UniProtKB - P49722 (PSA2_MOUSE)
Proteasome subunit alpha type-2
Psma2
Functioni
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
GO - Biological processi
- proteasomal protein catabolic process Source: GO_Central
- proteasomal ubiquitin-independent protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-202424, Downstream TCR signaling R-MMU-2467813, Separation of Sister Chromatids R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-382556, ABC-family proteins mediated transport R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689880, Ub-specific processing proteases R-MMU-6798695, Neutrophil degranulation R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69481, G2/M Checkpoints R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-9020702, Interleukin-1 signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Protein family/group databases
MEROPSi | T01.972 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit alpha type-2Alternative name(s): Macropain subunit C3 Multicatalytic endopeptidase complex subunit C3 Proteasome component C3 |
Gene namesi | Name:Psma2 Synonyms:Lmpc3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104885, Psma2 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- P-body Source: UniProtKB
- proteasome complex Source: MGI
- proteasome core complex Source: UniProtKB
- proteasome core complex, alpha-subunit complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000124078 | 2 – 234 | Proteasome subunit alpha type-2Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 6 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 14 | PhosphoserineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineBy similarity | 1 | |
Modified residuei | 24 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 70 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 76 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 121 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 171 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3940 |
EPDi | P49722 |
jPOSTi | P49722 |
PaxDbi | P49722 |
PeptideAtlasi | P49722 |
PRIDEi | P49722 |
TopDownProteomicsi | P49722 |
2D gel databases
COMPLUYEAST-2DPAGEi | P49722 |
REPRODUCTION-2DPAGEi | P49722 |
SWISS-2DPAGEi | P49722 |
PTM databases
iPTMneti | P49722 |
PhosphoSitePlusi | P49722 |
SwissPalmi | P49722 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000015671, Expressed in oocyte and 303 other tissues |
Genevisiblei | P49722, MM |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 202416, 62 interactors |
CORUMi | P49722 |
IntActi | P49722, 9 interactors |
MINTi | P49722 |
STRINGi | 10090.ENSMUSP00000129767 |
Miscellaneous databases
RNActi | P49722, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P49722 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0181, Eukaryota |
GeneTreei | ENSGT00550000074870 |
HOGENOMi | CLU_035750_4_1_1 |
InParanoidi | P49722 |
OMAi | CVYSGMG |
OrthoDBi | 1222564at2759 |
TreeFami | TF106207 |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR023332, Proteasome_alpha-type IPR000426, Proteasome_asu_N IPR001353, Proteasome_sua/b IPR034644, Proteasome_subunit_alpha2 |
PANTHERi | PTHR11599:SF16, PTHR11599:SF16, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit PF10584, Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948, Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388, PROTEASOME_ALPHA_1, 1 hit PS51475, PROTEASOME_ALPHA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAERGYSFSL TTFSPSGKLV QIEYALAAVA GGAPSVGIKA ANGVVLATEK
60 70 80 90 100
KQKSILYDER SVHKVEPITK HIGLVYSGMG PDYRVLVHRA RKLAQQYYLV
110 120 130 140 150
YQEPIPTAQL VQRVASVMQE YTQSGGVRPF GVSLLICGWN EGRPYLFQSD
160 170 180 190 200
PSGAYFAWKA TAMGKNYVNG KTFLEKRYNE DLELEDAIHT AILTLKESFE
210 220 230
GQMTEDNIEV GICNEAGFRR LTPTEVRDYL AAIA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8BKE0 | Q8BKE0_MOUSE | Proteasome subunit alpha type-2 | Psma2 | 183 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | E → K in CAA49782 (PubMed:7697131).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70303 mRNA Translation: CAA49782.1 AF099733 mRNA Translation: AAD50623.1 AK012119 mRNA Translation: BAB28045.1 AK035578 mRNA Translation: BAC29110.1 AK151883 mRNA Translation: BAE30769.1 AK152862 mRNA Translation: BAE31553.1 AK154011 mRNA Translation: BAE32314.1 AK167752 mRNA Translation: BAE39787.1 AC092710 Genomic DNA No translation available. CH466561 Genomic DNA Translation: EDL32738.1 BC026768 mRNA Translation: AAH26768.1 |
CCDSi | CCDS36602.1 |
RefSeqi | NP_032970.2, NM_008944.2 |
Genome annotation databases
Ensembli | ENSMUST00000170836; ENSMUSP00000129767; ENSMUSG00000015671 |
GeneIDi | 19166 |
KEGGi | mmu:19166 |
UCSCi | uc007pnl.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70303 mRNA Translation: CAA49782.1 AF099733 mRNA Translation: AAD50623.1 AK012119 mRNA Translation: BAB28045.1 AK035578 mRNA Translation: BAC29110.1 AK151883 mRNA Translation: BAE30769.1 AK152862 mRNA Translation: BAE31553.1 AK154011 mRNA Translation: BAE32314.1 AK167752 mRNA Translation: BAE39787.1 AC092710 Genomic DNA No translation available. CH466561 Genomic DNA Translation: EDL32738.1 BC026768 mRNA Translation: AAH26768.1 |
CCDSi | CCDS36602.1 |
RefSeqi | NP_032970.2, NM_008944.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3UNB | X-ray | 2.90 | A/O/c/q | 1-234 | [»] | |
3UNE | X-ray | 3.20 | A/O/c/q | 1-234 | [»] | |
3UNF | X-ray | 2.90 | A/O | 1-234 | [»] | |
3UNH | X-ray | 3.20 | A/O | 1-234 | [»] | |
SMRi | P49722 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 202416, 62 interactors |
CORUMi | P49722 |
IntActi | P49722, 9 interactors |
MINTi | P49722 |
STRINGi | 10090.ENSMUSP00000129767 |
Protein family/group databases
MEROPSi | T01.972 |
PTM databases
iPTMneti | P49722 |
PhosphoSitePlusi | P49722 |
SwissPalmi | P49722 |
2D gel databases
COMPLUYEAST-2DPAGEi | P49722 |
REPRODUCTION-2DPAGEi | P49722 |
SWISS-2DPAGEi | P49722 |
Proteomic databases
CPTACi | non-CPTAC-3940 |
EPDi | P49722 |
jPOSTi | P49722 |
PaxDbi | P49722 |
PeptideAtlasi | P49722 |
PRIDEi | P49722 |
TopDownProteomicsi | P49722 |
Genome annotation databases
Ensembli | ENSMUST00000170836; ENSMUSP00000129767; ENSMUSG00000015671 |
GeneIDi | 19166 |
KEGGi | mmu:19166 |
UCSCi | uc007pnl.1, mouse |
Organism-specific databases
CTDi | 5683 |
MGIi | MGI:104885, Psma2 |
Phylogenomic databases
eggNOGi | KOG0181, Eukaryota |
GeneTreei | ENSGT00550000074870 |
HOGENOMi | CLU_035750_4_1_1 |
InParanoidi | P49722 |
OMAi | CVYSGMG |
OrthoDBi | 1222564at2759 |
TreeFami | TF106207 |
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-202424, Downstream TCR signaling R-MMU-2467813, Separation of Sister Chromatids R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-382556, ABC-family proteins mediated transport R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689880, Ub-specific processing proteases R-MMU-6798695, Neutrophil degranulation R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69481, G2/M Checkpoints R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-9020702, Interleukin-1 signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 19166, 9 hits in 18 CRISPR screens |
ChiTaRSi | Psma2, mouse |
PROi | PR:P49722 |
RNActi | P49722, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015671, Expressed in oocyte and 303 other tissues |
Genevisiblei | P49722, MM |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR023332, Proteasome_alpha-type IPR000426, Proteasome_asu_N IPR001353, Proteasome_sua/b IPR034644, Proteasome_subunit_alpha2 |
PANTHERi | PTHR11599:SF16, PTHR11599:SF16, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit PF10584, Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948, Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388, PROTEASOME_ALPHA_1, 1 hit PS51475, PROTEASOME_ALPHA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSA2_MOUSE | |
Accessioni | P49722Primary (citable) accession number: P49722 Secondary accession number(s): E9Q3A4, Q6ZWV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 31, 2012 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families