Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinoic acid receptor responder protein 1

Gene

RARRES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.1 Publication

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc

Enzyme and pathway databases

SIGNORiP49788

Protein family/group databases

MEROPSiI47.002

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor responder protein 1
Alternative name(s):
Phorbol ester-induced gene 1 protein
Short name:
PERG-1
RAR-responsive protein TIG1
Tazarotene-induced gene 1 protein
Gene namesi
Name:RARRES1
Synonyms:PEIG1, TIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000118849.9
HGNCiHGNC:9867 RARRES1
MIMi605090 gene
neXtProtiNX_P49788

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20LumenalSequence analysisAdd BLAST20
Transmembranei21 – 42Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST22
Topological domaini43 – 294CytoplasmicSequence analysisAdd BLAST252

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5918
OpenTargetsiENSG00000118849
PharmGKBiPA34228

Chemistry databases

DrugBankiDB00755 Tretinoin

Polymorphism and mutation databases

BioMutaiRARRES1
DMDMi57014141

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913461 – 294Retinoic acid receptor responder protein 1Add BLAST294

Post-translational modificationi

Not glycosylated.

Proteomic databases

PaxDbiP49788
PeptideAtlasiP49788
PRIDEiP49788
ProteomicsDBi56117
56118 [P49788-2]
TopDownProteomicsiP49788-2 [P49788-2]

PTM databases

iPTMnetiP49788
PhosphoSitePlusiP49788

Expressioni

Inductioni

By tazarotene and by all the retinoic acid receptors tested.

Gene expression databases

BgeeiENSG00000118849 Expressed in 167 organ(s), highest expression level in pericardium
CleanExiHS_RARRES1
GenevisibleiP49788 HS

Organism-specific databases

HPAiHPA003892

Interactioni

Protein-protein interaction databases

BioGridi111853, 1 interactor
STRINGi9606.ENSP00000237696

Structurei

3D structure databases

ProteinModelPortaliP49788
SMRiP49788
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJZ8 Eukaryota
ENOG4111K9R LUCA
GeneTreeiENSGT00530000063813
HOGENOMiHOG000137506
HOVERGENiHBG101029
InParanoidiP49788
OMAiDAIDFDY
OrthoDBiEOG091G0I8X
PhylomeDBiP49788
TreeFamiTF332787

Family and domain databases

InterProiView protein in InterPro
IPR009684 Prot_inh_latexin
IPR027261 TAG1
PANTHERiPTHR28591 PTHR28591, 1 hit
PfamiView protein in Pfam
PF06907 Latexin, 1 hit
PIRSFiPIRSF011132 Prot_inh_latexin, 1 hit
PIRSF500784 TAG1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD023134 Prot_inh_latexin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: P49788-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ
60 70 80 90 100
DAGVPRRLLQ QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK
110 120 130 140 150
VHVVFSTERY NPESLLQEGE GRLGKCSARV FFKNQKPRPT INVTCTRLIE
160 170 180 190 200
KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN HGHIDPSLRL IWDLAFLGSS
210 220 230 240 250
YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH ELSTQEIIPC
260 270 280 290
RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF
Note: No experimental confirmation available.
Length:294
Mass (Da):33,285
Last modified:July 5, 2004 - v2
Checksum:iBDBA3E034F493032
GO
Isoform 1 (identifier: P49788-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-228: KTND → VRKT
     229-294: Missing.

Show »
Length:228
Mass (Da):25,812
Checksum:i36654EFCD24819EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62A → K in AAA99722 (PubMed:8601727).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06009442D → G1 PublicationCorresponds to variant dbSNP:rs7621322Ensembl.1
Natural variantiVAR_053612158D → V. Corresponds to variant dbSNP:rs11919919Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010697225 – 228KTND → VRKT in isoform 1. 1 Publication4
Alternative sequenceiVSP_010698229 – 294Missing in isoform 1. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27185 mRNA Translation: AAA99722.1
BC029640 mRNA Translation: AAH29640.1
CCDSiCCDS3184.1 [P49788-1]
CCDS54665.1 [P49788-2]
RefSeqiNP_002879.2, NM_002888.3 [P49788-2]
NP_996846.1, NM_206963.1 [P49788-1]
UniGeneiHs.131269

Genome annotation databases

EnsembliENST00000237696; ENSP00000237696; ENSG00000118849 [P49788-1]
ENST00000479756; ENSP00000418556; ENSG00000118849 [P49788-2]
GeneIDi5918
KEGGihsa:5918
UCSCiuc003fci.4 human [P49788-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27185 mRNA Translation: AAA99722.1
BC029640 mRNA Translation: AAH29640.1
CCDSiCCDS3184.1 [P49788-1]
CCDS54665.1 [P49788-2]
RefSeqiNP_002879.2, NM_002888.3 [P49788-2]
NP_996846.1, NM_206963.1 [P49788-1]
UniGeneiHs.131269

3D structure databases

ProteinModelPortaliP49788
SMRiP49788
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111853, 1 interactor
STRINGi9606.ENSP00000237696

Chemistry databases

DrugBankiDB00755 Tretinoin

Protein family/group databases

MEROPSiI47.002

PTM databases

iPTMnetiP49788
PhosphoSitePlusiP49788

Polymorphism and mutation databases

BioMutaiRARRES1
DMDMi57014141

Proteomic databases

PaxDbiP49788
PeptideAtlasiP49788
PRIDEiP49788
ProteomicsDBi56117
56118 [P49788-2]
TopDownProteomicsiP49788-2 [P49788-2]

Protocols and materials databases

DNASUi5918
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237696; ENSP00000237696; ENSG00000118849 [P49788-1]
ENST00000479756; ENSP00000418556; ENSG00000118849 [P49788-2]
GeneIDi5918
KEGGihsa:5918
UCSCiuc003fci.4 human [P49788-1]

Organism-specific databases

CTDi5918
DisGeNETi5918
EuPathDBiHostDB:ENSG00000118849.9
GeneCardsiRARRES1
HGNCiHGNC:9867 RARRES1
HPAiHPA003892
MIMi605090 gene
neXtProtiNX_P49788
OpenTargetsiENSG00000118849
PharmGKBiPA34228
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJZ8 Eukaryota
ENOG4111K9R LUCA
GeneTreeiENSGT00530000063813
HOGENOMiHOG000137506
HOVERGENiHBG101029
InParanoidiP49788
OMAiDAIDFDY
OrthoDBiEOG091G0I8X
PhylomeDBiP49788
TreeFamiTF332787

Enzyme and pathway databases

SIGNORiP49788

Miscellaneous databases

ChiTaRSiRARRES1 human
GeneWikiiRARRES1
GenomeRNAii5918
PROiPR:P49788
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118849 Expressed in 167 organ(s), highest expression level in pericardium
CleanExiHS_RARRES1
GenevisibleiP49788 HS

Family and domain databases

InterProiView protein in InterPro
IPR009684 Prot_inh_latexin
IPR027261 TAG1
PANTHERiPTHR28591 PTHR28591, 1 hit
PfamiView protein in Pfam
PF06907 Latexin, 1 hit
PIRSFiPIRSF011132 Prot_inh_latexin, 1 hit
PIRSF500784 TAG1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD023134 Prot_inh_latexin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTIG1_HUMAN
AccessioniPrimary (citable) accession number: P49788
Secondary accession number(s): Q8N1D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again