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UniProtKB - P49757 (NUMB_HUMAN)

Entry version 186 (23 Feb 2022)
Sequence version 2 (01 Jun 2001)
Previous versions | rss
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Protein

Protein numb homolog

Gene

NUMB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates clathrin-mediated receptor endocytosis (PubMed:18657069).

Plays a role in the process of neurogenesis (By similarity).

Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity).

Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity).

May also mediate local repair of brain ventricular wall damage (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49757

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-437239, Recycling pathway of L1
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5632684, Hedgehog 'on' state

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49757

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49757

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein numb homolog
Short name:
h-Numb
Alternative name(s):
Protein S171
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUMBImported
Synonyms:C14orf41Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8060, NUMB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603728, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49757

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000133961

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi102T → A: Loss of AAK1-mediated phosphorylation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8650

Open Targets

More...OpenTargetsi		ENSG00000133961

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31845

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49757, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NUMB

Domain mapping of disease mutations (DMDM)

More...DMDMi		14195675

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000580011 – 651Protein numb homologAdd BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102Phosphothreonine; by AAK11 Publication1
Modified residuei194PhosphoserineCombined sources1
Modified residuei243PhosphothreonineBy similarity1
Modified residuei244PhosphoserineCombined sources1
Modified residuei276Phosphoserine; by CaMK1By similarity1
Modified residuei295Phosphoserine; by CaMK1By similarity1
Modified residuei425PhosphoserineCombined sources1
Modified residuei436PhosphothreonineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-276 and Ser-295 by CaMK1.By similarity
Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49757

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49757

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49757

MaxQB - The MaxQuant DataBase

More...MaxQBi		P49757

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49757

PeptideAtlas

More...PeptideAtlasi		P49757

PRoteomics IDEntifications database

More...PRIDEi		P49757

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3393
3394
3395
3396
56075 [P49757-1]
56076 [P49757-2]
56077 [P49757-3]
56078 [P49757-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P49757, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49757

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P49757

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49757

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P49757

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133961, Expressed in monocyte and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49757, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49757, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000133961, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIAH1 (PubMed:11752454).

Interacts with LNX (By similarity).

Interacts with CDH1 (By similarity).

Interacts with TFAP2A and TFAP2B (By similarity).

Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis (PubMed:12775724).

Interacts with AAK1 (PubMed:18657069). May interact with DUOXA1 (PubMed:14670962).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114202, 157 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P49757

Database of interacting proteins

More...DIPi		DIP-37981N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P49757

Protein interaction database and analysis system

More...IntActi		P49757, 64 interactors

Molecular INTeraction database

More...MINTi		P49757

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000451300

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49757, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1651
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49757

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 193PIDPROSITE-ProRule annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni228 – 257DisorderedSequence analysisAdd BLAST30
Regioni419 – 483DisorderedSequence analysisAdd BLAST65
Regioni623 – 651DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi231 – 257Polar residuesSequence analysisAdd BLAST27
Compositional biasi463 – 477Pro residuesSequence analysisAdd BLAST15
Compositional biasi624 – 644Polar residuesSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3537, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156005

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031797_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49757

Identification of Orthologs from Complete Genome Data

More...OMAi		CSFPVKX

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49757

TreeFam database of animal gene trees

More...TreeFami		TF314159

Family and domain databases

Database of protein disorder

More...DisProti		DP01130

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016698, Numb/numb-like
IPR010449, Numb_domain
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06311, NumbF, 1 hit
PF00640, PID, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF017607, Numb/numb-like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00462, PTB, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01179, PID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49757-1) [UniParc]FASTAAdd to basket
Also known as: p72

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD 
        60         70         80         90        100
ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE 
       110        120        130        140        150
KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT 
       160        170        180        190        200
GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA 
       210        220        230        240        250
TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS SPTSPTSDAT 
       260        270        280        290        300
TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 
       310        320        330        340        350
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM 
       360        370        380        390        400
TKPVTVVAPQ SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA 
       410        420        430        440        450
PDAANKEIAA TCSGTEWGQS SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS 
       460        470        480        490        500
VRAQQPQASA APLQPVLQPP PPTAISQPAS PFQGNAFLTS QPVPVGVVPA 
       510        520        530        540        550
LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG TAGHPQAAHP 
       560        570        580        590        600
HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA 
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE 

L
Length:651
Mass (Da):70,804
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B590BE49A74FCF2
GO
Isoform 2 (identifier: P49757-2) [UniParc]FASTAAdd to basket
Also known as: p66

The sequence of this isoform differs from the canonical sequence as follows:
     366-413: Missing.

Show »
Length:603
Mass (Da):65,899
Checksum:iC7106FBD389F5E39
GO
Isoform 3 (identifier: P49757-3) [UniParc]FASTAAdd to basket
Also known as: p71

The sequence of this isoform differs from the canonical sequence as follows:
     68-78: Missing.

Show »
Length:640
Mass (Da):69,431
Checksum:i918C5B5DD5CD87B8
GO
Isoform 4 (identifier: P49757-4) [UniParc]FASTAAdd to basket
Also known as: p65

The sequence of this isoform differs from the canonical sequence as follows:
     68-78: Missing.
     366-413: Missing.

Show »
Length:592
Mass (Da):64,527
Checksum:i645599F01321222D
GO
Isoform 5 (identifier: P49757-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-316: Missing.
     366-413: Missing.

Show »
Length:505
Mass (Da):55,319
Checksum:i086027BD202D2782
GO
Isoform 6 (identifier: P49757-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-78: Missing.
     219-316: Missing.
     366-413: Missing.

Show »
Length:494
Mass (Da):53,947
Checksum:i7B90A93A1C41BEF7
GO
Isoform 7 (identifier: P49757-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-316: Missing.
     317-365: Missing.
     366-413: Missing.

Show »
Length:456
Mass (Da):50,198
Checksum:i6E557041549FBFB6
GO
Isoform 8 (identifier: P49757-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-78: Missing.
     219-316: Missing.
     317-365: Missing.
     366-413: Missing.

Show »
Length:445
Mass (Da):48,825
Checksum:iCF5A95DB5A1A91AE
GO
Isoform 9 (identifier: P49757-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
     366-413: Missing.

Show »
Length:349
Mass (Da):37,396
Checksum:iC2238BAC87304A30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3M5G3V3M5_HUMAN
Protein numb homolog
NUMB
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3Z8G3V3Z8_HUMAN
Protein numb homolog
NUMB
507Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3R1G3V3R1_HUMAN
Protein numb homolog
NUMB
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V433G3V433_HUMAN
Protein numb homolog
NUMB
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4S6G3V4S6_HUMAN
Protein numb homolog
NUMB
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH20788 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31G → S in AAD27959 (Ref. 4) Curated1
Sequence conflicti68E → Q in AAD27959 (Ref. 4) Curated1
Sequence conflicti193G → R in AAD27959 (Ref. 4) Curated1
Sequence conflicti450S → N in AAD27959 (Ref. 4) Curated1
Sequence conflicti533Q → K in AAH68476 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051249387V → I. Corresponds to variant dbSNP:rs17182272Ensembl.1
Natural variantiVAR_051250595G → D. Corresponds to variant dbSNP:rs17781919Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537451 – 254Missing in isoform 9. 2 PublicationsAdd BLAST254
Alternative sequenceiVSP_00434868 – 78Missing in isoform 3, isoform 4, isoform 6 and isoform 8. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_047756219 – 316Missing in isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_053763317 – 365Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_004349366 – 413Missing in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9. 6 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF015040 mRNA Translation: AAD01548.1
AF171938 mRNA Translation: AAD54279.1
AF171939 mRNA Translation: AAD54280.1
AF171940 mRNA Translation: AAD54281.1
AF171941 mRNA Translation: AAD54282.1
EU265734 mRNA Translation: ABY89090.1
EU265735 mRNA Translation: ABY89091.1
EU265736 mRNA Translation: ABY89092.1
EU265737 mRNA Translation: ABY89093.1
EU265738 mRNA Translation: ABY89094.1
AF108092 mRNA Translation: AAD27959.1
AK294591 mRNA Translation: BAG57779.1
AK304193 mRNA Translation: BAG65073.1
AC004846 Genomic DNA No translation available.
AC005280 Genomic DNA No translation available.
AL391733 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81106.1
BC020788 mRNA Translation: AAH20788.1 Sequence problems.
BC068476 mRNA Translation: AAH68476.1
BX248073 mRNA Translation: CAD62362.1
AF109907 Genomic DNA Translation: AAC97962.1
L40393 mRNA Translation: AAC42000.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32115.1 [P49757-2]
CCDS32116.1 [P49757-1]
CCDS55927.1 [P49757-4]
CCDS9814.1 [P49757-3]

NCBI Reference Sequences

More...RefSeqi		NP_001005743.1, NM_001005743.1 [P49757-1]
NP_001005744.1, NM_001005744.1 [P49757-2]
NP_001005745.1, NM_001005745.1 [P49757-4]
NP_001307043.1, NM_001320114.1 [P49757-2]
NP_003735.3, NM_003744.5 [P49757-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355058; ENSP00000347169; ENSG00000133961
ENST00000356296; ENSP00000348644; ENSG00000133961 [P49757-2]
ENST00000359560; ENSP00000352563; ENSG00000133961 [P49757-3]
ENST00000535282; ENSP00000441258; ENSG00000133961 [P49757-2]
ENST00000544991; ENSP00000446001; ENSG00000133961 [P49757-7]
ENST00000554521; ENSP00000450817; ENSG00000133961 [P49757-8]
ENST00000554546; ENSP00000452416; ENSG00000133961 [P49757-4]
ENST00000555238; ENSP00000451300; ENSG00000133961
ENST00000555394; ENSP00000451625; ENSG00000133961 [P49757-2]
ENST00000555738; ENSP00000452069; ENSG00000133961 [P49757-6]
ENST00000557597; ENSP00000451117; ENSG00000133961 [P49757-3]
ENST00000559312; ENSP00000452888; ENSG00000133961 [P49757-7]
ENST00000560335; ENSP00000453209; ENSG00000133961 [P49757-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8650

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000555238.6; ENSP00000451300.1; NM_001005743.2; NP_001005743.1

UCSC genome browser

More...UCSCi		uc001xny.2, human [P49757-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015040 mRNA Translation: AAD01548.1
AF171938 mRNA Translation: AAD54279.1
AF171939 mRNA Translation: AAD54280.1
AF171940 mRNA Translation: AAD54281.1
AF171941 mRNA Translation: AAD54282.1
EU265734 mRNA Translation: ABY89090.1
EU265735 mRNA Translation: ABY89091.1
EU265736 mRNA Translation: ABY89092.1
EU265737 mRNA Translation: ABY89093.1
EU265738 mRNA Translation: ABY89094.1
AF108092 mRNA Translation: AAD27959.1
AK294591 mRNA Translation: BAG57779.1
AK304193 mRNA Translation: BAG65073.1
AC004846 Genomic DNA No translation available.
AC005280 Genomic DNA No translation available.
AL391733 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81106.1
BC020788 mRNA Translation: AAH20788.1 Sequence problems.
BC068476 mRNA Translation: AAH68476.1
BX248073 mRNA Translation: CAD62362.1
AF109907 Genomic DNA Translation: AAC97962.1
L40393 mRNA Translation: AAC42000.1
CCDSiCCDS32115.1 [P49757-2]
CCDS32116.1 [P49757-1]
CCDS55927.1 [P49757-4]
CCDS9814.1 [P49757-3]
RefSeqiNP_001005743.1, NM_001005743.1 [P49757-1]
NP_001005744.1, NM_001005744.1 [P49757-2]
NP_001005745.1, NM_001005745.1 [P49757-4]
NP_001307043.1, NM_001320114.1 [P49757-2]
NP_003735.3, NM_003744.5 [P49757-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NJJX-ray2.70A/B/C/D20-175[»]
5NJKX-ray3.13A/B/C/D/E/F20-175[»]
SMRiP49757
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114202, 157 interactors
CORUMiP49757
DIPiDIP-37981N
ELMiP49757
IntActiP49757, 64 interactors
MINTiP49757
STRINGi9606.ENSP00000451300

PTM databases

GlyGeniP49757, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP49757
MetOSiteiP49757
PhosphoSitePlusiP49757
SwissPalmiP49757

Genetic variation databases

BioMutaiNUMB
DMDMi14195675

Proteomic databases

EPDiP49757
jPOSTiP49757
MassIVEiP49757
MaxQBiP49757
PaxDbiP49757
PeptideAtlasiP49757
PRIDEiP49757
ProteomicsDBi3393
3394
3395
3396
56075 [P49757-1]
56076 [P49757-2]
56077 [P49757-3]
56078 [P49757-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		131, 846 antibodies from 43 providers

The DNASU plasmid repository

More...DNASUi		8650

Genome annotation databases

EnsembliENST00000355058; ENSP00000347169; ENSG00000133961
ENST00000356296; ENSP00000348644; ENSG00000133961 [P49757-2]
ENST00000359560; ENSP00000352563; ENSG00000133961 [P49757-3]
ENST00000535282; ENSP00000441258; ENSG00000133961 [P49757-2]
ENST00000544991; ENSP00000446001; ENSG00000133961 [P49757-7]
ENST00000554521; ENSP00000450817; ENSG00000133961 [P49757-8]
ENST00000554546; ENSP00000452416; ENSG00000133961 [P49757-4]
ENST00000555238; ENSP00000451300; ENSG00000133961
ENST00000555394; ENSP00000451625; ENSG00000133961 [P49757-2]
ENST00000555738; ENSP00000452069; ENSG00000133961 [P49757-6]
ENST00000557597; ENSP00000451117; ENSG00000133961 [P49757-3]
ENST00000559312; ENSP00000452888; ENSG00000133961 [P49757-7]
ENST00000560335; ENSP00000453209; ENSG00000133961 [P49757-5]
GeneIDi8650
KEGGihsa:8650
MANE-SelectiENST00000555238.6; ENSP00000451300.1; NM_001005743.2; NP_001005743.1
UCSCiuc001xny.2, human [P49757-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8650
DisGeNETi8650

GeneCards: human genes, protein and diseases

More...GeneCardsi		NUMB
HGNCiHGNC:8060, NUMB
HPAiENSG00000133961, Low tissue specificity
MIMi603728, gene
neXtProtiNX_P49757
OpenTargetsiENSG00000133961
PharmGKBiPA31845
VEuPathDBiHostDB:ENSG00000133961

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3537, Eukaryota
GeneTreeiENSGT00940000156005
HOGENOMiCLU_031797_1_1_1
InParanoidiP49757
OMAiCSFPVKX
PhylomeDBiP49757
TreeFamiTF314159

Enzyme and pathway databases

PathwayCommonsiP49757
ReactomeiR-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-437239, Recycling pathway of L1
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5632684, Hedgehog 'on' state
SignaLinkiP49757
SIGNORiP49757

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8650, 14 hits in 1049 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NUMB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NUMB_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8650
PharosiP49757, Tbio

Protein Ontology

More...PROi		PR:P49757
RNActiP49757, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133961, Expressed in monocyte and 239 other tissues
ExpressionAtlasiP49757, baseline and differential
GenevisibleiP49757, HS

Family and domain databases

DisProtiDP01130
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016698, Numb/numb-like
IPR010449, Numb_domain
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
PfamiView protein in Pfam
PF06311, NumbF, 1 hit
PF00640, PID, 1 hit
PIRSFiPIRSF017607, Numb/numb-like, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 1 hit
PROSITEiView protein in PROSITE
PS01179, PID, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUMB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49757
Secondary accession number(s): B1P2N5
, B1P2N6, B1P2N7, B1P2N8, B1P2N9, B4E2B1, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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