Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P49747 (COMP_HUMAN)

Protein

Cartilage oligomeric matrix protein

Gene

COMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).By similarity3 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+Note: Binds 11-14 calcium ions per subunit.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processApoptosis, Cell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cartilage oligomeric matrix protein
Short name:
COMP
Alternative name(s):
Thrombospondin-5
Short name:
TSP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000105664.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:2227 COMP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600310 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49747

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Multiple epiphyseal dysplasia 1 (EDM1)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal.
See also OMIM:132400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066789167G → E in EDM1. 1 PublicationCorresponds to variant dbSNP:rs763887855Ensembl.1
Natural variantiVAR_026239276P → R in EDM1. 2 Publications1
Natural variantiVAR_066792298S → L in EDM1; phenotypic features overlapping with mild PSACH. 1 Publication1
Natural variantiVAR_066793311A → D in EDM1. 1 Publication1
Natural variantiVAR_066794317D → G in EDM1; atypical form. 1 Publication1
Natural variantiVAR_066795326D → G in EDM1. 1 Publication1
Natural variantiVAR_007617342D → Y in EDM1; Fairbank type. 2 PublicationsCorresponds to variant dbSNP:rs137852652EnsemblClinVar.1
Natural variantiVAR_066798348C → F in EDM1. 1 Publication1
Natural variantiVAR_007619361D → V in EDM1; Fairbank type. 1
Natural variantiVAR_007620361D → Y in EDM1; binds less calcium. 2 Publications1
Natural variantiVAR_007621367 – 368Missing in EDM1. 1 Publication2
Natural variantiVAR_007622371C → S in EDM1; Fairbank type. 2 Publications1
Natural variantiVAR_066800371C → Y in EDM1. 1 PublicationCorresponds to variant dbSNP:rs1057521130Ensembl.1
Natural variantiVAR_066801374D → N in EDM1. 1 Publication1
Natural variantiVAR_066802376D → N in EDM1. 1 Publication1
Natural variantiVAR_066804385D → N in EDM1; atypical form. 1 Publication1
Natural variantiVAR_066805385D → Y in EDM1; atypical form. 1 Publication1
Natural variantiVAR_066806385Missing in EDM1. 1 Publication1
Natural variantiVAR_066808397D → H in EDM1. 1 Publication1
Natural variantiVAR_066810404G → R in EDM1. 1 Publication1
Natural variantiVAR_007627408D → Y in EDM1. 1 Publication1
Natural variantiVAR_066811410C → Y in EDM1; phenotype overlapping with mild PSACH. 1 Publication1
Natural variantiVAR_066812415N → K in EDM1. 1 Publication1
Natural variantiVAR_026240420D → A in EDM1. 1 Publication1
Natural variantiVAR_066813427G → E in EDM1. 1 Publication1
Natural variantiVAR_066814430 – 432CDS → LWC in EDM1. 1 Publication3
Natural variantiVAR_007630453N → S in EDM1; Fairbank type. 1 PublicationCorresponds to variant dbSNP:rs28936668EnsemblClinVar.1
Natural variantiVAR_066817457Missing in EDM1. 1 Publication1
Natural variantiVAR_066818473D → DD in EDM1. 1 Publication1
Natural variantiVAR_066821501G → D in EDM1. 1 Publication1
Natural variantiVAR_007640523N → K in EDM1; Ribbing type. 2 PublicationsCorresponds to variant dbSNP:rs137852654EnsemblClinVar.1
Natural variantiVAR_066826718R → P in EDM1. 1 PublicationCorresponds to variant dbSNP:rs149551600EnsemblClinVar.1
Natural variantiVAR_066827718R → W in EDM1. 1 PublicationCorresponds to variant dbSNP:rs28936368EnsemblClinVar.1
Pseudoachondroplasia (PSACH)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA skeletal dysplasia usually manifesting in the second year of life and characterized by moderate to severe disproportionate short stature, deformity of the lower limbs, brachydactyly, ligamentous laxity, and degenerative joint disease.
See also OMIM:177170
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066790234P → S in PSACH. 1 PublicationCorresponds to variant dbSNP:rs557483957Ensembl.1
Natural variantiVAR_066791290D → G in PSACH. 1 Publication1
Natural variantiVAR_007614290D → N in PSACH; mild form. 1
Natural variantiVAR_007615299G → R in PSACH. 1 Publication1
Natural variantiVAR_066796326D → Y in PSACH. 1 Publication1
Natural variantiVAR_007616328C → R in PSACH; mild form. 2 PublicationsCorresponds to variant dbSNP:rs137852653EnsemblClinVar.1
Natural variantiVAR_066797341 – 342Missing in PSACH. 1 Publication2
Natural variantiVAR_017102348C → R in PSACH. 1 PublicationCorresponds to variant dbSNP:rs137852656EnsemblClinVar.1
Natural variantiVAR_007618349D → V in PSACH; mild form. 1
Natural variantiVAR_066799350 – 372Missing in PSACH. 1 PublicationAdd BLAST23
Natural variantiVAR_007623372Missing in PSACH. 1 Publication1
Natural variantiVAR_007624374Missing in PSACH; mild form. 1
Natural variantiVAR_066803378D → V in PSACH. 1 Publication1
Natural variantiVAR_007625387C → G in PSACH; mild form. 1
Natural variantiVAR_066807387C → R in PSACH. 1 Publication1
Natural variantiVAR_007626391 – 394PNSD → V in PSACH. 1 Publication4
Natural variantiVAR_066809402 – 404GIG → VC in PSACH. 1 Publication3
Natural variantiVAR_007628440G → E in PSACH; mild form. 1
Natural variantiVAR_007629440G → R in PSACH. 2 Publications1
Natural variantiVAR_066815446D → N in PSACH. 1 Publication1
Natural variantiVAR_066816448C → S in PSACH. 1 Publication1
Natural variantiVAR_007631459Missing in PSACH; severe form. 2 Publications1
Natural variantiVAR_007632468C → Y in PSACH; severe form. 2 PublicationsCorresponds to variant dbSNP:rs137852651EnsemblClinVar.1
Natural variantiVAR_007633469Missing in PSACH; severe form; MUT3 mutant; most common mutation; binds less calcium and causes misfolding of the protein; greatly reduced interaction with ACAN; reduced interaction with collagen. 3 Publications1
Natural variantiVAR_007634472D → Y in PSACH; severe form. 2 PublicationsCorresponds to variant dbSNP:rs137852650EnsemblClinVar.1
Natural variantiVAR_007635473D → G in PSACH; severe form. Corresponds to variant dbSNP:rs28936669EnsemblClinVar.1
Natural variantiVAR_066819473D → H in PSACH. 1 Publication1
Natural variantiVAR_007636473Missing in PSACH; severe form. 1 Publication1
Natural variantiVAR_066820475D → N in PSACH. 1 Publication1
Natural variantiVAR_007637482D → G in PSACH. 2 Publications1
Natural variantiVAR_066822507D → G in PSACH. 1 Publication1
Natural variantiVAR_066823511D → G in PSACH. 1 Publication1
Natural variantiVAR_007638513 – 516Missing in PSACH; mild form. 1 Publication4
Natural variantiVAR_066824515D → G in PSACH. 1 Publication1
Natural variantiVAR_007639518D → N in PSACH; mild form. 1
Natural variantiVAR_066825529T → I in PSACH. 1 PublicationCorresponds to variant dbSNP:rs312262903EnsemblClinVar.1
Natural variantiVAR_007641585T → M in PSACH; mild form and EDM1. 2 PublicationsCorresponds to variant dbSNP:rs312262900EnsemblClinVar.1
Natural variantiVAR_017103719G → D in PSACH; severe. 1 PublicationCorresponds to variant dbSNP:rs137852655EnsemblClinVar.1
Natural variantiVAR_066828719G → S in PSACH. 1 PublicationCorresponds to variant dbSNP:rs312262904EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		1311

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		COMP

MalaCards human disease database

More...MalaCardsi		COMP
MIMi132400 phenotype
177170 phenotype

Open Targets

More...OpenTargetsi		ENSG00000105664

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93308 Multiple epiphyseal dysplasia type 1
750 Pseudoachondroplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26744

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01373 Calcium

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COMP

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572601

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003585721 – 757Cartilage oligomeric matrix proteinAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69Interchain1 Publication
Disulfide bondi72Interchain1 Publication
Disulfide bondi91 ↔ 102PROSITE-ProRule annotation
Disulfide bondi96 ↔ 111PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 142PROSITE-ProRule annotation
Disulfide bondi136 ↔ 151PROSITE-ProRule annotation
Disulfide bondi154 ↔ 178PROSITE-ProRule annotation
Disulfide bondi184 ↔ 197PROSITE-ProRule annotation
Disulfide bondi191 ↔ 206PROSITE-ProRule annotation
Disulfide bondi209 ↔ 221PROSITE-ProRule annotation
Disulfide bondi229 ↔ 243PROSITE-ProRule annotation1 Publication
Disulfide bondi237 ↔ 253PROSITE-ProRule annotation1 Publication
Disulfide bondi255 ↔ 266PROSITE-ProRule annotation1 Publication
Disulfide bondi282 ↔ 287PROSITE-ProRule annotation1 Publication
Disulfide bondi292 ↔ 312PROSITE-ProRule annotation1 Publication
Disulfide bondi328 ↔ 348PROSITE-ProRule annotation1 Publication
Disulfide bondi351 ↔ 371PROSITE-ProRule annotation1 Publication
Disulfide bondi387 ↔ 407PROSITE-ProRule annotation1 Publication
Disulfide bondi410 ↔ 430PROSITE-ProRule annotation1 Publication
Disulfide bondi448 ↔ 468PROSITE-ProRule annotation1 Publication
Disulfide bondi484 ↔ 504PROSITE-ProRule annotation1 Publication
Disulfide bondi520 ↔ 741PROSITE-ProRule annotation1 Publication
Glycosylationi742N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49747

PeptideAtlas

More...PeptideAtlasi		P49747

PRoteomics IDEntifications database

More...PRIDEi		P49747

ProteomicsDB human proteome resource

More...ProteomicsDBi		56060

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1076

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49747

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49747

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P49747

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present during the earliest stages of limb maturation and is later found in regions where the joints develop.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105664 Expressed in 130 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

More...CleanExi		HS_COMP

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49747 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49747 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA077555

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca2+, Mg2+ or Mn2+). The greatest amount of binding is seen in the presence of Mn2+. Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12. Interacts with ITGA7 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107706, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1791 Thrombospondin 5 complex

Protein interaction database and analysis system

More...IntActi		P49747, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000222271

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1757
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P49747

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49747

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P49747

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 126EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini127 – 179EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST53
Domaini180 – 222EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini225 – 267EGF-like 4PROSITE-ProRule annotationAdd BLAST43
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati268 – 300TSP type-3 1Add BLAST33
Repeati301 – 336TSP type-3 2Add BLAST36
Repeati337 – 359TSP type-3 3Add BLAST23
Repeati360 – 395TSP type-3 4Add BLAST36
Repeati396 – 418TSP type-3 5Add BLAST23
Repeati419 – 456TSP type-3 6Add BLAST38
Repeati457 – 492TSP type-3 7Add BLAST36
Repeati493 – 528TSP type-3 8Add BLAST36
Domaini532 – 746TSP C-terminalPROSITE-ProRule annotationAdd BLAST215

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 86COMP N-terminalAdd BLAST65
Regioni527 – 757Mediates cell survival and induction of the IAP family of survival proteinsAdd BLAST231

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi367 – 369Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.1 Publication
The TSP C-terminal domain mediates interaction with FN1 and ACAN.1 Publication
Each of the eight TSP type-3 repeats binds two calcium ions. The TSP C-terminal domain binds three calcium ions.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFQQ Eukaryota
ENOG410XQKE LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007542

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG000636

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49747

KEGG Orthology (KO)

More...KOi		K04659

Identification of Orthologs from Complete Genome Data

More...OMAi		AQQDSDH

Database of Orthologous Groups

More...OrthoDBi		EOG091G00TV

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49747

TreeFam database of animal gene trees

More...TreeFami		TF324917

Family and domain databases

Conserved Domains Database

More...CDDi		cd16077 TSP-5cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1080.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR024665 Thbs/COMP_coiled-coil
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR028492 TSP-5
IPR039081 TSP-5_cc
IPR028974 TSP_type-3_rpt

The PANTHER Classification System

More...PANTHERi		PTHR10199 PTHR10199, 1 hit
PTHR10199:SF88 PTHR10199:SF88, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11598 COMP, 1 hit
PF07645 EGF_CA, 2 hits
PF02412 TSP_3, 6 hits
PF05735 TSP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 2 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P49747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPDTACVLL LTLAALGASG QGQSPLGSDL GPQMLRELQE TNAALQDVRE 
        60         70         80         90        100
LLRQQVREIT FLKNTVMECD ACGMQQSVRT GLPSVRPLLH CAPGFCFPGV 
       110        120        130        140        150
ACIQTESGAR CGPCPAGFTG NGSHCTDVNE CNAHPCFPRV RCINTSPGFR 
       160        170        180        190        200
CEACPPGYSG PTHQGVGLAF AKANKQVCTD INECETGQHN CVPNSVCINT 
       210        220        230        240        250
RGSFQCGPCQ PGFVGDQASG CQRRAQRFCP DGSPSECHEH ADCVLERDGS 
       260        270        280        290        300
RSCVCAVGWA GNGILCGRDT DLDGFPDEKL RCPERQCRKD NCVTVPNSGQ 
       310        320        330        340        350
EDVDRDGIGD ACDPDADGDG VPNEKDNCPL VRNPDQRNTD EDKWGDACDN 
       360        370        380        390        400
CRSQKNDDQK DTDQDGRGDA CDDDIDGDRI RNQADNCPRV PNSDQKDSDG 
       410        420        430        440        450
DGIGDACDNC PQKSNPDQAD VDHDFVGDAC DSDQDQDGDG HQDSRDNCPT 
       460        470        480        490        500
VPNSAQEDSD HDGQGDACDD DDDNDGVPDS RDNCRLVPNP GQEDADRDGV 
       510        520        530        540        550
GDVCQDDFDA DKVVDKIDVC PENAEVTLTD FRAFQTVVLD PEGDAQIDPN 
       560        570        580        590        600
WVVLNQGREI VQTMNSDPGL AVGYTAFNGV DFEGTFHVNT VTDDDYAGFI 
       610        620        630        640        650
FGYQDSSSFY VVMWKQMEQT YWQANPFRAV AEPGIQLKAV KSSTGPGEQL 
       660        670        680        690        700
RNALWHTGDT ESQVRLLWKD PRNVGWKDKK SYRWFLQHRP QVGYIRVRFY 
       710        720        730        740        750
EGPELVADSN VVLDTTMRGG RLGVFCFSQE NIIWANLRYR CNDTIPEDYE 

THQLRQA
Length:757
Mass (Da):82,860
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0B73AADB39FBC7B
GO
Isoform 2 (identifier: P49747-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-181: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):77,214
Checksum:i1126EE4088275D29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAP6G3XAP6_HUMAN
Cartilage oligomeric matrix protein
COMP hCG_37043
724Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB86501 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti256A → R in AAA57253 (PubMed:7713493).Curated1
Sequence conflicti256A → R in BAC53888 (Ref. 2) Curated1
Sequence conflicti340D → Y in AAB35270 (PubMed:7670472).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01625450E → D2 Publications1
Natural variantiVAR_01625551L → W2 Publications1
Natural variantiVAR_016257109A → G2 Publications1
Natural variantiVAR_066789167G → E in EDM1. 1 PublicationCorresponds to variant dbSNP:rs763887855Ensembl.1
Natural variantiVAR_016258224R → G2 Publications1
Natural variantiVAR_066790234P → S in PSACH. 1 PublicationCorresponds to variant dbSNP:rs557483957Ensembl.1
Natural variantiVAR_026239276P → R in EDM1. 2 Publications1
Natural variantiVAR_016261285R → P2 Publications1
Natural variantiVAR_066791290D → G in PSACH. 1 Publication1
Natural variantiVAR_007614290D → N in PSACH; mild form. 1
Natural variantiVAR_066792298S → L in EDM1; phenotypic features overlapping with mild PSACH. 1 Publication1
Natural variantiVAR_007615299G → R in PSACH. 1 Publication1
Natural variantiVAR_066793311A → D in EDM1. 1 Publication1
Natural variantiVAR_066794317D → G in EDM1; atypical form. 1 Publication1
Natural variantiVAR_066795326D → G in EDM1. 1 Publication1
Natural variantiVAR_066796326D → Y in PSACH. 1 Publication1
Natural variantiVAR_007616328C → R in PSACH; mild form. 2 PublicationsCorresponds to variant dbSNP:rs137852653EnsemblClinVar.1
Natural variantiVAR_066797341 – 342Missing in PSACH. 1 Publication2
Natural variantiVAR_007617342D → Y in EDM1; Fairbank type. 2 PublicationsCorresponds to variant dbSNP:rs137852652EnsemblClinVar.1
Natural variantiVAR_066798348C → F in EDM1. 1 Publication1
Natural variantiVAR_017102348C → R in PSACH. 1 PublicationCorresponds to variant dbSNP:rs137852656EnsemblClinVar.1
Natural variantiVAR_007618349D → V in PSACH; mild form. 1
Natural variantiVAR_066799350 – 372Missing in PSACH. 1 PublicationAdd BLAST23
Natural variantiVAR_007619361D → V in EDM1; Fairbank type. 1
Natural variantiVAR_007620361D → Y in EDM1; binds less calcium. 2 Publications1
Natural variantiVAR_007621367 – 368Missing in EDM1. 1 Publication2
Natural variantiVAR_007622371C → S in EDM1; Fairbank type. 2 Publications1
Natural variantiVAR_066800371C → Y in EDM1. 1 PublicationCorresponds to variant dbSNP:rs1057521130Ensembl.1
Natural variantiVAR_007623372Missing in PSACH. 1 Publication1
Natural variantiVAR_066801374D → N in EDM1. 1 Publication1
Natural variantiVAR_007624374Missing in PSACH; mild form. 1
Natural variantiVAR_066802376D → N in EDM1. 1 Publication1
Natural variantiVAR_066803378D → V in PSACH. 1 Publication1
Natural variantiVAR_046796381R → C. Corresponds to variant dbSNP:rs3179763Ensembl.1
Natural variantiVAR_066804385D → N in EDM1; atypical form. 1 Publication1
Natural variantiVAR_066805385D → Y in EDM1; atypical form. 1 Publication1
Natural variantiVAR_066806385Missing in EDM1. 1 Publication1
Natural variantiVAR_007625387C → G in PSACH; mild form. 1
Natural variantiVAR_066807387C → R in PSACH. 1 Publication1
Natural variantiVAR_007626391 – 394PNSD → V in PSACH. 1 Publication4
Natural variantiVAR_066808397D → H in EDM1. 1 Publication1
Natural variantiVAR_066809402 – 404GIG → VC in PSACH. 1 Publication3
Natural variantiVAR_066810404G → R in EDM1. 1 Publication1
Natural variantiVAR_007627408D → Y in EDM1. 1 Publication1
Natural variantiVAR_066811410C → Y in EDM1; phenotype overlapping with mild PSACH. 1 Publication1
Natural variantiVAR_066812415N → K in EDM1. 1 Publication1
Natural variantiVAR_026240420D → A in EDM1. 1 Publication1
Natural variantiVAR_066813427G → E in EDM1. 1 Publication1
Natural variantiVAR_066814430 – 432CDS → LWC in EDM1. 1 Publication3
Natural variantiVAR_007628440G → E in PSACH; mild form. 1
Natural variantiVAR_007629440G → R in PSACH. 2 Publications1
Natural variantiVAR_066815446D → N in PSACH. 1 Publication1
Natural variantiVAR_066816448C → S in PSACH. 1 Publication1
Natural variantiVAR_007630453N → S in EDM1; Fairbank type. 1 PublicationCorresponds to variant dbSNP:rs28936668EnsemblClinVar.1
Natural variantiVAR_066817457Missing in EDM1. 1 Publication1
Natural variantiVAR_007631459Missing in PSACH; severe form. 2 Publications1
Natural variantiVAR_007632468C → Y in PSACH; severe form. 2 PublicationsCorresponds to variant dbSNP:rs137852651EnsemblClinVar.1
Natural variantiVAR_007633469Missing in PSACH; severe form; MUT3 mutant; most common mutation; binds less calcium and causes misfolding of the protein; greatly reduced interaction with ACAN; reduced interaction with collagen. 3 Publications1
Natural variantiVAR_007634472D → Y in PSACH; severe form. 2 PublicationsCorresponds to variant dbSNP:rs137852650EnsemblClinVar.1
Natural variantiVAR_066818473D → DD in EDM1. 1 Publication1
Natural variantiVAR_007635473D → G in PSACH; severe form. Corresponds to variant dbSNP:rs28936669EnsemblClinVar.1
Natural variantiVAR_066819473D → H in PSACH. 1 Publication1
Natural variantiVAR_007636473Missing in PSACH; severe form. 1 Publication1
Natural variantiVAR_066820475D → N in PSACH. 1 Publication1
Natural variantiVAR_007637482D → G in PSACH. 2 Publications1
Natural variantiVAR_066821501G → D in EDM1. 1 Publication1
Natural variantiVAR_066822507D → G in PSACH. 1 Publication1
Natural variantiVAR_066823511D → G in PSACH. 1 Publication1
Natural variantiVAR_007638513 – 516Missing in PSACH; mild form. 1 Publication4
Natural variantiVAR_066824515D → G in PSACH. 1 Publication1
Natural variantiVAR_007639518D → N in PSACH; mild form. 1
Natural variantiVAR_007640523N → K in EDM1; Ribbing type. 2 PublicationsCorresponds to variant dbSNP:rs137852654EnsemblClinVar.1
Natural variantiVAR_066825529T → I in PSACH. 1 PublicationCorresponds to variant dbSNP:rs312262903EnsemblClinVar.1
Natural variantiVAR_007641585T → M in PSACH; mild form and EDM1. 2 PublicationsCorresponds to variant dbSNP:rs312262900EnsemblClinVar.1
Natural variantiVAR_007642585T → R in EDM1 and PSACH. 2 PublicationsCorresponds to variant dbSNP:rs312262900EnsemblClinVar.1
Natural variantiVAR_066826718R → P in EDM1. 1 PublicationCorresponds to variant dbSNP:rs149551600EnsemblClinVar.1
Natural variantiVAR_066827718R → W in EDM1. 1 PublicationCorresponds to variant dbSNP:rs28936368EnsemblClinVar.1
Natural variantiVAR_017103719G → D in PSACH; severe. 1 PublicationCorresponds to variant dbSNP:rs137852655EnsemblClinVar.1
Natural variantiVAR_066828719G → S in PSACH. 1 PublicationCorresponds to variant dbSNP:rs312262904EnsemblClinVar.1
Natural variantiVAR_066829756Q → R in a patient with multiple epiphyseal dysplasia. 1 PublicationCorresponds to variant dbSNP:rs61752496EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055758129 – 181Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L32137 mRNA Translation: AAA57253.1
AB086984 mRNA Translation: BAC53888.1
AK296586 mRNA Translation: BAG59205.1
AC003107 Genomic DNA Translation: AAB86501.1 Sequence problems.
CH471106 Genomic DNA Translation: EAW84737.1
BC110847 mRNA Translation: AAI10848.1
BC125092 mRNA Translation: AAI25093.1
S79499 Genomic DNA Translation: AAB35269.1
S79500 Genomic DNA Translation: AAB35270.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12385.1 [P49747-1]

NCBI Reference Sequences

More...RefSeqi		NP_000086.2, NM_000095.2 [P49747-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.1584

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000222271; ENSP00000222271; ENSG00000105664 [P49747-1]
ENST00000425807; ENSP00000403792; ENSG00000105664 [P49747-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1311

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1311

UCSC genome browser

More...UCSCi		uc002nke.4 human [P49747-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32137 mRNA Translation: AAA57253.1
AB086984 mRNA Translation: BAC53888.1
AK296586 mRNA Translation: BAG59205.1
AC003107 Genomic DNA Translation: AAB86501.1 Sequence problems.
CH471106 Genomic DNA Translation: EAW84737.1
BC110847 mRNA Translation: AAI10848.1
BC125092 mRNA Translation: AAI25093.1
S79499 Genomic DNA Translation: AAB35269.1
S79500 Genomic DNA Translation: AAB35270.1
CCDSiCCDS12385.1 [P49747-1]
RefSeqiNP_000086.2, NM_000095.2 [P49747-1]
UniGeneiHs.1584

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FBYX-ray3.15A/B/C225-757[»]
ProteinModelPortaliP49747
SMRiP49747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107706, 2 interactors
ComplexPortaliCPX-1791 Thrombospondin 5 complex
IntActiP49747, 12 interactors
STRINGi9606.ENSP00000222271

Chemistry databases

DrugBankiDB01373 Calcium

PTM databases

GlyConnecti1076
iPTMnetiP49747
PhosphoSitePlusiP49747

Polymorphism and mutation databases

BioMutaiCOMP
DMDMi209572601

Proteomic databases

PaxDbiP49747
PeptideAtlasiP49747
PRIDEiP49747
ProteomicsDBi56060

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1311
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222271; ENSP00000222271; ENSG00000105664 [P49747-1]
ENST00000425807; ENSP00000403792; ENSG00000105664 [P49747-2]
GeneIDi1311
KEGGihsa:1311
UCSCiuc002nke.4 human [P49747-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1311
DisGeNETi1311
EuPathDBiHostDB:ENSG00000105664.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		COMP
GeneReviewsiCOMP

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0014925
HGNCiHGNC:2227 COMP
HPAiHPA077555
MalaCardsiCOMP
MIMi132400 phenotype
177170 phenotype
600310 gene
neXtProtiNX_P49747
OpenTargetsiENSG00000105664
Orphaneti93308 Multiple epiphyseal dysplasia type 1
750 Pseudoachondroplasia
PharmGKBiPA26744

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00940000162169
HOGENOMiHOG000007542
HOVERGENiHBG000636
InParanoidiP49747
KOiK04659
OMAiAQQDSDH
OrthoDBiEOG091G00TV
PhylomeDBiP49747
TreeFamiTF324917

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COMP human
EvolutionaryTraceiP49747