Hepatocyte nuclear factor 4-alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• arachidonic acid binding Source: MGI
• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules."
    Faure A.J., Schmidt D., Watt S., Schwalie P.C., Wilson M.D., Xu H., Ramsay R.G., Odom D.T., Flicek P.
    Genome Res 22:2163-2175(2012) [PubMed] [Europe PMC] [Abstract]
• cis-regulatory region sequence-specific DNA binding Source: MGI
• DNA binding Source: MGIInferred from direct assayⁱ
  • "The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element."
    Pare J.F., Malenfant D., Courtemanche C., Jacob-Wagner M., Roy S., Allard D., Belanger L.
    J Biol Chem 279:21206-21216(2004) [PubMed] [Europe PMC] [Abstract]
  • "Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver."
    Kamiya A., Inoue Y., Kodama T., Gonzalez F.J.
    FEBS Lett. 578:63-68(2004) [PubMed] [Europe PMC] [Abstract]
  • "Plasticity and expanding complexity of the hepatic transcription factor network during liver development."
    Kyrmizi I., Hatzis P., Katrakili N., Tronche F., Gonzalez F.J., Talianidis I.
    Genes Dev 20:2293-2305(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression."
    Liu Q., Yang M., Fu X., Liu R., Sun C., Pan H., Wong C.W., Guan M.
    Mol Cell Endocrinol 436:93-101(2016) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion."
    Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., Duncan S.A., Kaestner K.H.
    J Clin Invest 115:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine."
    Antes T.J., Goodart S.A., Huynh C., Sullivan M., Young S.G., Levy-Wilson B.
    J Biol Chem 275:26637-26648(2000) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor binding Source: MGI
• fatty acid binding Source: MGI
• fatty-acyl-CoA binding Source: MGI
• long-chain fatty acyl-CoA binding Source: MGI
• nuclear receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• palmitoyl-CoA hydrolase activity Source: MGI
• protein-containing complex binding Source: MGI
• protein homodimerization activity Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Anks4b, a novel target of HNF4alpha protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic beta-cells."
    Sato Y., Hatta M., Karim M.F., Sawa T., Wei F.Y., Sato S., Magnuson M.A., Gonzalez F.J., Tomizawa K., Akaike T., Yoshizawa T., Yamagata K.
    J. Biol. Chem. 287:23236-23245(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Cited2, a coactivator of HNF4alpha, is essential for liver development."
    Qu X., Lam E., Doughman Y.Q., Chen Y., Chou Y.T., Lam M., Turakhia M., Dunwoodie S.L., Watanabe M., Xu B., Duncan S.A., Yang Y.C.
    EMBO J 26:4445-4456(2007) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins."
    Ang S.-L., Wierda A., Wong D., Stevens K.A., Cascio S., Rossant J., Zaret K.S.
    Development 119:1301-1315(1993) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• signaling receptor binding Source: MGI
• stearic acid binding Source: MGI
• transcription cis-regulatory region binding Source: BHF-UCLInferred from direct assayⁱ
  • "The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion."
    Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., Duncan S.A., Kaestner K.H.
    J Clin Invest 115:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• acyl-CoA metabolic process Source: MGI
• anatomical structure development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• blood coagulation Source: MGI
• cell-cell junction organization Source: MGI
• cell differentiation Source: MGI
• cholesterol homeostasis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis."
    Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., Gonzalez F.J.
    Mol Cell Biol 21:1393-1403(2001) [PubMed] [Europe PMC] [Abstract]
• establishment of tissue polarity Source: MGI
• glucose homeostasis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion."
    Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., Duncan S.A., Kaestner K.H.
    J Clin Invest 115:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
• hepatocyte differentiation Source: InterPro
• lipid homeostasis Source: MGI
• lipid metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping."
    Briancon N., Weiss M.C.
    EMBO J 25:1253-1262(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of activation of Janus kinase activity Source: MGI
• negative regulation of cell growth Source: MGI
• negative regulation of cell migration Source: MGI
• negative regulation of cell population proliferation Source: MGI
• negative regulation of DNA-binding transcription factor activity Source: MGI
• negative regulation of mitotic cell cycle Source: MGI
• negative regulation of protein import into nucleus Source: MGI
• negative regulation of transcription, DNA-templated Source: UniProtKB
• negative regulation of tyrosine phosphorylation of STAT protein Source: MGI
• ornithine metabolic process Source: MGI
• phospholipid homeostasis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis."
    Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., Gonzalez F.J.
    Mol Cell Biol 21:1393-1403(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid biosynthetic process Source: MGI
• positive regulation of gluconeogenesis Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.13

    "Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity."
    Zhang T., Yu F., Guo L., Chen M., Yuan X., Wu B.
    Theranostics 8:5246-5258(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion."
    Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., Duncan S.A., Kaestner K.H.
    J Clin Invest 115:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian rhythm Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.12

    "Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks."
    Qu M., Duffy T., Hirota T., Kay S.A.
    Proc. Natl. Acad. Sci. U.S.A. 115:E12305-E12312(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of gastrulation Source: MGIInferred from mutant phenotypeⁱ
  • "Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos."
    Chen W.S., Manova K., Weinstein D.C., Duncan S.A., Plump A.S., Prezioso V.R., Bachvarova R.F., Darnell J.E. Jr.
    Genes Dev 8:2466-2477(1994) [PubMed] [Europe PMC] [Abstract]
• regulation of insulin secretion Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion."
    Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., Duncan S.A., Kaestner K.H.
    J Clin Invest 115:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of lipid metabolic process Source: MGI
• regulation of microvillus assembly Source: MGI
• regulation of transcription, DNA-templated Source: MGIInferred from mutant phenotypeⁱ
  • "Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos."
    Duncan S.A., Nagy A., Chan W.
    Development 124:279-287(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • "Anks4b, a novel target of HNF4alpha protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic beta-cells."
    Sato Y., Hatta M., Karim M.F., Sawa T., Wei F.Y., Sato S., Magnuson M.A., Gonzalez F.J., Tomizawa K., Akaike T., Yoshizawa T., Yamagata K.
    J. Biol. Chem. 287:23236-23245(2012) [PubMed] [Europe PMC] [Abstract]
• response to glucose Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion."
    Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., Duncan S.A., Kaestner K.H.
    J Clin Invest 115:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
• rhythmic process Source: UniProtKB-KW
• sex differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver."
    Laz E.V., Holloway M.G., Chen C.S., Waxman D.J.
    Endocrinology 148:3327-3337(2007) [PubMed] [Europe PMC] [Abstract]
• signal transduction involved in regulation of gene expression Source: MGIInferred from direct assayⁱ
  • "ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification."
    Lee D., Park C., Lee H., Lugus J.J., Kim S.H., Arentson E., Chung Y.S., Gomez G., Kyba M., Lin S., Janknecht R., Lim D.S., Choi K.
    Cell Stem Cell 2:497-507(2008) [PubMed] [Europe PMC] [Abstract]
• SMAD protein signal transduction Source: MGIInferred from direct assayⁱ
  • "The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo."
    Sirard C., de la Pompa J.L., Elia A., Itie A., Mirtsos C., Cheung A., Hahn S., Wakeham A., Schwartz L., Kern S.E., Rossant J., Mak T.W.
    Genes Dev 12:107-119(1998) [PubMed] [Europe PMC] [Abstract]
• triglyceride homeostasis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis."
    Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., Gonzalez F.J.
    Mol Cell Biol 21:1393-1403(2001) [PubMed] [Europe PMC] [Abstract]
• type B pancreatic cell development Source: InterPro
• xenobiotic metabolic process Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• DNA-binding transcription factor binding Source: MGI
• protein homodimerization activity Source: MGI
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Cited2, a coactivator of HNF4alpha, is essential for liver development."
    Qu X., Lam E., Doughman Y.Q., Chen Y., Chou Y.T., Lam M., Turakhia M., Dunwoodie S.L., Watanabe M., Xu B., Duncan S.A., Yang Y.C.
    EMBO J 26:4445-4456(2007) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MRLSKTLAGM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGANLNS 
        60         70         80         90        100
SNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR 
       110        120        130        140        150
QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP 
       160        170        180        190        200
SINALLQAEV LSQQITSPIS GINGDIRAKK IANITDVCES MKEQLLVLVE 
       210        220        230        240        250
WAKYIPAFCE LLLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI 
       260        270        280        290        300
VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYACLK AIIFFDPDAK 
       310        320        330        340        350
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ 
       360        370        380        390        400
MIEQIQFIKL FGMAKIDNLL QEMLLGGSAS DAPHTHHPLH PHLMQEHMGT 
       410        420        430        440        450
NVIVANTMPS HLSNGQMCEW PRPRGQAATP ETPQPSPPSG SGSESYKLLP 
       460        470 
GAITTIVKPP SAIPQPTITK QEAI                             

        10         20         30         40         50
MRLSKTLAGM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGANLNS 
        60         70         80         90        100
SNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR 
       110        120        130        140        150
QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP 
       160        170        180        190        200
SINALLQAEV LSQQITSPIS GINGDIRAKK IANITDVCES MKEQLLVLVE 
       210        220        230        240        250
WAKYIPAFCE LLLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI 
       260        270        280        290        300
VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYACLK AIIFFDPDAK 
       310        320        330        340        350
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ 
       360        370        380        390        400
MIEQIQFIKL FGMAKIDNLL QEMLLGGSAS DAPHTHHPLH PHLMQEHMGT 
       410        420        430        440        450
NVIVANTMPS HLSNGQMSTP ETPQPSPPSG SGSESYKLLP GAITTIVKPP 
       460 
SAIPQPTITK QEAI                                        

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families