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Protein

RNA-binding protein 25

Gene

RBM25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 25
Alternative name(s):
Arg/Glu/Asp-rich protein of 120 kDa
Short name:
RED120
Protein S164
RNA-binding motif protein 25
RNA-binding region-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM25
Synonyms:RNPC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119707.13

Human Gene Nomenclature Database

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HGNCi
HGNC:23244 RBM25

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612427 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49756

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi734 – 736KRK → AAA: Reduced DNA/RNA binding. 1 Publication3
Mutagenesisi777 – 778KK → AA: Reduced DNA/RNA binding. 1 Publication2
Mutagenesisi825K → A: Reduced DNA/RNA binding; when associated with A-828. 1 Publication1
Mutagenesisi828R → A: Reduced DNA/RNA binding; when associated with A-825. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
58517

Open Targets

More...
OpenTargetsi
ENSG00000119707

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134912024

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBM25

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226693631

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817841 – 843RNA-binding protein 25Add BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei135N6-acetyllysineBy similarity1
Modified residuei226PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki261Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei583PhosphoserineCombined sources1
Cross-linki671Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei677PhosphoserineCombined sources1 Publication1
Modified residuei683PhosphoserineCombined sources1
Cross-linki688Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki697Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei703PhosphoserineCombined sources1
Cross-linki722Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P49756

MaxQB - The MaxQuant DataBase

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MaxQBi
P49756

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P49756

PeptideAtlas

More...
PeptideAtlasi
P49756

PRoteomics IDEntifications database

More...
PRIDEi
P49756

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56071
56072 [P49756-2]
56073 [P49756-3]
56074 [P49756-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49756

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P49756

SwissPalm database of S-palmitoylation events

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SwissPalmi
P49756

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119707 Expressed in 241 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

More...
CleanExi
HS_RBM25

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49756 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49756 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003025
HPA070713

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LUC7L3 and SRRM1. Specifically associates with functional splicing complexes, including Sm proteins and U1, U2, U4, U5 and U6 snRNAs. Associates with exon junction complex (EJC) proteins, including APEX1, BAT1, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121843, 88 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P49756

Protein interaction database and analysis system

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IntActi
P49756, 29 interactors

Molecular INTeraction database

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MINTi
P49756

STRING: functional protein association networks

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STRINGi
9606.ENSP00000261973

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1843
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P49756

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49756

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 164RRMPROSITE-ProRule annotationAdd BLAST78
Domaini750 – 843PWIPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni285 – 644Necessary for nuclear speckle localizationAdd BLAST360

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi292 – 608Glu-richAdd BLAST317
Compositional biasi309 – 549Arg-richAdd BLAST241

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PWI domain binds nucleic acids with significant help from its N-terminal flanking basic region. It has an equal preference for binding to single- or double-stranded species, and it contributes to RBM25 role in modulation of alternative splicing, maybe by mediating RNA-dependent association with LUC7L3.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2253 Eukaryota
ENOG410ZRGA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111019

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG068941

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49756

KEGG Orthology (KO)

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KOi
K12822

Identification of Orthologs from Complete Genome Data

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OMAi
IDRIPTQ

Database of Orthologous Groups

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OrthoDBi
EOG091G05NK

Database for complete collections of gene phylogenies

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PhylomeDBi
P49756

TreeFam database of animal gene trees

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TreeFami
TF320185

Family and domain databases

Conserved Domains Database

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CDDi
cd12446 RRM_RBM25, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR002483 PWI_dom
IPR036483 PWI_dom_sf
IPR035979 RBD_domain_sf
IPR034268 RBM25_RRM
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01480 PWI, 1 hit
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00311 PWI, 1 hit
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101233 SSF101233, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51025 PWI, 1 hit
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49756-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA
60 70 80 90 100
PTVLVPTVSM VGKHLGARKD HPGLKAKEND ENCGPTTTVF VGNISEKASD
110 120 130 140 150
MLIRQLLAKC GLVLSWKRVQ GASGKLQAFG FCEYKEPEST LRALRLLHDL
160 170 180 190 200
QIGEKKLLVK VDAKTKAQLD EWKAKKKASN GNARPETVTN DDEEALDEET
210 220 230 240 250
KRRDQMIKGA IEVLIREYSS ELNAPSQESD SHPRKKKKEK KEDIFRRFPV
260 270 280 290 300
APLIPYPLIT KEDINAIEME EDKRDLISRE ISKFRDTHKK LEEEKGKKEK
310 320 330 340 350
ERQEIEKERR ERERERERER ERRERERERE REREREKEKE RERERERDRD
360 370 380 390 400
RDRTKERDRD RDRERDRDRD RERSSDRNKD RSRSREKSRD RERERERERE
410 420 430 440 450
RERERERERE RERERERERE REREREKDKK RDREEDEEDA YERRKLERKL
460 470 480 490 500
REKEAAYQER LKNWEIRERK KTREYEKEAE REEERRREMA KEAKRLKEFL
510 520 530 540 550
EDYDDDRDDP KYYRGSALQK RLRDREKEME ADERDRKREK EELEEIRQRL
560 570 580 590 600
LAEGHPDPDA ELQRMEQEAE RRRQPQIKQE PESEEEEEEK QEKEEKREEP
610 620 630 640 650
MEEEEEPEQK PCLKPTLRPI SSAPSVSSAS GNATPNTPGD ESPCGIIIPH
660 670 680 690 700
ENSPDQQQPE EHRPKIGLSL KLGASNSPGQ PNSVKRKKLP VDSVFNKFED
710 720 730 740 750
EDSDDVPRKR KLVPLDYGED DKNATKGTVN TEEKRKHIKS LIEKIPTAKP
760 770 780 790 800
ELFAYPLDWS IVDSILMERR IRPWINKKII EYIGEEEATL VDFVCSKVMA
810 820 830 840
HSSPQSILDD VAMVLDEEAE VFIVKMWRLL IYETEAKKIG LVK
Length:843
Mass (Da):100,185
Last modified:April 14, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80534590147A342A
GO
Isoform 2 (identifier: P49756-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-294: KLEEE → RSYGD
     295-843: Missing.

Note: No experimental confirmation available.
Show »
Length:294
Mass (Da):32,822
Checksum:i184FE9019A3E3D95
GO
Isoform 3 (identifier: P49756-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-300: KLEEEKGKKEK → VVFLSFHLIPI
     301-843: Missing.

Show »
Length:300
Mass (Da):33,510
Checksum:i81D1498626DDD750
GO
Isoform 4 (identifier: P49756-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-164: KCGLVLSWKR...KKLLVKVDAK → PSDSVSTRSQ...QRRKLLMGLG
     165-843: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:164
Mass (Da):17,953
Checksum:i5D5562C8AAD78BAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQU5E9PQU5_HUMAN
RNA-binding protein 25
RBM25
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSE8E9PSE8_HUMAN
RNA-binding protein 25
RBM25
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE46H0YE46_HUMAN
RNA-binding protein 25
RBM25
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH62440 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH62440 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH83496 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG52915 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti428D → K in BAB15362 (PubMed:14702039).Curated1
Sequence conflicti571 – 574RRRQ → EAQE in AAC41999 (PubMed:7596406).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039881109 – 164KCGLV…KVDAK → PSDSVSTRSQNLPSVHSDYY MTCKLERKSYSLKLMQRQRH SWMNGKQRRKLLMGLG in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_039882165 – 843Missing in isoform 4. 1 PublicationAdd BLAST679
Alternative sequenceiVSP_036791290 – 300KLEEEKGKKEK → VVFLSFHLIPI in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_036792290 – 294KLEEE → RSYGD in isoform 2. 1 Publication5
Alternative sequenceiVSP_036793295 – 843Missing in isoform 2. 1 PublicationAdd BLAST549
Alternative sequenceiVSP_036794301 – 843Missing in isoform 3. 1 PublicationAdd BLAST543

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK026107 mRNA Translation: BAB15362.1
AK094697 mRNA Translation: BAG52915.1 Sequence problems.
AL442663 Genomic DNA No translation available.
AC004858 Genomic DNA Translation: AAF19255.1
CH471061 Genomic DNA Translation: EAW81087.1
BC062440 mRNA Translation: AAH62440.1 Sequence problems.
BC083496 mRNA Translation: AAH83496.1 Different initiation.
BC111066 mRNA Translation: AAI11067.1
BC113389 mRNA Translation: AAI13390.1
BC113391 mRNA Translation: AAI13392.1
BC136775 mRNA Translation: AAI36776.1
BC136776 mRNA Translation: AAI36777.1
BC144407 mRNA Translation: AAI44408.1
AF109907 Genomic DNA Translation: AAC97961.1
L40392 mRNA Translation: AAC41999.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32113.1 [P49756-1]

NCBI Reference Sequences

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RefSeqi
NP_067062.1, NM_021239.2 [P49756-1]
XP_011535346.1, XM_011537044.2 [P49756-1]
XP_011535347.1, XM_011537045.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.531106

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261973; ENSP00000261973; ENSG00000119707 [P49756-1]
ENST00000525321; ENSP00000436868; ENSG00000119707 [P49756-3]
ENST00000526754; ENSP00000436225; ENSG00000119707 [P49756-2]
ENST00000527432; ENSP00000431150; ENSG00000119707 [P49756-1]
ENST00000528081; ENSP00000434444; ENSG00000119707 [P49756-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58517

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:58517

UCSC genome browser

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UCSCi
uc001xnn.5 human [P49756-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026107 mRNA Translation: BAB15362.1
AK094697 mRNA Translation: BAG52915.1 Sequence problems.
AL442663 Genomic DNA No translation available.
AC004858 Genomic DNA Translation: AAF19255.1
CH471061 Genomic DNA Translation: EAW81087.1
BC062440 mRNA Translation: AAH62440.1 Sequence problems.
BC083496 mRNA Translation: AAH83496.1 Different initiation.
BC111066 mRNA Translation: AAI11067.1
BC113389 mRNA Translation: AAI13390.1
BC113391 mRNA Translation: AAI13392.1
BC136775 mRNA Translation: AAI36776.1
BC136776 mRNA Translation: AAI36777.1
BC144407 mRNA Translation: AAI44408.1
AF109907 Genomic DNA Translation: AAC97961.1
L40392 mRNA Translation: AAC41999.1
CCDSiCCDS32113.1 [P49756-1]
RefSeqiNP_067062.1, NM_021239.2 [P49756-1]
XP_011535346.1, XM_011537044.2 [P49756-1]
XP_011535347.1, XM_011537045.2
UniGeneiHs.531106

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V53X-ray2.90A/B/C/D/E734-843[»]
ProteinModelPortaliP49756
SMRiP49756
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121843, 88 interactors
CORUMiP49756
IntActiP49756, 29 interactors
MINTiP49756
STRINGi9606.ENSP00000261973

PTM databases

iPTMnetiP49756
PhosphoSitePlusiP49756
SwissPalmiP49756

Polymorphism and mutation databases

BioMutaiRBM25
DMDMi226693631

Proteomic databases

EPDiP49756
MaxQBiP49756
PaxDbiP49756
PeptideAtlasiP49756
PRIDEiP49756
ProteomicsDBi56071
56072 [P49756-2]
56073 [P49756-3]
56074 [P49756-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
58517
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261973; ENSP00000261973; ENSG00000119707 [P49756-1]
ENST00000525321; ENSP00000436868; ENSG00000119707 [P49756-3]
ENST00000526754; ENSP00000436225; ENSG00000119707 [P49756-2]
ENST00000527432; ENSP00000431150; ENSG00000119707 [P49756-1]
ENST00000528081; ENSP00000434444; ENSG00000119707 [P49756-4]
GeneIDi58517
KEGGihsa:58517
UCSCiuc001xnn.5 human [P49756-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58517
DisGeNETi58517
EuPathDBiHostDB:ENSG00000119707.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RBM25
HGNCiHGNC:23244 RBM25
HPAiHPA003025
HPA070713
MIMi612427 gene
neXtProtiNX_P49756
OpenTargetsiENSG00000119707
PharmGKBiPA134912024

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2253 Eukaryota
ENOG410ZRGA LUCA
GeneTreeiENSGT00730000111019
HOVERGENiHBG068941
InParanoidiP49756
KOiK12822
OMAiIDRIPTQ
OrthoDBiEOG091G05NK
PhylomeDBiP49756
TreeFamiTF320185

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBM25 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RBM25

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58517

Protein Ontology

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PROi
PR:P49756

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119707 Expressed in 241 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_RBM25
ExpressionAtlasiP49756 baseline and differential
GenevisibleiP49756 HS

Family and domain databases

CDDicd12446 RRM_RBM25, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR002483 PWI_dom
IPR036483 PWI_dom_sf
IPR035979 RBD_domain_sf
IPR034268 RBM25_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF01480 PWI, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00311 PWI, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF101233 SSF101233, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51025 PWI, 1 hit
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM25_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49756
Secondary accession number(s): A0PJL9
, B2RNA8, B3KT03, Q2TA72, Q5XJ17, Q6P665, Q9H6A1, Q9UEQ5, Q9UIE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 14, 2009
Last modified: December 5, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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