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UniProtKB - P49786 (BCCP_BACSU)
Protein
Biotin carboxyl carrier protein of acetyl-CoA carboxylase
Gene
accB
Organism
Bacillus subtilis (strain 168)
Status
Functioni
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA (By similarity).
Binds biotin (PubMed:7592499).
By similarity1 Publication: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | Biotin |
Enzyme and pathway databases
BioCyci | BSUB:BSU24350-MONOMER |
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: Biotin carboxyl carrier protein of acetyl-CoA carboxylase1 PublicationShort name: BCCP1 Publication |
Gene namesi | Name:accB1 Publication Synonyms:fabE, yqhW Ordered Locus Names:BSU24350 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146801 | 1 – 159 | Biotin carboxyl carrier protein of acetyl-CoA carboxylaseAdd BLAST | 159 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 123 | N6-biotinyllysinePROSITE-ProRule annotationBy similarity | 1 |
Proteomic databases
jPOSTi | P49786 |
PaxDbi | P49786 |
PRIDEi | P49786 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 224308.BSU24350 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 157 | Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 53 – 77 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 70 | Polar residuesSequence analysisAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | COG0511, Bacteria |
InParanoidi | P49786 |
OMAi | IKSPIIG |
PhylomeDBi | P49786 |
Family and domain databases
InterProi | View protein in InterPro IPR001249, AcCoA_biotinCC IPR001882, Biotin_BS IPR000089, Biotin_lipoyl IPR011053, Single_hybrid_motif |
Pfami | View protein in Pfam PF00364, Biotin_lipoyl, 1 hit |
PRINTSi | PR01071, ACOABIOTINCC |
SUPFAMi | SSF51230, SSF51230, 1 hit |
TIGRFAMsi | TIGR00531, BCCP, 1 hit |
PROSITEi | View protein in PROSITE PS00188, BIOTIN, 1 hit PS50968, BIOTINYL_LIPOYL, 1 hit |
i Sequence
Sequence statusi: Complete.
P49786-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNIKEIHEL IKAIDESTID EFVYENEGVS LKLKKHEAGT VQVMQQAPAA
60 70 80 90 100
PVQAQAPQAV QPQAQQAAAP AQEAPKQDEN LHKITSPMVG TFYASSSPEA
110 120 130 140 150
GPYVTAGSKV NENTVVCIVE AMKLFNEIEA EVKGEIVEVL VENGQLVEYG
QPLFLVKAE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 64 – 65 | AQ → GE in AAB00182 (PubMed:7592499).Curated | 2 | |
Sequence conflicti | 126 | N → I in AAB00182 (PubMed:7592499).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36245 Genomic DNA Translation: AAB00182.1 D84432 Genomic DNA Translation: BAA12568.1 AL009126 Genomic DNA Translation: CAB14366.1 U35252 Genomic DNA Translation: AAA76728.1 |
PIRi | H69580 |
RefSeqi | NP_390315.1, NC_000964.3 WP_003230252.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14366; CAB14366; BSU_24350 |
GeneIDi | 938587 |
KEGGi | bsu:BSU24350 |
PATRICi | fig|224308.179.peg.2653 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36245 Genomic DNA Translation: AAB00182.1 D84432 Genomic DNA Translation: BAA12568.1 AL009126 Genomic DNA Translation: CAB14366.1 U35252 Genomic DNA Translation: AAA76728.1 |
PIRi | H69580 |
RefSeqi | NP_390315.1, NC_000964.3 WP_003230252.1, NZ_JNCM01000036.1 |
3D structure databases
SMRi | P49786 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU24350 |
Proteomic databases
jPOSTi | P49786 |
PaxDbi | P49786 |
PRIDEi | P49786 |
Genome annotation databases
EnsemblBacteriai | CAB14366; CAB14366; BSU_24350 |
GeneIDi | 938587 |
KEGGi | bsu:BSU24350 |
PATRICi | fig|224308.179.peg.2653 |
Phylogenomic databases
eggNOGi | COG0511, Bacteria |
InParanoidi | P49786 |
OMAi | IKSPIIG |
PhylomeDBi | P49786 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
BioCyci | BSUB:BSU24350-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR001249, AcCoA_biotinCC IPR001882, Biotin_BS IPR000089, Biotin_lipoyl IPR011053, Single_hybrid_motif |
Pfami | View protein in Pfam PF00364, Biotin_lipoyl, 1 hit |
PRINTSi | PR01071, ACOABIOTINCC |
SUPFAMi | SSF51230, SSF51230, 1 hit |
TIGRFAMsi | TIGR00531, BCCP, 1 hit |
PROSITEi | View protein in PROSITE PS00188, BIOTIN, 1 hit PS50968, BIOTINYL_LIPOYL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BCCP_BACSU | |
Accessioni | P49786Primary (citable) accession number: P49786 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | August 4, 2003 | |
Last modified: | June 2, 2021 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways