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Entry version 151 (13 Feb 2019)
Sequence version 4 (28 Mar 2018)
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Protein

YLP motif-containing protein 1

Gene

YLPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
YLP motif-containing protein 1
Alternative name(s):
Nuclear protein ZAP3
ZAP113
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YLPM1
Synonyms:C14orf170, ZAP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119596.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17798 YLPM1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56252

Open Targets

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OpenTargetsi
ENSG00000119596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134962086

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
YLPM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
57015374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000662981 – 2146YLP motif-containing protein 1Add BLAST2146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei735N6-methyllysineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei814Omega-N-methylarginineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei831Omega-N-methylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki891Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki983Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki983Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1053Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1053Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1119PhosphoserineCombined sources1
Modified residuei1402PhosphoserineCombined sources1
Cross-linki1652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49750

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49750

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P49750

PeptideAtlas

More...
PeptideAtlasi
P49750

PRoteomics IDEntifications database

More...
PRIDEi
P49750

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56063
56064 [P49750-3]
56065 [P49750-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49750

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000119596 Expressed in 229 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49750 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49750 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048070
HPA061123

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121117, 61 interactors

Database of interacting proteins

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DIPi
DIP-53676N

Protein interaction database and analysis system

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IntActi
P49750, 34 interactors

Molecular INTeraction database

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MINTi
P49750

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324463

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P49750

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49750

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2096 – 2103Involved in interaction with PPP1CABy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 205Pro-richAdd BLAST191
Compositional biasi382 – 430Gln-richAdd BLAST49
Compositional biasi1002 – 1404Arg-richAdd BLAST403
Compositional biasi1683 – 1772Arg-richAdd BLAST90

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2400 Eukaryota
ENOG410YIR5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00440000039837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168351

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079363

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49750

KEGG Orthology (KO)

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KOi
K17602

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYNREDR

Database of Orthologous Groups

More...
OrthoDBi
58727at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49750

TreeFam database of animal gene trees

More...
TreeFami
TF329361

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR026314 YLP_motif_con_p1

The PANTHER Classification System

More...
PANTHERi
PTHR13413 PTHR13413, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: P49750-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF
60 70 80 90 100
MSFREQHLAQ LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW
110 120 130 140 150
QPPPPPMPPP PGPALSYQKQ QQYKHQMLHH QRDGPPGLVP MELESPPESP
160 170 180 190 200
PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS QPYLPPAQPS PSQSPPSQSY
210 220 230 240 250
LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS KSQLLAPPPP
260 270 280 290 300
SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ
310 320 330 340 350
HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE
360 370 380 390 400
PPLPPPNEEV PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF
410 420 430 440 450
QYQGIMQKHT QLQQILQQYQ QIIQPPPHIQ TMSVDMQLRH YEMQQQQFQH
460 470 480 490 500
LYQEWEREFQ LWEEQLHSYP HKDQLQEYEK QWKTWQGHMK ATQSYLQEKV
510 520 530 540 550
NSFQNMKNQY MGNMSMPPPF VPYSQMPPPL PTMPPPVLPP SLPPPVMPPA
560 570 580 590 600
LPATVPPPGM PPPVMPPSLP TSVPPPGMPP SLSSAGPPPV LPPPSLSSAG
610 620 630 640 650
PPPVLPPPSL SSTAPPPVMP LPPLSSATPP PGIPPPGVPQ GIPPQLTAAP
660 670 680 690 700
VPPASSSQSS QVPEKPRPAL LPTPVSFGSA PPTTYHPPLQ SAGPSEQVNS
710 720 730 740 750
KAPLSKSALP YSSFSSDQGL GESSAAPSQP ITAVKDMPVR SGGLLPDPPR
760 770 780 790 800
SSYLESPRGP RFDGPRRFED LGSRCEGPRP KGPRFEGNRP DGPRPRYEGH
810 820 830 840 850
PAEGTKSKWG MIPRGPASQF YITPSTSLSP RQSGPQWKGP KPAFGQQHQQ
860 870 880 890 900
QPKSQAEPLS GNKEPLADTS SNQQKNFKMQ SAAFSIAADV KDVKAAQSNE
910 920 930 940 950
NLSDSQQEPP KSEVSEGPVE PSNWDQNVQS METQIDKAQA VTQPVPLANK
960 970 980 990 1000
PVPAQSTFPS KTGGMEGGTA VATSSLTADN DFKPVGIGLP HSENNQDKGL
1010 1020 1030 1040 1050
PRPDNRDNRL EGNRGNSSSY RGPGQSRMED TRDKGLVNRG RGQAISRGPG
1060 1070 1080 1090 1100
LVKQEDFRDK MMGRREDSRE KMNRGEGSRD RGLVRPGSSR EKVPGGLQGS
1110 1120 1130 1140 1150
QDRGAAGSRE RGPPRRAGSQ ERGPLRRAGS RERIPPRRAG SRERGPPRGP
1160 1170 1180 1190 1200
GSRERGLGRS DFGRDRGPFR PEPGDGGEKM YPYHRDEPPR APWNHGEERG
1210 1220 1230 1240 1250
HEEFPLDGRN APMERERLDD WDRERYWREC ERDYQDDTLE LYNREDRFSA
1260 1270 1280 1290 1300
PPSRSHDGDR RGPWWDDWER DQDMDEDYNR EMERDMDRDV DRISRPMDMY
1310 1320 1330 1340 1350
DRSLDNEWDR DYGRPLDEQE SQFRERDIPS LPPLPPLPPL PPLDRYRDDR
1360 1370 1380 1390 1400
WREERNREHG YDRDFRDRGE LRIREYPERG DTWREKRDYV PDRMDWERER
1410 1420 1430 1440 1450
LSDRWYPSDV DRHSPMAEHM PSSHHSSEMM GSDASLDSDQ GLGGVMVLSQ
1460 1470 1480 1490 1500
RQHEIILKAA QELKMLREQK EQLQKMKDFG SEPQMADHLP PQESRLQNTS
1510 1520 1530 1540 1550
SRPGMYPPPG SYRPPPPMGK PPGSIVRPSA PPARSSVPVT RPPVPIPPPP
1560 1570 1580 1590 1600
PPPPLPPPPP VIKPQTSAVE QERWDEDSFY GLWDTNDEQG LNSEFKSETA
1610 1620 1630 1640 1650
AIPSAPVLPP PPVHSSIPPP GPVPMGMPPM SKPPPVQQTV DYGHGRDIST
1660 1670 1680 1690 1700
NKVEQIPYGE RITLRPDPLP ERSTFETEHA GQRDRYDRER DREPYFDRQS
1710 1720 1730 1740 1750
NVIADHRDFK RDRETHRDRD RDRGVIDYDR DRFDRERRPR DDRAQSYRDK
1760 1770 1780 1790 1800
KDHSSSRRGG FDRPSYDRKS DRPVYEGPSM FGGERRTYPE ERMPLPAPSL
1810 1820 1830 1840 1850
SHQPPPAPRV EKKPESKNVD DILKPPGRES RPERIVVIMR GLPGSGKTHV
1860 1870 1880 1890 1900
AKLIRDKEVE FGGPAPRVLS LDDYFITEVE KEEKDPDSGK KVKKKVMEYE
1910 1920 1930 1940 1950
YEAEMEETYR TSMFKTFKKT LDDGFFPFII LDAINDRVRH FDQFWSAAKT
1960 1970 1980 1990 2000
KGFEVYLAEM SADNQTCGKR NIHGRKLKEI NKMADHWETA PRHMMRLDIR
2010 2020 2030 2040 2050
SLLQDAAIEE VEMEDFDANI EEQKEEKKDA EEEESELGYI PKSKWEMDTS
2060 2070 2080 2090 2100
EAKLDKLDGL RTGTKRKRDW EAIASRMEDY LQLPDDYDTR ASEPGKKRVR
2110 2120 2130 2140
WADLEEKKDA DRKRAIGFVV GQTDWEKITD ESGHLAEKAL NRTKYI
Length:2,146
Mass (Da):241,645
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C8F694D43061047
GO
Isoform 3 (identifier: P49750-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-627: TMSVDMQLRH...VMPLPPLSSA → AT
     2038-2057: GYIPKSKWEMDTSEAKLDKL → VGDRPTTLNSVSLLKFLKKV
     2058-2146: Missing.

Show »
Length:1,862
Mass (Da):209,483
Checksum:i98C60B71D7C50896
GO
Isoform 1 (identifier: P49750-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-627: TMSVDMQLRH...VMPLPPLSSA → AT

Show »
Length:1,951
Mass (Da):219,985
Checksum:i11A41E942E59FFE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU51F8VU51_HUMAN
YLP motif-containing protein 1
YLPM1
1,440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI23H0YI23_HUMAN
YLP motif-containing protein 1
YLPM1
466Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIQ2H0YIQ2_HUMAN
YLP motif-containing protein 1
YLPM1
1,595Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQT9U3KQT9_HUMAN
YLP motif-containing protein 1
YLPM1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC42008 differs from that shown. Reason: Frameshift at position 1723.Curated
The sequence AAF61275 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti421Q → R in AK095760 (PubMed:14702039).Curated1
Sequence conflicti524S → P in AK095760 (PubMed:14702039).Curated1
Sequence conflicti816P → S in AAC42006 (PubMed:7596406).Curated1
Sequence conflicti1599T → I in AAC42008 (PubMed:7596406).Curated1
Isoform 3 (identifier: P49750-3)
Sequence conflicti1861K → E in AAC42008 (PubMed:7596406).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059470431 – 627TMSVD…PLSSA → AT in isoform 1 and isoform 3. Add BLAST197
Alternative sequenceiVSP_0594712038 – 2057GYIPK…KLDKL → VGDRPTTLNSVSLLKFLKKV in isoform 3. Add BLAST20
Alternative sequenceiVSP_0594722058 – 2146Missing in isoform 3. Add BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC007956 Genomic DNA Translation: AAF61275.1 Sequence problems.
AK095760 mRNA No translation available.
L40403 mRNA Translation: AAC42008.1 Frameshift.
L40400 mRNA Translation: AAC42006.1
BC007792 mRNA Translation: AAH07792.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45135.1 [P49750-4]

NCBI Reference Sequences

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RefSeqi
NP_062535.2, NM_019589.2 [P49750-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.531111

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000325680; ENSP00000324463; ENSG00000119596 [P49750-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56252

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56252

UCSC genome browser

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UCSCi
uc001xqj.5 human [P49750-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007956 Genomic DNA Translation: AAF61275.1 Sequence problems.
AK095760 mRNA No translation available.
L40403 mRNA Translation: AAC42008.1 Frameshift.
L40400 mRNA Translation: AAC42006.1
BC007792 mRNA Translation: AAH07792.1
CCDSiCCDS45135.1 [P49750-4]
RefSeqiNP_062535.2, NM_019589.2 [P49750-4]
UniGeneiHs.531111

3D structure databases

ProteinModelPortaliP49750
SMRiP49750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121117, 61 interactors
DIPiDIP-53676N
IntActiP49750, 34 interactors
MINTiP49750
STRINGi9606.ENSP00000324463

PTM databases

iPTMnetiP49750
PhosphoSitePlusiP49750

Polymorphism and mutation databases

BioMutaiYLPM1
DMDMi57015374

Proteomic databases

EPDiP49750
jPOSTiP49750
PaxDbiP49750
PeptideAtlasiP49750
PRIDEiP49750
ProteomicsDBi56063
56064 [P49750-3]
56065 [P49750-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325680; ENSP00000324463; ENSG00000119596 [P49750-4]
GeneIDi56252
KEGGihsa:56252
UCSCiuc001xqj.5 human [P49750-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56252
DisGeNETi56252
EuPathDBiHostDB:ENSG00000119596.17

GeneCards: human genes, protein and diseases

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GeneCardsi
YLPM1
HGNCiHGNC:17798 YLPM1
HPAiHPA048070
HPA061123
neXtProtiNX_P49750
OpenTargetsiENSG00000119596
PharmGKBiPA134962086

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2400 Eukaryota
ENOG410YIR5 LUCA
GeneTreeiENSGT00440000039837
HOGENOMiHOG000168351
HOVERGENiHBG079363
InParanoidiP49750
KOiK17602
OMAiPYNREDR
OrthoDBi58727at2759
PhylomeDBiP49750
TreeFamiTF329361

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
YLPM1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
YLPM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56252

Protein Ontology

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PROi
PR:P49750

Gene expression databases

BgeeiENSG00000119596 Expressed in 229 organ(s), highest expression level in kidney
ExpressionAtlasiP49750 baseline and differential
GenevisibleiP49750 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR026314 YLP_motif_con_p1
PANTHERiPTHR13413 PTHR13413, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYLPM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49750
Secondary accession number(s): P49752, Q96I64, Q9P1V7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 28, 2018
Last modified: February 13, 2019
This is version 151 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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