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Protein

Vascular endothelial growth factor B

Gene

VEGFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-194313 VEGF ligand-receptor interactions
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization
SignaLinkiP49765
SIGNORiP49765

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor B
Short name:
VEGF-B
Alternative name(s):
VEGF-related factor
Short name:
VRF
Gene namesi
Name:VEGFB
Synonyms:VRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173511.9
HGNCiHGNC:12681 VEGFB
MIMi601398 gene
neXtProtiNX_P49765

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7423
OpenTargetsiENSG00000173511
PharmGKBiPA37303

Chemistry databases

ChEMBLiCHEMBL3580488
DrugBankiDB08885 Aflibercept

Polymorphism and mutation databases

BioMutaiVEGFB
DMDMi17380554

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002339822 – 207Vascular endothelial growth factor BAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 891 Publication
Disulfide bondi72Interchain1 Publication
Disulfide bondi78 ↔ 1221 Publication
Disulfide bondi81Interchain1 Publication
Disulfide bondi82 ↔ 1241 Publication

Post-translational modificationi

VEGF-B186 is O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49765
PeptideAtlasiP49765
PRIDEiP49765
ProteomicsDBi56103
56104 [P49765-2]

PTM databases

PhosphoSitePlusiP49765

Expressioni

Tissue specificityi

Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Gene expression databases

BgeeiENSG00000173511
CleanExiHS_VEGFB
ExpressionAtlasiP49765 baseline and differential
GenevisibleiP49765 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Can also form heterodimer with VEGF.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113266, 14 interactors
DIPiDIP-6045N
IntActiP49765, 4 interactors
STRINGi9606.ENSP00000311127

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni33 – 35Combined sources3
Helixi38 – 45Combined sources8
Beta strandi46 – 55Combined sources10
Turni58 – 60Combined sources3
Beta strandi61 – 64Combined sources4
Beta strandi66 – 81Combined sources16
Beta strandi83 – 86Combined sources4
Beta strandi88 – 105Combined sources18
Beta strandi108 – 125Combined sources18

3D structure databases

ProteinModelPortaliP49765
SMRiP49765
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49765

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II0A Eukaryota
ENOG410ZN1X LUCA
GeneTreeiENSGT00730000110791
HOGENOMiHOG000230896
HOVERGENiHBG000105
InParanoidiP49765
KOiK16858
OMAiTMELMGT
OrthoDBiEOG091G0G6M
PhylomeDBiP49765
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform VEGF-B186 (identifier: P49765-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLLRRLLL AALLQLAPAQ APVSQPDAPG HQRKVVSWID VYTRATCQPR
60 70 80 90 100
EVVVPLTVEL MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ
110 120 130 140 150
ILMIRYPSSQ LGEMSLEEHS QCECRPKKKD SAVKPDRAAT PHHRPQPRSV
160 170 180 190 200
PGWDSAPGAP SPADITHPTP APGPSAHAAP STTSALTPGP AAAAADAAAS

SVAKGGA
Length:207
Mass (Da):21,602
Last modified:November 16, 2001 - v2
Checksum:iEDE4B1C0DFDAD6BC
GO
Isoform VEGF-B167 (identifier: P49765-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-188: RAATPHHRPQ...APSTTSALTP → SPRPLCPRCT...DTCRCRKLRR
     189-207: Missing.

Show »
Length:188
Mass (Da):21,261
Checksum:iF04654D5A3727194
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004639137 – 188RAATP…SALTP → SPRPLCPRCTQHHQRPDPRT CRCRCRRRSFLRCQGRGLEL NPDTCRCRKLRR in isoform VEGF-B167. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_004640189 – 207Missing in isoform VEGF-B167. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43368 mRNA Translation: AAA91462.1
U43369 mRNA Translation: AAA91463.1
U52819 mRNA Translation: AAC50721.1
U48801 mRNA Translation: AAB06274.1
BC008818 mRNA Translation: AAH08818.1
CCDSiCCDS58144.1 [P49765-2]
CCDS8062.1 [P49765-1]
RefSeqiNP_001230662.1, NM_001243733.1 [P49765-2]
NP_003368.1, NM_003377.4 [P49765-1]
UniGeneiHs.732095

Genome annotation databases

EnsembliENST00000309422; ENSP00000311127; ENSG00000173511 [P49765-1]
ENST00000426086; ENSP00000401550; ENSG00000173511 [P49765-2]
GeneIDi7423
KEGGihsa:7423
UCSCiuc001nyx.4 human [P49765-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVEGFB_HUMAN
AccessioniPrimary (citable) accession number: P49765
Secondary accession number(s): Q16528
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: June 20, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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