CLK3

Functionⁱ

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	334	ATPPROSITE-ProRule annotation		1
Active siteⁱ	431	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	310 – 318	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
protein serine/threonine kinase activity Source: UniProtKB
protein tyrosine kinase activity Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein autophosphorylation Source: Ensembl
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 9637771
regulation of RNA splicing
Source: UniProtKB
Inferred from direct assayⁱ
- 9637771

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.12.1 2681
SignaLinkⁱ	P49761
SIGNORⁱ	P49761

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity protein kinase CLK3 (EC:2.7.12.1) Alternative name(s): CDC-like kinase 3
Gene namesⁱ	Name:CLK3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179335.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2071 CLK3
MIMⁱ	602990 gene
neXtProtⁱ	NX_P49761

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000179335
PharmGKBⁱ	PA26597

Chemistry databases

ChEMBLⁱ	CHEMBL4226
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1992

Polymorphism and mutation databases

BioMutaⁱ	CLK3
DMDMⁱ	148887358

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085870	1 – 638	Dual specificity protein kinase CLK3Add BLAST		638

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	155	PhosphotyrosineCombined sources	1
Modified residueⁱ	157	PhosphoserineCombined sources	1
Modified residueⁱ	197	PhosphoserineCombined sources	1
Modified residueⁱ	199	PhosphoserineCombined sources	1
Modified residueⁱ	215	PhosphoserineCombined sources	1
Modified residueⁱ	224	PhosphoserineCombined sources	1
Modified residueⁱ	226	PhosphoserineCombined sources	1
Modified residueⁱ	283	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Autophosphorylates on all three types of residues.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P49761
PaxDbⁱ	P49761
PeptideAtlas More...PeptideAtlasⁱ	P49761
PRIDEⁱ	P49761
ProteomicsDBⁱ	56096 56097 [P49761-1] 56098 [P49761-2] 56099 [P49761-3]

PTM databases

iPTMnetⁱ	P49761
PhosphoSitePlusⁱ	P49761

Expressionⁱ

Tissue specificityⁱ

Endothelial cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000179335 Expressed in 219 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_CLK3
ExpressionAtlasⁱ	P49761 baseline and differential
Genevisibleⁱ	P49761 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046817

HPAⁱ

HPA046817

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		3	EBI-745579,EBI-745579
CLK2	P49760	12	EBI-745579,EBI-750020
HOXB6	P17509	5	EBI-745579,EBI-741308
HOXB7	P09629	5	EBI-745579,EBI-1248457
OAS2	P29728	3	EBI-745579,EBI-10211452
RBMX	P38159	3	EBI-745579,EBI-743526
RBMY1A1	P0DJD3	3	EBI-745579,EBI-8638511
RBMY1J	Q15415	3	EBI-745579,EBI-8642021
RSRP1	Q9BUV0	8	EBI-745579,EBI-745604
SDCBP	O00560	5	EBI-745579,EBI-727004
SRPK2	P78362	4	EBI-745579,EBI-593303
SUV39H1	O43463	2	EBI-745579,EBI-349968
TINF2	Q9BSI4	2	EBI-745579,EBI-717399
TRA2B	P62995	5	EBI-745579,EBI-725485
ZNF263	O14978	3	EBI-745579,EBI-744493

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107609, 106 interactors
IntActⁱ	P49761, 69 interactors
Molecular INTeraction database More...MINTⁱ	P49761
STRINGⁱ	9606.ENSP00000378505

Chemistry databases

BindingDBⁱ

P49761

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	301 – 303	Combined sources	3
Beta strandⁱ	304 – 313	Combined sources	10
Beta strandⁱ	316 – 323	Combined sources	8
Turnⁱ	324 – 328	Combined sources	5
Beta strandⁱ	330 – 336	Combined sources	7
Helixⁱ	340 – 359	Combined sources	20
Beta strandⁱ	370 – 376	Combined sources	7
Beta strandⁱ	379 – 385	Combined sources	7
Helixⁱ	391 – 397	Combined sources	7
Turnⁱ	398 – 400	Combined sources	3
Helixⁱ	405 – 423	Combined sources	19
Turnⁱ	424 – 426	Combined sources	3
Helixⁱ	434 – 436	Combined sources	3
Beta strandⁱ	437 – 440	Combined sources	4
Beta strandⁱ	444 – 448	Combined sources	5
Turnⁱ	450 – 453	Combined sources	4
Beta strandⁱ	456 – 460	Combined sources	5
Beta strandⁱ	464 – 466	Combined sources	3
Helixⁱ	469 – 471	Combined sources	3
Helixⁱ	486 – 488	Combined sources	3
Helixⁱ	491 – 494	Combined sources	4
Helixⁱ	502 – 517	Combined sources	16
Helixⁱ	527 – 538	Combined sources	12
Helixⁱ	543 – 548	Combined sources	6
Helixⁱ	552 – 554	Combined sources	3
Helixⁱ	567 – 575	Combined sources	9
Helixⁱ	579 – 582	Combined sources	4
Helixⁱ	588 – 600	Combined sources	13
Turnⁱ	605 – 607	Combined sources	3
Helixⁱ	611 – 614	Combined sources	4
Helixⁱ	618 – 622	Combined sources	5
Helixⁱ	625 – 628	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P49761
SMRⁱ	P49761
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49761

EvolutionaryTraceⁱ

P49761

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	304 – 620	Protein kinasePROSITE-ProRule annotationAdd BLAST		317

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	167 – 264	Arg-richAdd BLAST		98

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0671 Eukaryota ENOG410XQF2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00580000081366
HOGENOMⁱ	HOG000203417
HOVERGENⁱ	HBG107720
InParanoidⁱ	P49761
KEGG Orthology (KO) More...KOⁱ	K08823
OMAⁱ	WDENTSD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G033A
PhylomeDBⁱ	P49761
TreeFamⁱ	TF101041

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show all Align All

Isoform 4 (identifier: P49761-4) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG 
        60         70         80         90        100
TYVRRDTAGG GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR 
       110        120        130        140        150
PPSRVEPRLA TAASREGAGL PRAEVAAGSG RGARSGEWGL AAAGAWETMH 
       160        170        180        190        200
HCKRYRSPEP DPYLSYRWKR RRSYSREHEG RLRYPSRREP PPRRSRSRSH 
       210        220        230        240        250
DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR RRSRERGPYR 
       260        270        280        290        300
TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
       310        320        330        340        350
QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI 
       360        370        380        390        400
NVLKKIKEKD KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF 
       410        420        430        440        450
QPYPLPHVRH MAYQLCHALR FLHENQLTHT DLKPENILFV NSEFETLYNE 
       460        470        480        490        500
HKSCEEKSVK NTSIRVADFG SATFDHEHHT TIVATRHYRP PEVILELGWA 
       510        520        530        540        550
QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP IPSHMIHRTR 
       560        570        580        590        600
KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
       610        620        630 
LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR

Length:638

Mass (Da):73,515

Last modified:June 12, 2007 - v3

Checksum:ⁱD3B60A9DB4ECEC94

GO

Isoform 1 (identifier: P49761-1) [UniParc]FASTA Add to basket

Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
1-148: Missing.

« Hide

        10         20         30         40         50
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR 
        60         70         80         90        100
SHDRLPYQRR YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP 
       110        120        130        140        150
YRTRKHAHHC HKRRTRSCSS ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD 
       160        170        180        190        200
WLQERYEIVG NLGEGTFGKV VECLDHARGK SQVALKIIRN VGKYREAARL 
       210        220        230        240        250
EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG KNTFEFLKEN 
       260        270        280        290        300
NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY 
       310        320        330        340        350
NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG 
       360        370        380        390        400
WAQPCDVWSI GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR 
       410        420        430        440        450
TRKQKYFYKG GLVWDENSSD GRYVKENCKP LKSYMLQDSL EHVQLFDLMR 
       460        470        480        490
RMLEFDPAQR ITLAEALLHP FFAGLTPEER SFHTSRNPSR

Show »

Length:490

Mass (Da):58,588

Checksum:ⁱ86A342ABB8AB24CA

GO

Isoform 2 (identifier: P49761-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     272-300: RSQQSSKRSSRSVEDDKEGHLVCRIGDWL → MRLWGTWVKAPLARWWSAWTMPEGSLRLP
     301-638: Missing.

« Hide

        10         20         30         40         50
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR 
        60         70         80         90        100
SHDRLPYQRR YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP 
       110        120        130        140        150
YRTRKHAHHC HKRRTRSCSS ASSMRLWGTW VKAPLARWWS AWTMPEGSLR 

LP

Note: Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:152

Mass (Da):18,971

Checksum:ⁱ5BABA6574A0E9801

GO

Isoform 3 (identifier: P49761-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-148: Missing.
306-328: Missing.

« Hide

        10         20         30         40         50
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR 
        60         70         80         90        100
SHDRLPYQRR YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP 
       110        120        130        140        150
YRTRKHAHHC HKRRTRSCSS ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD 
       160        170        180        190        200
WLQERYESQV ALKIIRNVGK YREAARLEIN VLKKIKEKDK ENKFLCVLMS 
       210        220        230        240        250
DWFNFHGHMC IAFELLGKNT FEFLKENNFQ PYPLPHVRHM AYQLCHALRF 
       260        270        280        290        300
LHENQLTHTD LKPENILFVN SEFETLYNEH KSCEEKSVKN TSIRVADFGS 
       310        320        330        340        350
ATFDHEHHTT IVATRHYRPP EVILELGWAQ PCDVWSIGCI LFEYYRGFTL 
       360        370        380        390        400
FQTHENREHL VMMEKILGPI PSHMIHRTRK QKYFYKGGLV WDENSSDGRY 
       410        420        430        440        450
VKENCKPLKS YMLQDSLEHV QLFDLMRRML EFDPAQRITL AEALLHPFFA 
       460 
GLTPEERSFH TSRNPSR

Show »

Length:467

Mass (Da):56,207

Checksum:ⁱ2890E88AE23AE7BC

GO

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	H3BQG1	H3BQG1_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	306	Annotation score:
	H3BVF8	H3BVF8_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	239	Annotation score:
	H3BUL5	H3BUL5_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	224	Annotation score:
	H3BNQ5	H3BNQ5_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	193	Annotation score:
	H3BRE4	H3BRE4_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	190	Annotation score:
	H3BRT8	H3BRT8_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	117	Annotation score:
	H3BV35	H3BV35_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	160	Annotation score:
	H3BRW2	H3BRW2_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	70	Annotation score:
	H3BQR7	H3BQR7_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	145	Annotation score:
	H3BNC8	H3BNC8_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK3	CLK3	59	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAH02555 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH19881 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	280 – 281	SS → TG in AAA61484 (PubMed:7990150).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040413	486	R → C1 Publication	1
Natural variantⁱVAR_045579	607	Q → R1 PublicationCorresponds to variant dbSNP:rs910378995Ensembl.	1
Natural variantⁱVAR_045580	628	R → W1 PublicationCorresponds to variant dbSNP:rs920443187Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_026138	1 – 148	Missing in isoform 1, isoform 2 and isoform 3. 3 PublicationsAdd BLAST	148
Alternative sequenceⁱVSP_004858	272 – 300	RSQQS…IGDWL → MRLWGTWVKAPLARWWSAWT MPEGSLRLP in isoform 2. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_004859	301 – 638	Missing in isoform 2. 1 PublicationAdd BLAST	338
Alternative sequenceⁱVSP_004860	306 – 328	Missing in isoform 3. 1 PublicationAdd BLAST	23

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29220 mRNA Translation: AAA61483.1 L29217 mRNA Translation: AAA61484.1 BT006993 mRNA Translation: AAP35639.1 AC100835 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99321.1 CH471136 Genomic DNA Translation: EAW99322.1 BC002555 mRNA Translation: AAH02555.1 Different initiation. BC006103 mRNA Translation: AAH06103.1 BC019881 mRNA Translation: AAH19881.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10265.1 [P49761-1] CCDS45304.1 [P49761-4]
PIRⁱ	S53639 S53640
NCBI Reference Sequences More...RefSeqⁱ	NP_001123500.1, NM_001130028.1 [P49761-4] NP_003983.2, NM_003992.4 [P49761-1] XP_016877398.1, XM_017021909.1 [P49761-1] XP_016877399.1, XM_017021910.1 [P49761-1]
UniGeneⁱ	Hs.511790 Hs.584748

Genome annotation databases

Ensemblⁱ	ENST00000345005; ENSP00000344112; ENSG00000179335 [P49761-1] ENST00000395066; ENSP00000378505; ENSG00000179335 [P49761-4] ENST00000483723; ENSP00000431825; ENSG00000179335 [P49761-2]
GeneIDⁱ	1198
KEGGⁱ	hsa:1198
UCSC genome browser More...UCSCⁱ	uc002ayg.4 human [P49761-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49761	Uncharacterized protein		NOMLE		645	UniRef90_P49761
Uncharacterized protein		OTOGA		639
cDNA FLJ34373 fis, clone FEBRA2017333, highly similar to Dual specificity protein kinase CLK3		HUMAN		638
CDC like kinase 3		PANTR		638
Uncharacterized protein		PROCO		638
+23
P49761-1	CLK3 isoform 3		PANTR		490	UniRef90_P49761-1
Dual specificity protein kinase CLK3 isoform a (Fragment)		MACMU		486
Uncharacterized protein		SAIBB		490
CLK3 isoform 3		PONAB		490
CDC like kinase 3		CHLSB		490
+41
P49761-2	Dual-specificity protein kinase CLK3 (Fragment)		HUMAN		173	UniRef90_P49761-2
Dual-specificity protein kinase CLK3 (Fragment)		MOUSE		191
CLK3 isoform 4		PONAB		152
CLK3 isoform 15 (Fragment)		PANTR		145
Dual-specificity protein kinase CLK3 (Fragment)		HUMAN		145
+4
P49761-3	Dual specificity protein kinase CLK3		TUPCH		469	UniRef90_P49761-3
UPI00064A72D3		SORAR		467
UPI000B5298F0		TARSY		467

Protein	Similar proteins		Species	Score	Length	Source
P49761	Dual specificity protein kinase CLK2	)	HUMAN		499	UniRef50_P49760
Dual specificity protein kinase CLK2		MOUSE		499
Dual specificity protein kinase CLK3		BOVIN		490
Dual specificity protein kinase CLK3		RAT		490
Uncharacterized protein		Cebus capucinus imitator		539
+834
P49761-2	Dual-specificity protein kinase CLK3 (Fragment)		HUMAN		173	UniRef50_P49761-2
Dual-specificity protein kinase CLK3 (Fragment)		MOUSE		191
CLK3 isoform 4		PANTR		152
CLK3 isoform 4		PONAB		152
Uncharacterized protein		NEOLE		134
+12
P49761-3	Dual specificity protein kinase CLK3		TUPCH		469	UniRef50_P49761-3
Similar to Dual specificity protein kinase CLK2 (CDC like kinase 2)		HUMAN		413
CDC-like kinase 2a		TETNG		432
Uncharacterized protein		XENLA		485
CDC like kinase 3		PIG		417
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29220 mRNA Translation: AAA61483.1 L29217 mRNA Translation: AAA61484.1 BT006993 mRNA Translation: AAP35639.1 AC100835 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99321.1 CH471136 Genomic DNA Translation: EAW99322.1 BC002555 mRNA Translation: AAH02555.1 Different initiation. BC006103 mRNA Translation: AAH06103.1 BC019881 mRNA Translation: AAH19881.1 Different initiation.
CCDSⁱ	CCDS10265.1 [P49761-1] CCDS45304.1 [P49761-4]
PIRⁱ	S53639 S53640
RefSeqⁱ	NP_001123500.1, NM_001130028.1 [P49761-4] NP_003983.2, NM_003992.4 [P49761-1] XP_016877398.1, XM_017021909.1 [P49761-1] XP_016877399.1, XM_017021910.1 [P49761-1]
UniGeneⁱ	Hs.511790 Hs.584748

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EU9	X-ray	1.53	A	284-638	[»]
	2EXE	X-ray	2.35	A	275-631	[»]
	2WU6	X-ray	1.92	A	275-632	[»]
	2WU7	X-ray	2.25	A	275-632	[»]
	3RAW	X-ray	2.09	A/B	275-632	[»]
	6FT7	X-ray	2.02	A/B	275-632	[»]
	6FYP	X-ray	2.29	A	275-632	[»]
	6FYR	X-ray	1.42	A	275-632	[»]
ProteinModelPortalⁱ	P49761
SMRⁱ	P49761
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107609, 106 interactors
IntActⁱ	P49761, 69 interactors
MINTⁱ	P49761
STRINGⁱ	9606.ENSP00000378505

Chemistry databases

BindingDBⁱ	P49761
ChEMBLⁱ	CHEMBL4226
GuidetoPHARMACOLOGYⁱ	1992

PTM databases

iPTMnetⁱ	P49761
PhosphoSitePlusⁱ	P49761

Polymorphism and mutation databases

BioMutaⁱ	CLK3
DMDMⁱ	148887358

Proteomic databases

EPDⁱ	P49761
PaxDbⁱ	P49761
PeptideAtlasⁱ	P49761
PRIDEⁱ	P49761
ProteomicsDBⁱ	56096 56097 [P49761-1] 56098 [P49761-2] 56099 [P49761-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1198
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000345005; ENSP00000344112; ENSG00000179335 [P49761-1] ENST00000395066; ENSP00000378505; ENSG00000179335 [P49761-4] ENST00000483723; ENSP00000431825; ENSG00000179335 [P49761-2]
GeneIDⁱ	1198
KEGGⁱ	hsa:1198
UCSCⁱ	uc002ayg.4 human [P49761-4]

Organism-specific databases

CTDⁱ	1198
EuPathDBⁱ	HostDB:ENSG00000179335.18
GeneCardsⁱ	CLK3
HGNCⁱ	HGNC:2071 CLK3
HPAⁱ	HPA046817
MIMⁱ	602990 gene
neXtProtⁱ	NX_P49761
OpenTargetsⁱ	ENSG00000179335
PharmGKBⁱ	PA26597
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0671 Eukaryota ENOG410XQF2 LUCA
GeneTreeⁱ	ENSGT00580000081366
HOGENOMⁱ	HOG000203417
HOVERGENⁱ	HBG107720
InParanoidⁱ	P49761
KOⁱ	K08823
OMAⁱ	WDENTSD
OrthoDBⁱ	EOG091G033A
PhylomeDBⁱ	P49761
TreeFamⁱ	TF101041

Enzyme and pathway databases

BRENDAⁱ	2.7.12.1 2681
SignaLinkⁱ	P49761
SIGNORⁱ	P49761

Miscellaneous databases

ChiTaRSⁱ	CLK3 human
EvolutionaryTraceⁱ	P49761
GeneWikiⁱ	CLK3_(gene)
GenomeRNAiⁱ	1198
Protein Ontology More...PROⁱ	PR:P49761
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179335 Expressed in 219 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_CLK3
ExpressionAtlasⁱ	P49761 baseline and differential
Genevisibleⁱ	P49761 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLK3_HUMAN
Accessionⁱ	P49761Primary (citable) accession number: P49761 Secondary accession number(s): D3DW59 , Q53Y48, Q9BRS3, Q9BUJ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	June 12, 2007
	Last modified:	October 10, 2018
	This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P49761 (CLK3_HUMAN)

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Dual specificity protein kinase CLK3

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

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Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ