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Entry version 194 (07 Apr 2021)
Sequence version 2 (15 Dec 1998)
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Protein

Transmembrane emp24 domain-containing protein 10

Gene

TMED10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (PubMed:10052452, PubMed:11726511, PubMed:16641999, PubMed:17288597, PubMed:19296914, PubMed:20427317, PubMed:21219331, PubMed:27569046). The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (PubMed:10052452). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side (PubMed:20427317, PubMed:27569046). Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:10052452, PubMed:10852829, PubMed:12237308). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (PubMed:20427317, PubMed:27569046). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment (PubMed:11726511). Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (PubMed:17288597). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation (PubMed:11726511). Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus (PubMed:19296914). Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization (PubMed:21219331). In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC (PubMed:32272059). Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 (PubMed:32272059). Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (PubMed:16641999).1 PublicationBy similarity11 Publications

Miscellaneous

Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization (PubMed:10852829). Interaction of TMED10 with TMED2 is both necessary and sufficient for transport of the couple to the cis-Golgi network, and TMED3 and/or TMED9 contribute to facilitating the process (PubMed:10852829).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P49755

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-5694530, Cargo concentration in the ER
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49755

Protein family/group databases

Transport Classification Database

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TCDBi
9.B.188.1.4, the transmembrane emp24 domain-containing protein (tmed) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 10
Short name:
Protein TMED10
Alternative name(s):
21 kDa transmembrane-trafficking protein
S31I125
S31III125
Tmp-21-I
Transmembrane protein Tmp21
p23
p24 family protein delta-1
Short name:
p24delta1
p24delta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMED10Imported
Synonyms:TMP21
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16998, TMED10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605406, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49755

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000170348.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 185LumenalCuratedAdd BLAST154
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 219CytoplasmicCuratedAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi211 – 212FF → AA: Disrupts interaction with COPG1 and association with coatomer; when associated with 215-A-A-216. 3 Publications2
Mutagenesisi211 – 212FF → AA: No decrease in binding to COPG1. Disrupts interaction with SEC23A. 3 Publications2
Mutagenesisi215 – 216KK → AA: Disrupts interaction with COPG1 and association with coatomer; when associated with 211-A-A-212. 3 Publications2
Mutagenesisi215 – 216KK → AA: Significant reduction in binding to COPG1. 3 Publications2

Organism-specific databases

DisGeNET

More...
DisGeNETi
10972

Open Targets

More...
OpenTargetsi
ENSG00000170348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394579

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49755, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4295772

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMED10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3915893

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Combined sources1 PublicationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001039932 – 219Transmembrane emp24 domain-containing protein 10Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei171Dimethylated arginineBy similarity1
Modified residuei176Dimethylated arginineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49755

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P49755

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P49755

MaxQB - The MaxQuant DataBase

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MaxQBi
P49755

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49755

PeptideAtlas

More...
PeptideAtlasi
P49755

PRoteomics IDEntifications database

More...
PRIDEi
P49755

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56070

Consortium for Top Down Proteomics

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TopDownProteomicsi
P49755

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P49755, 2 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P49755

MetOSite database of methionine sulfoxide sites

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MetOSitei
P49755

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49755

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P49755

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170348, Expressed in parotid gland and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49755, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49755, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170348, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Predominantly dimeric and to a lesser extent monomeric in the ER (PubMed:12237308). Monomer and dimer in ERGIC and cis-Golgi network (PubMed:12237308). Forms homooligomer (via GOLD domain); the assembly is promoted by direct binding with leaderless cargos and may form a protein channel that facilitates cargo entry into the ERGIC (PubMed:32272059). Forms heterooligomeric complexes with other members of the p24 family such as TMED2, TMED7 and TMED9 (PubMed:9472029, PubMed:10359607, PubMed:20427317, PubMed:32272059).

Interacts (via GOLD domain) with TMED2 (via GOLD domain); the complex is required for export of TMED10 from the ER to the cis-Golgi network; the complex is proposed to be involved in cis-Golgi network dynamics and / or biogenesis (PubMed:10852829, PubMed:27569046). Associates with the COPI vesicle coat subunits (coatomer) (PubMed:9472029, PubMed:11056392, PubMed:16940185). Tetramerization of the cytoplasmic domain at the Golgi membrane in vitro; the complex is proposed to interact with COPI coatomer and induce budding of the vesicles (By similarity).

Interacts with COPG1; the interaction involves TMED10 homodimer (PubMed:16940185).

Interacts with ARF1 (GDP-bound); the interaction probably involves a TMED10 oligomer (PubMed:11726511).

Interacts with SEC23A, SEC24B, SEC24C and SEC24D components of the coat protein complex II/COPII, indicative of an association of TMED10 with the COPII vesicle coat (PubMed:9472029).

Interacts with CD59 (PubMed:20427317).

Interacts with MPPE1/PGAP5; the complex might recruit and sort GPI-anchored proteins to the ER-exit site, or the interaction might lead to recycling of PGAP5 between the ER and the Golgi (PubMed:19837036).

Interacts with F2LR1/PAR2 (PubMed:21219331).

Interacts with KDELR2/ERD2; the interaction is disrupted by KDELR2 ligand (By similarity).

Found in a complex composed at least of SURF4, TMED2 and TMED10 (PubMed:18287528). Associates with the presenilin-dependent gamma-secretase complex (PubMed:16641999).

Interacts with STX17; the interaction is direct (PubMed:21545355).

Interacts with IL-1; the interaction is direct (PubMed:32272059).

Interacts with RAB21 (active GTP-bound form); the interaction is indirect and regulates TMED10 abundance and localization at the Golgi (PubMed:31455601).

By similarity16 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116169, 96 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P49755

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P49755

Protein interaction database and analysis system

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IntActi
P49755, 64 interactors

Molecular INTeraction database

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MINTi
P49755

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000303145

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P49755, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49755

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 193GOLDPROSITE-ProRule annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 142Required for interaction with STX171 PublicationAdd BLAST142
Regioni147 – 178Required for TMED10 and TMED2 cis-Golgi network localizationAdd BLAST32
Regioni204 – 219Interaction with COPG1Add BLAST16
Regioni207 – 219Interaction with ARF1 and IL1B2 PublicationsAdd BLAST13

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi211 – 219COPI vesicle coat-binding9
Motifi211 – 212COPII vesicle coat-binding2

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GOLD domain is required for proper p24 heterooligomeric complex formation and efficient transport of GPI-anchored proteins.1 Publication
The lumenal domain mediates localization to the plasma membrane by partially overriding the ER retention by the cytoplasmic domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1691, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074954

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_066963_3_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49755

Identification of Orthologs from Complete Genome Data

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OMAi
KERCIRN

Database of Orthologous Groups

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OrthoDBi
1370889at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P49755

TreeFam database of animal gene trees

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TreeFami
TF313729

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015720, Emp24-like
IPR009038, GOLD_dom

The PANTHER Classification System

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PANTHERi
PTHR22811, PTHR22811, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01105, EMP24_GP25L, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01190, EMP24_GP25L, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50866, GOLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49755-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLSGPPAR RGPFPLALLL LFLLGPRLVL AISFHLPINS RKCLREEIHK
60 70 80 90 100
DLLVTGAYEI SDQSGGAGGL RSHLKITDSA GHILYSKEDA TKGKFAFTTE
110 120 130 140 150
DYDMFEVCFE SKGTGRIPDQ LVILDMKHGV EAKNYEEIAK VEKLKPLEVE
160 170 180 190 200
LRRLEDLSES IVNDFAYMKK REEEMRDTNE STNTRVLYFS IFSMFCLIGL
210
ATWQVFYLRR FFKAKKLIE
Length:219
Mass (Da):24,976
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A0486BE65C4DBBB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2K7G3V2K7_HUMAN
Transmembrane emp24 domain-containi...
TMED10
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC42003 differs from that shown. Reason: Frameshift.Curated
The sequence CAD66561 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75K → R in CAD89913 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01205164S → Y. Corresponds to variant dbSNP:rs4929Ensembl.1
Natural variantiVAR_049111152R → G. Corresponds to variant dbSNP:rs17103066Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X97442 mRNA Translation: CAA66071.1
X97444 mRNA Translation: CAA66073.1
U61734 Genomic DNA Translation: AAB03625.1
L40397 mRNA Translation: AAC42003.1 Frameshift.
AJ004913 mRNA Translation: CAA06213.1
BX248754 mRNA Translation: CAD66561.1 Different initiation.
AK312384 mRNA Translation: BAG35302.1
AL832012 mRNA Translation: CAD89913.1
AC007055 Genomic DNA Translation: AAD31941.1
CH471061 Genomic DNA Translation: EAW81223.1
BC001496 mRNA Translation: AAH01496.1
BC001825 mRNA Translation: AAH01825.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9840.1

Protein sequence database of the Protein Information Resource

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PIRi
G01159

NCBI Reference Sequences

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RefSeqi
NP_006818.3, NM_006827.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000303575; ENSP00000303145; ENSG00000170348

Database of genes from NCBI RefSeq genomes

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GeneIDi
10972

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10972

UCSC genome browser

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UCSCi
uc001xrm.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97442 mRNA Translation: CAA66071.1
X97444 mRNA Translation: CAA66073.1
U61734 Genomic DNA Translation: AAB03625.1
L40397 mRNA Translation: AAC42003.1 Frameshift.
AJ004913 mRNA Translation: CAA06213.1
BX248754 mRNA Translation: CAD66561.1 Different initiation.
AK312384 mRNA Translation: BAG35302.1
AL832012 mRNA Translation: CAD89913.1
AC007055 Genomic DNA Translation: AAD31941.1
CH471061 Genomic DNA Translation: EAW81223.1
BC001496 mRNA Translation: AAH01496.1
BC001825 mRNA Translation: AAH01825.1
CCDSiCCDS9840.1
PIRiG01159
RefSeqiNP_006818.3, NM_006827.5

3D structure databases

SMRiP49755
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116169, 96 interactors
CORUMiP49755
ELMiP49755
IntActiP49755, 64 interactors
MINTiP49755
STRINGi9606.ENSP00000303145

Chemistry databases

ChEMBLiCHEMBL4295772

Protein family/group databases

TCDBi9.B.188.1.4, the transmembrane emp24 domain-containing protein (tmed) family

PTM databases

GlyGeniP49755, 2 sites, 1 O-linked glycan (1 site)
iPTMnetiP49755
MetOSiteiP49755
PhosphoSitePlusiP49755
SwissPalmiP49755

Genetic variation databases

BioMutaiTMED10
DMDMi3915893

Proteomic databases

EPDiP49755
jPOSTiP49755
MassIVEiP49755
MaxQBiP49755
PaxDbiP49755
PeptideAtlasiP49755
PRIDEiP49755
ProteomicsDBi56070
TopDownProteomicsiP49755

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25817, 423 antibodies

The DNASU plasmid repository

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DNASUi
10972

Genome annotation databases

EnsembliENST00000303575; ENSP00000303145; ENSG00000170348
GeneIDi10972
KEGGihsa:10972
UCSCiuc001xrm.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10972
DisGeNETi10972

GeneCards: human genes, protein and diseases

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GeneCardsi
TMED10
HGNCiHGNC:16998, TMED10
HPAiENSG00000170348, Low tissue specificity
MIMi605406, gene
neXtProtiNX_P49755
OpenTargetsiENSG00000170348
PharmGKBiPA128394579
VEuPathDBiHostDB:ENSG00000170348.8

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1691, Eukaryota
GeneTreeiENSGT00550000074954
HOGENOMiCLU_066963_3_1_1
InParanoidiP49755
OMAiKERCIRN
OrthoDBi1370889at2759
PhylomeDBiP49755
TreeFamiTF313729

Enzyme and pathway databases

PathwayCommonsiP49755
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-5694530, Cargo concentration in the ER
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
SIGNORiP49755

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10972, 335 hits in 1008 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMED10, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TMED10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10972
PharosiP49755, Tbio

Protein Ontology

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PROi
PR:P49755
RNActiP49755, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170348, Expressed in parotid gland and 249 other tissues
ExpressionAtlasiP49755, baseline and differential
GenevisibleiP49755, HS

Family and domain databases

InterProiView protein in InterPro
IPR015720, Emp24-like
IPR009038, GOLD_dom
PANTHERiPTHR22811, PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105, EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190, EMP24_GP25L, 1 hit
PROSITEiView protein in PROSITE
PS50866, GOLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMEDA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49755
Secondary accession number(s): B2R605
, Q15602, Q16536, Q86TC2, Q86TS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 15, 1998
Last modified: April 7, 2021
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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