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Entry version 191 (26 Feb 2020)
Sequence version 6 (24 Nov 2009)
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Protein

Acyl-coenzyme A thioesterase 2, mitochondrial

Gene

ACOT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:16940157, PubMed:10944470). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).1 PublicationBy similarity2 Publications

Caution

Was originally (PubMed:10944470) thought to be peroxisomal but was later shown (PubMed:16940157) to be mitochondrial.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=40.3 µM for C10-acyl-CoA1 Publication
  2. KM=8.9 µM for C12-acyl-CoA1 Publication
  3. KM=1.6 µM for C14-acyl-CoA1 Publication
  4. KM=2.0 µM for C16-acyl-CoA1 Publication
  5. KM=2.8 µM for C18-acyl-CoA1 Publication
  6. KM=4.8 µM for C20-acyl-CoA1 Publication
  7. KM=4.5 µM for C16:1-acyl-CoA1 Publication
  8. KM=6.1 µM for C18:1-acyl-CoA1 Publication
  9. KM=4.3 µM for C18:1-trans-acyl-CoA1 Publication
  1. Vmax=212 nmol/min/mg enzyme with C10-acyl-CoA as substrate1 Publication
  2. Vmax=681 nmol/min/mg enzyme with C12-acyl-CoA as substrate1 Publication
  3. Vmax=766 nmol/min/mg enzyme with C14-acyl-CoA as substrate1 Publication
  4. Vmax=656 nmol/min/mg enzyme with C16-acyl-CoA as substrate1 Publication
  5. Vmax=488 nmol/min/mg enzyme with C18-acyl-CoA as substrate1 Publication
  6. Vmax=408 nmol/min/mg enzyme with C20-acyl-CoA as substrate1 Publication
  7. Vmax=661 nmol/min/mg enzyme with C16:1-acyl-CoA as substrate1 Publication
  8. Vmax=304 nmol/min/mg enzyme with C18:1-acyl-CoA as substrate1 Publication
  9. Vmax=418 nmol/min/mg enzyme with C18:1-trans-acyl-CoA as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.2 Publications
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei294Charge relay system1 Publication1
Active sitei388Charge relay system1 Publication1
Active sitei422Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS04318-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.2.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
R-HSA-9033241 Peroxisomal protein import

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P49753

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00199

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-ACOT2 Acyl-CoA_Thioesterase

MEROPS protease database

More...
MEROPSi
S09.942

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000590

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 2, mitochondrial (EC:3.1.2.22 Publications)
Short name:
Acyl-CoA thioesterase 2
Alternative name(s):
Acyl-coenzyme A thioester hydrolase 2a
CTE-Ia
Long-chain acyl-CoA thioesterase 2
ZAP128
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACOT2
Synonyms:PTE2, PTE2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18431 ACOT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609972 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10965

Open Targets

More...
OpenTargetsi
ENSG00000119673

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672653

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49753 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2189135

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACOT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849771

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000202147? – 483Acyl-coenzyme A thioesterase 2, mitochondrial

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104N6-acetyllysineBy similarity1
Modified residuei470N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49753

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49753

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49753

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49753

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49753

PeptideAtlas

More...
PeptideAtlasi
P49753

PRoteomics IDEntifications database

More...
PRIDEi
P49753

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56066 [P49753-1]
56067 [P49753-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P49753

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49753

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P49753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119673 Expressed in lower esophagus and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49753 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49753 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043705
HPA060170

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9NZ94-22EBI-1052865,EBI-16423037

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116164, 18 interactors

Protein interaction database and analysis system

More...
IntActi
P49753, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000238651

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P49753 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1483
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49753

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49753

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi481 – 483Microbody targeting signalSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the C/M/P thioester hydrolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II3X Eukaryota
COG1073 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182784

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49753

KEGG Orthology (KO)

More...
KOi
K01068

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERTWANT

Database of Orthologous Groups

More...
OrthoDBi
1260385at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49753

TreeFam database of animal gene trees

More...
TreeFami
TF314911

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2240, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR016662 Acyl-CoA_thioEstase_long-chain
IPR014940 BAAT_C
IPR006862 Thio_Ohase/aa_AcTrfase
IPR042490 Thio_Ohase/BAAT_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08840 BAAT_C, 1 hit
PF04775 Bile_Hydr_Trans, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016521 Acyl-CoA_hydro, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49753-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNKLLSPHP HSVVLRSEFK MASSPAVLRA SRLYQWSLKS SAQFLGSPQL
60 70 80 90 100
RQVGQIIRVP ARMAATLILE PAGRCCWDEP VRIAVRGLAP EQPVTLRASL
110 120 130 140 150
RDEKGALFQA HARYRADTLG ELDLERAPAL GGSFAGLEPM GLLWALEPEK
160 170 180 190 200
PLVRLVKRDV RTPLAVELEV LDGHDPDPGR LLCQTRHERY FLPPGVRREP
210 220 230 240 250
VRVGRVRGTL FLPPEPGPFP GIVDMFGTGG GLLEYRASLL AGKGFAVMAL
260 270 280 290 300
AYYNYEDLPK TMETLHLEYF EEAMNYLLSH PEVKGPGVGL LGISKGGELC
310 320 330 340 350
LSMASFLKGI TAAVVINGSV ANVGGTLHYK GETLPPVGVN RNRIKVTKDG
360 370 380 390 400
YADIVDVLNS PLEGPDQKSF IPVERAESTF LFLVGQDDHN WKSEFYANEA
410 420 430 440 450
CKRLQAHGRR KPQIICYPET GHYIEPPYFP LCRASLHALV GSPIIWGGEP
460 470 480
RAHAMAQVDA WKQLQTFFHK HLGGHEGTIP SKV
Length:483
Mass (Da):53,218
Last modified:November 24, 2009 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAEDD42BBBD935E4
GO
Isoform 2 (identifier: P49753-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     53-214: Missing.

Show »
Length:301
Mass (Da):32,959
Checksum:iD157DF13EAF26EC6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0W7A0A087X0W7_HUMAN
Acyl-coenzyme A thioesterase 2, mit...
ACOT2
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT95A0A087WT95_HUMAN
Acyl-coenzyme A thioesterase 2, mit...
ACOT2
463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VI00F6VI00_HUMAN
Acyl-coenzyme A thioesterase 2, mit...
ACOT2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC42007 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167E → V in AAZ31237 (PubMed:16940157).Curated1
Sequence conflicti167E → V in BAA91989 (PubMed:14702039).Curated1
Sequence conflicti328H → R in AAZ31237 (PubMed:16940157).Curated1
Sequence conflicti328H → R in BAA91989 (PubMed:14702039).Curated1
Sequence conflicti328H → R in BAD97355 (Ref. 4) Curated1
Sequence conflicti328H → R in AAH04436 (PubMed:15489334).Curated1
Sequence conflicti328H → R in AAH06335 (PubMed:15489334).Curated1
Sequence conflicti328H → R in AAH06500 (PubMed:15489334).Curated1
Sequence conflicti328H → R in AAF97985 (PubMed:10944470).Curated1
Sequence conflicti454A → V in AAH06335 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05727116R → S. Corresponds to variant dbSNP:rs11545741Ensembl.1
Natural variantiVAR_016136475H → R4 PublicationsCorresponds to variant dbSNP:rs7494Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0122251 – 20Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_01222653 – 214Missing in isoform 2. 1 PublicationAdd BLAST162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L40401 mRNA Translation: AAC42007.1 Frameshift.
DQ082755 mRNA Translation: AAZ31237.1
AK001939 mRNA Translation: BAA91989.1
AK223635 mRNA Translation: BAD97355.1
BC004436 mRNA Translation: AAH04436.2
BC006335 mRNA Translation: AAH06335.1
BC006500 mRNA Translation: AAH06500.4
AY005822 mRNA Translation: AAF97985.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9816.1 [P49753-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC7367

NCBI Reference Sequences

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RefSeqi
NP_006812.3, NM_006821.5 [P49753-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000238651; ENSP00000238651; ENSG00000119673 [P49753-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10965

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10965

UCSC genome browser

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UCSCi
uc001xon.6 human [P49753-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40401 mRNA Translation: AAC42007.1 Frameshift.
DQ082755 mRNA Translation: AAZ31237.1
AK001939 mRNA Translation: BAA91989.1
AK223635 mRNA Translation: BAD97355.1
BC004436 mRNA Translation: AAH04436.2
BC006335 mRNA Translation: AAH06335.1
BC006500 mRNA Translation: AAH06500.4
AY005822 mRNA Translation: AAF97985.1
CCDSiCCDS9816.1 [P49753-1]
PIRiJC7367
RefSeqiNP_006812.3, NM_006821.5 [P49753-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HLKX-ray2.10A/B46-483[»]
SMRiP49753
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116164, 18 interactors
IntActiP49753, 12 interactors
STRINGi9606.ENSP00000238651

Chemistry databases

ChEMBLiCHEMBL2189135
SwissLipidsiSLP:000000590

Protein family/group databases

ESTHERihuman-ACOT2 Acyl-CoA_Thioesterase
MEROPSiS09.942

PTM databases

CarbonylDBiP49753
iPTMnetiP49753
PhosphoSitePlusiP49753
SwissPalmiP49753

Polymorphism and mutation databases

BioMutaiACOT2
DMDMi269849771

Proteomic databases

EPDiP49753
jPOSTiP49753
MassIVEiP49753
MaxQBiP49753
PaxDbiP49753
PeptideAtlasiP49753
PRIDEiP49753
ProteomicsDBi56066 [P49753-1]
56067 [P49753-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10965

Genome annotation databases

EnsembliENST00000238651; ENSP00000238651; ENSG00000119673 [P49753-1]
GeneIDi10965
KEGGihsa:10965
UCSCiuc001xon.6 human [P49753-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10965
DisGeNETi10965

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACOT2
HGNCiHGNC:18431 ACOT2
HPAiHPA043705
HPA060170
MIMi609972 gene
neXtProtiNX_P49753
OpenTargetsiENSG00000119673
PharmGKBiPA142672653

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II3X Eukaryota
COG1073 LUCA
GeneTreeiENSGT00950000182784
InParanoidiP49753
KOiK01068
OMAiERTWANT
OrthoDBi1260385at2759
PhylomeDBiP49753
TreeFamiTF314911

Enzyme and pathway databases

UniPathwayiUPA00199
BioCyciMetaCyc:HS04318-MONOMER
BRENDAi3.1.2.2 2681
ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
R-HSA-9033241 Peroxisomal protein import
SABIO-RKiP49753

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ACOT2 human
EvolutionaryTraceiP49753

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ACOT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10965
PharosiP49753 Tbio

Protein Ontology

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PROi
PR:P49753
RNActiP49753 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119673 Expressed in lower esophagus and 93 other tissues
ExpressionAtlasiP49753 baseline and differential
GenevisibleiP49753 HS

Family and domain databases

Gene3Di2.60.40.2240, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR016662 Acyl-CoA_thioEstase_long-chain
IPR014940 BAAT_C
IPR006862 Thio_Ohase/aa_AcTrfase
IPR042490 Thio_Ohase/BAAT_N
PfamiView protein in Pfam
PF08840 BAAT_C, 1 hit
PF04775 Bile_Hydr_Trans, 1 hit
PIRSFiPIRSF016521 Acyl-CoA_hydro, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49753
Secondary accession number(s): Q3I5F8, Q53EK4, Q9NUX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 24, 2009
Last modified: February 26, 2020
This is version 191 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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