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Protein

Regulator of G-protein signaling 19

Gene

RGS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
SignaLinkiP49795
SIGNORiP49795

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 19
Short name:
RGS19
Alternative name(s):
G-alpha-interacting protein
Short name:
GAIP
Gene namesi
Name:RGS19
Synonyms:GAIP, GNAI3IP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171700.13
HGNCiHGNC:13735 RGS19
MIMi605071 gene
neXtProtiNX_P49795

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi151S → A: Diminishes gap activity towards G(i)-alpha3 and autophagy in colon cancer cells. 1 Publication1

Organism-specific databases

DisGeNETi10287
OpenTargetsiENSG00000171700
PharmGKBiPA34370

Chemistry databases

ChEMBLiCHEMBL3707468

Polymorphism and mutation databases

BioMutaiRGS19
DMDMi1730186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042291 – 217Regulator of G-protein signaling 19Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei151Phosphoserine; by MAPK1 and MAPK31 Publication1

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif.1 Publication
Phosphorylated, mainly on serine residues.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP49795
MaxQBiP49795
PaxDbiP49795
PeptideAtlasiP49795
PRIDEiP49795
ProteomicsDBi56122

PTM databases

iPTMnetiP49795
PhosphoSitePlusiP49795
SwissPalmiP49795

Expressioni

Tissue specificityi

Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Gene expression databases

BgeeiENSG00000171700 Expressed in 218 organ(s), highest expression level in blood
CleanExiHS_RGS19
GenevisibleiP49795 HS

Organism-specific databases

HPAiHPA056384
HPA069984

Interactioni

Subunit structurei

Interacts with GIPC PDZ domain.

Binary interactionsi

WithEntry#Exp.IntActNotes
Gnai3P087534EBI-874907,EBI-874897From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115576, 13 interactors
CORUMiP49795
IntActiP49795, 15 interactors
MINTiP49795
STRINGi9606.ENSP00000333194

Chemistry databases

BindingDBiP49795

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49795
SMRiP49795
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49795

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 206RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 217Interaction with GIPCAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 49Poly-CysAdd BLAST11

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiP49795
KOiK16449
OMAiQEPSAHT
OrthoDBiEOG091G0BDG
PhylomeDBiP49795
TreeFamiTF315837

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

P49795-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTPHEAEKQ ITGPEEADRP PSMSSHDTAS PAAPSRNPCC LCWCCCCSCS
60 70 80 90 100
WNQERRRAWQ ASRESKLQPL PSCEVCATPS PEEVQSWAQS FDKLMHSPAG
110 120 130 140 150
RSVFRAFLRT EYSEENMLFW LACEELKAEA NQHVVDEKAR LIYEDYVSIL
160 170 180 190 200
SPKEVSLDSR VREGINKKMQ EPSAHTFDDA QLQIYTLMHR DSYPRFLSSP
210
TYRALLLQGP SQSSSEA
Length:217
Mass (Da):24,636
Last modified:October 1, 1996 - v1
Checksum:i925A5687DC222CBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204A → V in AAM12653 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91809 mRNA Translation: CAA62919.1
AF493939 mRNA Translation: AAM12653.1
AY585188 mRNA Translation: AAS94232.1
BT009804 mRNA Translation: AAP88806.1
AK290081 mRNA Translation: BAF82770.1
AL590548 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75166.1
CH471077 Genomic DNA Translation: EAW75167.1
BC001318 mRNA Translation: AAH01318.1
BC054337 mRNA Translation: AAH54337.1
BC063010 mRNA Translation: AAH63010.1
CCDSiCCDS13555.1
RefSeqiNP_001034556.1, NM_001039467.1
NP_005864.1, NM_005873.2
XP_011526787.1, XM_011528485.2
XP_011526788.1, XM_011528486.2
UniGeneiHs.422336

Genome annotation databases

EnsembliENST00000332298; ENSP00000333194; ENSG00000171700
ENST00000395042; ENSP00000378483; ENSG00000171700
GeneIDi10287
KEGGihsa:10287
UCSCiuc002yhy.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91809 mRNA Translation: CAA62919.1
AF493939 mRNA Translation: AAM12653.1
AY585188 mRNA Translation: AAS94232.1
BT009804 mRNA Translation: AAP88806.1
AK290081 mRNA Translation: BAF82770.1
AL590548 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75166.1
CH471077 Genomic DNA Translation: EAW75167.1
BC001318 mRNA Translation: AAH01318.1
BC054337 mRNA Translation: AAH54337.1
BC063010 mRNA Translation: AAH63010.1
CCDSiCCDS13555.1
RefSeqiNP_001034556.1, NM_001039467.1
NP_005864.1, NM_005873.2
XP_011526787.1, XM_011528485.2
XP_011526788.1, XM_011528486.2
UniGeneiHs.422336

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CMZNMR-A79-206[»]
ProteinModelPortaliP49795
SMRiP49795
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115576, 13 interactors
CORUMiP49795
IntActiP49795, 15 interactors
MINTiP49795
STRINGi9606.ENSP00000333194

Chemistry databases

BindingDBiP49795
ChEMBLiCHEMBL3707468

PTM databases

iPTMnetiP49795
PhosphoSitePlusiP49795
SwissPalmiP49795

Polymorphism and mutation databases

BioMutaiRGS19
DMDMi1730186

Proteomic databases

EPDiP49795
MaxQBiP49795
PaxDbiP49795
PeptideAtlasiP49795
PRIDEiP49795
ProteomicsDBi56122

Protocols and materials databases

DNASUi10287
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332298; ENSP00000333194; ENSG00000171700
ENST00000395042; ENSP00000378483; ENSG00000171700
GeneIDi10287
KEGGihsa:10287
UCSCiuc002yhy.4 human

Organism-specific databases

CTDi10287
DisGeNETi10287
EuPathDBiHostDB:ENSG00000171700.13
GeneCardsiRGS19
HGNCiHGNC:13735 RGS19
HPAiHPA056384
HPA069984
MIMi605071 gene
neXtProtiNX_P49795
OpenTargetsiENSG00000171700
PharmGKBiPA34370
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiP49795
KOiK16449
OMAiQEPSAHT
OrthoDBiEOG091G0BDG
PhylomeDBiP49795
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
SignaLinkiP49795
SIGNORiP49795

Miscellaneous databases

ChiTaRSiRGS19 human
EvolutionaryTraceiP49795
GeneWikiiRGS19
GenomeRNAii10287
PROiPR:P49795
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171700 Expressed in 218 organ(s), highest expression level in blood
CleanExiHS_RGS19
GenevisibleiP49795 HS

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS19_HUMAN
AccessioniPrimary (citable) accession number: P49795
Secondary accession number(s): A8K216
, E1P5G9, Q53XN0, Q8TD60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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