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Entry version 140 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Nuclear pore complex protein Nup153

Gene

Nup153

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC (By similarity). The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC) (By similarity).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds at least 4 zinc ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi664Zinc 12 Publications1
Metal bindingi667Zinc 12 Publications1
Metal bindingi678Zinc 12 Publications1
Metal bindingi681Zinc 12 Publications1
Metal bindingi727Zinc 22 Publications1
Metal bindingi730Zinc 22 Publications1
Metal bindingi741Zinc 22 Publications1
Metal bindingi744Zinc 22 Publications1
Metal bindingi795Zinc 32 Publications1
Metal bindingi798Zinc 32 Publications1
Metal bindingi809Zinc 32 Publications1
Metal bindingi812Zinc 32 Publications1
Metal bindingi852Zinc 42 Publications1
Metal bindingi855Zinc 42 Publications1
Metal bindingi866Zinc 42 Publications1
Metal bindingi869Zinc 42 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri657 – 687RanBP2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri721 – 750RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri789 – 818RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri846 – 875RanBP2-type 4PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processmRNA transport, Protein transport, Translocation, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-159227 Transport of the SLBP independent Mature mRNA
R-RNO-159230 Transport of the SLBP Dependant Mature mRNA
R-RNO-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3232142 SUMOylation of ubiquitinylation proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4085377 SUMOylation of SUMOylation proteins
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4570464 SUMOylation of RNA binding proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup153
Alternative name(s):
153 kDa nucleoporin
Nucleoporin Nup153
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup153
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3216 Nup153

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi714F → A: Reduces affinity for RAN; when associated with A-718. 1 Publication1
Mutagenesisi718F → A: Reduces affinity for RAN; when associated with A-714. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048432 – 1468Nuclear pore complex protein Nup153Add BLAST1467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei97PhosphothreonineCombined sources1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei186PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei241PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei331PhosphoserineCombined sources1
Modified residuei334PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei339PhosphoserineCombined sources1
Modified residuei344PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki354Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei370PhosphothreonineBy similarity1
Modified residuei385N6-acetyllysineBy similarity1
Modified residuei389PhosphothreonineBy similarity1
Modified residuei500PhosphoserineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei529PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi534O-linked (GlcNAc) serineBy similarity1
Glycosylationi544O-linked (GlcNAc) serineBy similarity1
Modified residuei607PhosphoserineBy similarity1
Modified residuei619PhosphoserineBy similarity1
Modified residuei633PhosphoserineBy similarity1
Modified residuei717N6-acetyllysineBy similarity1
Modified residuei886PhosphoserineBy similarity1
Glycosylationi902O-linked (GlcNAc) serineBy similarity1
Modified residuei947N6-acetyllysineBy similarity1
Glycosylationi1106O-linked (GlcNAc) serineBy similarity1
Modified residuei1450PhosphoserineBy similarity1
Modified residuei1454PhosphoserineBy similarity1
Modified residuei1456PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of the nuclear pore complex during mitosis.
O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49791

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49791

PRoteomics IDEntifications database

More...
PRIDEi
P49791

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49791

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49791

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (NPC).

Interacts with TPR (via coiled coil region); the interaction is direct and provides a link between the core structure and the TPR-containing nuclear basket of the nuclear pore complex (NPC).

Interacts with HIKESHI, SENP2 and XPO5 (By similarity).

Interacts with RAN; the interaction occurs in a GTP- and GDP-independent manner.

Interacts with MCM3AP; this interaction is required for MCM3AP localization at the nuclear pore complex (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P49791

Database of interacting proteins

More...
DIPi
DIP-46027N

Protein interaction database and analysis system

More...
IntActi
P49791, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001979

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49791

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49791

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 15Gly-richAdd BLAST12
Compositional biasi442 – 446Poly-Gly5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains F-X-F-G repeats.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUP153 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri657 – 687RanBP2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri721 – 750RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri789 – 818RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri846 – 875RanBP2-type 4PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4719 Eukaryota
ENOG41107SV LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49791

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49791

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026054 Nucleoporin
IPR013913 Nup153_N
IPR018892 Retro-transposon_transp_CS
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23193 PTHR23193, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08604 Nup153, 1 hit
PF10599 Nup_retrotrp_bd, 1 hit
PF00641 zf-RanBP, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00547 ZnF_RBZ, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90209 SSF90209, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01358 ZF_RANBP2_1, 4 hits
PS50199 ZF_RANBP2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49791-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGAGGIGG GGGGGKIRTR RCHQGPVKPY QQGRPQHQGI LSRVTESVKN
60 70 80 90 100
IVPGWLQRYF NKSENACSCS VNADEVPRWP ENREDEREIY VDENTNTDDG
110 120 130 140 150
RTTPEPTGSN TEEPSTTSTA SNYPDVLTRP SLHRSHLNFS VLESPALHCQ
160 170 180 190 200
PSTSSAFPIG SSGFSLVKEI KDSTSQHDDD NISTTSGFSS RASEKDIAVS
210 220 230 240 250
KNTSLPPLWS PEAERSHSLS QHTAISSKKP AFNLSAFGTL STSLGNSSIL
260 270 280 290 300
KTSQLGDSPF YPGKTTYGGA AAAVRQNKVR STPYQAPVRR QMKAKQLNAQ
310 320 330 340 350
SYGVTSSTAR RILQSLEKMS SPLADAKRIP SAVSSPLNSP LDRSGIDSTV
360 370 380 390 400
FQAKKEKVDS QYPPVQRLMT PKPVSIATNR TVYFKPSLTP SGDLRKTNQR
410 420 430 440 450
IDKKNSTVDE KNISRQNREQ ESGFSYPNFS IPAANGLSSG VGGGGGKMRR
460 470 480 490 500
ERTTHFVASK PSEEEEVEVP LLPQISLPIS SSSLPTFNFS SPAISAASSS
510 520 530 540 550
SVSPSQPLSN KVQMTSLGST GNPVFTFSSP IVKSTQADVL PPASIGFTFS
560 570 580 590 600
VPLAKTELSG PNSSSETVLS SSVTAQDNTV VNSSSSKKRS APCEDPFTPA
610 620 630 640 650
KILREGSVLD ILKTPGFMSP KVDSPALQPT TTSSIVYTRP AISTFSSSGV
660 670 680 690 700
EFGESLKAGS SWQCDTCLLQ NKVTDNKCIA CQAAKLPLKE TAKQTGIGTP
710 720 730 740 750
SKSDKPASTS GTGFGDKFKP AIGTWDCDTC LVQNKPEAVK CVACETPKPG
760 770 780 790 800
TGVKRALPLT VASESPVTAS SSTTVTTGTL GFGDKFKRPV GSWECPVCCV
810 820 830 840 850
SNKAEDSRCV SCTSEKPGLV SASSSNSVPV SLPSGGCLGL DKFKKPEGSW
860 870 880 890 900
DCEVCLVQNK ADSTKCIACE SAKPGTKSEF KGFGTSSSLN PAPSAFKFGI
910 920 930 940 950
PSSSSGLSQT FTSTGNFKFG DQGGFKLGTS SDSGSTNTMN TNFKFPKPTG
960 970 980 990 1000
DFKFGVLPDS KPEEIKNDSK NDNFQFGPSS GLSNPASSAP FQFGVSTLGQ
1010 1020 1030 1040 1050
QEKKEELPQS SSAGFSFGAG VANPSSAAID TTVTSENKSG FNFGTIDTKS
1060 1070 1080 1090 1100
VSVTPFTYKT TEAKKEDASA TKGGFTFGKV DSAALSSPSM FVLGRTEEKQ
1110 1120 1130 1140 1150
QEPVTSTSLV FGKKADNEEP KCQPVFSFGN SEQTKDESSS KPTFSFSVAK
1160 1170 1180 1190 1200
PSVKESDQLA KATFAFGNQT NTTTDQGAAK PAFSFLNSSS SSSSTPATSS
1210 1220 1230 1240 1250
SASIFGSSTS SSSPPVAAFV FGQASNPVSS SAFGNSAESS TSQPLLFPQD
1260 1270 1280 1290 1300
GKPATTSSTA SAAPPFVFGT GASSNSTVSS GFTFGATTTS SSSGSFFVFG
1310 1320 1330 1340 1350
TGHSAPSASP AFGANQTPTF GQSQGASQPN PPSFGSISSS TALFSAGSQP
1360 1370 1380 1390 1400
VPPPTFGTVS SSSQPPVFGQ QPSQSAFGSG TANASSVFQF GSSTTNFNFT
1410 1420 1430 1440 1450
NNNPSGVFTF GASPSTPAAA AQPSGSGGFS FSQSPASFTV GSNGKNMFSS
1460
SGTSVSGRKI KTAVRRKK
Length:1,468
Mass (Da):152,824
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3DFD9697C556A7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V662G3V662_RAT
Nuclear pore complex protein Nup153
Nup153 rCG_44020
1,468Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L06821 mRNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
A44345

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06821 mRNA No translation available.
PIRiA44345

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K0CNMR-A703-755[»]
3CH5X-ray2.10B703-754[»]
3GJ3X-ray1.79B723-750[»]
3GJ4X-ray2.15B/D790-817[»]
3GJ5X-ray1.79B/D848-876[»]
3GJ6X-ray2.70B658-686[»]
3GJ7X-ray1.93B/D658-750[»]
3GJ8X-ray1.82B/D790-876[»]
SMRiP49791
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

CORUMiP49791
DIPiDIP-46027N
IntActiP49791, 4 interactors
STRINGi10116.ENSRNOP00000001979

PTM databases

iPTMnetiP49791
PhosphoSitePlusiP49791

Proteomic databases

jPOSTiP49791
PaxDbiP49791
PRIDEiP49791

Organism-specific databases

RGDi3216 Nup153

Phylogenomic databases

eggNOGiKOG4719 Eukaryota
ENOG41107SV LUCA
InParanoidiP49791
PhylomeDBiP49791

Enzyme and pathway databases

ReactomeiR-RNO-159227 Transport of the SLBP independent Mature mRNA
R-RNO-159230 Transport of the SLBP Dependant Mature mRNA
R-RNO-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3232142 SUMOylation of ubiquitinylation proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4085377 SUMOylation of SUMOylation proteins
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4570464 SUMOylation of RNA binding proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs

Miscellaneous databases

EvolutionaryTraceiP49791

Protein Ontology

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PROi
PR:P49791

Family and domain databases

InterProiView protein in InterPro
IPR026054 Nucleoporin
IPR013913 Nup153_N
IPR018892 Retro-transposon_transp_CS
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR23193 PTHR23193, 1 hit
PfamiView protein in Pfam
PF08604 Nup153, 1 hit
PF10599 Nup_retrotrp_bd, 1 hit
PF00641 zf-RanBP, 4 hits
SMARTiView protein in SMART
SM00547 ZnF_RBZ, 4 hits
SUPFAMiSSF90209 SSF90209, 4 hits
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 4 hits
PS50199 ZF_RANBP2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU153_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49791
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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