115 – 1129	Combined sources	15
Helixⁱ	1142 – 1150	Combined sources	9
Turnⁱ	1157 – 1160	Combined sources	4
Helixⁱ	1161 – 1173	Combined sources	13
Helixⁱ	1175 – 1181	Combined sources	7
Helixⁱ	1183 – 1186	Combined sources	4
Turnⁱ	1187 – 1189	Combined sources	3

Show more details

3D structure databases

BMRBⁱ	P49796
SMRⁱ	P49796
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49796

EvolutionaryTraceⁱ

P49796

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	137 – 256	C2PROSITE-ProRule annotationAdd BLAST	120
Domainⁱ	299 – 376	PDZPROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	1073 – 1198	RGSPROSITE-ProRule annotationAdd BLAST	126

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	669 – 933	DisorderedSequence analysisAdd BLAST	265
Regionⁱ	1007 – 1026	DisorderedSequence analysisAdd BLAST	20
Regionⁱ	1032 – 1056	DisorderedSequence analysisAdd BLAST	25

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	680 – 697	Basic and acidic residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	710 – 724	Pro residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	725 – 750	Polar residuesSequence analysisAdd BLAST	26
Compositional biasⁱ	753 – 777	Pro residuesSequence analysisAdd BLAST	25
Compositional biasⁱ	876 – 906	Acidic residuesSequence analysisAdd BLAST	31
Compositional biasⁱ	1008 – 1026	Basic and acidic residuesSequence analysisAdd BLAST	19

Phylogenomic databases

eggNOGⁱ	KOG3589, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154416
HOGENOMⁱ	CLU_005574_0_0_1
InParanoidⁱ	P49796
OMAⁱ	PESKMFE
Database of Orthologous Groups More...OrthoDBⁱ	201302at2759
PhylomeDBⁱ	P49796
TreeFamⁱ	TF351952

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08713, RGS_RGS3, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits 2.30.29.30, 1 hit 2.30.42.10, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR016137, RGS IPR034951, RGS_RGS3 IPR036305, RGS_sf IPR024066, RGS_subdom1/3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168, C2, 1 hit PF00595, PDZ, 1 hit PF00615, RGS, 1 hit
PRINTSⁱ	PR01301, RGSPROTEIN
SMARTⁱ	View protein in SMART SM00239, C2, 1 hit SM00228, PDZ, 1 hit SM00315, RGS, 1 hit
SUPFAMⁱ	SSF48097, SSF48097, 1 hit SSF49562, SSF49562, 1 hit SSF50156, SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004, C2, 1 hit PS50106, PDZ, 1 hit PS50132, RGS, 1 hit

Sequences (9+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 9 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 9 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 3 (identifier: P49796-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MPVIPALWEV EMGRSQGQEI ETILANRSHS DSTPLPNFLS GSHRPECCTC 
        60         70         80         90        100
RLLTASGAQD SLPFGRRLYS GPWRSCEEVC HVSVLSVLST SCGLSLSLPI 
       110        120        130        140        150
FPGWMEWLSP DIALPRRDEW TQTSPARKRI THAKVQGAGQ LRLSIDAQDR 
       160        170        180        190        200
VLLLHIIEGK GLISKQPGTC DPYVKISLIP EDSRLRHQKT QTVPDCRDPA 
       210        220        230        240        250
FHEHFFFPVQ EEDDQKRLLV TVWNRASQSR QSGLIGCMSF GVKSLLTPDK 
       260        270        280        290        300
EISGWYYLLG EHLGRTKHLK VARRRLRPLR DPLLRMPGGG DTENGKKLKI 
       310        320        330        340        350
TIPRGKDGFG FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE 
       360        370        380        390        400
HWKCVELAHE IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ 
       410        420        430        440        450
SPPNKREKNC THGVQARPEQ RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG 
       460        470        480        490        500
QHTLPALSRA TAPTDPNYII LAPLNPGSQL LRPVYQEDTI PEESGSPSKG 
       510        520        530        540        550
KSYTGLGKKS RLMKTVQTMK GHGNYQNCPV VRPHATHSSY GTYVTLAPKV 
       560        570        580        590        600
LVFPVFVQPL DLCNPARTLL LSEELLLYEG RNKAAEVTLF AYSDLLLFTK 
       610        620        630        640        650
EDEPGRCDVL RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS 
       660        670        680        690        700
QEQKKRVCWC LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG 
       710        720        730        740        750
AEDSPPSKEP SPGQELPPGQ DLPPNKDSPS GQEPAPSQEP LSSKDSATSE 
       760        770        780        790        800
GSPPGPDAPP SKDVPPCQEP PPAQDLSPCQ DLPAGQEPLP HQDPLLTKDL 
       810        820        830        840        850
PAIQESPTRD LPPCQDLPPS QVSLPAKALT EDTMSSGDLL AATGDPPAAP 
       860        870        880        890        900
RPAFVIPEVR LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE GEEGEEDEDE 
       910        920        930        940        950
DTSDDNYGER SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE 
       960        970        980        990       1000
PRGPCFASDT TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF 
      1010       1020       1030       1040       1050
TGHRKMSGAD TVGDDDEASR KRKSKNLAKD MKNKLGIFRR RNESPGAPPA 
      1060       1070       1080       1090       1100
GKADKMMKSF KPTSEEALKW GESLEKLLVH KYGLAVFQAF LRTEFSEENL 
      1110       1120       1130       1140       1150
EFWLACEDFK KVKSQSKMAS KAKKIFAEYI AIQACKEVNL DSYTREHTKD 
      1160       1170       1180       1190 
NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL

Length:1,198

Mass (Da):132,336

Last modified:June 7, 2005 - v2

Checksum:ⁱE615DA49022EFFE4

GO

Isoform 1 (identifier: P49796-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-679: Missing.

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        10         20         30         40         50
MFETEADEKR EMALEEGKGP GAEDSPPSKE PSPGQELPPG QDLPPNKDSP 
        60         70         80         90        100
SGQEPAPSQE PLSSKDSATS EGSPPGPDAP PSKDVPPCQE PPPAQDLSPC 
       110        120        130        140        150
QDLPAGQEPL PHQDPLLTKD LPAIQESPTR DLPPCQDLPP SQVSLPAKAL 
       160        170        180        190        200
TEDTMSSGDL LAATGDPPAA PRPAFVIPEV RLDSTYSQKA GAEQGCSGDE 
       210        220        230        240        250
EDAEEAEEVE EGEEGEEDED EDTSDDNYGE RSEAKRSSMI ETGQGAEGGL 
       260        270        280        290        300
SLRVQNSLRR RTHSEGSLLQ EPRGPCFASD TTLHCSDGEG AASTWGMPSP 
       310        320        330        340        350
STLKKELGRN GGSMHHLSLF FTGHRKMSGA DTVGDDDEAS RKRKSKNLAK 
       360        370        380        390        400
DMKNKLGIFR RRNESPGAPP AGKADKMMKS FKPTSEEALK WGESLEKLLV 
       410        420        430        440        450
HKYGLAVFQA FLRTEFSEEN LEFWLACEDF KKVKSQSKMA SKAKKIFAEY 
       460        470        480        490        500
IAIQACKEVN LDSYTREHTK DNLQSVTRGC FDLAQKRIFG LMEKDSYPRF 
       510 
LRSDLYLDLI NQKKMSPPL

Show »

Length:519

Mass (Da):56,602

Checksum:ⁱF1CFE3F27D4673A0

GO

Isoform 2 (identifier: P49796-2) [UniParc]FASTA Add to basket

Also known as: RGS3T

The sequence of this isoform differs from the canonical sequence as follows:
1-992: Missing.

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        10         20         30         40         50
MHHLSLFFTG HRKMSGADTV GDDDEASRKR KSKNLAKDMK NKLGIFRRRN 
        60         70         80         90        100
ESPGAPPAGK ADKMMKSFKP TSEEALKWGE SLEKLLVHKY GLAVFQAFLR 
       110        120        130        140        150
TEFSEENLEF WLACEDFKKV KSQSKMASKA KKIFAEYIAI QACKEVNLDS 
       160        170        180        190        200
YTREHTKDNL QSVTRGCFDL AQKRIFGLME KDSYPRFLRS DLYLDLINQK 

KMSPPL

Note: Nuclear.1 Publication

Show »

Length:206

Mass (Da):23,725

Checksum:ⁱE24047B4952692D4

GO

Isoform 4 (identifier: P49796-4) [UniParc]FASTA Add to basket

Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
1-281: Missing.
282-299: PLLRMPGGGDTENGKKLK → MNRFNGLCKVCSERRYRQ

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        10         20         30         40         50
MNRFNGLCKV CSERRYRQIT IPRGKDGFGF TICCDSPVRV QAVDSGGPAE 
        60         70         80         90        100
RAGLQQLDTV LQLNERPVEH WKCVELAHEI RSCPSEIILL VWRMVPQVKP 
       110        120        130        140        150
GPDGGVLRRA SCKSTHDLQS PPNKREKNCT HGVQARPEQR HSCHLVCDSS 
       160        170        180        190        200
DGLLLGGWER YTEVAKRGGQ HTLPALSRAT APTDPNYIIL APLNPGSQLL 
       210        220        230        240        250
RPVYQEDTIP EESGSPSKGK SYTGLGKKSR LMKTVQTMKG HGNYQNCPVV 
       260        270        280        290        300
RPHATHSSYG TYVTLAPKVL VFPVFVQPLD LCNPARTLLL SEELLLYEGR 
       310        320        330        340        350
NKAAEVTLFA YSDLLLFTKE DEPGRCDVLR NPLYLQSVKL QEGSSEDLKF 
       360        370        380        390        400
CVLYLAEKAE CLFTLEAHSQ EQKKRVCWCL SENIAKQQQL AASPPDSKMF 
       410        420        430        440        450
ETEADEKREM ALEEGKGPGA EDSPPSKEPS PGQELPPGQD LPPNKDSPSG 
       460        470        480        490        500
QEPAPSQEPL SSKDSATSEG SPPGPDAPPS KDVPPCQEPP PAQDLSPCQD 
       510        520        530        540        550
LPAGQEPLPH QDPLLTKDLP AIQESPTRDL PPCQDLPPSQ VSLPAKALTE 
       560        570        580        590        600
DTMSSGDLLA ATGDPPAAPR PAFVIPEVRL DSTYSQKAGA EQGCSGDEED 
       610        620        630        640        650
AEEAEEVEEG EEGEEDEDED TSDDNYGERS EAKRSSMIET GQGAEGGLSL 
       660        670        680        690        700
RVQNSLRRRT HSEGSLLQEP RGPCFASDTT LHCSDGEGAA STWGMPSPST 
       710        720        730        740        750
LKKELGRNGG SMHHLSLFFT GHRKMSGADT VGDDDEASRK RKSKNLAKDM 
       760        770        780        790        800
KNKLGIFRRR NESPGAPPAG KADKMMKSFK PTSEEALKWG ESLEKLLVHK 
       810        820        830        840        850
YGLAVFQAFL RTEFSEENLE FWLACEDFKK VKSQSKMASK AKKIFAEYIA 
       860        870        880        890        900
IQACKEVNLD SYTREHTKDN LQSVTRGCFD LAQKRIFGLM EKDSYPRFLR 
       910 
SDLYLDLINQ KKMSPPL

Show »

Length:917

Mass (Da):100,948

Checksum:ⁱ17D77BE23D0A1C52

GO

Isoform 5 (identifier: P49796-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-138: ALPRRDEWTQTSPARKRITHAKVQGA → MERSLHRVSLGSRRAHPDLSFYLTTF
     680-714: MFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQ → KLHPFGSLQQEMGPVNSTNATQDRSFTSPGQTLIG
     715-1198: Missing.

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        10         20         30         40         50
MERSLHRVSL GSRRAHPDLS FYLTTFGQLR LSIDAQDRVL LLHIIEGKGL 
        60         70         80         90        100
ISKQPGTCDP YVKISLIPED SRLRHQKTQT VPDCRDPAFH EHFFFPVQEE 
       110        120        130        140        150
DDQKRLLVTV WNRASQSRQS GLIGCMSFGV KSLLTPDKEI SGWYYLLGEH 
       160        170        180        190        200
LGRTKHLKVA RRRLRPLRDP LLRMPGGGDT ENGKKLKITI PRGKDGFGFT 
       210        220        230        240        250
ICCDSPVRVQ AVDSGGPAER AGLQQLDTVL QLNERPVEHW KCVELAHEIR 
       260        270        280        290        300
SCPSEIILLV WRMVPQVKPG PDGGVLRRAS CKSTHDLQSP PNKREKNCTH 
       310        320        330        340        350
GVQARPEQRH SCHLVCDSSD GLLLGGWERY TEVAKRGGQH TLPALSRATA 
       360        370        380        390        400
PTDPNYIILA PLNPGSQLLR PVYQEDTIPE ESGSPSKGKS YTGLGKKSRL 
       410        420        430        440        450
MKTVQTMKGH GNYQNCPVVR PHATHSSYGT YVTLAPKVLV FPVFVQPLDL 
       460        470        480        490        500
CNPARTLLLS EELLLYEGRN KAAEVTLFAY SDLLLFTKED EPGRCDVLRN 
       510        520        530        540        550
PLYLQSVKLQ EGSSEDLKFC VLYLAEKAEC LFTLEAHSQE QKKRVCWCLS 
       560        570        580        590        600
ENIAKQQQLA ASPPDSKKLH PFGSLQQEMG PVNSTNATQD RSFTSPGQTL 

IG

Show »

Length:602

Mass (Da):67,282

Checksum:ⁱ1976A77C3FC3933F

GO

Isoform 6 (identifier: P49796-6) [UniParc]FASTA Add to basket

Also known as: C2PA-RGS3

The sequence of this isoform differs from the canonical sequence as follows:
1-104: Missing.

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        10         20         30         40         50
MEWLSPDIAL PRRDEWTQTS PARKRITHAK VQGAGQLRLS IDAQDRVLLL 
        60         70         80         90        100
HIIEGKGLIS KQPGTCDPYV KISLIPEDSR LRHQKTQTVP DCRDPAFHEH 
       110        120        130        140        150
FFFPVQEEDD QKRLLVTVWN RASQSRQSGL IGCMSFGVKS LLTPDKEISG 
       160        170        180        190        200
WYYLLGEHLG RTKHLKVARR RLRPLRDPLL RMPGGGDTEN GKKLKITIPR 
       210        220        230        240        250
GKDGFGFTIC CDSPVRVQAV DSGGPAERAG LQQLDTVLQL NERPVEHWKC 
       260        270        280        290        300
VELAHEIRSC PSEIILLVWR MVPQVKPGPD GGVLRRASCK STHDLQSPPN 
       310        320        330        340        350
KREKNCTHGV QARPEQRHSC HLVCDSSDGL LLGGWERYTE VAKRGGQHTL 
       360        370        380        390        400
PALSRATAPT DPNYIILAPL NPGSQLLRPV YQEDTIPEES GSPSKGKSYT 
       410        420        430        440        450
GLGKKSRLMK TVQTMKGHGN YQNCPVVRPH ATHSSYGTYV TLAPKVLVFP 
       460        470        480        490        500
VFVQPLDLCN PARTLLLSEE LLLYEGRNKA AEVTLFAYSD LLLFTKEDEP 
       510        520        530        540        550
GRCDVLRNPL YLQSVKLQEG SSEDLKFCVL YLAEKAECLF TLEAHSQEQK 
       560        570        580        590        600
KRVCWCLSEN IAKQQQLAAS PPDSKMFETE ADEKREMALE EGKGPGAEDS 
       610        620        630        640        650
PPSKEPSPGQ ELPPGQDLPP NKDSPSGQEP APSQEPLSSK DSATSEGSPP 
       660        670        680        690        700
GPDAPPSKDV PPCQEPPPAQ DLSPCQDLPA GQEPLPHQDP LLTKDLPAIQ 
       710        720        730        740        750
ESPTRDLPPC QDLPPSQVSL PAKALTEDTM SSGDLLAATG DPPAAPRPAF 
       760        770        780        790        800
VIPEVRLDST YSQKAGAEQG CSGDEEDAEE AEEVEEGEEG EEDEDEDTSD 
       810        820        830        840        850
DNYGERSEAK RSSMIETGQG AEGGLSLRVQ NSLRRRTHSE GSLLQEPRGP 
       860        870        880        890        900
CFASDTTLHC SDGEGAASTW GMPSPSTLKK ELGRNGGSMH HLSLFFTGHR 
       910        920        930        940        950
KMSGADTVGD DDEASRKRKS KNLAKDMKNK LGIFRRRNES PGAPPAGKAD 
       960        970        980        990       1000
KMMKSFKPTS EEALKWGESL EKLLVHKYGL AVFQAFLRTE FSEENLEFWL 
      1010       1020       1030       1040       1050
ACEDFKKVKS QSKMASKAKK IFAEYIAIQA CKEVNLDSYT REHTKDNLQS 
      1060       1070       1080       1090 
VTRGCFDLAQ KRIFGLMEKD SYPRFLRSDL YLDLINQKKM SPPL

Show »

Length:1,094

Mass (Da):121,008

Checksum:ⁱ9465608DAA6F95B6

GO

Isoform 7 (identifier: P49796-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1027: MPVIPALWEV...ASRKRKSKNL → MVTRRPVTNS...NLQRRHTMKE

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        10         20         30         40         50
MVTRRPVTNS WDWLPAGAAP EAVPCRHMPL SRLPLRVGQK EFFFPLPLLV 
        60         70         80         90        100
PPISWLLLSE SQPRLVPGSP VIRPGFQRAC VAAACTVAAR CPGRGVGDRS 
       110        120        130        140        150
QSGASYRPIC GPKVGGPTEM LRGMYLTRNG NLQRRHTMKE AKDMKNKLGI 
       160        170        180        190        200
FRRRNESPGA PPAGKADKMM KSFKPTSEEA LKWGESLEKL LVHKYGLAVF 
       210        220        230        240        250
QAFLRTEFSE ENLEFWLACE DFKKVKSQSK MASKAKKIFA EYIAIQACKE 
       260        270        280        290        300
VNLDSYTREH TKDNLQSVTR GCFDLAQKRI FGLMEKDSYP RFLRSDLYLD 
       310 
LINQKKMSPP L

Show »

Length:311

Mass (Da):35,108

Checksum:ⁱ6886A35CF3ADF13E

GO

Isoform 8 (identifier: P49796-8) [UniParc]FASTA Add to basket

Also known as: RGS3S

The sequence of this isoform differs from the canonical sequence as follows:
1-1027: MPVIPALWEV...ASRKRKSKNL → MVTRRPVTNS...NLQRRHTMKE
1198-1198: L → LDYKDDDDK

« Hide

        10         20         30         40         50
MVTRRPVTNS WDWLPAGAAP EAVPCRHMPL SRLPLRVGQK EFFFPLPLLV 
        60         70         80         90        100
PPISWLLLSE SQPRLVPGSP VIRPGFQRAC VAAACTVAAR CPGRGVGDRS 
       110        120        130        140        150
QSGASYRPIC GPKVGGPTEM LRGMYLTRNG NLQRRHTMKE AKDMKNKLGI 
       160        170        180        190        200
FRRRNESPGA PPAGKADKMM KSFKPTSEEA LKWGESLEKL LVHKYGLAVF 
       210        220        230        240        250
QAFLRTEFSE ENLEFWLACE DFKKVKSQSK MASKAKKIFA EYIAIQACKE 
       260        270        280        290        300
VNLDSYTREH TKDNLQSVTR GCFDLAQKRI FGLMEKDSYP RFLRSDLYLD 
       310 
LINQKKMSPP LDYKDDDDK

Show »

Length:319

Mass (Da):36,103

Checksum:ⁱB667E606719743CF

GO

Isoform 9 (identifier: P49796-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
     282-299: PLLRMPGGGDTENGKKLK → MNRFNGLCKVCSERRYRQ
     679-1004: Missing.

« Hide

        10         20         30         40         50
MNRFNGLCKV CSERRYRQIT IPRGKDGFGF TICCDSPVRV QAVDSGGPAE 
        60         70         80         90        100
RAGLQQLDTV LQLNERPVEH WKCVELAHEI RSCPSEIILL VWRMVPQVKP 
       110        120        130        140        150
GPDGGVLRRA SCKSTHDLQS PPNKREKNCT HGVQARPEQR HSCHLVCDSS 
       160        170        180        190        200
DGLLLGGWER YTEVAKRGGQ HTLPALSRAT APTDPNYIIL APLNPGSQLL 
       210        220        230        240        250
RPVYQEDTIP EESGSPSKGK SYTGLGKKSR LMKTVQTMKG HGNYQNCPVV 
       260        270        280        290        300
RPHATHSSYG TYVTLAPKVL VFPVFVQPLD LCNPARTLLL SEELLLYEGR 
       310        320        330        340        350
NKAAEVTLFA YSDLLLFTKE DEPGRCDVLR NPLYLQSVKL QEGSSEDLKF 
       360        370        380        390        400
CVLYLAEKAE CLFTLEAHSQ EQKKRVCWCL SENIAKQQQL AASPPDSKMS 
       410        420        430        440        450
GADTVGDDDE ASRKRKSKNL AKDMKNKLGI FRRRNESPGA PPAGKADKMM 
       460        470        480        490        500
KSFKPTSEEA LKWGESLEKL LVHKYGLAVF QAFLRTEFSE ENLEFWLACE 
       510        520        530        540        550
DFKKVKSQSK MASKAKKIFA EYIAIQACKE VNLDSYTREH TKDNLQSVTR 
       560        570        580        590 
GCFDLAQKRI FGLMEKDSYP RFLRSDLYLD LINQKKMSPP L

Show »

Length:591

Mass (Da):66,478

Checksum:ⁱ379E2AA9DB27D837

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5VXC0	Q5VXC0_HUMAN	Regulator of G-protein-signaling 3 Regulator of G-protein-signaling 3	RGS3	340	Annotation score:
H7C539	H7C539_HUMAN	Regulator of G-protein-signaling 3 Regulator of G-protein-signaling 3	RGS3	214	Annotation score:
C9J582	C9J582_HUMAN	Regulator of G-protein-signaling 3 Regulator of G-protein-signaling 3	RGS3	247	Annotation score:
C9J6G2	C9J6G2_HUMAN	Regulator of G-protein-signaling 3 Regulator of G-protein-signaling 3	RGS3	74	Annotation score:
A0A087WUY2	A0A087WUY2_HUMAN	Regulator of G-protein-signaling 3 Regulator of G-protein-signaling 3	RGS3	192	Annotation score:
H7BXY1	H7BXY1_HUMAN	Regulator of G-protein signalling 3... Regulator of G-protein signalling 3, isoform CRA_i (Regulator of G-protein-signaling 3)	RGS3 hCG_29191	168	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	170	C → W in AAM33254 (PubMed:12036301).Curated	1
Sequence conflictⁱ	206	F → S in BAC11328 (PubMed:14702039).Curated	1
Sequence conflictⁱ	266	T → A in AAM33254 (PubMed:12036301).Curated	1
Sequence conflictⁱ	462	A → V in AAL68829 (Ref. 4) Curated	1
Sequence conflictⁱ	585	A → V in AAM33255 (PubMed:12036301).Curated	1
Sequence conflictⁱ	632	C → R in BAC11328 (PubMed:14702039).Curated	1
Sequence conflictⁱ	705	Missing in AAM33254 (PubMed:12036301).Curated	1
Sequence conflictⁱ	725	N → S in AAH42555 (PubMed:15489334).Curated	1
Sequence conflictⁱ	873	Q → H in AAM33254 (PubMed:12036301).Curated	1
Sequence conflictⁱ	883 – 884	EE → KQ in AAM33254 (PubMed:12036301).Curated	2
Sequence conflictⁱ	984	K → R in AAM12641 (Ref. 5) Curated	1
Sequence conflictⁱ	1127	A → V in AAM33253 (PubMed:12036301).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051794	129	R → K. Corresponds to variant dbSNP:rs16933949Ensembl.		1
Natural variantⁱVAR_061769	809	R → Q. Corresponds to variant dbSNP:rs41305473Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047029	1 – 1027	MPVIP…KSKNL → MVTRRPVTNSWDWLPAGAAP EAVPCRHMPLSRLPLRVGQK EFFFPLPLLVPPISWLLLSE SQPRLVPGSPVIRPGFQRAC VAAACTVAARCPGRGVGDRS QSGASYRPICGPKVGGPTEM LRGMYLTRNGNLQRRHTMKE in isoform 7 and isoform 8. 1 PublicationAdd BLAST	1027
Alternative sequenceⁱVSP_005662	1 – 992	Missing in isoform 2. 1 PublicationAdd BLAST	992
Alternative sequenceⁱVSP_013958	1 – 679	Missing in isoform 1. 4 PublicationsAdd BLAST	679
Alternative sequenceⁱVSP_013959	1 – 281	Missing in isoform 4 and isoform 9. 5 PublicationsAdd BLAST	281
Alternative sequenceⁱVSP_013961	1 – 112	Missing in isoform 5. 1 PublicationAdd BLAST	112
Alternative sequenceⁱVSP_013960	1 – 104	Missing in isoform 6. 1 PublicationAdd BLAST	104
Alternative sequenceⁱVSP_013962	113 – 138	ALPRR…KVQGA → MERSLHRVSLGSRRAHPDLS FYLTTF in isoform 5. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_013963	282 – 299	PLLRM…GKKLK → MNRFNGLCKVCSERRYRQ in isoform 4 and isoform 9. 5 PublicationsAdd BLAST	18
Alternative sequenceⁱVSP_054690	679 – 1004	Missing in isoform 9. 1 PublicationAdd BLAST	326
Alternative sequenceⁱVSP_013964	680 – 714	MFETE…PSPGQ → KLHPFGSLQQEMGPVNSTNA TQDRSFTSPGQTLIG in isoform 5. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_013965	715 – 1198	Missing in isoform 5. 1 PublicationAdd BLAST	484
Alternative sequenceⁱVSP_053533	1198	L → LDYKDDDDK in isoform 8. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U27655 mRNA Translation: AAC50394.1 AF490838 mRNA Translation: AAM33253.1 AF490839 mRNA Translation: AAM33254.1 AF490840 mRNA Translation: AAM33255.1 AK074977 mRNA Translation: BAC11328.1 AK096840 mRNA Translation: BAG53374.1 AK128127 mRNA Translation: BAC87285.1 AK289666 mRNA Translation: BAF82355.1 AF493927 mRNA Translation: AAM12641.1 AF493941 mRNA Translation: AAM12655.1 AY585192 mRNA Translation: AAT79495.1 AF463495 Genomic DNA Translation: AAL68829.1 AL137066 Genomic DNA No translation available. AL162727 Genomic DNA No translation available. AL359455 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87388.1 CH471090 Genomic DNA Translation: EAW87391.1 CH471090 Genomic DNA Translation: EAW87393.1 BC019039 mRNA Translation: AAH19039.3 BC042555 mRNA Translation: AAH42555.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35113.1 [P49796-5] CCDS43869.1 [P49796-3] CCDS65111.1 [P49796-9] CCDS6797.1 [P49796-4] CCDS6798.1 [P49796-1]
PIRⁱ	S78089
NCBI Reference Sequences More...RefSeqⁱ	NP_001263189.1, NM_001276260.1 [P49796-1] NP_001263190.1, NM_001276261.1 [P49796-9] NP_001263191.1, NM_001276262.1 NP_001269851.1, NM_001282922.1 [P49796-1] NP_001269852.1, NM_001282923.1 NP_060260.3, NM_017790.4 [P49796-5] NP_570613.2, NM_130795.3 [P49796-4] NP_602299.1, NM_134427.2 NP_652759.3, NM_144488.5 [P49796-3] NP_652760.2, NM_144489.3 [P49796-7] XP_006717282.1, XM_006717219.2 XP_006717289.1, XM_006717226.2 XP_006717293.1, XM_006717230.3 XP_011517198.1, XM_011518896.1 XP_011517199.1, XM_011518897.2 XP_011517200.1, XM_011518898.1 XP_011517202.1, XM_011518900.1 XP_011517203.1, XM_011518901.1 XP_016870494.1, XM_017015005.1 XP_016870495.1, XM_017015006.1

Genome annotation databases

Ensemblⁱ	ENST00000317613; ENSP00000312844; ENSG00000138835 [P49796-5] ENST00000343817; ENSP00000340284; ENSG00000138835 [P49796-4] ENST00000350696; ENSP00000259406; ENSG00000138835 [P49796-3] ENST00000374134; ENSP00000363249; ENSG00000138835 [P49796-1] ENST00000374140; ENSP00000363255; ENSG00000138835 [P49796-3] ENST00000394646; ENSP00000378141; ENSG00000138835 [P49796-9] ENST00000462143; ENSP00000420356; ENSG00000138835 [P49796-1] ENST00000462403; ENSP00000436168; ENSG00000138835 [P49796-7] ENST00000613049; ENSP00000482612; ENSG00000138835 [P49796-7]
GeneIDⁱ	5998
KEGGⁱ	hsa:5998
UCSC genome browser More...UCSCⁱ	uc004bhq.5, human [P49796-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49796	Isoform 2 of Regulator of G-protein signaling 3		HUMAN		206	UniRef100_P49796
RGS3 isoform 1		PONAB		168
RGS3 isoform 1		PANTR		168
Regulator of G protein signaling 3		CERAT		168
Regulator of G protein signaling 3		PANPA		168
+10
P49796-4	Regulator of G-protein signalling 3, isoform CRA_a		HUMAN		917	UniRef100_A0A024R841
P49796-7	Regulator of G-protein signalling 3, isoform CRA_b		HUMAN		311	UniRef100_A0A024R833
Isoform 8 of Regulator of G-protein signaling 3		HUMAN		319
P49796-9	RGS3 isoform 2		PONAB		591	UniRef100_A0A2J8WRR3
RGS3 isoform 2		PANTR		591
Regulator of G protein signaling 3		GORGO		591

Protein	Similar proteins		Species	Score	Length	Source
P49796	Isoform 2 of Regulator of G-protein signaling 3		HUMAN		206	UniRef90_P49796
RGS3 isoform 1		PONAB		168
RGS3 isoform 1		PANTR		168
Regulator of G protein signaling 3		CERAT		168
Regulator of G protein signaling 3		PANPA		168
+51
P49796-4	Regulator of G-protein signalling 3, isoform CRA_a		HUMAN		917	UniRef90_A0A024R841
Regulator of G protein signaling 3		SAIBB		1091
regulator of G-protein signaling 3 isoform X6		CARSF		168
Regulator of G protein signaling 3		PROCO		913
Regulator of G protein signaling 3		SAIBB		168
+8
P49796-5	Regulator of G protein signaling 3		MACMU		607	UniRef90_P49796-5
Uncharacterized protein		RHIBE		602
Regulator of G protein signaling 3		RHIFE		602
Regulator of G protein signaling 3		GORGO		602
Uncharacterized protein		NOMLE		602
+30
P49796-7	RGS domain-containing protein		NOMLE		312	UniRef90_A0A2I3HRN5
Regulator of G-protein signalling 3, isoform CRA_b		HUMAN		311
RGS domain-containing protein		CALJA		311
regulator of G-protein signaling 3 isoform X5		CARSF		192
Regulator of G protein signaling 3		CEBIM		311
+18
P49796-9	Uncharacterized protein		CALJA		705	UniRef90_F6RBR2
Regulator of G protein signaling 3		HORSE		591
regulator of G-protein signaling 3 isoform X2		CHRAS		591
Regulator of G protein signaling 3		MACNE		591
Uncharacterized protein		RHIRO		591
+14

Protein	Similar proteins		Species	Score	Length	Source
P49796	Regulator of G-protein signaling 3	)	MOUSE		966	UniRef50_P49796
Regulator of G-protein signaling 3		RAT		967
Isoform 2 of Regulator of G-protein signaling 3		HUMAN		206
RGS3 isoform 1		PONAB		168
RGS3 isoform 1		PANTR		168
+276
P49796-4	Regulator of G-protein signalling 3, isoform CRA_a		HUMAN		917	UniRef50_A0A024R841
Regulator of G protein signaling 3		SAIBB		1091
regulator of G-protein signaling 3 isoform X6		CARSF		168
Regulator of G protein signaling 3		PROCO		913
regulator of G-protein signaling 3 isoform X1		VICPA		1091
+37
P49796-5	Regulator of G protein signaling 3		MACMU		607	UniRef50_P49796-5
Regulator of G protein signaling 3		CERAT		602
regulator of G-protein signaling 3 isoform X8		SAPAP		602
Regulator of G protein signaling 3		CEBIM		602
Regulator of G protein signaling 3		AOTNA		602
+139
P49796-7	RGS domain-containing protein		NOMLE		371	UniRef50_A0A2I3FQR2
Macaca fascicularis brain cDNA clone: QmoA-10084, similar to human regulator of G-protein signalling 3 (RGS3), transcriptvariant 1, mRNA, RefSeq: NM_130795.1		MACFA		366
Regulator of G protein signaling 3		PANTR		365
RGS domain-containing protein		RHIRO		365
RGS domain-containing protein		RHIBE		365
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U27655 mRNA Translation: AAC50394.1 AF490838 mRNA Translation: AAM33253.1 AF490839 mRNA Translation: AAM33254.1 AF490840 mRNA Translation: AAM33255.1 AK074977 mRNA Translation: BAC11328.1 AK096840 mRNA Translation: BAG53374.1 AK128127 mRNA Translation: BAC87285.1 AK289666 mRNA Translation: BAF82355.1 AF493927 mRNA Translation: AAM12641.1 AF493941 mRNA Translation: AAM12655.1 AY585192 mRNA Translation: AAT79495.1 AF463495 Genomic DNA Translation: AAL68829.1 AL137066 Genomic DNA No translation available. AL162727 Genomic DNA No translation available. AL359455 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87388.1 CH471090 Genomic DNA Translation: EAW87391.1 CH471090 Genomic DNA Translation: EAW87393.1 BC019039 mRNA Translation: AAH19039.3 BC042555 mRNA Translation: AAH42555.1
CCDSⁱ	CCDS35113.1 [P49796-5] CCDS43869.1 [P49796-3] CCDS65111.1 [P49796-9] CCDS6797.1 [P49796-4] CCDS6798.1 [P49796-1]
PIRⁱ	S78089
RefSeqⁱ	NP_001263189.1, NM_001276260.1 [P49796-1] NP_001263190.1, NM_001276261.1 [P49796-9] NP_001263191.1, NM_001276262.1 NP_001269851.1, NM_001282922.1 [P49796-1] NP_001269852.1, NM_001282923.1 NP_060260.3, NM_017790.4 [P49796-5] NP_570613.2, NM_130795.3 [P49796-4] NP_602299.1, NM_134427.2 NP_652759.3, NM_144488.5 [P49796-3] NP_652760.2, NM_144489.3 [P49796-7] XP_006717282.1, XM_006717219.2 XP_006717289.1, XM_006717226.2 XP_006717293.1, XM_006717230.3 XP_011517198.1, XM_011518896.1 XP_011517199.1, XM_011518897.2 XP_011517200.1, XM_011518898.1 XP_011517202.1, XM_011518900.1 XP_011517203.1, XM_011518901.1 XP_016870494.1, XM_017015005.1 XP_016870495.1, XM_017015006.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2F5Y	X-ray	2.39	A/B	300-384	[»]
	2OJ4	X-ray	2.30	A	1064-1190	[»]
	3FBK	X-ray	2.00	A/B	134-276	[»]
BMRBⁱ	P49796
SMRⁱ	P49796
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111930, 59 interactors
IntActⁱ	P49796, 53 interactors
STRINGⁱ	9606.ENSP00000363255

PTM databases

iPTMnetⁱ	P49796
PhosphoSitePlusⁱ	P49796
SwissPalmⁱ	P49796

Genetic variation databases

BioMutaⁱ	RGS3
DMDMⁱ	67477383

Proteomic databases

EPDⁱ	P49796
jPOSTⁱ	P49796
MassIVEⁱ	P49796
PaxDbⁱ	P49796
PeptideAtlasⁱ	P49796
PRIDEⁱ	P49796
ProteomicsDBⁱ	3705 56123 [P49796-3] 56124 [P49796-1] 56125 [P49796-2] 56126 [P49796-4] 56127 [P49796-5] 56128 [P49796-6] 65662

Protocols and materials databases

Antibodypediaⁱ	15339, 173 antibodies
The DNASU plasmid repository More...DNASUⁱ	5998

Genome annotation databases

Organism-specific databases

CTDⁱ	5998
DisGeNETⁱ	5998
GeneCardsⁱ	RGS3
HGNCⁱ	HGNC:9999, RGS3
HPAⁱ	ENSG00000138835, Low tissue specificity
MIMⁱ	602189, gene
neXtProtⁱ	NX_P49796
OpenTargetsⁱ	ENSG00000138835
PharmGKBⁱ	PA34374
VEuPathDBⁱ	HostDB:ENSG00000138835
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3589, Eukaryota
GeneTreeⁱ	ENSGT00940000154416
HOGENOMⁱ	CLU_005574_0_0_1
InParanoidⁱ	P49796
OMAⁱ	PESKMFE
OrthoDBⁱ	201302at2759
PhylomeDBⁱ	P49796
TreeFamⁱ	TF351952

Enzyme and pathway databases

PathwayCommonsⁱ	P49796
Reactomeⁱ	R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events

Miscellaneous databases

BioGRID-ORCSⁱ	5998, 9 hits in 1014 CRISPR screens
ChiTaRSⁱ	RGS3, human
EvolutionaryTraceⁱ	P49796
GeneWikiⁱ	RGS3
GenomeRNAiⁱ	5998
Pharosⁱ	P49796, Tbio
Protein Ontology More...PROⁱ	PR:P49796
RNActⁱ	P49796, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000138835, Expressed in left coronary artery and 239 other tissues
ExpressionAtlasⁱ	P49796, baseline and differential
Genevisibleⁱ	P49796, HS

Family and domain databases

CDDⁱ	cd08713, RGS_RGS3, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits 2.30.29.30, 1 hit 2.30.42.10, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR016137, RGS IPR034951, RGS_RGS3 IPR036305, RGS_sf IPR024066, RGS_subdom1/3
Pfamⁱ	View protein in Pfam PF00168, C2, 1 hit PF00595, PDZ, 1 hit PF00615, RGS, 1 hit
PRINTSⁱ	PR01301, RGSPROTEIN
SMARTⁱ	View protein in SMART SM00239, C2, 1 hit SM00228, PDZ, 1 hit SM00315, RGS, 1 hit
SUPFAMⁱ	SSF48097, SSF48097, 1 hit SSF49562, SSF49562, 1 hit SSF50156, SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004, C2, 1 hit PS50106, PDZ, 1 hit PS50132, RGS, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS3_HUMAN
Accessionⁱ	P49796Primary (citable) accession number: P49796 Secondary accession number(s): A6NHA0 Q8WXA0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	June 7, 2005
	Last modified:	September 29, 2021
	This is version 214 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

Annotation systems

Supporting data

UniProtKB - P49796 (RGS3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Regulator of G-protein signaling 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Cytoplasm and Cytosol

Cytosol

Nucleus

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ