UniProtKB - P49771 (FLT3L_HUMAN)

BLAST

>sp|P49771|FLT3L_HUMAN Fms-related tyrosine kinase 3 ligand OS=Homo sapiens OX=9606 GN=FLT3LG PE=1 SV=1
MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH

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History
Entry version 156 (12 Sep 2018)
Sequence version 1 (01 Oct 1996)
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Protein

Fms-related tyrosine kinase 3 ligand

Gene

FLT3LG

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase activity Source: Reactome
cytokine activity Source: UniProtKB-KW
protein homodimerization activity Source: Ensembl
Ras guanyl-nucleotide exchange factor activity Source: Reactome
receptor tyrosine kinase binding Source: Ensembl
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 8180375

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytokine-mediated signaling pathway Source: Reactome
embryonic hemopoiesis
Source: DFLAT
Inferred from direct assayⁱ
- 21149635
homeostasis of number of cells within a tissue Source: Ensembl
lymphocyte differentiation Source: Ensembl
MAPK cascade Source: Reactome
negative regulation of apoptotic process in bone marrow Source: Ensembl
positive regulation of cell cycle Source: Ensembl
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 8180375
positive regulation of cell proliferation in bone marrow Source: Ensembl
positive regulation of myoblast differentiation Source: Ensembl
positive regulation of myoblast fusion Source: Ensembl
positive regulation of natural killer cell differentiation Source: Ensembl
positive regulation of natural killer cell proliferation Source: Ensembl
positive regulation of osteoclast proliferation Source: Ensembl
positive regulation of protein phosphorylation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of myeloid dendritic cell activation Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8180375

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-449836 Other interleukin signaling R-HSA-5673001 RAF/MAP kinase cascade
SIGNORⁱ	P49771

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fms-related tyrosine kinase 3 ligand Short name: Flt3 ligand Short name: Flt3L Alternative name(s): SL cytokine
Gene namesⁱ	Name:FLT3LG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000090554.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3766 FLT3LG
MIMⁱ	600007 gene
neXtProtⁱ	NX_P49771

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 184	ExtracellularSequence analysisAdd BLAST	158
Transmembraneⁱ	185 – 205	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	206 – 235	CytoplasmicSequence analysisAdd BLAST	30

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2323
Open Targets More...OpenTargetsⁱ	ENSG00000090554
PharmGKBⁱ	PA28182

Polymorphism and mutation databases

BioMutaⁱ	FLT3LG
DMDMⁱ	1706818

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000021281	27 – 235	Fms-related tyrosine kinase 3 ligandAdd BLAST		209

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	30 ↔ 111
Disulfide bondⁱ	70 ↔ 153
Disulfide bondⁱ	119 ↔ 158
Glycosylationⁱ	126	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	149	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P49771
PeptideAtlas More...PeptideAtlasⁱ	P49771
PRIDEⁱ	P49771
ProteomicsDBⁱ	56114 56115 [P49771-2]

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090554 Expressed in 88 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_FLT3LG
ExpressionAtlasⁱ	P49771 baseline and differential
Genevisibleⁱ	P49771 HS

Interactionⁱ

Subunit structureⁱ

Homodimer (isoform 2).

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
protein homodimerization activity Source: Ensembl
Ras guanyl-nucleotide exchange factor activity Source: Reactome
receptor tyrosine kinase binding Source: Ensembl
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 8180375

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108611, 2 interactors
Database of interacting proteins More...DIPⁱ	DIP-6220N
IntActⁱ	P49771, 3 interactors
STRINGⁱ	9606.ENSP00000468977

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	41 – 49	Combined sources	9
Beta strandⁱ	57 – 62	Combined sources	6
Turnⁱ	68 – 70	Combined sources	3
Helixⁱ	71 – 87	Combined sources	17
Helixⁱ	92 – 105	Combined sources	14
Helixⁱ	106 – 110	Combined sources	5
Beta strandⁱ	122 – 126	Combined sources	5
Helixⁱ	127 – 141	Combined sources	15
Turnⁱ	142 – 147	Combined sources	6
Helixⁱ	151 – 153	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P49771
SMRⁱ	P49771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49771

EvolutionaryTraceⁱ

P49771

Family & Domainsⁱ

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IXDX Eukaryota ENOG41118N3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064424
HOGENOMⁱ	HOG000029239
HOVERGENⁱ	HBG051630
InParanoidⁱ	P49771
KEGG Orthology (KO) More...KOⁱ	K05454
OMAⁱ	GCLELQC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R0Y
PhylomeDBⁱ	P49771
TreeFamⁱ	TF338225

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR004213 Flt3_lig
PANTHERⁱ	PTHR11032 PTHR11032, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02947 Flt3_lig, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P49771-1) [UniParc]FASTA Add to basket

Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD 
        60         70         80         90        100
YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER 
       110        120        130        140        150
VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF 
       160        170        180        190        200
SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA 
       210        220        230 
AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH

Length:235

Mass (Da):26,416

Last modified:October 1, 1996 - v1

Checksum:ⁱ73B95BF693B4CECF

Isoform 2 (identifier: P49771-2) [UniParc]FASTA Add to basket

Also known as: Soluble

The sequence of this isoform differs from the canonical sequence as follows:
161-178: DSSTLPPPWSPRPLEATA → VETVFHRVSQDGLDLLTS
179-235: Missing.

« Hide

        10         20         30         40         50
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD 
        60         70         80         90        100
YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER 
       110        120        130        140        150
VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF 
       160        170 
SRCLELQCQP VETVFHRVSQ DGLDLLTS

Show »

Length:178

Mass (Da):20,142

Checksum:ⁱD9E7D4C5FBD370D8

Isoform 3 (identifier: P49771-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-82: Missing.

« Hide

        10         20         30         40         50
MERLKTVAGS KMQGLLERVN TEIHFVTKCA FQPPPSCLRF VQTNISRLLQ 
        60         70         80         90        100
ETSEQLVALK PWITRQNFSR CLELQCQPDS STLPPPWSPR PLEATAPTAP 
       110        120        130        140        150
QPPLLLLLLL PVGLLLLAAA WCLHWQRTRR RTPRPGEQVP PVPSPQDLLL 

VEH

Show »

Length:153

Mass (Da):17,290

Checksum:ⁱ84FB972427691E35

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
M0QYM9	M0QYM9_HUMAN	Fms-related tyrosine kinase 3 ligan... Fms-related tyrosine kinase 3 ligand	FLT3LG	217	Annotation score:
M0R2K0	M0R2K0_HUMAN	Fms-related tyrosine kinase 3 ligan... Fms-related tyrosine kinase 3 ligand	FLT3LG	58	Annotation score:
M0R3A6	M0R3A6_HUMAN	Fms-related tyrosine kinase 3 ligan... Fms-related tyrosine kinase 3 ligand	FLT3LG	132	Annotation score:
M0QXI0	M0QXI0_HUMAN	Fms-related tyrosine kinase 3 ligan... Fms-related tyrosine kinase 3 ligand	FLT3LG	187	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	72	G → A in AAA17999 (PubMed:8145851).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_054599	1 – 82	Missing in isoform 3. 2 PublicationsAdd BLAST	82
Alternative sequenceⁱVSP_004251	161 – 178	DSSTL…LEATA → VETVFHRVSQDGLDLLTS in isoform 2. CuratedAdd BLAST	18
Alternative sequenceⁱVSP_004252	179 – 235	Missing in isoform 2. CuratedAdd BLAST	57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U04806 mRNA Translation: AAA17999.1 U03858 mRNA Translation: AAA19825.1 U29874 Genomic DNA Translation: AAA90949.1 U29874 Genomic DNA Translation: AAA90950.1 AK301136 mRNA Translation: BAG62728.1 AC010619 Genomic DNA No translation available. BC028001 mRNA Translation: AAH28001.1 BC126293 mRNA Translation: AAI26294.1 BC136464 mRNA Translation: AAI36465.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12767.1 [P49771-1] CCDS62753.1 [P49771-3]
PIRⁱ	I38440 I39076
NCBI Reference Sequences More...RefSeqⁱ	NP_001191431.1, NM_001204502.1 [P49771-1] NP_001191432.1, NM_001204503.1 [P49771-1] NP_001265566.1, NM_001278637.1 [P49771-3] NP_001265567.1, NM_001278638.1 [P49771-3] NP_001450.2, NM_001459.3 [P49771-1] XP_011524984.1, XM_011526682.2 [P49771-3]
UniGeneⁱ	Hs.428

Genome annotation databases

Ensemblⁱ	ENST00000204637; ENSP00000204637; ENSG00000090554 [P49771-3] ENST00000594009; ENSP00000469613; ENSG00000090554 [P49771-1] ENST00000595510; ENSP00000471226; ENSG00000090554 [P49771-3] ENST00000597551; ENSP00000468977; ENSG00000090554 [P49771-1] ENST00000600429; ENSP00000470453; ENSG00000090554 [P49771-1]
GeneIDⁱ	2323
KEGGⁱ	hsa:2323
UCSC genome browser More...UCSCⁱ	uc002pnu.4 human [P49771-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49771	FLT3LG isoform 4		PANTR		153	UniRef100_P49771
Fms related tyrosine kinase 3 ligand		GORGO		153
Isoform 3 of Fms-related tyrosine kinase 3 ligand		HUMAN		153

Protein	Similar proteins		Species	Score	Length	Source
P49771	FLT3LG isoform 4		PANTR		153	UniRef90_P49771
Fms related tyrosine kinase 3 ligand		GORGO		153
Isoform 3 of Fms-related tyrosine kinase 3 ligand		HUMAN		153
Fms related tyrosine kinase 3 ligand		COLAP		236
Fms related tyrosine kinase 3 ligand		CERAT		236
+12

Protein	Similar proteins		Species	Score	Length	Source
P49771	FLT3LG isoform 4		PANTR		153	UniRef50_P49771
Fms related tyrosine kinase 3 ligand		GORGO		153
Isoform 3 of Fms-related tyrosine kinase 3 ligand		HUMAN		153
Fms related tyrosine kinase 3 ligand		COLAP		236
Fms related tyrosine kinase 3 ligand		CERAT		236
+27
P49771-2	Isoform 2 of Fms-related tyrosine kinase 3 ligand		MOUSE		220	UniRef50_P49772-2
Uncharacterized protein		NOMLE		223
Fms-related tyrosine kinase 3 ligand transcript variant 3 (Fragment)		PIG		217
UPI0007DBBEDA		PANTR		222
UPI0005B7E73F		PTEVA		195
+9

Entry informationⁱ

Entry nameⁱ	FLT3L_HUMAN
Accessionⁱ	P49771Primary (citable) accession number: P49771 Secondary accession number(s): A0AVC2, B9EGH2, Q05C96
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P49771 (FLT3L_HUMAN)

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Fms-related tyrosine kinase 3 ligand

FLT3LG

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ