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Entry version 183 (16 Oct 2019)
Sequence version 5 (25 Nov 2008)
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Protein

Regulator of G-protein signaling 6

Gene

RGS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • GTPase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594 G alpha (i) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49758

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 6
Short name:
RGS6
Alternative name(s):
S914
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10002 RGS6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603894 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi297D → A: Loss of interaction with GNB5. 1 Publication1
Mutagenesisi309W → F: Diminishes interaction with GNB5. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9628

Open Targets

More...
OpenTargetsi
ENSG00000182732

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34377

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49758

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RGS6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274268

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041921 – 472Regulator of G-protein signaling 6Add BLAST472

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49758

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49758

PeptideAtlas

More...
PeptideAtlasi
P49758

PRoteomics IDEntifications database

More...
PRIDEi
P49758

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56079 [P49758-4]
56080 [P49758-10]
56081 [P49758-11]
56082 [P49758-12]
56083 [P49758-2]
56084 [P49758-3]
56085 [P49758-5]
56086 [P49758-6]
56087 [P49758-7]
56088 [P49758-8]
56089 [P49758-9]
69197
69198
69199
69200

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49758

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49758

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182732 Expressed in 127 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49758 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49758 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003067

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNB5 (PubMed:12761221, PubMed:10339615, PubMed:10521509).

Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (By similarity).

Interacts with GNAI1 (PubMed:18434541).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P082382EBI-6426927,EBI-352572

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114987, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P49758

Protein interaction database and analysis system

More...
IntActi
P49758, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000451030

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49758

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49758

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 115DEPPROSITE-ProRule annotationAdd BLAST76
Domaini261 – 330G protein gammaAdd BLAST70
Domaini336 – 441RGSPROSITE-ProRule annotationAdd BLAST106

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157159

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220864

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49758

KEGG Orthology (KO)

More...
KOi
K16449

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRRERNP

Database of Orthologous Groups

More...
OrthoDBi
582058at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49758

TreeFam database of animal gene trees

More...
TreeFami
TF351956

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00068 GGL, 1 hit
cd08737 RGS_RGS6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.10.196.10, 2 hits
4.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR037956 RGS6_RGS
IPR040759 RGS_DHEX
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PF18148 RGS_DHEX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (15+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 15 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.1 Publication

This entry has 15 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49758-4) [UniParc]FASTAAdd to basket
Also known as: RGS6Lalpha2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK
60 70 80 90 100
SFLSKIPSVV TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH
110 120 130 140 150
VLTMKDDGTF YRFQAPYFWP SNCWEPENTD YAIYLCKRTM QNKARLELAD
160 170 180 190 200
YEAENLARLQ RAFARKWEFI FMQAEAQVKI DRKKDKTERK ILDSQERAFW
210 220 230 240 250
DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES QAQSPVHVLS
260 270 280 290 300
QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI
310 320 330 340 350
TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF
360 370 380 390 400
LRFLESEFSS ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI
410 420 430 440 450
NLDSHSYEIT SQNVKDGGRY TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL
460 470
LLAKKKGKSL AGKRLTGLMQ SS
Length:472
Mass (Da):54,423
Last modified:November 25, 2008 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1424518EA697CD76
GO
Isoform 2 (identifier: P49758-2) [UniParc]FASTAAdd to basket
Also known as: RGS6Lgamma1, RGS6Lbeta11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Show »
Length:485
Mass (Da):56,138
Checksum:i06D282213979376C
GO
Isoform 3 (identifier: P49758-3) [UniParc]FASTAAdd to basket
Also known as: RGS6Lalpha1

The sequence of this isoform differs from the canonical sequence as follows:
     456-456: K → KPESEQGRRTSLEKFTRSV

Show »
Length:490
Mass (Da):56,512
Checksum:iC8BD1254D593D1F5
GO
Isoform 5 (identifier: P49758-5) [UniParc]FASTAAdd to basket
Also known as: RGS6Lbeta

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

Show »
Length:465
Mass (Da):53,787
Checksum:i2027294E5EF69596
GO
Isoform 6 (identifier: P49758-6) [UniParc]FASTAAdd to basket
Also known as: RGS6Lbeta-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

Show »
Length:428
Mass (Da):49,520
Checksum:iA2C52E54E4569178
GO
Isoform 7 (identifier: P49758-7) [UniParc]FASTAAdd to basket
Also known as: RGS6Lalpha2-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.

Show »
Length:435
Mass (Da):50,155
Checksum:i95405495A89187D4
GO
Isoform 8 (identifier: P49758-8) [UniParc]FASTAAdd to basket
Also known as: RGS6Lgamma2, RGS6Lbeta21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

Show »
Length:467
Mass (Da):54,049
Checksum:iF2CE01A6D57BFD91
GO
Isoform 9 (identifier: P49758-9) [UniParc]FASTAAdd to basket
Also known as: RGS6Lalpha1-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     456-456: K → KPESEQGRRTSLEKFTRSV

Show »
Length:453
Mass (Da):52,245
Checksum:i78F9B10D25DF6B44
GO
Isoform 10 (identifier: P49758-10) [UniParc]FASTAAdd to basket
Also known as: RGS6Lgamma1-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Show »
Length:448
Mass (Da):51,870
Checksum:i5A6833E6530ADBAB
GO
Isoform 11 (identifier: P49758-11) [UniParc]FASTAAdd to basket
Also known as: RGS6Lgamma2-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

Show »
Length:430
Mass (Da):49,781
Checksum:iF484A344D2614731
GO
Isoform 12 (identifier: P49758-12) [UniParc]FASTAAdd to basket
Also known as: RGS6Sbeta11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Show »
Length:346
Mass (Da):40,588
Checksum:iA0462F5A1DBDC9EA
GO
Isoform 13 (identifier: P49758-13) [UniParc]FASTAAdd to basket
Also known as: RGS6Lepsilon

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVG

Show »
Length:475
Mass (Da):54,953
Checksum:iDBD7BC0ADF638F51
GO
Isoform 14 (identifier: P49758-14) [UniParc]FASTAAdd to basket
Also known as: RGS6Ldelta

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLLF

Show »
Length:477
Mass (Da):55,270
Checksum:iB8212487BC0ADF63
GO
Isoform 15 (identifier: P49758-15) [UniParc]FASTAAdd to basket
Also known as: RGS6Lgamma

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVCLQLLF

Show »
Length:480
Mass (Da):55,614
Checksum:i6781EF37312D17BC
GO
Isoform 16 (identifier: P49758-16) [UniParc]FASTAAdd to basket
Also known as: RGS6Leta

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → VWLL

Show »
Length:460
Mass (Da):53,319
Checksum:i829707C9624AD2A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRA9A0A0A0MRA9_HUMAN
Regulator of G-protein-signaling 6
RGS6
418Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z7N5B7Z7N5_HUMAN
Regulator of G-protein-signaling 6
RGS6
539Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z2N1B7Z2N1_HUMAN
Regulator of G-protein-signaling 6
RGS6
437Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTW9A0A087WTW9_HUMAN
Regulator of G-protein-signaling 6
RGS6
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y8A2A0A2R8Y8A2_HUMAN
Regulator of G-protein-signaling 6
RGS6
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC42001 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti165R → K in AAC26049 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03004 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03005 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03006 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03007 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03008 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03009 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03010 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03011 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03012 (PubMed:12761221).Curated1
Sequence conflicti165R → K in AAM03013 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAC26049 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03004 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03005 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03006 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03007 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03008 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03009 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03010 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03011 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03012 (PubMed:12761221).Curated1
Sequence conflicti210V → L in AAM03013 (PubMed:12761221).Curated1
Sequence conflicti312 – 313DD → EE in AAC26049 (PubMed:12761221).Curated2
Sequence conflicti312 – 313DD → EE in AAM03004 (PubMed:12761221).Curated2
Sequence conflicti312 – 313DD → EE in AAM03005 (PubMed:12761221).Curated2
Sequence conflicti312 – 313DD → EE in AAM03006 (PubMed:12761221).Curated2
Sequence conflicti312 – 313DD → EE in AAM03009 (PubMed:12761221).Curated2
Sequence conflicti312 – 313DD → EE in AAM03010 (PubMed:12761221).Curated2
Sequence conflicti324E → D in AAC26049 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03004 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03005 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03006 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03007 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03008 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03009 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03010 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03011 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03012 (PubMed:12761221).Curated1
Sequence conflicti324E → D in AAM03013 (PubMed:12761221).Curated1
Sequence conflicti465L → C in AAC42001 (PubMed:7596406).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0358451 – 139Missing in isoform 12. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_035846285 – 321Missing in isoform 6, isoform 7, isoform 9, isoform 10 and isoform 11. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_035847456K → KPESEQGRRTSLEKFTRSV in isoform 3 and isoform 9. 2 Publications1
Alternative sequenceiVSP_047806457 – 472GKSLA…LMQSS → PESEQGRRTSLEKFTRSVG in isoform 13. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_047807457 – 472GKSLA…LMQSS → PESEQGRRTSLEKFTRSVLL F in isoform 14. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_047808457 – 472GKSLA…LMQSS → PESEQGRRTSLEKFTRSVCL QLLF in isoform 15. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_047809457 – 472GKSLA…LMQSS → VWLL in isoform 16. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_035848457 – 472GKSLA…LMQSS → PESEQGRRTSLEKFTRSVLY SNTPLAKRP in isoform 2, isoform 10 and isoform 12. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_035849457 – 472GKSLA…LMQSS → KVSKVVELP in isoform 5 and isoform 6. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_035850457 – 472GKSLA…LMQSS → LYSNTPLAKRP in isoform 8 and isoform 11. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF073920 mRNA Translation: AAC26049.2
AF073921 mRNA Translation: AAC26050.1
AY309097 mRNA Translation: AAP74386.1
AY309098 mRNA Translation: AAP74387.1
AY309099 mRNA Translation: AAP74388.1
AY309100 mRNA Translation: AAP74389.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03004.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03005.1
AF465726
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03006.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03007.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03008.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03009.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03010.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03011.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03012.1
AF465726
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03013.1
AF107619 mRNA Translation: AAD34717.1
AF107620 mRNA Translation: AAD34718.1
AF156932 mRNA Translation: AAD40183.1
AC004828 Genomic DNA No translation available.
AC005157 Genomic DNA Translation: AAC83180.1
AC005226 Genomic DNA No translation available.
AC005227 Genomic DNA No translation available.
AC005477 Genomic DNA Translation: AAD05031.1
AC005533 Genomic DNA No translation available.
AC005857 Genomic DNA No translation available.
AC005993 Genomic DNA No translation available.
L40394 mRNA Translation: AAC42001.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55924.1 [P49758-3]
CCDS9808.1 [P49758-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001191345.1, NM_001204416.2 [P49758-3]
NP_001191346.1, NM_001204417.2 [P49758-2]
NP_001191347.1, NM_001204418.2 [P49758-8]
NP_001191348.1, NM_001204419.2 [P49758-9]
NP_001191349.1, NM_001204420.2 [P49758-7]
NP_001191350.1, NM_001204421.2 [P49758-10]
NP_001191351.1, NM_001204422.2 [P49758-11]
NP_001191352.1, NM_001204423.1
NP_001191353.1, NM_001204424.1 [P49758-3]
NP_004287.3, NM_004296.6 [P49758-4]
XP_016877315.1, XM_017021826.1 [P49758-13]
XP_016877318.1, XM_017021829.1
XP_016877319.1, XM_017021830.1 [P49758-5]
XP_016877321.1, XM_017021832.1 [P49758-16]
XP_016877323.1, XM_017021834.1 [P49758-12]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355512; ENSP00000347699; ENSG00000182732 [P49758-16]
ENST00000404301; ENSP00000385243; ENSG00000182732 [P49758-15]
ENST00000406236; ENSP00000384218; ENSG00000182732 [P49758-13]
ENST00000407322; ENSP00000384612; ENSG00000182732 [P49758-14]
ENST00000553525; ENSP00000451030; ENSG00000182732 [P49758-3]
ENST00000553530; ENSP00000452331; ENSG00000182732 [P49758-4]
ENST00000554474; ENSP00000450858; ENSG00000182732 [P49758-5]
ENST00000554782; ENSP00000451912; ENSG00000182732 [P49758-12]
ENST00000555571; ENSP00000450936; ENSG00000182732 [P49758-4]
ENST00000556437; ENSP00000451855; ENSG00000182732 [P49758-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9628

UCSC genome browser

More...
UCSCi
uc001xmy.5 human [P49758-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073920 mRNA Translation: AAC26049.2
AF073921 mRNA Translation: AAC26050.1
AY309097 mRNA Translation: AAP74386.1
AY309098 mRNA Translation: AAP74387.1
AY309099 mRNA Translation: AAP74388.1
AY309100 mRNA Translation: AAP74389.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03004.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03005.1
AF465726
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03006.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03007.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA Translation: AAM03008.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03009.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03010.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03011.1
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03012.1
AF465726
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA Translation: AAM03013.1
AF107619 mRNA Translation: AAD34717.1
AF107620 mRNA Translation: AAD34718.1
AF156932 mRNA Translation: AAD40183.1
AC004828 Genomic DNA No translation available.
AC005157 Genomic DNA Translation: AAC83180.1
AC005226 Genomic DNA No translation available.
AC005227 Genomic DNA No translation available.
AC005477 Genomic DNA Translation: AAD05031.1
AC005533 Genomic DNA No translation available.
AC005857 Genomic DNA No translation available.
AC005993 Genomic DNA No translation available.
L40394 mRNA Translation: AAC42001.1 Frameshift.
CCDSiCCDS55924.1 [P49758-3]
CCDS9808.1 [P49758-4]
RefSeqiNP_001191345.1, NM_001204416.2 [P49758-3]
NP_001191346.1, NM_001204417.2 [P49758-2]
NP_001191347.1, NM_001204418.2 [P49758-8]
NP_001191348.1, NM_001204419.2 [P49758-9]
NP_001191349.1, NM_001204420.2 [P49758-7]
NP_001191350.1, NM_001204421.2 [P49758-10]
NP_001191351.1, NM_001204422.2 [P49758-11]
NP_001191352.1, NM_001204423.1
NP_001191353.1, NM_001204424.1 [P49758-3]
NP_004287.3, NM_004296.6 [P49758-4]
XP_016877315.1, XM_017021826.1 [P49758-13]
XP_016877318.1, XM_017021829.1
XP_016877319.1, XM_017021830.1 [P49758-5]
XP_016877321.1, XM_017021832.1 [P49758-16]
XP_016877323.1, XM_017021834.1 [P49758-12]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ES0X-ray2.10A325-470[»]
SMRiP49758
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114987, 10 interactors
CORUMiP49758
IntActiP49758, 9 interactors
STRINGi9606.ENSP00000451030

PTM databases

iPTMnetiP49758
PhosphoSitePlusiP49758

Polymorphism and mutation databases

BioMutaiRGS6
DMDMi215274268

Proteomic databases

MassIVEiP49758
PaxDbiP49758
PeptideAtlasiP49758
PRIDEiP49758
ProteomicsDBi56079 [P49758-4]
56080 [P49758-10]
56081 [P49758-11]
56082 [P49758-12]
56083 [P49758-2]
56084 [P49758-3]
56085 [P49758-5]
56086 [P49758-6]
56087 [P49758-7]
56088 [P49758-8]
56089 [P49758-9]
69197
69198
69199
69200

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9628

Genome annotation databases

EnsembliENST00000355512; ENSP00000347699; ENSG00000182732 [P49758-16]
ENST00000404301; ENSP00000385243; ENSG00000182732 [P49758-15]
ENST00000406236; ENSP00000384218; ENSG00000182732 [P49758-13]
ENST00000407322; ENSP00000384612; ENSG00000182732 [P49758-14]
ENST00000553525; ENSP00000451030; ENSG00000182732 [P49758-3]
ENST00000553530; ENSP00000452331; ENSG00000182732 [P49758-4]
ENST00000554474; ENSP00000450858; ENSG00000182732 [P49758-5]
ENST00000554782; ENSP00000451912; ENSG00000182732 [P49758-12]
ENST00000555571; ENSP00000450936; ENSG00000182732 [P49758-4]
ENST00000556437; ENSP00000451855; ENSG00000182732 [P49758-3]
GeneIDi9628
KEGGihsa:9628
UCSCiuc001xmy.5 human [P49758-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9628
DisGeNETi9628

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RGS6
HGNCiHGNC:10002 RGS6
HPAiHPA003067
MIMi603894 gene
neXtProtiNX_P49758
OpenTargetsiENSG00000182732
PharmGKBiPA34377

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000157159
HOGENOMiHOG000220864
InParanoidiP49758
KOiK16449
OMAiCRRERNP
OrthoDBi582058at2759
PhylomeDBiP49758
TreeFamiTF351956

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiP49758

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RGS6 human
EvolutionaryTraceiP49758

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RGS6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9628
PharosiP49758

Protein Ontology

More...
PROi
PR:P49758

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182732 Expressed in 127 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP49758 baseline and differential
GenevisibleiP49758 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
cd08737 RGS_RGS6, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.196.10, 2 hits
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR037956 RGS6_RGS
IPR040759 RGS_DHEX
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PF18148 RGS_DHEX, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49758
Secondary accession number(s): C9JE95
, F8W7W5, O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: October 16, 2019
This is version 183 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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