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UniProtKB - P49750 (YLPM1_HUMAN)

Entry version 162 (02 Dec 2020)
Sequence version 4 (28 Mar 2018)
Previous versions | rss
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Protein

YLP motif-containing protein 1

Gene

YLPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49750

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
YLP motif-containing protein 1
Alternative name(s):
Nuclear protein ZAP3
ZAP113
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YLPM1
Synonyms:C14orf170, ZAP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000119596.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:17798, YLPM1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56252

Open Targets

More...OpenTargetsi		ENSG00000119596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134962086

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49750, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YLPM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		57015374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000662981 – 2146YLP motif-containing protein 1Add BLAST2146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei735N6-methyllysineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei814Omega-N-methylarginineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei831Omega-N-methylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki891Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki983Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki983Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1053Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1053Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1119PhosphoserineCombined sources1
Modified residuei1402PhosphoserineCombined sources1
Cross-linki1652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49750

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49750

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49750

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49750

PeptideAtlas

More...PeptideAtlasi		P49750

PRoteomics IDEntifications database

More...PRIDEi		P49750

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56063 [P49750-1]
56064 [P49750-3]
56065 [P49750-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P49750, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49750

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000119596, Expressed in kidney and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49750, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49750, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000119596, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPP1CA and NCOA5.

Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121117, 69 interactors

Database of interacting proteins

More...DIPi		DIP-53676N

Protein interaction database and analysis system

More...IntActi		P49750, 39 interactors

Molecular INTeraction database

More...MINTi		P49750

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000324463

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49750, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49750

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2096 – 2103Involved in interaction with PPP1CABy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 205Pro-richAdd BLAST191
Compositional biasi382 – 430Gln-richAdd BLAST49
Compositional biasi1002 – 1404Arg-richAdd BLAST403
Compositional biasi1683 – 1772Arg-richAdd BLAST90

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2400, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000039837

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49750

Identification of Orthologs from Complete Genome Data

More...OMAi		LWHEQFQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49750

TreeFam database of animal gene trees

More...TreeFami		TF329361

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR026314, YLP_motif_con_p1

The PANTHER Classification System

More...PANTHERi		PTHR13413, PTHR13413, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: P49750-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF 
        60         70         80         90        100
MSFREQHLAQ LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW 
       110        120        130        140        150
QPPPPPMPPP PGPALSYQKQ QQYKHQMLHH QRDGPPGLVP MELESPPESP 
       160        170        180        190        200
PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS QPYLPPAQPS PSQSPPSQSY 
       210        220        230        240        250
LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS KSQLLAPPPP 
       260        270        280        290        300
SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ 
       310        320        330        340        350
HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE 
       360        370        380        390        400
PPLPPPNEEV PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF 
       410        420        430        440        450
QYQGIMQKHT QLQQILQQYQ QIIQPPPHIQ TMSVDMQLRH YEMQQQQFQH 
       460        470        480        490        500
LYQEWEREFQ LWEEQLHSYP HKDQLQEYEK QWKTWQGHMK ATQSYLQEKV 
       510        520        530        540        550
NSFQNMKNQY MGNMSMPPPF VPYSQMPPPL PTMPPPVLPP SLPPPVMPPA 
       560        570        580        590        600
LPATVPPPGM PPPVMPPSLP TSVPPPGMPP SLSSAGPPPV LPPPSLSSAG 
       610        620        630        640        650
PPPVLPPPSL SSTAPPPVMP LPPLSSATPP PGIPPPGVPQ GIPPQLTAAP 
       660        670        680        690        700
VPPASSSQSS QVPEKPRPAL LPTPVSFGSA PPTTYHPPLQ SAGPSEQVNS 
       710        720        730        740        750
KAPLSKSALP YSSFSSDQGL GESSAAPSQP ITAVKDMPVR SGGLLPDPPR 
       760        770        780        790        800
SSYLESPRGP RFDGPRRFED LGSRCEGPRP KGPRFEGNRP DGPRPRYEGH 
       810        820        830        840        850
PAEGTKSKWG MIPRGPASQF YITPSTSLSP RQSGPQWKGP KPAFGQQHQQ 
       860        870        880        890        900
QPKSQAEPLS GNKEPLADTS SNQQKNFKMQ SAAFSIAADV KDVKAAQSNE 
       910        920        930        940        950
NLSDSQQEPP KSEVSEGPVE PSNWDQNVQS METQIDKAQA VTQPVPLANK 
       960        970        980        990       1000
PVPAQSTFPS KTGGMEGGTA VATSSLTADN DFKPVGIGLP HSENNQDKGL 
      1010       1020       1030       1040       1050
PRPDNRDNRL EGNRGNSSSY RGPGQSRMED TRDKGLVNRG RGQAISRGPG 
      1060       1070       1080       1090       1100
LVKQEDFRDK MMGRREDSRE KMNRGEGSRD RGLVRPGSSR EKVPGGLQGS 
      1110       1120       1130       1140       1150
QDRGAAGSRE RGPPRRAGSQ ERGPLRRAGS RERIPPRRAG SRERGPPRGP 
      1160       1170       1180       1190       1200
GSRERGLGRS DFGRDRGPFR PEPGDGGEKM YPYHRDEPPR APWNHGEERG 
      1210       1220       1230       1240       1250
HEEFPLDGRN APMERERLDD WDRERYWREC ERDYQDDTLE LYNREDRFSA 
      1260       1270       1280       1290       1300
PPSRSHDGDR RGPWWDDWER DQDMDEDYNR EMERDMDRDV DRISRPMDMY 
      1310       1320       1330       1340       1350
DRSLDNEWDR DYGRPLDEQE SQFRERDIPS LPPLPPLPPL PPLDRYRDDR 
      1360       1370       1380       1390       1400
WREERNREHG YDRDFRDRGE LRIREYPERG DTWREKRDYV PDRMDWERER 
      1410       1420       1430       1440       1450
LSDRWYPSDV DRHSPMAEHM PSSHHSSEMM GSDASLDSDQ GLGGVMVLSQ 
      1460       1470       1480       1490       1500
RQHEIILKAA QELKMLREQK EQLQKMKDFG SEPQMADHLP PQESRLQNTS 
      1510       1520       1530       1540       1550
SRPGMYPPPG SYRPPPPMGK PPGSIVRPSA PPARSSVPVT RPPVPIPPPP 
      1560       1570       1580       1590       1600
PPPPLPPPPP VIKPQTSAVE QERWDEDSFY GLWDTNDEQG LNSEFKSETA 
      1610       1620       1630       1640       1650
AIPSAPVLPP PPVHSSIPPP GPVPMGMPPM SKPPPVQQTV DYGHGRDIST 
      1660       1670       1680       1690       1700
NKVEQIPYGE RITLRPDPLP ERSTFETEHA GQRDRYDRER DREPYFDRQS 
      1710       1720       1730       1740       1750
NVIADHRDFK RDRETHRDRD RDRGVIDYDR DRFDRERRPR DDRAQSYRDK 
      1760       1770       1780       1790       1800
KDHSSSRRGG FDRPSYDRKS DRPVYEGPSM FGGERRTYPE ERMPLPAPSL 
      1810       1820       1830       1840       1850
SHQPPPAPRV EKKPESKNVD DILKPPGRES RPERIVVIMR GLPGSGKTHV 
      1860       1870       1880       1890       1900
AKLIRDKEVE FGGPAPRVLS LDDYFITEVE KEEKDPDSGK KVKKKVMEYE 
      1910       1920       1930       1940       1950
YEAEMEETYR TSMFKTFKKT LDDGFFPFII LDAINDRVRH FDQFWSAAKT 
      1960       1970       1980       1990       2000
KGFEVYLAEM SADNQTCGKR NIHGRKLKEI NKMADHWETA PRHMMRLDIR 
      2010       2020       2030       2040       2050
SLLQDAAIEE VEMEDFDANI EEQKEEKKDA EEEESELGYI PKSKWEMDTS 
      2060       2070       2080       2090       2100
EAKLDKLDGL RTGTKRKRDW EAIASRMEDY LQLPDDYDTR ASEPGKKRVR 
      2110       2120       2130       2140 
WADLEEKKDA DRKRAIGFVV GQTDWEKITD ESGHLAEKAL NRTKYI
Length:2,146
Mass (Da):241,645
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C8F694D43061047
GO
Isoform 3 (identifier: P49750-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-627: TMSVDMQLRH...VMPLPPLSSA → AT
     2038-2057: GYIPKSKWEMDTSEAKLDKL → VGDRPTTLNSVSLLKFLKKV
     2058-2146: Missing.

Show »
Length:1,862
Mass (Da):209,483
Checksum:i98C60B71D7C50896
GO
Isoform 1 (identifier: P49750-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-627: TMSVDMQLRH...VMPLPPLSSA → AT

Show »
Length:1,951
Mass (Da):219,985
Checksum:i11A41E942E59FFE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU51F8VU51_HUMAN
YLP motif-containing protein 1
YLPM1
1,440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI23H0YI23_HUMAN
YLP motif-containing protein 1
YLPM1
466Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIQ2H0YIQ2_HUMAN
YLP motif-containing protein 1
YLPM1
1,595Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQT9U3KQT9_HUMAN
YLP motif-containing protein 1
YLPM1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC42008 differs from that shown. Reason: Frameshift.Curated
The sequence AAF61275 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti421Q → R in AK095760 (PubMed:14702039).Curated1
Sequence conflicti524S → P in AK095760 (PubMed:14702039).Curated1
Sequence conflicti816P → S in AAC42006 (PubMed:7596406).Curated1
Sequence conflicti1599T → I in AAC42008 (PubMed:7596406).Curated1
Isoform 3 (identifier: P49750-3)
Sequence conflicti1861K → E in AAC42008 (PubMed:7596406).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059470431 – 627TMSVD…PLSSA → AT in isoform 1 and isoform 3. Add BLAST197
Alternative sequenceiVSP_0594712038 – 2057GYIPK…KLDKL → VGDRPTTLNSVSLLKFLKKV in isoform 3. Add BLAST20
Alternative sequenceiVSP_0594722058 – 2146Missing in isoform 3. Add BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC007956 Genomic DNA Translation: AAF61275.1 Sequence problems.
AK095760 mRNA No translation available.
L40403 mRNA Translation: AAC42008.1 Frameshift.
L40400 mRNA Translation: AAC42006.1
BC007792 mRNA Translation: AAH07792.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45135.1 [P49750-4]

NCBI Reference Sequences

More...RefSeqi		NP_062535.2, NM_019589.2 [P49750-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000325680; ENSP00000324463; ENSG00000119596 [P49750-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56252

UCSC genome browser

More...UCSCi		uc001xqj.5, human [P49750-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007956 Genomic DNA Translation: AAF61275.1 Sequence problems.
AK095760 mRNA No translation available.
L40403 mRNA Translation: AAC42008.1 Frameshift.
L40400 mRNA Translation: AAC42006.1
BC007792 mRNA Translation: AAH07792.1
CCDSiCCDS45135.1 [P49750-4]
RefSeqiNP_062535.2, NM_019589.2 [P49750-4]

3D structure databases

SMRiP49750
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121117, 69 interactors
DIPiDIP-53676N
IntActiP49750, 39 interactors
MINTiP49750
STRINGi9606.ENSP00000324463

PTM databases

GlyGeniP49750, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP49750
PhosphoSitePlusiP49750

Polymorphism and mutation databases

BioMutaiYLPM1
DMDMi57015374

Proteomic databases

EPDiP49750
jPOSTiP49750
MassIVEiP49750
PaxDbiP49750
PeptideAtlasiP49750
PRIDEiP49750
ProteomicsDBi56063 [P49750-1]
56064 [P49750-3]
56065 [P49750-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		62380, 14 antibodies

Genome annotation databases

EnsembliENST00000325680; ENSP00000324463; ENSG00000119596 [P49750-4]
GeneIDi56252
KEGGihsa:56252
UCSCiuc001xqj.5, human [P49750-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56252
DisGeNETi56252
EuPathDBiHostDB:ENSG00000119596.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		YLPM1
HGNCiHGNC:17798, YLPM1
HPAiENSG00000119596, Low tissue specificity
neXtProtiNX_P49750
OpenTargetsiENSG00000119596
PharmGKBiPA134962086

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2400, Eukaryota
GeneTreeiENSGT00440000039837
InParanoidiP49750
OMAiLWHEQFQ
PhylomeDBiP49750
TreeFamiTF329361

Enzyme and pathway databases

PathwayCommonsiP49750

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56252, 33 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YLPM1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YLPM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56252
PharosiP49750, Tdark

Protein Ontology

More...PROi		PR:P49750
RNActiP49750, protein

Gene expression databases

BgeeiENSG00000119596, Expressed in kidney and 240 other tissues
ExpressionAtlasiP49750, baseline and differential
GenevisibleiP49750, HS

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR026314, YLP_motif_con_p1
PANTHERiPTHR13413, PTHR13413, 3 hits
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYLPM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49750
Secondary accession number(s): P49752, Q96I64, Q9P1V7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 28, 2018
Last modified: December 2, 2020
This is version 162 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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