Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fms-related tyrosine kinase 3 ligand

Gene

FLT3LG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-449836 Other interleukin signaling
R-HSA-5673001 RAF/MAP kinase cascade
SIGNORiP49771

Names & Taxonomyi

Protein namesi
Recommended name:
Fms-related tyrosine kinase 3 ligand
Short name:
Flt3 ligand
Short name:
Flt3L
Alternative name(s):
SL cytokine
Gene namesi
Name:FLT3LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000090554.12
HGNCiHGNC:3766 FLT3LG
MIMi600007 gene
neXtProtiNX_P49771

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 184ExtracellularSequence analysisAdd BLAST158
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 235CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2323
OpenTargetsiENSG00000090554
PharmGKBiPA28182

Polymorphism and mutation databases

BioMutaiFLT3LG
DMDMi1706818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002128127 – 235Fms-related tyrosine kinase 3 ligandAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 111
Disulfide bondi70 ↔ 153
Disulfide bondi119 ↔ 158
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49771
PeptideAtlasiP49771
PRIDEiP49771
ProteomicsDBi56114
56115 [P49771-2]

Expressioni

Gene expression databases

BgeeiENSG00000090554 Expressed in 88 organ(s), highest expression level in leukocyte
CleanExiHS_FLT3LG
ExpressionAtlasiP49771 baseline and differential
GenevisibleiP49771 HS

Interactioni

Subunit structurei

Homodimer (isoform 2).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108611, 2 interactors
DIPiDIP-6220N
IntActiP49771, 3 interactors
STRINGi9606.ENSP00000468977

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49771
SMRiP49771
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49771

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXDX Eukaryota
ENOG41118N3 LUCA
GeneTreeiENSGT00530000064424
HOGENOMiHOG000029239
HOVERGENiHBG051630
InParanoidiP49771
KOiK05454
OMAiGCLELQC
OrthoDBiEOG091G0R0Y
PhylomeDBiP49771
TreeFamiTF338225

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR004213 Flt3_lig
PANTHERiPTHR11032 PTHR11032, 1 hit
PfamiView protein in Pfam
PF02947 Flt3_lig, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P49771-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD
60 70 80 90 100
YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER
110 120 130 140 150
VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF
160 170 180 190 200
SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA
210 220 230
AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH
Length:235
Mass (Da):26,416
Last modified:October 1, 1996 - v1
Checksum:i73B95BF693B4CECF
GO
Isoform 2 (identifier: P49771-2) [UniParc]FASTAAdd to basket
Also known as: Soluble

The sequence of this isoform differs from the canonical sequence as follows:
     161-178: DSSTLPPPWSPRPLEATA → VETVFHRVSQDGLDLLTS
     179-235: Missing.

Show »
Length:178
Mass (Da):20,142
Checksum:iD9E7D4C5FBD370D8
GO
Isoform 3 (identifier: P49771-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,290
Checksum:i84FB972427691E35
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYM9M0QYM9_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
217Annotation score:
M0R2K0M0R2K0_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
58Annotation score:
M0R3A6M0R3A6_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
132Annotation score:
M0QXI0M0QXI0_HUMAN
Fms-related tyrosine kinase 3 ligan...
FLT3LG
187Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72G → A in AAA17999 (PubMed:8145851).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545991 – 82Missing in isoform 3. 2 PublicationsAdd BLAST82
Alternative sequenceiVSP_004251161 – 178DSSTL…LEATA → VETVFHRVSQDGLDLLTS in isoform 2. CuratedAdd BLAST18
Alternative sequenceiVSP_004252179 – 235Missing in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04806 mRNA Translation: AAA17999.1
U03858 mRNA Translation: AAA19825.1
U29874 Genomic DNA Translation: AAA90949.1
U29874 Genomic DNA Translation: AAA90950.1
AK301136 mRNA Translation: BAG62728.1
AC010619 Genomic DNA No translation available.
BC028001 mRNA Translation: AAH28001.1
BC126293 mRNA Translation: AAI26294.1
BC136464 mRNA Translation: AAI36465.1
CCDSiCCDS12767.1 [P49771-1]
CCDS62753.1 [P49771-3]
PIRiI38440
I39076
RefSeqiNP_001191431.1, NM_001204502.1 [P49771-1]
NP_001191432.1, NM_001204503.1 [P49771-1]
NP_001265566.1, NM_001278637.1 [P49771-3]
NP_001265567.1, NM_001278638.1 [P49771-3]
NP_001450.2, NM_001459.3 [P49771-1]
XP_011524984.1, XM_011526682.2 [P49771-3]
UniGeneiHs.428

Genome annotation databases

EnsembliENST00000204637; ENSP00000204637; ENSG00000090554 [P49771-3]
ENST00000594009; ENSP00000469613; ENSG00000090554 [P49771-1]
ENST00000595510; ENSP00000471226; ENSG00000090554 [P49771-3]
ENST00000597551; ENSP00000468977; ENSG00000090554 [P49771-1]
ENST00000600429; ENSP00000470453; ENSG00000090554 [P49771-1]
GeneIDi2323
KEGGihsa:2323
UCSCiuc002pnu.4 human [P49771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFLT3L_HUMAN
AccessioniPrimary (citable) accession number: P49771
Secondary accession number(s): A0AVC2, B9EGH2, Q05C96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again