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UniProtKB - P49771 (FLT3L_HUMAN)

Entry version 178 (25 May 2022)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Fms-related tyrosine kinase 3 ligand

Gene

FLT3LG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49771

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-109704, PI3K Cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9607240, FLT3 Signaling
R-HSA-9645135, STAT5 Activation
R-HSA-9706369, Negative regulation of FLT3
R-HSA-9706374, FLT3 signaling through SRC family kinases
R-HSA-9706377, FLT3 signaling by CBL mutants

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49771

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49771

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fms-related tyrosine kinase 3 ligand
Short name:
Flt3 ligand
Short name:
Flt3L
Alternative name(s):
SL cytokine
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLT3LG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3766, FLT3LG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600007, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49771

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000090554

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 184ExtracellularSequence analysisAdd BLAST158
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 235CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2323

Open Targets

More...OpenTargetsi		ENSG00000090554

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28182

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49771, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FLT3LG

Domain mapping of disease mutations (DMDM)

More...DMDMi		1706818

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002128127 – 235Fms-related tyrosine kinase 3 ligandAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 111
Disulfide bondi70 ↔ 153
Disulfide bondi119 ↔ 158
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49771

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49771

PeptideAtlas

More...PeptideAtlasi		P49771

PRoteomics IDEntifications database

More...PRIDEi		P49771

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56114 [P49771-1]
56115 [P49771-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P49771, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49771

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49771

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000090554, Expressed in testis and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49771, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49771, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000090554, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (isoform 2).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108611, 3 interactors

Database of interacting proteins

More...DIPi		DIP-6220N

Protein interaction database and analysis system

More...IntActi		P49771, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000469613

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49771, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P49771

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49771

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P49771

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni213 – 235DisorderedSequence analysisAdd BLAST23

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SAIE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01040000244310

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_082442_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49771

Identification of Orthologs from Complete Genome Data

More...OMAi		GCLELQC

Database of Orthologous Groups

More...OrthoDBi		1596773at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49771

TreeFam database of animal gene trees

More...TreeFami		TF338225

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR004213, Flt3_lig

The PANTHER Classification System

More...PANTHERi		PTHR11032, PTHR11032, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02947, Flt3_lig, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47266, SSF47266, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49771-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD 
        60         70         80         90        100
YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER 
       110        120        130        140        150
VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF 
       160        170        180        190        200
SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA 
       210        220        230 
AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH
Length:235
Mass (Da):26,416
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73B95BF693B4CECF
GO
Isoform 2 (identifier: P49771-2) [UniParc]FASTAAdd to basket
Also known as: Soluble

The sequence of this isoform differs from the canonical sequence as follows:
     161-178: DSSTLPPPWSPRPLEATA → VETVFHRVSQDGLDLLTS
     179-235: Missing.

Show »
Length:178
Mass (Da):20,142
Checksum:iD9E7D4C5FBD370D8
GO
Isoform 3 (identifier: P49771-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,290
Checksum:i84FB972427691E35
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYM9M0QYM9_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXI0M0QXI0_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2K0M0R2K0_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3A6M0R3A6_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72G → A in AAA17999 (PubMed:8145851).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545991 – 82Missing in isoform 3. 2 PublicationsAdd BLAST82
Alternative sequenceiVSP_004251161 – 178DSSTL…LEATA → VETVFHRVSQDGLDLLTS in isoform 2. CuratedAdd BLAST18
Alternative sequenceiVSP_004252179 – 235Missing in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U04806 mRNA Translation: AAA17999.1
U03858 mRNA Translation: AAA19825.1
U29874 Genomic DNA Translation: AAA90949.1
U29874 Genomic DNA Translation: AAA90950.1
AK301136 mRNA Translation: BAG62728.1
AC010619 Genomic DNA No translation available.
BC028001 mRNA Translation: AAH28001.1
BC126293 mRNA Translation: AAI26294.1
BC136464 mRNA Translation: AAI36465.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12767.1 [P49771-1]
CCDS62753.1 [P49771-3]

Protein sequence database of the Protein Information Resource

More...PIRi		I38440
I39076

NCBI Reference Sequences

More...RefSeqi		NP_001191431.1, NM_001204502.1 [P49771-1]
NP_001191432.1, NM_001204503.1 [P49771-1]
NP_001265566.1, NM_001278637.1 [P49771-3]
NP_001265567.1, NM_001278638.1 [P49771-3]
NP_001450.2, NM_001459.3 [P49771-1]
XP_011524984.1, XM_011526682.2 [P49771-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000204637.6; ENSP00000204637.2; ENSG00000090554.13 [P49771-3]
ENST00000594009.5; ENSP00000469613.1; ENSG00000090554.13
ENST00000595510.1; ENSP00000471226.1; ENSG00000090554.13 [P49771-3]
ENST00000597551.6; ENSP00000468977.1; ENSG00000090554.13
ENST00000600429.5; ENSP00000470453.1; ENSG00000090554.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2323

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2323

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000597551.6; ENSP00000468977.1; NM_001459.4; NP_001450.2

UCSC genome browser

More...UCSCi		uc002pnu.4, human [P49771-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04806 mRNA Translation: AAA17999.1
U03858 mRNA Translation: AAA19825.1
U29874 Genomic DNA Translation: AAA90949.1
U29874 Genomic DNA Translation: AAA90950.1
AK301136 mRNA Translation: BAG62728.1
AC010619 Genomic DNA No translation available.
BC028001 mRNA Translation: AAH28001.1
BC126293 mRNA Translation: AAI26294.1
BC136464 mRNA Translation: AAI36465.1
CCDSiCCDS12767.1 [P49771-1]
CCDS62753.1 [P49771-3]
PIRiI38440
I39076
RefSeqiNP_001191431.1, NM_001204502.1 [P49771-1]
NP_001191432.1, NM_001204503.1 [P49771-1]
NP_001265566.1, NM_001278637.1 [P49771-3]
NP_001265567.1, NM_001278638.1 [P49771-3]
NP_001450.2, NM_001459.3 [P49771-1]
XP_011524984.1, XM_011526682.2 [P49771-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETEX-ray2.20A/B/C/D27-160[»]
3QS7X-ray4.30A/B/C/D27-160[»]
3QS9X-ray7.80A/B/C/D27-160[»]
7NBIX-ray1.65A/B27-160[»]
AlphaFoldDBiP49771
SMRiP49771
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108611, 3 interactors
DIPiDIP-6220N
IntActiP49771, 5 interactors
STRINGi9606.ENSP00000469613

PTM databases

GlyGeniP49771, 2 sites
iPTMnetiP49771
PhosphoSitePlusiP49771

Genetic variation databases

BioMutaiFLT3LG
DMDMi1706818

Proteomic databases

jPOSTiP49771
PaxDbiP49771
PeptideAtlasiP49771
PRIDEiP49771
ProteomicsDBi56114 [P49771-1]
56115 [P49771-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P49771, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2271, 426 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		2323

Genome annotation databases

EnsembliENST00000204637.6; ENSP00000204637.2; ENSG00000090554.13 [P49771-3]
ENST00000594009.5; ENSP00000469613.1; ENSG00000090554.13
ENST00000595510.1; ENSP00000471226.1; ENSG00000090554.13 [P49771-3]
ENST00000597551.6; ENSP00000468977.1; ENSG00000090554.13
ENST00000600429.5; ENSP00000470453.1; ENSG00000090554.13
GeneIDi2323
KEGGihsa:2323
MANE-SelectiENST00000597551.6; ENSP00000468977.1; NM_001459.4; NP_001450.2
UCSCiuc002pnu.4, human [P49771-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2323
DisGeNETi2323

GeneCards: human genes, protein and diseases

More...GeneCardsi		FLT3LG
HGNCiHGNC:3766, FLT3LG
HPAiENSG00000090554, Low tissue specificity
MIMi600007, gene
neXtProtiNX_P49771
OpenTargetsiENSG00000090554
PharmGKBiPA28182
VEuPathDBiHostDB:ENSG00000090554

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SAIE, Eukaryota
GeneTreeiENSGT01040000244310
HOGENOMiCLU_082442_1_0_1
InParanoidiP49771
OMAiGCLELQC
OrthoDBi1596773at2759
PhylomeDBiP49771
TreeFamiTF338225

Enzyme and pathway databases

PathwayCommonsiP49771
ReactomeiR-HSA-109704, PI3K Cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9607240, FLT3 Signaling
R-HSA-9645135, STAT5 Activation
R-HSA-9706369, Negative regulation of FLT3
R-HSA-9706374, FLT3 signaling through SRC family kinases
R-HSA-9706377, FLT3 signaling by CBL mutants
SignaLinkiP49771
SIGNORiP49771

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2323, 27 hits in 1087 CRISPR screens
EvolutionaryTraceiP49771

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FLT3LG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2323
PharosiP49771, Tbio

Protein Ontology

More...PROi		PR:P49771
RNActiP49771, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000090554, Expressed in testis and 114 other tissues
ExpressionAtlasiP49771, baseline and differential
GenevisibleiP49771, HS

Family and domain databases

Gene3Di1.20.1250.10, 1 hit
InterProiView protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR004213, Flt3_lig
PANTHERiPTHR11032, PTHR11032, 1 hit
PfamiView protein in Pfam
PF02947, Flt3_lig, 1 hit
SUPFAMiSSF47266, SSF47266, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLT3L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49771
Secondary accession number(s): A0AVC2, B9EGH2, Q05C96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 25, 2022
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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