UniProtKB - P49716 (CEBPD_HUMAN)
Protein
CCAAT/enhancer-binding protein delta
Gene
CEBPD
Organism
Homo sapiens (Human)
Status
Functioni
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).1 Publication
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cytokine-mediated signaling pathway Source: Reactome
- regulation of cell differentiation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: ProtInc
- viral life cycle Source: Reactome
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P49716 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9610379, HCMV Late Events |
SignaLinki | P49716 |
SIGNORi | P49716 |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein deltaShort name: C/EBP delta Alternative name(s): Nuclear factor NF-IL6-beta1 Publication Short name: NF-IL6-beta1 Publication |
Gene namesi | Name:CEBPD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1835, CEBPD |
MIMi | 116898, gene |
neXtProti | NX_P49716 |
VEuPathDBi | HostDB:ENSG00000221869.4 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: Reactome
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 120 | K → A: Loss of sumoylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1052 |
OpenTargetsi | ENSG00000221869 |
PharmGKBi | PA26378 |
Miscellaneous databases
Pharosi | P49716, Tbio |
Genetic variation databases
BioMutai | CEBPD |
DMDMi | 160332350 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000076621 | 2 – 269 | CCAAT/enhancer-binding protein deltaAdd BLAST | 268 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Cross-linki | 120 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P49716 |
jPOSTi | P49716 |
MassIVEi | P49716 |
MaxQBi | P49716 |
PaxDbi | P49716 |
PeptideAtlasi | P49716 |
PRIDEi | P49716 |
ProteomicsDBi | 56055 |
PTM databases
iPTMneti | P49716 |
PhosphoSitePlusi | P49716 |
Expressioni
Gene expression databases
Bgeei | ENSG00000221869, Expressed in female gonad and 249 other tissues |
Genevisiblei | P49716, HS |
Organism-specific databases
HPAi | ENSG00000221869, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP49716
Protein-protein interaction databases
BioGRIDi | 107481, 39 interactors |
DIPi | DIP-146N |
ELMi | P49716 |
IntActi | P49716, 26 interactors |
MINTi | P49716 |
STRINGi | 9606.ENSP00000386165 |
Miscellaneous databases
RNActi | P49716, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 191 – 254 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 195 – 222 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 226 – 254 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000163032 |
HOGENOMi | CLU_043327_2_1_1 |
InParanoidi | P49716 |
OMAi | LKREPDW |
OrthoDBi | 1284308at2759 |
PhylomeDBi | P49716 |
TreeFami | TF105008 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P49716-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL
110 120 130 140 150
LPGGPARPLG PGPAAPRLLK REPDWGDGDA PGSLLPAQVA ACAQTVVSLA
160 170 180 190 200
AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK SAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLAGLRQF
260
FKQLPSPPFL PAAGTADCR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | S → T in AAA59927 (PubMed:1741402).Curated | 1 | |
Sequence conflicti | 13 | R → G in AAA59927 (PubMed:1741402).Curated | 1 | |
Sequence conflicti | 140 – 141 | AA → GP in AAA59927 (PubMed:1741402).Curated | 2 | |
Sequence conflicti | 140 – 141 | AA → GP in AAB27293 (PubMed:8314590).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037087 | 248 | R → W. Corresponds to variant dbSNP:rs34948549Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83667 mRNA Translation: AAA59927.1 S63168 Genomic DNA Translation: AAB27293.1 CH471068 Genomic DNA Translation: EAW86679.1 BC105109 mRNA Translation: AAI05110.1 |
CCDSi | CCDS6142.1 |
PIRi | A47008 |
RefSeqi | NP_005186.2, NM_005195.3 |
Genome annotation databases
Ensembli | ENST00000408965; ENSP00000386165; ENSG00000221869 |
GeneIDi | 1052 |
KEGGi | hsa:1052 |
UCSCi | uc003xqh.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83667 mRNA Translation: AAA59927.1 S63168 Genomic DNA Translation: AAB27293.1 CH471068 Genomic DNA Translation: EAW86679.1 BC105109 mRNA Translation: AAI05110.1 |
CCDSi | CCDS6142.1 |
PIRi | A47008 |
RefSeqi | NP_005186.2, NM_005195.3 |
3D structure databases
SMRi | P49716 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107481, 39 interactors |
DIPi | DIP-146N |
ELMi | P49716 |
IntActi | P49716, 26 interactors |
MINTi | P49716 |
STRINGi | 9606.ENSP00000386165 |
PTM databases
iPTMneti | P49716 |
PhosphoSitePlusi | P49716 |
Genetic variation databases
BioMutai | CEBPD |
DMDMi | 160332350 |
Proteomic databases
EPDi | P49716 |
jPOSTi | P49716 |
MassIVEi | P49716 |
MaxQBi | P49716 |
PaxDbi | P49716 |
PeptideAtlasi | P49716 |
PRIDEi | P49716 |
ProteomicsDBi | 56055 |
Protocols and materials databases
Antibodypediai | 24255, 256 antibodies |
DNASUi | 1052 |
Genome annotation databases
Ensembli | ENST00000408965; ENSP00000386165; ENSG00000221869 |
GeneIDi | 1052 |
KEGGi | hsa:1052 |
UCSCi | uc003xqh.2, human |
Organism-specific databases
CTDi | 1052 |
DisGeNETi | 1052 |
GeneCardsi | CEBPD |
HGNCi | HGNC:1835, CEBPD |
HPAi | ENSG00000221869, Low tissue specificity |
MIMi | 116898, gene |
neXtProti | NX_P49716 |
OpenTargetsi | ENSG00000221869 |
PharmGKBi | PA26378 |
VEuPathDBi | HostDB:ENSG00000221869.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000163032 |
HOGENOMi | CLU_043327_2_1_1 |
InParanoidi | P49716 |
OMAi | LKREPDW |
OrthoDBi | 1284308at2759 |
PhylomeDBi | P49716 |
TreeFami | TF105008 |
Enzyme and pathway databases
PathwayCommonsi | P49716 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9610379, HCMV Late Events |
SignaLinki | P49716 |
SIGNORi | P49716 |
Miscellaneous databases
BioGRID-ORCSi | 1052, 20 hits in 1017 CRISPR screens |
ChiTaRSi | CEBPD, human |
GeneWikii | CEBPD |
GenomeRNAii | 1052 |
Pharosi | P49716, Tbio |
PROi | PR:P49716 |
RNActi | P49716, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000221869, Expressed in female gonad and 249 other tissues |
Genevisiblei | P49716, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPD_HUMAN | |
Accessioni | P49716Primary (citable) accession number: P49716 Secondary accession number(s): Q14937, Q2M2X9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 13, 2007 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families