UniProtKB - P49771 (FLT3L_HUMAN)
Fms-related tyrosine kinase 3 ligand
FLT3LG
Functioni
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- receptor tyrosine kinase binding Source: GO_Central
- signaling receptor binding Source: ProtInc
GO - Biological processi
- embryonic hemopoiesis Source: DFLAT
- positive regulation of cell population proliferation Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
PathwayCommonsi | P49771 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9607240, FLT3 Signaling R-HSA-9645135, STAT5 Activation R-HSA-9706369, Negative regulation of FLT3 R-HSA-9706374, FLT3 signaling through SRC family kinases R-HSA-9706377, FLT3 signaling by CBL mutants |
SignaLinki | P49771 |
SIGNORi | P49771 |
Names & Taxonomyi
Protein namesi | Recommended name: Fms-related tyrosine kinase 3 ligandShort name: Flt3 ligand Short name: Flt3L Alternative name(s): SL cytokine |
Gene namesi | Name:FLT3LG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3766, FLT3LG |
MIMi | 600007, gene |
neXtProti | NX_P49771 |
VEuPathDBi | HostDB:ENSG00000090554 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell surface Source: GO_Central
- integral component of membrane Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 184 | ExtracellularSequence analysisAdd BLAST | 158 | |
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 235 | CytoplasmicSequence analysisAdd BLAST | 30 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2323 |
OpenTargetsi | ENSG00000090554 |
PharmGKBi | PA28182 |
Miscellaneous databases
Pharosi | P49771, Tbio |
Genetic variation databases
BioMutai | FLT3LG |
DMDMi | 1706818 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000021281 | 27 – 235 | Fms-related tyrosine kinase 3 ligandAdd BLAST | 209 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 111 | |||
Disulfide bondi | 70 ↔ 153 | |||
Disulfide bondi | 119 ↔ 158 | |||
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 149 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P49771 |
PaxDbi | P49771 |
PeptideAtlasi | P49771 |
PRIDEi | P49771 |
ProteomicsDBi | 56114 [P49771-1] 56115 [P49771-2] |
PTM databases
GlyGeni | P49771, 2 sites |
iPTMneti | P49771 |
PhosphoSitePlusi | P49771 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090554, Expressed in testis and 114 other tissues |
ExpressionAtlasi | P49771, baseline and differential |
Genevisiblei | P49771, HS |
Organism-specific databases
HPAi | ENSG00000090554, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (isoform 2).
Binary interactionsi
P49771
With | #Exp. | IntAct |
---|---|---|
KRTAP5-9 [P26371] | 3 | EBI-724977,EBI-3958099 |
Isoform 3 [P49771-3]
With | #Exp. | IntAct |
---|---|---|
LAMP2 - isoform LAMP-2B [P13473-2] | 3 | EBI-25872794,EBI-21591415 |
SH3GLB1 [Q9Y371] | 3 | EBI-25872794,EBI-2623095 |
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- receptor tyrosine kinase binding Source: GO_Central
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 108611, 3 interactors |
DIPi | DIP-6220N |
IntActi | P49771, 5 interactors |
STRINGi | 9606.ENSP00000469613 |
Miscellaneous databases
RNActi | P49771, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P49771 |
SMRi | P49771 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P49771 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 213 – 235 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SAIE, Eukaryota |
GeneTreei | ENSGT01040000244310 |
HOGENOMi | CLU_082442_1_0_1 |
InParanoidi | P49771 |
OMAi | GCLELQC |
OrthoDBi | 1596773at2759 |
PhylomeDBi | P49771 |
TreeFami | TF338225 |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR004213, Flt3_lig |
PANTHERi | PTHR11032, PTHR11032, 1 hit |
Pfami | View protein in Pfam PF02947, Flt3_lig, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD
60 70 80 90 100
YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER
110 120 130 140 150
VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF
160 170 180 190 200
SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA
210 220 230
AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QYM9 | M0QYM9_HUMAN | Fms-related tyrosine kinase 3 ligan... | FLT3LG | 217 | Annotation score: | ||
M0QXI0 | M0QXI0_HUMAN | Fms-related tyrosine kinase 3 ligan... | FLT3LG | 187 | Annotation score: | ||
M0R2K0 | M0R2K0_HUMAN | Fms-related tyrosine kinase 3 ligan... | FLT3LG | 58 | Annotation score: | ||
M0R3A6 | M0R3A6_HUMAN | Fms-related tyrosine kinase 3 ligan... | FLT3LG | 132 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | G → A in AAA17999 (PubMed:8145851).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054599 | 1 – 82 | Missing in isoform 3. 2 PublicationsAdd BLAST | 82 | |
Alternative sequenceiVSP_004251 | 161 – 178 | DSSTL…LEATA → VETVFHRVSQDGLDLLTS in isoform 2. CuratedAdd BLAST | 18 | |
Alternative sequenceiVSP_004252 | 179 – 235 | Missing in isoform 2. CuratedAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04806 mRNA Translation: AAA17999.1 U03858 mRNA Translation: AAA19825.1 U29874 Genomic DNA Translation: AAA90949.1 U29874 Genomic DNA Translation: AAA90950.1 AK301136 mRNA Translation: BAG62728.1 AC010619 Genomic DNA No translation available. BC028001 mRNA Translation: AAH28001.1 BC126293 mRNA Translation: AAI26294.1 BC136464 mRNA Translation: AAI36465.1 |
CCDSi | CCDS12767.1 [P49771-1] CCDS62753.1 [P49771-3] |
PIRi | I38440 I39076 |
RefSeqi | NP_001191431.1, NM_001204502.1 [P49771-1] NP_001191432.1, NM_001204503.1 [P49771-1] NP_001265566.1, NM_001278637.1 [P49771-3] NP_001265567.1, NM_001278638.1 [P49771-3] NP_001450.2, NM_001459.3 [P49771-1] XP_011524984.1, XM_011526682.2 [P49771-3] |
Genome annotation databases
Ensembli | ENST00000204637.6; ENSP00000204637.2; ENSG00000090554.13 [P49771-3] ENST00000594009.5; ENSP00000469613.1; ENSG00000090554.13 ENST00000595510.1; ENSP00000471226.1; ENSG00000090554.13 [P49771-3] ENST00000597551.6; ENSP00000468977.1; ENSG00000090554.13 ENST00000600429.5; ENSP00000470453.1; ENSG00000090554.13 |
GeneIDi | 2323 |
KEGGi | hsa:2323 |
MANE-Selecti | ENST00000597551.6; ENSP00000468977.1; NM_001459.4; NP_001450.2 |
UCSCi | uc002pnu.4, human [P49771-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04806 mRNA Translation: AAA17999.1 U03858 mRNA Translation: AAA19825.1 U29874 Genomic DNA Translation: AAA90949.1 U29874 Genomic DNA Translation: AAA90950.1 AK301136 mRNA Translation: BAG62728.1 AC010619 Genomic DNA No translation available. BC028001 mRNA Translation: AAH28001.1 BC126293 mRNA Translation: AAI26294.1 BC136464 mRNA Translation: AAI36465.1 |
CCDSi | CCDS12767.1 [P49771-1] CCDS62753.1 [P49771-3] |
PIRi | I38440 I39076 |
RefSeqi | NP_001191431.1, NM_001204502.1 [P49771-1] NP_001191432.1, NM_001204503.1 [P49771-1] NP_001265566.1, NM_001278637.1 [P49771-3] NP_001265567.1, NM_001278638.1 [P49771-3] NP_001450.2, NM_001459.3 [P49771-1] XP_011524984.1, XM_011526682.2 [P49771-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ETE | X-ray | 2.20 | A/B/C/D | 27-160 | [»] | |
3QS7 | X-ray | 4.30 | A/B/C/D | 27-160 | [»] | |
3QS9 | X-ray | 7.80 | A/B/C/D | 27-160 | [»] | |
7NBI | X-ray | 1.65 | A/B | 27-160 | [»] | |
AlphaFoldDBi | P49771 | |||||
SMRi | P49771 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108611, 3 interactors |
DIPi | DIP-6220N |
IntActi | P49771, 5 interactors |
STRINGi | 9606.ENSP00000469613 |
PTM databases
GlyGeni | P49771, 2 sites |
iPTMneti | P49771 |
PhosphoSitePlusi | P49771 |
Genetic variation databases
BioMutai | FLT3LG |
DMDMi | 1706818 |
Proteomic databases
jPOSTi | P49771 |
PaxDbi | P49771 |
PeptideAtlasi | P49771 |
PRIDEi | P49771 |
ProteomicsDBi | 56114 [P49771-1] 56115 [P49771-2] |
Protocols and materials databases
ABCDi | P49771, 7 sequenced antibodies |
Antibodypediai | 2271, 426 antibodies from 33 providers |
DNASUi | 2323 |
Genome annotation databases
Ensembli | ENST00000204637.6; ENSP00000204637.2; ENSG00000090554.13 [P49771-3] ENST00000594009.5; ENSP00000469613.1; ENSG00000090554.13 ENST00000595510.1; ENSP00000471226.1; ENSG00000090554.13 [P49771-3] ENST00000597551.6; ENSP00000468977.1; ENSG00000090554.13 ENST00000600429.5; ENSP00000470453.1; ENSG00000090554.13 |
GeneIDi | 2323 |
KEGGi | hsa:2323 |
MANE-Selecti | ENST00000597551.6; ENSP00000468977.1; NM_001459.4; NP_001450.2 |
UCSCi | uc002pnu.4, human [P49771-1] |
Organism-specific databases
CTDi | 2323 |
DisGeNETi | 2323 |
GeneCardsi | FLT3LG |
HGNCi | HGNC:3766, FLT3LG |
HPAi | ENSG00000090554, Low tissue specificity |
MIMi | 600007, gene |
neXtProti | NX_P49771 |
OpenTargetsi | ENSG00000090554 |
PharmGKBi | PA28182 |
VEuPathDBi | HostDB:ENSG00000090554 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SAIE, Eukaryota |
GeneTreei | ENSGT01040000244310 |
HOGENOMi | CLU_082442_1_0_1 |
InParanoidi | P49771 |
OMAi | GCLELQC |
OrthoDBi | 1596773at2759 |
PhylomeDBi | P49771 |
TreeFami | TF338225 |
Enzyme and pathway databases
PathwayCommonsi | P49771 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9607240, FLT3 Signaling R-HSA-9645135, STAT5 Activation R-HSA-9706369, Negative regulation of FLT3 R-HSA-9706374, FLT3 signaling through SRC family kinases R-HSA-9706377, FLT3 signaling by CBL mutants |
SignaLinki | P49771 |
SIGNORi | P49771 |
Miscellaneous databases
BioGRID-ORCSi | 2323, 27 hits in 1087 CRISPR screens |
EvolutionaryTracei | P49771 |
GeneWikii | FLT3LG |
GenomeRNAii | 2323 |
Pharosi | P49771, Tbio |
PROi | PR:P49771 |
RNActi | P49771, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090554, Expressed in testis and 114 other tissues |
ExpressionAtlasi | P49771, baseline and differential |
Genevisiblei | P49771, HS |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR004213, Flt3_lig |
PANTHERi | PTHR11032, PTHR11032, 1 hit |
Pfami | View protein in Pfam PF02947, Flt3_lig, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FLT3L_HUMAN | |
Accessioni | P49771Primary (citable) accession number: P49771 Secondary accession number(s): A0AVC2, B9EGH2, Q05C96 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references