CLK1

Functionⁱ

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	191	ATPPROSITE-ProRule annotation		1
Active siteⁱ	288	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	167 – 175	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
non-membrane spanning protein tyrosine kinase activity
Source: ProtInc
Traceable author statementⁱ
- 1825055
protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10480872

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 1704889
peptidyl-serine phosphorylation Source: Ensembl
peptidyl-threonine phosphorylation Source: Ensembl
protein autophosphorylation Source: Ensembl
regulation of RNA splicing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19168442

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.12.1 2681
SignaLinkⁱ	P49759
SIGNORⁱ	P49759

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity protein kinase CLK1 (EC:2.7.12.1) Alternative name(s): CDC-like kinase 1
Gene namesⁱ	Name:CLK1 Synonyms:CLK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000013441.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2068 CLK1
MIMⁱ	601951 gene
neXtProtⁱ	NX_P49759

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1195
Open Targets More...OpenTargetsⁱ	ENSG00000013441
PharmGKBⁱ	PA26594

Chemistry databases

ChEMBLⁱ	CHEMBL4224
Drug and drug target database More...DrugBankⁱ	DB04367 Debromohymenialdisine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1990

Polymorphism and mutation databases

BioMutaⁱ	CLK1
DMDMⁱ	206729857

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085866	1 – 484	Dual specificity protein kinase CLK1Add BLAST		484

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	61	PhosphoserineCombined sources	1
Modified residueⁱ	138	PhosphothreonineCombined sources	1
Modified residueⁱ	140	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Autophosphorylates on all three types of residues.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P49759
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P49759
PaxDbⁱ	P49759
PeptideAtlas More...PeptideAtlasⁱ	P49759
PRIDEⁱ	P49759
ProteomicsDBⁱ	56090 56091 [P49759-2] 56092 [P49759-3]

PTM databases

iPTMnetⁱ	P49759
PhosphoSitePlusⁱ	P49759

Expressionⁱ

Tissue specificityⁱ

Endothelial cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000013441 Expressed in 236 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_CLK1
ExpressionAtlasⁱ	P49759 baseline and differential
Genevisibleⁱ	P49759 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB033141 HPA062405

HPAⁱ

CAB033141
HPA062405

Interactionⁱ

Subunit structureⁱ

Interacts with PPIG and UBL5.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CLK2	P49760	4	EBI-11981867,EBI-750020
KRTAP10-7	P60409	3	EBI-473775,EBI-10172290
PDE9A	O76083	3	EBI-473775,EBI-742764

Protein-protein interaction databases

BioGridⁱ	107606, 168 interactors
IntActⁱ	P49759, 34 interactors
Molecular INTeraction database More...MINTⁱ	P49759
STRINGⁱ	9606.ENSP00000394734

Chemistry databases

BindingDBⁱ

P49759

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	148 – 150	Combined sources	3
Turnⁱ	158 – 160	Combined sources	3
Beta strandⁱ	161 – 170	Combined sources	10
Beta strandⁱ	173 – 180	Combined sources	8
Turnⁱ	181 – 185	Combined sources	5
Beta strandⁱ	187 – 193	Combined sources	7
Helixⁱ	197 – 216	Combined sources	20
Beta strandⁱ	227 – 233	Combined sources	7
Beta strandⁱ	236 – 242	Combined sources	7
Helixⁱ	248 – 254	Combined sources	7
Turnⁱ	255 – 257	Combined sources	3
Helixⁱ	262 – 281	Combined sources	20
Helixⁱ	291 – 293	Combined sources	3
Beta strandⁱ	294 – 297	Combined sources	4
Beta strandⁱ	301 – 306	Combined sources	6
Turnⁱ	307 – 310	Combined sources	4
Beta strandⁱ	311 – 317	Combined sources	7
Beta strandⁱ	321 – 323	Combined sources	3
Helixⁱ	343 – 345	Combined sources	3
Helixⁱ	348 – 351	Combined sources	4
Helixⁱ	359 – 374	Combined sources	16
Helixⁱ	384 – 395	Combined sources	12
Helixⁱ	400 – 405	Combined sources	6
Helixⁱ	409 – 411	Combined sources	3
Helixⁱ	424 – 432	Combined sources	9
Helixⁱ	436 – 439	Combined sources	4
Helixⁱ	445 – 457	Combined sources	13
Turnⁱ	462 – 464	Combined sources	3
Helixⁱ	468 – 471	Combined sources	4
Helixⁱ	475 – 481	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P49759
SMRⁱ	P49759
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49759

EvolutionaryTraceⁱ

P49759

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	161 – 477	Protein kinasePROSITE-ProRule annotationAdd BLAST		317

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0671 Eukaryota ENOG410XQF2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00580000081366
HOGENOMⁱ	HOG000203417
HOVERGENⁱ	HBG107720
InParanoidⁱ	P49759
KEGG Orthology (KO) More...KOⁱ	K08823
OMAⁱ	RHRDHES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G033A
PhylomeDBⁱ	P49759
TreeFamⁱ	TF101041

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P49759-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK 
        60         70         80         90        100
MCDSHYLESR SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH 
       110        120        130        140        150
SSKSSGRSGR SSYKSKHRIH HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI 
       160        170        180        190        200
CQSGDVLSAR YEIVDTLGEG AFGKVVECID HKAGGRHVAV KIVKNVDRYC 
       210        220        230        240        250
EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV FELLGLSTYD 
       260        270        280        290        300
FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD 
       310        320        330        340        350
YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV 
       360        370        380        390        400
ILALGWSQPC DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK 
       410        420        430        440        450
HMIQKTRKRK YFHHDRLDWD EHSSAGRYVS RRCKPLKEFM LSQDVEHERL 
       460        470        480 
FDLIQKMLEY DPAKRITLRE ALKHPFFDLL KKSI

Length:484

Mass (Da):57,291

Last modified:September 23, 2008 - v2

Checksum:ⁱF34B5B44988BD118

GO

Isoform 2 (identifier: P49759-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
131-136: KSHRRK → MKLLIL
137-484: Missing.

« Hide

        10         20         30         40         50
MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK 
        60         70         80         90        100
MCDSHYLESR SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH 
       110        120        130 
SSKSSGRSGR SSYKSKHRIH HSTSHRRSHG MKLLIL

Note: Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:136

Mass (Da):16,570

Checksum:ⁱ3A1B92FD19E2A521

GO

Isoform 3 (identifier: P49759-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAAGRRPASALWPERRGSPLRGDLLGFQNVREPSSCGETLSGM

« Hide

        10         20         30         40         50
MAAGRRPASA LWPERRGSPL RGDLLGFQNV REPSSCGETL SGMRHSKRTY 
        60         70         80         90        100
CPDWDDKDWD YGKWRSSSSH KRRKRSHSSA QENKRCKYNH SKMCDSHYLE 
       110        120        130        140        150
SRSINEKDYH SRRYIDEYRN DYTQGCEPGH RQRDHESRYQ NHSSKSSGRS 
       160        170        180        190        200
GRSSYKSKHR IHHSTSHRRS HGKSHRRKRT RSVEDDEEGH LICQSGDVLS 
       210        220        230        240        250
ARYEIVDTLG EGAFGKVVEC IDHKAGGRHV AVKIVKNVDR YCEAARSEIQ 
       260        270        280        290        300
VLEHLNTTDP NSTFRCVQML EWFEHHGHIC IVFELLGLST YDFIKENGFL 
       310        320        330        340        350
PFRLDHIRKM AYQICKSVNF LHSNKLTHTD LKPENILFVQ SDYTEAYNPK 
       360        370        380        390        400
IKRDERTLIN PDIKVVDFGS ATYDDEHHST LVSTRHYRAP EVILALGWSQ 
       410        420        430        440        450
PCDVWSIGCI LIEYYLGFTV FPTHDSKEHL AMMERILGPL PKHMIQKTRK 
       460        470        480        490        500
RKYFHHDRLD WDEHSSAGRY VSRRCKPLKE FMLSQDVEHE RLFDLIQKML 
       510        520 
EYDPAKRITL REALKHPFFD LLKKSI

Note: No experimental confirmation available.

Show »

Length:526

Mass (Da):61,757

Checksum:ⁱ8514814549CC0655

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WBF5	F8WBF5_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK1	CLK1	355	Annotation score:
A0A087WVK0	A0A087WVK0_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK1	CLK1	454	Annotation score:
B8ZZR0	B8ZZR0_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK1	CLK1	307	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	432	R → A in AAA61480 (PubMed:1704889).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040409	61	S → F1 PublicationCorresponds to variant dbSNP:rs55989135Ensembl.	1
Natural variantⁱVAR_046551	99	N → D. Corresponds to variant dbSNP:rs6735666Ensembl.	1
Natural variantⁱVAR_040410	118	R → G1 PublicationCorresponds to variant dbSNP:rs56135616Ensembl.	1
Natural variantⁱVAR_040411	307	P → S1 PublicationCorresponds to variant dbSNP:rs35412475Ensembl.	1
Natural variantⁱVAR_040412	440	M → T1 PublicationCorresponds to variant dbSNP:rs35393352Ensembl.	1
Natural variantⁱVAR_051620	459	E → G. Corresponds to variant dbSNP:rs12709Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043578	1	M → MAAGRRPASALWPERRGSPL RGDLLGFQNVREPSSCGETL SGM in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_004852	131 – 136	KSHRRK → MKLLIL in isoform 2. 3 Publications	6
Alternative sequenceⁱVSP_004853	137 – 484	Missing in isoform 2. 3 PublicationsAdd BLAST	348

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29219 mRNA Translation: AAA61480.1 L29222 mRNA Translation: AAB59459.1 AK289365 mRNA Translation: BAF82054.1 AK294295 mRNA Translation: BAG57578.1 AC005037 Genomic DNA Translation: AAY14722.1 CH471063 Genomic DNA Translation: EAW70217.1 BC028149 mRNA Translation: AAH28149.1 BC031549 mRNA Translation: AAH31549.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2331.1 [P49759-1] CCDS54427.1 [P49759-3]
PIRⁱ	S53641
NCBI Reference Sequences More...RefSeqⁱ	NP_001155879.1, NM_001162407.1 [P49759-3] NP_004062.2, NM_004071.3 [P49759-1]
UniGeneⁱ	Hs.433732

Genome annotation databases

Ensemblⁱ	ENST00000321356; ENSP00000326830; ENSG00000013441 [P49759-1] ENST00000432425; ENSP00000400487; ENSG00000013441 [P49759-2] ENST00000434813; ENSP00000394734; ENSG00000013441 [P49759-3]
GeneIDⁱ	1195
KEGGⁱ	hsa:1195
UCSC genome browser More...UCSCⁱ	uc002uwe.3 human [P49759-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49759-2	Peptidyl-prolyl cis-trans isomerase		HUMAN		282	UniRef100_B4DN80

Protein	Similar proteins		Species	Score	Length	Source
P49759	Isoform 3 of Dual specificity protein kinase CLK1		HUMAN		526	UniRef90_P49759
CDC like kinase 1		CALJA		560
CDC like kinase 1		SAIBB		532
Uncharacterized protein		MACMU		522
Uncharacterized protein		MACNE		492
+15
P49759-2	Peptidyl-prolyl cis-trans isomerase		HUMAN		282	UniRef90_B4DN80

Protein	Similar proteins		Species	Score	Length	Source
P49759	Dual specificity protein kinase CLK1		MOUSE		483	UniRef50_P49759
Isoform 3 of Dual specificity protein kinase CLK1		HUMAN		526
CDC like kinase 1		CALJA		560
CDC like kinase 1		SAIBB		532
Uncharacterized protein		MACMU		522
+223
P49759-2	Peptidyl-prolyl cis-trans isomerase		LOALO		241	UniRef50_A0A1S0TTP8
Peptidyl-prolyl cis-trans isomerase		Melipona quadrifasciata		240
Peptidyl-prolyl cis-trans isomerase		FOLCA		234
Peptidyl-prolyl cis-trans isomerase		HUMAN		282
Peptidyl-prolyl cis-trans isomerase (Fragment)		Ancylostoma duodenale		232
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29219 mRNA Translation: AAA61480.1 L29222 mRNA Translation: AAB59459.1 AK289365 mRNA Translation: BAF82054.1 AK294295 mRNA Translation: BAG57578.1 AC005037 Genomic DNA Translation: AAY14722.1 CH471063 Genomic DNA Translation: EAW70217.1 BC028149 mRNA Translation: AAH28149.1 BC031549 mRNA Translation: AAH31549.1
CCDSⁱ	CCDS2331.1 [P49759-1] CCDS54427.1 [P49759-3]
PIRⁱ	S53641
RefSeqⁱ	NP_001155879.1, NM_001162407.1 [P49759-3] NP_004062.2, NM_004071.3 [P49759-1]
UniGeneⁱ	Hs.433732

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Z57	X-ray	1.70	A	148-484	[»]
	2VAG	X-ray	1.80	A	148-484	[»]
	5J1V	X-ray	2.52	A/B/C	148-484	[»]
	5J1W	X-ray	2.42	A/B/C	148-484	[»]
	5X8I	X-ray	1.90	A/B	148-484	[»]
	6FT8	X-ray	1.45	A	148-484	[»]
	6FT9	X-ray	1.87	A/B/C	148-484	[»]
	6FYO	X-ray	2.32	A	148-484	[»]
	6G33	X-ray	2.05	A/B/C	148-484	[»]
ProteinModelPortalⁱ	P49759
SMRⁱ	P49759
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107606, 168 interactors
IntActⁱ	P49759, 34 interactors
MINTⁱ	P49759
STRINGⁱ	9606.ENSP00000394734

Chemistry databases

BindingDBⁱ	P49759
ChEMBLⁱ	CHEMBL4224
DrugBankⁱ	DB04367 Debromohymenialdisine
GuidetoPHARMACOLOGYⁱ	1990

PTM databases

iPTMnetⁱ	P49759
PhosphoSitePlusⁱ	P49759

Polymorphism and mutation databases

BioMutaⁱ	CLK1
DMDMⁱ	206729857

Proteomic databases

EPDⁱ	P49759
MaxQBⁱ	P49759
PaxDbⁱ	P49759
PeptideAtlasⁱ	P49759
PRIDEⁱ	P49759
ProteomicsDBⁱ	56090 56091 [P49759-2] 56092 [P49759-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1195
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000321356; ENSP00000326830; ENSG00000013441 [P49759-1] ENST00000432425; ENSP00000400487; ENSG00000013441 [P49759-2] ENST00000434813; ENSP00000394734; ENSG00000013441 [P49759-3]
GeneIDⁱ	1195
KEGGⁱ	hsa:1195
UCSCⁱ	uc002uwe.3 human [P49759-1]

Organism-specific databases

CTDⁱ	1195
DisGeNETⁱ	1195
EuPathDBⁱ	HostDB:ENSG00000013441.15
GeneCardsⁱ	CLK1
HGNCⁱ	HGNC:2068 CLK1
HPAⁱ	CAB033141 HPA062405
MIMⁱ	601951 gene
neXtProtⁱ	NX_P49759
OpenTargetsⁱ	ENSG00000013441
PharmGKBⁱ	PA26594
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0671 Eukaryota ENOG410XQF2 LUCA
GeneTreeⁱ	ENSGT00580000081366
HOGENOMⁱ	HOG000203417
HOVERGENⁱ	HBG107720
InParanoidⁱ	P49759
KOⁱ	K08823
OMAⁱ	RHRDHES
OrthoDBⁱ	EOG091G033A
PhylomeDBⁱ	P49759
TreeFamⁱ	TF101041

Enzyme and pathway databases

BRENDAⁱ	2.7.12.1 2681
SignaLinkⁱ	P49759
SIGNORⁱ	P49759

Miscellaneous databases

ChiTaRSⁱ	CLK1 human
EvolutionaryTraceⁱ	P49759
GeneWikiⁱ	CLK1
GenomeRNAiⁱ	1195
Protein Ontology More...PROⁱ	PR:P49759
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000013441 Expressed in 236 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_CLK1
ExpressionAtlasⁱ	P49759 baseline and differential
Genevisibleⁱ	P49759 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLK1_HUMAN
Accessionⁱ	P49759Primary (citable) accession number: P49759 Secondary accession number(s): B4DFW7, Q0P694, Q8N5V8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	September 23, 2008
	Last modified:	October 10, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P49759 (CLK1_HUMAN)

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Dual specificity protein kinase CLK1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ