NUMB

Functionⁱ

Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Neurogenesis

Enzyme and pathway databases

PathwayCommonsⁱ	P49757
Reactomeⁱ	R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-437239, Recycling pathway of L1 R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5632684, Hedgehog 'on' state
SignaLinkⁱ	P49757
SIGNORⁱ	P49757

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein numb homolog Short name: h-Numb Alternative name(s): Protein S171
Gene namesⁱ	Name:NUMBImported Synonyms:C14orf41Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000133961.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8060, NUMB
MIMⁱ	603728, gene
neXtProtⁱ	NX_P49757

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	102	T → A: Loss of AAK1-mediated phosphorylation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8650
Open Targets More...OpenTargetsⁱ	ENSG00000133961
PharmGKBⁱ	PA31845

Miscellaneous databases

Pharosⁱ	P49757, Tbio

Pharosⁱ

P49757, Tbio

Polymorphism and mutation databases

BioMutaⁱ	NUMB
DMDMⁱ	14195675

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058001	1 – 651	Protein numb homologAdd BLAST		651

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	102	Phosphothreonine; by AAK11 Publication	1
Modified residueⁱ	194	PhosphoserineCombined sources	1
Modified residueⁱ	243	PhosphothreonineBy similarity	1
Modified residueⁱ	244	PhosphoserineCombined sources	1
Modified residueⁱ	276	Phosphoserine; by CaMK1By similarity	1
Modified residueⁱ	295	Phosphoserine; by CaMK1By similarity	1
Modified residueⁱ	425	PhosphoserineCombined sources	1
Modified residueⁱ	436	PhosphothreonineCombined sources	1
Modified residueⁱ	438	PhosphoserineCombined sources	1
Modified residueⁱ	634	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on Ser-276 and Ser-295 by CaMK1.By similarity

Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P49757
jPOSTⁱ	P49757
MassIVEⁱ	P49757
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P49757
PaxDbⁱ	P49757
PeptideAtlas More...PeptideAtlasⁱ	P49757
PRIDEⁱ	P49757
ProteomicsDBⁱ	3393 3394 3395 3396 56075 [P49757-1] 56076 [P49757-2] 56077 [P49757-3] 56078 [P49757-4]

PTM databases

iPTMnetⁱ	P49757
MetOSiteⁱ	P49757
PhosphoSitePlusⁱ	P49757
SwissPalmⁱ	P49757

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000133961, Expressed in monocyte and 238 other tissues
ExpressionAtlasⁱ	P49757, baseline and differential
Genevisibleⁱ	P49757, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000133961, Low tissue specificity

HPAⁱ

ENSG00000133961, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts with SIAH1 (PubMed:11752454).

Interacts with LNX (By similarity).

Interacts with CDH1 (By similarity).

Interacts with TFAP2A and TFAP2B (By similarity).

Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis (PubMed:12775724).

Interacts with AAK1 (PubMed:18657069). May interact with DUOXA1 (PubMed:14670962).

By similarity4 Publications

Binary interactionsⁱ

Hide details

P49757

With	#Exp.	IntAct
CTNNB1 [P35222]	2	EBI-915016,EBI-491549
MDM2 [Q00987]	6	EBI-915016,EBI-389668
REPS1 [Q96D71]	3	EBI-915016,EBI-1171195
TP53 [P04637]	5	EBI-915016,EBI-366083

Isoform 1 [P49757-1]

With	#Exp.	IntAct
PRKCZ [Q05513]	4	EBI-7199607,EBI-295351

Isoform 3 [P49757-3]

With	#Exp.	IntAct
CTNNB1 [P35222]	3	EBI-10692196,EBI-491549

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	114202, 87 interactors
CORUMⁱ	P49757
Database of interacting proteins More...DIPⁱ	DIP-37981N
ELMⁱ	P49757
IntActⁱ	P49757, 60 interactors
Molecular INTeraction database More...MINTⁱ	P49757
STRINGⁱ	9606.ENSP00000451300

Miscellaneous databases

RNActⁱ	P49757, protein

RNActⁱ

P49757, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	28 – 33	Combined sources	6
Beta strandⁱ	38 – 48	Combined sources	11
Beta strandⁱ	50 – 53	Combined sources	4
Helixⁱ	55 – 71	Combined sources	17
Turnⁱ	72 – 74	Combined sources	3
Helixⁱ	77 – 79	Combined sources	3
Beta strandⁱ	84 – 90	Combined sources	7
Beta strandⁱ	92 – 99	Combined sources	8
Turnⁱ	100 – 102	Combined sources	3
Beta strandⁱ	105 – 110	Combined sources	6
Helixⁱ	111 – 113	Combined sources	3
Beta strandⁱ	114 – 119	Combined sources	6
Beta strandⁱ	126 – 133	Combined sources	8
Turnⁱ	134 – 137	Combined sources	4
Beta strandⁱ	138 – 149	Combined sources	12
Helixⁱ	151 – 168	Combined sources	18

Show more details

3D structure databases

SMRⁱ	P49757
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 193	PIDPROSITE-ProRule annotationAdd BLAST		161

Phylogenomic databases

eggNOGⁱ	KOG3537, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156005
HOGENOMⁱ	CLU_031797_1_1_1
InParanoidⁱ	P49757
KEGG Orthology (KO) More...KOⁱ	K06057
OMAⁱ	CSFPVKX
PhylomeDBⁱ	P49757
TreeFamⁱ	TF314159

Family and domain databases

Database of protein disorder More...DisProtⁱ	DP01130
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR016698, Numb/numb-like IPR010449, Numb_domain IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06311, NumbF, 1 hit PF00640, PID, 1 hit
PIRSFⁱ	PIRSF017607, Numb/numb-like, 1 hit
SMARTⁱ	View protein in SMART SM00462, PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179, PID, 1 hit

Sequences (9+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 9 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 9 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P49757-1) [UniParc]FASTA Add to basket

Also known as: p72

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE 
       110        120        130        140        150
KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT 
       160        170        180        190        200
GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA 
       210        220        230        240        250
TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS SPTSPTSDAT 
       260        270        280        290        300
TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 
       310        320        330        340        350
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM 
       360        370        380        390        400
TKPVTVVAPQ SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA 
       410        420        430        440        450
PDAANKEIAA TCSGTEWGQS SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS 
       460        470        480        490        500
VRAQQPQASA APLQPVLQPP PPTAISQPAS PFQGNAFLTS QPVPVGVVPA 
       510        520        530        540        550
LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG TAGHPQAAHP 
       560        570        580        590        600
HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA 
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE 

L

Length:651

Mass (Da):70,804

Last modified:June 1, 2001 - v2

Checksum:ⁱ5B590BE49A74FCF2

GO

Isoform 2 (identifier: P49757-2) [UniParc]FASTA Add to basket

Also known as: p66

The sequence of this isoform differs from the canonical sequence as follows:
366-413: Missing.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE 
       110        120        130        140        150
KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT 
       160        170        180        190        200
GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA 
       210        220        230        240        250
TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS SPTSPTSDAT 
       260        270        280        290        300
TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 
       310        320        330        340        350
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM 
       360        370        380        390        400
TKPVTVVAPQ SPTFQGTEWG QSSGAASPGL FQAGHRRTPS EADRWLEEVS 
       410        420        430        440        450
KSVRAQQPQA SAAPLQPVLQ PPPPTAISQP ASPFQGNAFL TSQPVPVGVV 
       460        470        480        490        500
PALQPAFVPA QSYPVANGMP YPAPNVPVVG ITPSQMVANV FGTAGHPQAA 
       510        520        530        540        550
HPHQSPSLVR QQTFPHYEAS SATTSPFFKP PAQHLNGSAA FNGVDDGRLA 
       560        570        580        590        600
SADRHTEVPT GTCPVDPFEA QWAALENKSK QRTNPSPTNP FSSDLQKTFE 

IEL

Show »

Length:603

Mass (Da):65,899

Checksum:ⁱC7106FBD389F5E39

GO

Isoform 3 (identifier: P49757-3) [UniParc]FASTA Add to basket

Also known as: p71

The sequence of this isoform differs from the canonical sequence as follows:
68-78: Missing.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKATGK KAVKAVLWVS ADGLRVVDEK TKDLIVDQTI 
       110        120        130        140        150
EKVSFCAPDR NFDRAFSYIC RDGTTRRWIC HCFMAVKDTG ERLSHAVGCA 
       160        170        180        190        200
FAACLERKQK REKECGVTAT FDASRTTFTR EGSFRVTTAT EQAEREEIMK 
       210        220        230        240        250
QMQDAKKAET DKIVVGSSVA PGNTAPSPSS PTSPTSDATT SLEMNNPHAI 
       260        270        280        290        300
PRRHAPIEQL ARQGSFRGFP ALSQKMSPFK RQLSLRINEL PSTMQRKTDF 
       310        320        330        340        350
PIKNAVPEVE GEAESISSLC SQITNAFSTP EDPFSSAPMT KPVTVVAPQS 
       360        370        380        390        400
PTFQANGTDS AFHVLAKPAH TALAPVAMPV RETNPWAHAP DAANKEIAAT 
       410        420        430        440        450
CSGTEWGQSS GAASPGLFQA GHRRTPSEAD RWLEEVSKSV RAQQPQASAA 
       460        470        480        490        500
PLQPVLQPPP PTAISQPASP FQGNAFLTSQ PVPVGVVPAL QPAFVPAQSY 
       510        520        530        540        550
PVANGMPYPA PNVPVVGITP SQMVANVFGT AGHPQAAHPH QSPSLVRQQT 
       560        570        580        590        600
FPHYEASSAT TSPFFKPPAQ HLNGSAAFNG VDDGRLASAD RHTEVPTGTC 
       610        620        630        640
PVDPFEAQWA ALENKSKQRT NPSPTNPFSS DLQKTFEIEL

Show »

Length:640

Mass (Da):69,431

Checksum:ⁱ918C5B5DD5CD87B8

GO

Isoform 4 (identifier: P49757-4) [UniParc]FASTA Add to basket

Also known as: p65

The sequence of this isoform differs from the canonical sequence as follows:
68-78: Missing.
366-413: Missing.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKATGK KAVKAVLWVS ADGLRVVDEK TKDLIVDQTI 
       110        120        130        140        150
EKVSFCAPDR NFDRAFSYIC RDGTTRRWIC HCFMAVKDTG ERLSHAVGCA 
       160        170        180        190        200
FAACLERKQK REKECGVTAT FDASRTTFTR EGSFRVTTAT EQAEREEIMK 
       210        220        230        240        250
QMQDAKKAET DKIVVGSSVA PGNTAPSPSS PTSPTSDATT SLEMNNPHAI 
       260        270        280        290        300
PRRHAPIEQL ARQGSFRGFP ALSQKMSPFK RQLSLRINEL PSTMQRKTDF 
       310        320        330        340        350
PIKNAVPEVE GEAESISSLC SQITNAFSTP EDPFSSAPMT KPVTVVAPQS 
       360        370        380        390        400
PTFQGTEWGQ SSGAASPGLF QAGHRRTPSE ADRWLEEVSK SVRAQQPQAS 
       410        420        430        440        450
AAPLQPVLQP PPPTAISQPA SPFQGNAFLT SQPVPVGVVP ALQPAFVPAQ 
       460        470        480        490        500
SYPVANGMPY PAPNVPVVGI TPSQMVANVF GTAGHPQAAH PHQSPSLVRQ 
       510        520        530        540        550
QTFPHYEASS ATTSPFFKPP AQHLNGSAAF NGVDDGRLAS ADRHTEVPTG 
       560        570        580        590 
TCPVDPFEAQ WAALENKSKQ RTNPSPTNPF SSDLQKTFEI EL

Show »

Length:592

Mass (Da):64,527

Checksum:ⁱ645599F01321222D

GO

Isoform 5 (identifier: P49757-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
219-316: Missing.
366-413: Missing.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE 
       110        120        130        140        150
KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT 
       160        170        180        190        200
GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA 
       210        220        230        240        250
TEQAEREEIM KQMQDAKKVP EVEGEAESIS SLCSQITNAF STPEDPFSSA 
       260        270        280        290        300
PMTKPVTVVA PQSPTFQGTE WGQSSGAASP GLFQAGHRRT PSEADRWLEE 
       310        320        330        340        350
VSKSVRAQQP QASAAPLQPV LQPPPPTAIS QPASPFQGNA FLTSQPVPVG 
       360        370        380        390        400
VVPALQPAFV PAQSYPVANG MPYPAPNVPV VGITPSQMVA NVFGTAGHPQ 
       410        420        430        440        450
AAHPHQSPSL VRQQTFPHYE ASSATTSPFF KPPAQHLNGS AAFNGVDDGR 
       460        470        480        490        500
LASADRHTEV PTGTCPVDPF EAQWAALENK SKQRTNPSPT NPFSSDLQKT 

FEIEL

Show »

Length:505

Mass (Da):55,319

Checksum:ⁱ086027BD202D2782

GO

Isoform 6 (identifier: P49757-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-78: Missing.
     219-316: Missing.
     366-413: Missing.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKATGK KAVKAVLWVS ADGLRVVDEK TKDLIVDQTI 
       110        120        130        140        150
EKVSFCAPDR NFDRAFSYIC RDGTTRRWIC HCFMAVKDTG ERLSHAVGCA 
       160        170        180        190        200
FAACLERKQK REKECGVTAT FDASRTTFTR EGSFRVTTAT EQAEREEIMK 
       210        220        230        240        250
QMQDAKKVPE VEGEAESISS LCSQITNAFS TPEDPFSSAP MTKPVTVVAP 
       260        270        280        290        300
QSPTFQGTEW GQSSGAASPG LFQAGHRRTP SEADRWLEEV SKSVRAQQPQ 
       310        320        330        340        350
ASAAPLQPVL QPPPPTAISQ PASPFQGNAF LTSQPVPVGV VPALQPAFVP 
       360        370        380        390        400
AQSYPVANGM PYPAPNVPVV GITPSQMVAN VFGTAGHPQA AHPHQSPSLV 
       410        420        430        440        450
RQQTFPHYEA SSATTSPFFK PPAQHLNGSA AFNGVDDGRL ASADRHTEVP 
       460        470        480        490 
TGTCPVDPFE AQWAALENKS KQRTNPSPTN PFSSDLQKTF EIEL

Show »

Length:494

Mass (Da):53,947

Checksum:ⁱ7B90A93A1C41BEF7

GO

Isoform 7 (identifier: P49757-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-316: Missing.
     317-365: Missing.
     366-413: Missing.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE 
       110        120        130        140        150
KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT 
       160        170        180        190        200
GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA 
       210        220        230        240        250
TEQAEREEIM KQMQDAKKGT EWGQSSGAAS PGLFQAGHRR TPSEADRWLE 
       260        270        280        290        300
EVSKSVRAQQ PQASAAPLQP VLQPPPPTAI SQPASPFQGN AFLTSQPVPV 
       310        320        330        340        350
GVVPALQPAF VPAQSYPVAN GMPYPAPNVP VVGITPSQMV ANVFGTAGHP 
       360        370        380        390        400
QAAHPHQSPS LVRQQTFPHY EASSATTSPF FKPPAQHLNG SAAFNGVDDG 
       410        420        430        440        450
RLASADRHTE VPTGTCPVDP FEAQWAALEN KSKQRTNPSP TNPFSSDLQK 

TFEIEL

Show »

Length:456

Mass (Da):50,198

Checksum:ⁱ6E557041549FBFB6

GO

Isoform 8 (identifier: P49757-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-78: Missing.
     219-316: Missing.
     317-365: Missing.
     366-413: Missing.

« Hide

        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKATGK KAVKAVLWVS ADGLRVVDEK TKDLIVDQTI 
       110        120        130        140        150
EKVSFCAPDR NFDRAFSYIC RDGTTRRWIC HCFMAVKDTG ERLSHAVGCA 
       160        170        180        190        200
FAACLERKQK REKECGVTAT FDASRTTFTR EGSFRVTTAT EQAEREEIMK 
       210        220        230        240        250
QMQDAKKGTE WGQSSGAASP GLFQAGHRRT PSEADRWLEE VSKSVRAQQP 
       260        270        280        290        300
QASAAPLQPV LQPPPPTAIS QPASPFQGNA FLTSQPVPVG VVPALQPAFV 
       310        320        330        340        350
PAQSYPVANG MPYPAPNVPV VGITPSQMVA NVFGTAGHPQ AAHPHQSPSL 
       360        370        380        390        400
VRQQTFPHYE ASSATTSPFF KPPAQHLNGS AAFNGVDDGR LASADRHTEV 
       410        420        430        440 
PTGTCPVDPF EAQWAALENK SKQRTNPSPT NPFSSDLQKT FEIEL

Show »

Length:445

Mass (Da):48,825

Checksum:ⁱCF5A95DB5A1A91AE

GO

Isoform 9 (identifier: P49757-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-254: Missing.
366-413: Missing.

« Hide

        10         20         30         40         50
MNNPHAIPRR HAPIEQLARQ GSFRGFPALS QKMSPFKRQL SLRINELPST 
        60         70         80         90        100
MQRKTDFPIK NAVPEVEGEA ESISSLCSQI TNAFSTPEDP FSSAPMTKPV 
       110        120        130        140        150
TVVAPQSPTF QGTEWGQSSG AASPGLFQAG HRRTPSEADR WLEEVSKSVR 
       160        170        180        190        200
AQQPQASAAP LQPVLQPPPP TAISQPASPF QGNAFLTSQP VPVGVVPALQ 
       210        220        230        240        250
PAFVPAQSYP VANGMPYPAP NVPVVGITPS QMVANVFGTA GHPQAAHPHQ 
       260        270        280        290        300
SPSLVRQQTF PHYEASSATT SPFFKPPAQH LNGSAAFNGV DDGRLASADR 
       310        320        330        340 
HTEVPTGTCP VDPFEAQWAA LENKSKQRTN PSPTNPFSSD LQKTFEIEL

Show »

Length:349

Mass (Da):37,396

Checksum:ⁱC2238BAC87304A30

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V3M5	G3V3M5_HUMAN	Protein numb homolog Protein numb homolog	NUMB	223	Annotation score:
G3V3Z8	G3V3Z8_HUMAN	Protein numb homolog Protein numb homolog	NUMB	507	Annotation score:
G3V3R1	G3V3R1_HUMAN	Protein numb homolog Protein numb homolog	NUMB	258	Annotation score:
G3V433	G3V433_HUMAN	Protein numb homolog Protein numb homolog	NUMB	80	Annotation score:
G3V4S6	G3V4S6_HUMAN	Protein numb homolog Protein numb homolog	NUMB	67	Annotation score:

Sequence cautionⁱ

The sequence AAH20788 differs from that shown. Intron retention.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	31	G → S in AAD27959 (Ref. 4) Curated	1
Sequence conflictⁱ	68	E → Q in AAD27959 (Ref. 4) Curated	1
Sequence conflictⁱ	193	G → R in AAD27959 (Ref. 4) Curated	1
Sequence conflictⁱ	450	S → N in AAD27959 (Ref. 4) Curated	1
Sequence conflictⁱ	533	Q → K in AAH68476 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051249	387	V → I. Corresponds to variant dbSNP:rs17182272Ensembl.		1
Natural variantⁱVAR_051250	595	G → D. Corresponds to variant dbSNP:rs17781919Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053745	1 – 254	Missing in isoform 9. 2 PublicationsAdd BLAST	254
Alternative sequenceⁱVSP_004348	68 – 78	Missing in isoform 3, isoform 4, isoform 6 and isoform 8. 3 PublicationsAdd BLAST	11
Alternative sequenceⁱVSP_047756	219 – 316	Missing in isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationAdd BLAST	98
Alternative sequenceⁱVSP_053763	317 – 365	Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST	49
Alternative sequenceⁱVSP_004349	366 – 413	Missing in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9. 6 PublicationsAdd BLAST	48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015040 mRNA Translation: AAD01548.1 AF171938 mRNA Translation: AAD54279.1 AF171939 mRNA Translation: AAD54280.1 AF171940 mRNA Translation: AAD54281.1 AF171941 mRNA Translation: AAD54282.1 EU265734 mRNA Translation: ABY89090.1 EU265735 mRNA Translation: ABY89091.1 EU265736 mRNA Translation: ABY89092.1 EU265737 mRNA Translation: ABY89093.1 EU265738 mRNA Translation: ABY89094.1 AF108092 mRNA Translation: AAD27959.1 AK294591 mRNA Translation: BAG57779.1 AK304193 mRNA Translation: BAG65073.1 AC004846 Genomic DNA No translation available. AC005280 Genomic DNA No translation available. AL391733 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81106.1 BC020788 mRNA Translation: AAH20788.1 Sequence problems. BC068476 mRNA Translation: AAH68476.1 BX248073 mRNA Translation: CAD62362.1 AF109907 Genomic DNA Translation: AAC97962.1 L40393 mRNA Translation: AAC42000.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32115.1 [P49757-2] CCDS32116.1 [P49757-1] CCDS55927.1 [P49757-4] CCDS9814.1 [P49757-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005743.1, NM_001005743.1 [P49757-1] NP_001005744.1, NM_001005744.1 [P49757-2] NP_001005745.1, NM_001005745.1 [P49757-4] NP_001307043.1, NM_001320114.1 [P49757-2] NP_003735.3, NM_003744.5 [P49757-3]

Genome annotation databases

Ensemblⁱ	ENST00000355058; ENSP00000347169; ENSG00000133961 [P49757-1] ENST00000356296; ENSP00000348644; ENSG00000133961 [P49757-2] ENST00000359560; ENSP00000352563; ENSG00000133961 [P49757-3] ENST00000535282; ENSP00000441258; ENSG00000133961 [P49757-2] ENST00000544991; ENSP00000446001; ENSG00000133961 [P49757-7] ENST00000554521; ENSP00000450817; ENSG00000133961 [P49757-8] ENST00000554546; ENSP00000452416; ENSG00000133961 [P49757-4] ENST00000555238; ENSP00000451300; ENSG00000133961 [P49757-1] ENST00000555394; ENSP00000451625; ENSG00000133961 [P49757-2] ENST00000555738; ENSP00000452069; ENSG00000133961 [P49757-6] ENST00000557597; ENSP00000451117; ENSG00000133961 [P49757-3] ENST00000559312; ENSP00000452888; ENSG00000133961 [P49757-7] ENST00000560335; ENSP00000453209; ENSG00000133961 [P49757-5]
GeneIDⁱ	8650
KEGGⁱ	hsa:8650
UCSC genome browser More...UCSCⁱ	uc001xny.2, human [P49757-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49757	Numb homolog (Drosophila), isoform CRA_d		HUMAN		651	UniRef100_P49757
Protein numb homolog		HUMAN		507
NUMB protein		HUMAN		135
P49757-2	Numb homolog (Drosophila), isoform CRA_f		HUMAN		603	UniRef100_A0A024R681
Isoform 9 of Protein numb homolog		HUMAN		349
P49757-3	Numb homolog (Drosophila), isoform CRA_a		HUMAN		640	UniRef100_A0A024R6C4
P49757-4	Numb homolog (Drosophila), isoform CRA_e		HUMAN		592	UniRef100_A0A024R684

Protein	Similar proteins		Species	Score	Length	Source
P49757	Protein numb homolog	)	MOUSE		653	UniRef90_Q9QZS3
Protein numb homolog		RAT		652
Protein numb homolog (Fragment)		HUMAN		67
NUMB isoform 16 (Fragment)		PONAB		67
NUMB isoform 26 (Fragment)		PANTR		67
+348
P49757-3	Numb homolog (Drosophila), isoform CRA_a		HUMAN		640	UniRef90_A0A024R6C4
+1
P49757-4	Protein numb homolog		NOMLE		603	UniRef90_A0A2I3HE81
Protein numb homolog		MONDO		603
Numb homolog (Drosophila), isoform CRA_e		HUMAN		592
+11
P49757-5	Protein numb homolog		RHIRO		505	UniRef90_P49757-5
Protein numb homolog		NOMLE		505
Protein numb homolog		GORGO		505
Protein numb homolog		PANPA		505
Protein numb homolog		COLAP		505
+11
P49757-7	Protein numb homolog		HORSE		506	UniRef90_P49757-7
PID domain-containing protein		BOBOX		456
Isoform 8 of Protein numb homolog		HUMAN		445
PID domain-containing protein		BOBOX		456

Protein	Similar proteins		Species	Score	Length	Source
P49757	Protein numb homolog	)	MOUSE		653	UniRef50_Q9QZS3
Protein numb homolog		RAT		652
Protein numb homolog (Fragment)		HUMAN		67
NUMB isoform 16 (Fragment)		PONAB		67
NUMB isoform 26 (Fragment)		PANTR		67
+443
P49757-3	Protein numb homolog		ANOCA		653	UniRef50_G1KS68
Protein numb-like protein isoform 1		BOIIR		660
protein numb homolog isoform X1		mainland tiger snake		657
Uncharacterized protein		Micrurus lemniscatus carvalhoi		118
protein numb homolog		Thamnophis sirtalis		657
+730
P49757-5	Protein numb homolog		PANPA		505	UniRef50_P49757-5
Protein numb homolog		MACFA		505
Protein numb homolog		PAPAN		505
Protein numb homolog		MACNE		505
Protein numb homolog		RHIRO		505
+84

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015040 mRNA Translation: AAD01548.1 AF171938 mRNA Translation: AAD54279.1 AF171939 mRNA Translation: AAD54280.1 AF171940 mRNA Translation: AAD54281.1 AF171941 mRNA Translation: AAD54282.1 EU265734 mRNA Translation: ABY89090.1 EU265735 mRNA Translation: ABY89091.1 EU265736 mRNA Translation: ABY89092.1 EU265737 mRNA Translation: ABY89093.1 EU265738 mRNA Translation: ABY89094.1 AF108092 mRNA Translation: AAD27959.1 AK294591 mRNA Translation: BAG57779.1 AK304193 mRNA Translation: BAG65073.1 AC004846 Genomic DNA No translation available. AC005280 Genomic DNA No translation available. AL391733 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81106.1 BC020788 mRNA Translation: AAH20788.1 Sequence problems. BC068476 mRNA Translation: AAH68476.1 BX248073 mRNA Translation: CAD62362.1 AF109907 Genomic DNA Translation: AAC97962.1 L40393 mRNA Translation: AAC42000.1
CCDSⁱ	CCDS32115.1 [P49757-2] CCDS32116.1 [P49757-1] CCDS55927.1 [P49757-4] CCDS9814.1 [P49757-3]
RefSeqⁱ	NP_001005743.1, NM_001005743.1 [P49757-1] NP_001005744.1, NM_001005744.1 [P49757-2] NP_001005745.1, NM_001005745.1 [P49757-4] NP_001307043.1, NM_001320114.1 [P49757-2] NP_003735.3, NM_003744.5 [P49757-3]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5NJJ	X-ray	2.70	A/B/C/D	20-175	[»]
	5NJK	X-ray	3.13	A/B/C/D/E/F	20-175	[»]
SMRⁱ	P49757
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	114202, 87 interactors
CORUMⁱ	P49757
DIPⁱ	DIP-37981N
ELMⁱ	P49757
IntActⁱ	P49757, 60 interactors
MINTⁱ	P49757
STRINGⁱ	9606.ENSP00000451300

PTM databases

iPTMnetⁱ	P49757
MetOSiteⁱ	P49757
PhosphoSitePlusⁱ	P49757
SwissPalmⁱ	P49757

Polymorphism and mutation databases

BioMutaⁱ	NUMB
DMDMⁱ	14195675

Proteomic databases

EPDⁱ	P49757
jPOSTⁱ	P49757
MassIVEⁱ	P49757
MaxQBⁱ	P49757
PaxDbⁱ	P49757
PeptideAtlasⁱ	P49757
PRIDEⁱ	P49757
ProteomicsDBⁱ	3393 3394 3395 3396 56075 [P49757-1] 56076 [P49757-2] 56077 [P49757-3] 56078 [P49757-4]

Protocols and materials databases

Antibodypediaⁱ	131, 827 antibodies
The DNASU plasmid repository More...DNASUⁱ	8650

Genome annotation databases

Ensemblⁱ	ENST00000355058; ENSP00000347169; ENSG00000133961 [P49757-1] ENST00000356296; ENSP00000348644; ENSG00000133961 [P49757-2] ENST00000359560; ENSP00000352563; ENSG00000133961 [P49757-3] ENST00000535282; ENSP00000441258; ENSG00000133961 [P49757-2] ENST00000544991; ENSP00000446001; ENSG00000133961 [P49757-7] ENST00000554521; ENSP00000450817; ENSG00000133961 [P49757-8] ENST00000554546; ENSP00000452416; ENSG00000133961 [P49757-4] ENST00000555238; ENSP00000451300; ENSG00000133961 [P49757-1] ENST00000555394; ENSP00000451625; ENSG00000133961 [P49757-2] ENST00000555738; ENSP00000452069; ENSG00000133961 [P49757-6] ENST00000557597; ENSP00000451117; ENSG00000133961 [P49757-3] ENST00000559312; ENSP00000452888; ENSG00000133961 [P49757-7] ENST00000560335; ENSP00000453209; ENSG00000133961 [P49757-5]
GeneIDⁱ	8650
KEGGⁱ	hsa:8650
UCSCⁱ	uc001xny.2, human [P49757-1]

Organism-specific databases

CTDⁱ	8650
DisGeNETⁱ	8650
EuPathDBⁱ	HostDB:ENSG00000133961.19
GeneCardsⁱ	NUMB
HGNCⁱ	HGNC:8060, NUMB
HPAⁱ	ENSG00000133961, Low tissue specificity
MIMⁱ	603728, gene
neXtProtⁱ	NX_P49757
OpenTargetsⁱ	ENSG00000133961
PharmGKBⁱ	PA31845
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3537, Eukaryota
GeneTreeⁱ	ENSGT00940000156005
HOGENOMⁱ	CLU_031797_1_1_1
InParanoidⁱ	P49757
KOⁱ	K06057
OMAⁱ	CSFPVKX
PhylomeDBⁱ	P49757
TreeFamⁱ	TF314159

Enzyme and pathway databases

PathwayCommonsⁱ	P49757
Reactomeⁱ	R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-437239, Recycling pathway of L1 R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5632684, Hedgehog 'on' state
SignaLinkⁱ	P49757
SIGNORⁱ	P49757

Miscellaneous databases

BioGRID-ORCSⁱ	8650, 9 hits in 875 CRISPR screens
ChiTaRSⁱ	NUMB, human
GeneWikiⁱ	NUMB_(gene)
GenomeRNAiⁱ	8650
Pharosⁱ	P49757, Tbio
Protein Ontology More...PROⁱ	PR:P49757
RNActⁱ	P49757, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133961, Expressed in monocyte and 238 other tissues
ExpressionAtlasⁱ	P49757, baseline and differential
Genevisibleⁱ	P49757, HS

Family and domain databases

DisProtⁱ	DP01130
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR016698, Numb/numb-like IPR010449, Numb_domain IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom
Pfamⁱ	View protein in Pfam PF06311, NumbF, 1 hit PF00640, PID, 1 hit
PIRSFⁱ	PIRSF017607, Numb/numb-like, 1 hit
SMARTⁱ	View protein in SMART SM00462, PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179, PID, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUMB_HUMAN
Accessionⁱ	P49757Primary (citable) accession number: P49757 Secondary accession number(s): B1P2N5 Q9UQJ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	June 1, 2001
	Last modified:	October 7, 2020
	This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

Annotation systems

Supporting data

UniProtKB - P49757 (NUMB_HUMAN)

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Protein numb homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Endosome

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ