CEBPD

Functionⁱ

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).1 Publication

GO - Molecular functionⁱ

RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytokine-mediated signaling pathway Source: Reactome
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8314590

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P49716
SIGNORⁱ	P49716

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CCAAT/enhancer-binding protein delta Short name: C/EBP delta Alternative name(s): Nuclear factor NF-IL6-beta1 Publication Short name: NF-IL6-beta1 Publication
Gene namesⁱ	Name:CEBPD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000221869.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1835 CEBPD
MIMⁱ	116898 gene
neXtProtⁱ	NX_P49716

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	120	K → A: Loss of sumoylation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1052
Open Targets More...OpenTargetsⁱ	ENSG00000221869
PharmGKBⁱ	PA26378

Polymorphism and mutation databases

BioMutaⁱ	CEBPD
DMDMⁱ	160332350

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000076621	2 – 269	CCAAT/enhancer-binding protein deltaAdd BLAST		268

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1
Cross-linkⁱ	120	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P49716
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P49716
PaxDbⁱ	P49716
PeptideAtlas More...PeptideAtlasⁱ	P49716
PRIDEⁱ	P49716
ProteomicsDBⁱ	56055

PTM databases

iPTMnetⁱ	P49716
PhosphoSitePlusⁱ	P49716

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000221869 Expressed in 238 organ(s), highest expression level in female gonad
CleanExⁱ	HS_CEBPD
Genevisibleⁱ	P49716 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067581

HPAⁱ

HPA067581

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ATF4	P18848	2	EBI-7962058,EBI-492498
CEBPA	P49715	2	EBI-7962058,EBI-1172054
CEBPG	P53567	2	EBI-7962058,EBI-740209
DDIT3	P35638	2	EBI-7962058,EBI-742651
FANCD2	Q9BXW9	8	EBI-7962058,EBI-359343
IPO4	Q8TEX9	5	EBI-7962058,EBI-395967

Protein-protein interaction databases

BioGridⁱ	107481, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-146N
ELMⁱ	P49716
IntActⁱ	P49716, 14 interactors
Molecular INTeraction database More...MINTⁱ	P49716
STRINGⁱ	9606.ENSP00000386165

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P49716
SMRⁱ	P49716
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	191 – 254	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	195 – 222	Basic motifPROSITE-ProRule annotationAdd BLAST		28
Regionⁱ	226 – 254	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410ISXU Eukaryota ENOG4111S4B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063192
HOGENOMⁱ	HOG000013112
HOVERGENⁱ	HBG050879
InParanoidⁱ	P49716
KEGG Orthology (KO) More...KOⁱ	K10050
OMAⁱ	VPNLELC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11FC
PhylomeDBⁱ	P49716
TreeFamⁱ	TF105008

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016468 C/EBP_chordates
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
PIRSFⁱ	PIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P49716-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP 
        60         70         80         90        100
AMYDDESAID FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL 
       110        120        130        140        150
LPGGPARPLG PGPAAPRLLK REPDWGDGDA PGSLLPAQVA ACAQTVVSLA 
       160        170        180        190        200
AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK SAGKRGPDRG SPEYRQRRER 
       210        220        230        240        250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLAGLRQF 
       260 
FKQLPSPPFL PAAGTADCR

Length:269

Mass (Da):28,467

Last modified:November 13, 2007 - v2

Checksum:ⁱAFDE9E2244BDF84A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	S → T in AAA59927 (PubMed:1741402).Curated	1
Sequence conflictⁱ	13	R → G in AAA59927 (PubMed:1741402).Curated	1
Sequence conflictⁱ	140 – 141	AA → GP in AAA59927 (PubMed:1741402).Curated	2
Sequence conflictⁱ	140 – 141	AA → GP in AAB27293 (PubMed:8314590).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_037087	248	R → W. Corresponds to variant dbSNP:rs34948549Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83667 mRNA Translation: AAA59927.1 S63168 Genomic DNA Translation: AAB27293.1 CH471068 Genomic DNA Translation: EAW86679.1 BC105109 mRNA Translation: AAI05110.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6142.1
PIRⁱ	A47008
NCBI Reference Sequences More...RefSeqⁱ	NP_005186.2, NM_005195.3
UniGeneⁱ	Hs.440829

Genome annotation databases

Ensemblⁱ	ENST00000408965; ENSP00000386165; ENSG00000221869
GeneIDⁱ	1052
KEGGⁱ	hsa:1052
UCSC genome browser More...UCSCⁱ	uc003xqh.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49716	Uncharacterized protein (Fragment)		MACMU		74	UniRef100_P49716

Protein	Similar proteins		Species	Score	Length	Source
P49716	Uncharacterized protein (Fragment)		MACMU		74	UniRef90_P49716
CCAAT/enhancer-binding protein delta		CASCN		272
CCAAT/enhancer binding protein delta		CASFI		272
CCAAT/enhancer-binding protein delta		HETGA		270
Uncharacterized protein		MACNE		269
+21

Protein	Similar proteins		Species	Score	Length	Source
P49716	Uncharacterized protein (Fragment)		MACMU		74	UniRef50_P49716
CCAAT/enhancer binding protein delta		CASFI		272
CCAAT/enhancer-binding protein delta		CASCN		272
CCAAT/enhancer-binding protein delta		HETGA		270
Uncharacterized protein		MACNE		269
+86

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83667 mRNA Translation: AAA59927.1 S63168 Genomic DNA Translation: AAB27293.1 CH471068 Genomic DNA Translation: EAW86679.1 BC105109 mRNA Translation: AAI05110.1
CCDSⁱ	CCDS6142.1
PIRⁱ	A47008
RefSeqⁱ	NP_005186.2, NM_005195.3
UniGeneⁱ	Hs.440829

3D structure databases

ProteinModelPortalⁱ	P49716
SMRⁱ	P49716
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107481, 23 interactors
DIPⁱ	DIP-146N
ELMⁱ	P49716
IntActⁱ	P49716, 14 interactors
MINTⁱ	P49716
STRINGⁱ	9606.ENSP00000386165

PTM databases

iPTMnetⁱ	P49716
PhosphoSitePlusⁱ	P49716

Polymorphism and mutation databases

BioMutaⁱ	CEBPD
DMDMⁱ	160332350

Proteomic databases

EPDⁱ	P49716
MaxQBⁱ	P49716
PaxDbⁱ	P49716
PeptideAtlasⁱ	P49716
PRIDEⁱ	P49716
ProteomicsDBⁱ	56055

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1052
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000408965; ENSP00000386165; ENSG00000221869
GeneIDⁱ	1052
KEGGⁱ	hsa:1052
UCSCⁱ	uc003xqh.2 human

Organism-specific databases

CTDⁱ	1052
DisGeNETⁱ	1052
EuPathDBⁱ	HostDB:ENSG00000221869.4
GeneCardsⁱ	CEBPD
HGNCⁱ	HGNC:1835 CEBPD
HPAⁱ	HPA067581
MIMⁱ	116898 gene
neXtProtⁱ	NX_P49716
OpenTargetsⁱ	ENSG00000221869
PharmGKBⁱ	PA26378
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ISXU Eukaryota ENOG4111S4B LUCA
GeneTreeⁱ	ENSGT00530000063192
HOGENOMⁱ	HOG000013112
HOVERGENⁱ	HBG050879
InParanoidⁱ	P49716
KOⁱ	K10050
OMAⁱ	VPNLELC
OrthoDBⁱ	EOG091G11FC
PhylomeDBⁱ	P49716
TreeFamⁱ	TF105008

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P49716
SIGNORⁱ	P49716

Miscellaneous databases

GeneWikiⁱ	CEBPD
GenomeRNAiⁱ	1052
Protein Ontology More...PROⁱ	PR:P49716
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000221869 Expressed in 238 organ(s), highest expression level in female gonad
CleanExⁱ	HS_CEBPD
Genevisibleⁱ	P49716 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016468 C/EBP_chordates
Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
PIRSFⁱ	PIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEBPD_HUMAN
Accessionⁱ	P49716Primary (citable) accession number: P49716 Secondary accession number(s): Q14937, Q2M2X9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 13, 2007
	Last modified:	September 12, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - P49716 (CEBPD_HUMAN)

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CCAAT/enhancer-binding protein delta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ