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Protein

Thrombospondin-3

Gene

THBS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • heparin binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-186797 Signaling by PDGF

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-3
Gene namesi
Name:THBS3
Synonyms:TSP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169231.13
HGNCiHGNC:11787 THBS3
MIMi188062 gene
neXtProtiNX_P49746

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7059
OpenTargetsiENSG00000169231
PharmGKBiPA36499

Polymorphism and mutation databases

BioMutaiTHBS3
DMDMi1717814

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003584923 – 956Thrombospondin-3Add BLAST934

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi266InterchainCurated
Disulfide bondi269InterchainCurated
Disulfide bondi278 ↔ 289PROSITE-ProRule annotation
Disulfide bondi283 ↔ 300PROSITE-ProRule annotation
Disulfide bondi303 ↔ 314PROSITE-ProRule annotation
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi320 ↔ 332PROSITE-ProRule annotation
Disulfide bondi326 ↔ 341PROSITE-ProRule annotation
Disulfide bondi344 ↔ 368PROSITE-ProRule annotation
Disulfide bondi374 ↔ 388PROSITE-ProRule annotation
Disulfide bondi382 ↔ 397PROSITE-ProRule annotation
Disulfide bondi400 ↔ 412PROSITE-ProRule annotation
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi418 ↔ 432PROSITE-ProRule annotation
Disulfide bondi426 ↔ 442PROSITE-ProRule annotation
Disulfide bondi444 ↔ 455PROSITE-ProRule annotation
Disulfide bondi471 ↔ 478PROSITE-ProRule annotation
Disulfide bondi483 ↔ 503PROSITE-ProRule annotation
Disulfide bondi519 ↔ 539PROSITE-ProRule annotation
Disulfide bondi542 ↔ 562PROSITE-ProRule annotation
Disulfide bondi578 ↔ 598PROSITE-ProRule annotation
Disulfide bondi601 ↔ 621PROSITE-ProRule annotation
Disulfide bondi639 ↔ 659PROSITE-ProRule annotation
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi679 ↔ 699PROSITE-ProRule annotation
Disulfide bondi715 ↔ 936PROSITE-ProRule annotation
Glycosylationi937N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP49746
PaxDbiP49746
PeptideAtlasiP49746
PRIDEiP49746
ProteomicsDBi56059

PTM databases

iPTMnetiP49746
PhosphoSitePlusiP49746

Expressioni

Gene expression databases

BgeeiENSG00000169231
CleanExiHS_THBS3
ExpressionAtlasiP49746 baseline and differential
GenevisibleiP49746 HS

Organism-specific databases

HPAiHPA006293
HPA073242

Interactioni

Subunit structurei

Oligomer; disulfide-linked.

Protein-protein interaction databases

BioGridi112917, 72 interactors
ComplexPortaliCPX-1789 Thrombospondin 3 complex
STRINGi9606.ENSP00000357362

Structurei

3D structure databases

ProteinModelPortaliP49746
SMRiP49746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 193Laminin G-likeAdd BLAST171
Domaini316 – 354EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini370 – 410EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini414 – 456EGF-like 3PROSITE-ProRule annotationAdd BLAST43
Repeati457 – 491TSP type-3 1Add BLAST35
Repeati492 – 527TSP type-3 2Add BLAST36
Repeati528 – 550TSP type-3 3Add BLAST23
Repeati551 – 586TSP type-3 4Add BLAST36
Repeati587 – 609TSP type-3 5Add BLAST23
Repeati610 – 647TSP type-3 6Add BLAST38
Repeati648 – 687TSP type-3 7Add BLAST40
Repeati688 – 723TSP type-3 8Add BLAST36
Domaini727 – 941TSP C-terminalPROSITE-ProRule annotationAdd BLAST215

Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00850000132273
HOGENOMiHOG000007542
HOVERGENiHBG000636
InParanoidiP49746
KOiK04659
OMAiCNDGNNG
OrthoDBiEOG091G00TV
PhylomeDBiP49746
TreeFamiTF324917

Family and domain databases

Gene3Di4.10.1080.10, 3 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G
IPR024665 Thbs/COMP_coiled-coil
IPR037349 Thrombospondin
IPR028507 Thrombospondin-3
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR028974 TSP_type-3_rpt
PANTHERiPTHR10199 PTHR10199, 1 hit
PTHR10199:SF89 PTHR10199:SF89, 1 hit
PfamiView protein in Pfam
PF11598 COMP, 1 hit
PF07645 EGF_CA, 2 hits
PF02412 TSP_3, 6 hits
PF05735 TSP_C, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 2 hits
SM00210 TSPN, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 2 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQELRGAL ALLLLCFFTS ASQDLQVIDL LTVGESRQMV AVAEKIRTAL
60 70 80 90 100
LTAGDIYLLS TFRLPPKQGG VLFGLYSRQD NTRWLEASVV GKINKVLVRY
110 120 130 140 150
QREDGKVHAV NLQQAGLADG RTHTVLLRLR GPSRPSPALH LYVDCKLGDQ
160 170 180 190 200
HAGLPALAPI PPAEVDGLEI RTGQKAYLRM QGFVESMKII LGGSMARVGA
210 220 230 240 250
LSECPFQGDE SIHSAVTNAL HSILGEQTKA LVTQLTLFNQ ILVELRDDIR
260 270 280 290 300
DQVKEMSLIR NTIMECQVCG FHEQRSHCSP NPCFRGVDCM EVYEYPGYRC
310 320 330 340 350
GPCPPGLQGN GTHCSDINEC AHADPCFPGS SCINTMPGFH CEACPRGYKG
360 370 380 390 400
TQVSGVGIDY ARASKQVCND IDECNDGNNG GCDPNSICTN TVGSFKCGPC
410 420 430 440 450
RLGFLGNQSQ GCLPARTCHS PAHSPCHIHA HCLFERNGAV SCQCNVGWAG
460 470 480 490 500
NGNVCGTDTD IDGYPDQALP CMDNNKHCKQ DNCLLTPNSG QEDADNDGVG
510 520 530 540 550
DQCDDDADGD GIKNVEDNCR LFPNKDQQNS DTDSFGDACD NCPNVPNNDQ
560 570 580 590 600
KDTDGNGEGD ACDNDVDGDG IPNGLDNCPK VPNPLQTDRD EDGVGDACDS
610 620 630 640 650
CPEMSNPTQT DADSDLVGDV CDTNEDSDGD GHQDTKDNCP QLPNSSQLDS
660 670 680 690 700
DNDGLGDECD GDDDNDGIPD YVPPGPDNCR LVPNPNQKDS DGNGVGDVCE
710 720 730 740 750
DDFDNDAVVD PLDVCPESAE VTLTDFRAYQ TVVLDPEGDA QIDPNWVVLN
760 770 780 790 800
QGMEIVQTMN SDPGLAVGYT AFNGVDFEGT FHVNTVTDDD YAGFLFSYQD
810 820 830 840 850
SGRFYVVMWK QTEQTYWQAT PFRAVAQPGL QLKAVTSVSG PGEHLRNALW
860 870 880 890 900
HTGHTPDQVR LLWTDPRNVG WRDKTSYRWQ LLHRPQVGYI RVKLYEGPQL
910 920 930 940 950
VADSGVIIDT SMRGGRLGVF CFSQENIIWS NLQYRCNDTV PEDFEPFRRQ

LLQGRV
Length:956
Mass (Da):104,201
Last modified:October 1, 1996 - v1
Checksum:iAE9B136DF0FFE5B8
GO
Isoform 2 (identifier: P49746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-215: Missing.

Show »
Length:836
Mass (Da):91,297
Checksum:i8D7AA90E4B21CA96
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052658279S → G. Corresponds to variant dbSNP:rs35154152Ensembl.1
Natural variantiVAR_035808955R → G in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04532896 – 215Missing in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38969 mRNA Translation: AAC41762.1
AL713999 Genomic DNA No translation available.
AF023268 Genomic DNA Translation: AAC51818.1
AK298592 mRNA Translation: BAG60782.1
CH471121 Genomic DNA Translation: EAW53110.1
BC018786 mRNA Translation: AAH18786.1
CCDSiCCDS1099.1 [P49746-1]
CCDS58034.1 [P49746-2]
PIRiA57121
RefSeqiNP_001239536.1, NM_001252607.1
NP_001239537.1, NM_001252608.1 [P49746-2]
NP_009043.1, NM_007112.4 [P49746-1]
UniGeneiHs.169875
Hs.658188

Genome annotation databases

EnsembliENST00000368378; ENSP00000357362; ENSG00000169231 [P49746-1]
ENST00000457183; ENSP00000392207; ENSG00000169231 [P49746-2]
GeneIDi7059
KEGGihsa:7059
UCSCiuc001fix.4 human [P49746-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSP3_HUMAN
AccessioniPrimary (citable) accession number: P49746
Secondary accession number(s): B1AVR8, B4DQ20, Q8WV34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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