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Protein

CCAAT/enhancer-binding protein delta

Gene

CEBPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-6785807 Interleukin-4 and 13 signaling
SignaLinkiP49716
SIGNORiP49716

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein delta
Short name:
C/EBP delta
Alternative name(s):
Nuclear factor NF-IL6-beta1 Publication
Short name:
NF-IL6-beta1 Publication
Gene namesi
Name:CEBPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000221869.4
HGNCiHGNC:1835 CEBPD
MIMi116898 gene
neXtProtiNX_P49716

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi120K → A: Loss of sumoylation. 1 Publication1

Organism-specific databases

DisGeNETi1052
OpenTargetsiENSG00000221869
PharmGKBiPA26378

Polymorphism and mutation databases

BioMutaiCEBPD
DMDMi160332350

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000766212 – 269CCAAT/enhancer-binding protein deltaAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP49716
MaxQBiP49716
PaxDbiP49716
PeptideAtlasiP49716
PRIDEiP49716
ProteomicsDBi56055

PTM databases

iPTMnetiP49716
PhosphoSitePlusiP49716

Expressioni

Gene expression databases

BgeeiENSG00000221869
CleanExiHS_CEBPD
GenevisibleiP49716 HS

Organism-specific databases

HPAiHPA067581

Interactioni

Subunit structurei

Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107481, 23 interactors
DIPiDIP-146N
ELMiP49716
IntActiP49716, 14 interactors
MINTiP49716
STRINGi9606.ENSP00000386165

Structurei

3D structure databases

ProteinModelPortaliP49716
SMRiP49716
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 254bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 222Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni226 – 254Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISXU Eukaryota
ENOG4111S4B LUCA
GeneTreeiENSGT00530000063192
HOGENOMiHOG000013112
HOVERGENiHBG050879
InParanoidiP49716
KOiK10050
OMAiVPNLELC
OrthoDBiEOG091G11FC
PhylomeDBiP49716
TreeFamiTF105008

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016468 C/EBP_chordates
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
PIRSFiPIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL
110 120 130 140 150
LPGGPARPLG PGPAAPRLLK REPDWGDGDA PGSLLPAQVA ACAQTVVSLA
160 170 180 190 200
AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK SAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLAGLRQF
260
FKQLPSPPFL PAAGTADCR
Length:269
Mass (Da):28,467
Last modified:November 13, 2007 - v2
Checksum:iAFDE9E2244BDF84A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → T in AAA59927 (PubMed:1741402).Curated1
Sequence conflicti13R → G in AAA59927 (PubMed:1741402).Curated1
Sequence conflicti140 – 141AA → GP in AAA59927 (PubMed:1741402).Curated2
Sequence conflicti140 – 141AA → GP in AAB27293 (PubMed:8314590).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037087248R → W. Corresponds to variant dbSNP:rs34948549Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83667 mRNA Translation: AAA59927.1
S63168 Genomic DNA Translation: AAB27293.1
CH471068 Genomic DNA Translation: EAW86679.1
BC105109 mRNA Translation: AAI05110.1
CCDSiCCDS6142.1
PIRiA47008
RefSeqiNP_005186.2, NM_005195.3
UniGeneiHs.440829

Genome annotation databases

EnsembliENST00000408965; ENSP00000386165; ENSG00000221869
GeneIDi1052
KEGGihsa:1052
UCSCiuc003xqh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCEBPD_HUMAN
AccessioniPrimary (citable) accession number: P49716
Secondary accession number(s): Q14937, Q2M2X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 13, 2007
Last modified: June 20, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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