Hnf4a

Functionⁱ

Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

Miscellaneous

Binds fatty acids.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	57 – 132	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	60 – 80	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	96 – 120	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

arachidonic acid binding Source: MGI
DNA binding
Source: MGI
Inferred from direct assayⁱ
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: MGI
Inferred from direct assayⁱ
- 22780989
DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15761495
fatty acid binding Source: MGI
fatty-acyl-CoA binding Source: MGI
long-chain fatty acyl-CoA binding Source: MGI
nuclear receptor activity Source: InterPro
palmitoyl-CoA hydrolase activity Source: MGI
protein homodimerization activity Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
proximal promoter sequence-specific DNA binding Source: MGI
repressing transcription factor binding Source: MGI
RNA polymerase II activating transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17932483
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 22589549
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 8306889
signaling receptor binding Source: MGI
stearic acid binding Source: MGI
steroid hormone receptor activity Source: InterPro
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: MGI
Inferred from direct assayⁱ
- 10859308
transcription factor binding Source: MGI
transcription regulatory region DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 15761495
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acyl-CoA metabolic process Source: MGI
blood coagulation Source: MGI
cell-cell junction organization Source: MGI
cell differentiation Source: MGI
cholesterol homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11158324
endocrine pancreas development Source: Reactome
establishment of tissue polarity Source: MGI
glucose homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15761495
hepatocyte differentiation Source: InterPro
lipid homeostasis Source: MGI
lipid metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16498401
negative regulation of activation of Janus kinase activity Source: MGI
negative regulation of cell growth Source: MGI
negative regulation of cell migration Source: MGI
negative regulation of cell proliferation Source: MGI
negative regulation of DNA-binding transcription factor activity Source: MGI
negative regulation of mitotic cell cycle Source: MGI
negative regulation of protein import into nucleus, translocation Source: MGI
negative regulation of tyrosine phosphorylation of STAT protein Source: MGI
ornithine metabolic process Source: MGI
phospholipid homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11158324
positive regulation of fatty acid biosynthetic process Source: MGI
positive regulation of gluconeogenesis Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 9408084
- 9421506
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 15761495
regulation of gastrulation
Source: MGI
Inferred from mutant phenotypeⁱ
- 7958910
regulation of insulin secretion
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15761495
regulation of lipid metabolic process Source: MGI
regulation of microvillus assembly Source: MGI
regulation of transcription, DNA-templated
Source: MGI
Inferred from mutant phenotypeⁱ
- 9053305
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from mutant phenotypeⁱ
- 22589549
response to glucose
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15761495
sex differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17412818
signal transduction involved in regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 18462699
SMAD protein signal transduction
Source: MGI
Inferred from direct assayⁱ
- 9420335
triglyceride homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11158324
type B pancreatic cell development Source: InterPro
xenobiotic metabolic process Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepatocyte nuclear factor 4-alpha Short name: HNF-4-alpha Alternative name(s): Nuclear receptor subfamily 2 group A member 1 Transcription factor 14 Short name: TCF-14 Transcription factor HNF-4
Gene namesⁱ	Name:Hnf4a Synonyms:Hnf-4, Hnf4, Nr2a1, Tcf14
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:109128 Hnf4a

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Pancreatic beta-cells-specific knockout results in hyperinsulinemia and hypoglycemia.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053559	1 – 474	Hepatocyte nuclear factor 4-alphaAdd BLAST		474

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	142	PhosphoserineBy similarity	1
Modified residueⁱ	143	PhosphoserineBy similarity	1
Modified residueⁱ	144	PhosphotyrosineBy similarity	1
Modified residueⁱ	166	PhosphothreonineBy similarity	1
Modified residueⁱ	167	PhosphoserineBy similarity	1
Cross-linkⁱ	234	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	307	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	313	Phosphoserine; by AMPKBy similarity	1
Modified residueⁱ	429	PhosphothreonineCombined sources	1
Modified residueⁱ	432	PhosphothreonineCombined sources	1
Modified residueⁱ	436	PhosphoserineCombined sources	1
Modified residueⁱ	458	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity).By similarity

Acetylation at Lys-458 lowers transcriptional activation by about two-fold.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P49698
PaxDbⁱ	P49698
PeptideAtlas More...PeptideAtlasⁱ	P49698
PRIDEⁱ	P49698

PTM databases

iPTMnetⁱ	P49698
PhosphoSitePlusⁱ	P49698
SwissPalmⁱ	P49698

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000017950 Expressed in 144 organ(s), highest expression level in ileum
CleanExⁱ	MM_HNF4A
ExpressionAtlasⁱ	P49698 baseline and differential
Genevisibleⁱ	P49698 MM

Interactionⁱ

Subunit structureⁱ

Homodimerization is required for HNF4-alpha to bind to its recognition site. Interacts with PER2.1 Publication

GO - Molecular functionⁱ

protein homodimerization activity Source: MGI
repressing transcription factor binding Source: MGI
RNA polymerase II activating transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17932483
signaling receptor binding Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200354, 4 interactors
CORUMⁱ	P49698
IntActⁱ	P49698, 3 interactors
Molecular INTeraction database More...MINTⁱ	P49698
STRINGⁱ	10090.ENSMUSP00000018094

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P49698
SMRⁱ	P49698
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	147 – 377	NR LBDPROSITE-ProRule annotationAdd BLAST		231

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR2 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	60 – 80	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	96 – 120	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4215 Eukaryota ENOG410XQT8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118948
HOGENOMⁱ	HOG000260822
HOVERGENⁱ	HBG005606
InParanoidⁱ	P49698
KEGG Orthology (KO) More...KOⁱ	K07292
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A89
PhylomeDBⁱ	P49698
TreeFamⁱ	TF352097

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR039067 HNF4A IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24083:SF41 PTHR24083:SF41, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform Long (identifier: P49698-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLSKTLAGM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGANLNS 
        60         70         80         90        100
SNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR 
       110        120        130        140        150
QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP 
       160        170        180        190        200
SINALLQAEV LSQQITSPIS GINGDIRAKK IANITDVCES MKEQLLVLVE 
       210        220        230        240        250
WAKYIPAFCE LLLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI 
       260        270        280        290        300
VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYACLK AIIFFDPDAK 
       310        320        330        340        350
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ 
       360        370        380        390        400
MIEQIQFIKL FGMAKIDNLL QEMLLGGSAS DAPHTHHPLH PHLMQEHMGT 
       410        420        430        440        450
NVIVANTMPS HLSNGQMCEW PRPRGQAATP ETPQPSPPSG SGSESYKLLP 
       460        470 
GAITTIVKPP SAIPQPTITK QEAI

Length:474

Mass (Da):52,684

Last modified:May 29, 2007 - v2

Checksum:ⁱ10843D528EAE87EE

GO

Isoform Short (identifier: P49698-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
418-428: CEWPRPRGQAA → S

« Hide

        10         20         30         40         50
MRLSKTLAGM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGANLNS 
        60         70         80         90        100
SNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR 
       110        120        130        140        150
QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP 
       160        170        180        190        200
SINALLQAEV LSQQITSPIS GINGDIRAKK IANITDVCES MKEQLLVLVE 
       210        220        230        240        250
WAKYIPAFCE LLLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI 
       260        270        280        290        300
VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYACLK AIIFFDPDAK 
       310        320        330        340        350
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ 
       360        370        380        390        400
MIEQIQFIKL FGMAKIDNLL QEMLLGGSAS DAPHTHHPLH PHLMQEHMGT 
       410        420        430        440        450
NVIVANTMPS HLSNGQMSTP ETPQPSPPSG SGSESYKLLP GAITTIVKPP 
       460 
SAIPQPTITK QEAI

Show »

Length:464

Mass (Da):51,518

Checksum:ⁱ4C293463C33B2D76

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A2A5I6	A2A5I6_MOUSE	Hepatocyte nuclear factor 4-alpha Hepatocyte nuclear factor 4-alpha	Hnf4a	191	Annotation score:
Z4YKX0	Z4YKX0_MOUSE	Hepatic nuclear factor 4, alpha, is... Hepatic nuclear factor 4, alpha, isoform CRA_b (Hepatocyte nuclear factor 4-alpha)	Hnf4a mCG_5450	465	Annotation score:
A2A5I4	A2A5I4_MOUSE	Hepatocyte nuclear factor 4-alpha Hepatocyte nuclear factor 4-alpha	Hnf4a	100	Annotation score:

Sequence cautionⁱ

The sequence BAA06101 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	55	G → S in BAA06101 (PubMed:7999795).Curated	1
Sequence conflictⁱ	365	K → R in BAE25624 (PubMed:16141072).Curated	1
Sequence conflictⁱ	378	S → L in ABM69091 (Ref. 6) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003676	418 – 428	CEWPRPRGQAA → S in isoform Short. 1 PublicationAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D29015 mRNA Translation: BAA06101.1 Different initiation. AY902317 Genomic DNA Translation: AAX90602.1 AK143948 mRNA Translation: BAE25624.1 AL591488 Genomic DNA No translation available. BC039220 mRNA Translation: AAH39220.1 EF193393 mRNA Translation: ABM69091.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17012.1 [P49698-1]
PIRⁱ	S52074
NCBI Reference Sequences More...RefSeqⁱ	NP_032287.2, NM_008261.3 [P49698-1] XP_006498850.1, XM_006498787.1 [P49698-2]
UniGeneⁱ	Mm.202383

Genome annotation databases

Ensemblⁱ	ENSMUST00000018094; ENSMUSP00000018094; ENSMUSG00000017950 [P49698-1]
GeneIDⁱ	15378
KEGGⁱ	mmu:15378
UCSC genome browser More...UCSCⁱ	uc008nta.2 mouse [P49698-1] uc012cit.1 mouse [P49698-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49698	Hepatic nuclear factor 4, alpha, isoform CRA_b		MOUSE		465	UniRef100_P49698

Protein	Similar proteins		Species	Score	Length	Source
P49698	Hepatic nuclear factor 4, alpha, isoform CRA_b		MOUSE		465	UniRef90_P49698
Uncharacterized protein		PIG		484
UPI00038EE815		CHILA		504
UPI0006431F04		MICMU		481
UPI0004ED4EA5		NANGA		474
+4
P49698-2	Isoform Short of Hepatocyte nuclear factor 4-alpha		RAT		464	UniRef90_P49698-2
UPI000643D613		MICMU		471
UPI0000F2B6F4		MONDO		464
UPI0003339811		ECHTE		464
UPI000B4F9AF5		MERUN		464
+5

Protein	Similar proteins		Species	Score	Length	Source
P49698	Isoform HNF4-Alpha-4 of Hepatocyte nuclear factor 4-alpha		HUMAN		504	UniRef50_P41235-4
Hepatocyte nuclear factor 4-gamma		MOUSE		408
Hepatocyte nuclear factor 4-alpha	)	RAT		474
Hepatocyte nuclear factor 4 alpha		OTOGA		476
Uncharacterized protein		SHEEP		476
+486
P49698-2	Isoform Short of Hepatocyte nuclear factor 4-alpha		RAT		464	UniRef50_P49698-2
Transcription factor HNF-4-like protein		CAMFO		426
Uncharacterized protein		ATTCE		483
Transcription factor HNF-4 like protein		Trachymyrmex zeteki		442
Transcription factor HNF-4-like protein		ACREC		440
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D29015 mRNA Translation: BAA06101.1 Different initiation. AY902317 Genomic DNA Translation: AAX90602.1 AK143948 mRNA Translation: BAE25624.1 AL591488 Genomic DNA No translation available. BC039220 mRNA Translation: AAH39220.1 EF193393 mRNA Translation: ABM69091.1
CCDSⁱ	CCDS17012.1 [P49698-1]
PIRⁱ	S52074
RefSeqⁱ	NP_032287.2, NM_008261.3 [P49698-1] XP_006498850.1, XM_006498787.1 [P49698-2]
UniGeneⁱ	Mm.202383

3D structure databases

ProteinModelPortalⁱ	P49698
SMRⁱ	P49698
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200354, 4 interactors
CORUMⁱ	P49698
IntActⁱ	P49698, 3 interactors
MINTⁱ	P49698
STRINGⁱ	10090.ENSMUSP00000018094

PTM databases

iPTMnetⁱ	P49698
PhosphoSitePlusⁱ	P49698
SwissPalmⁱ	P49698

Proteomic databases

MaxQBⁱ	P49698
PaxDbⁱ	P49698
PeptideAtlasⁱ	P49698
PRIDEⁱ	P49698

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000018094; ENSMUSP00000018094; ENSMUSG00000017950 [P49698-1]
GeneIDⁱ	15378
KEGGⁱ	mmu:15378
UCSCⁱ	uc008nta.2 mouse [P49698-1] uc012cit.1 mouse [P49698-2]

Organism-specific databases

CTDⁱ	3172
MGIⁱ	MGI:109128 Hnf4a

Phylogenomic databases

eggNOGⁱ	KOG4215 Eukaryota ENOG410XQT8 LUCA
GeneTreeⁱ	ENSGT00760000118948
HOGENOMⁱ	HOG000260822
HOVERGENⁱ	HBG005606
InParanoidⁱ	P49698
KOⁱ	K07292
OrthoDBⁱ	EOG091G0A89
PhylomeDBⁱ	P49698
TreeFamⁱ	TF352097

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSⁱ	Hnf4a mouse
Protein Ontology More...PROⁱ	PR:P49698
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017950 Expressed in 144 organ(s), highest expression level in ileum
CleanExⁱ	MM_HNF4A
ExpressionAtlasⁱ	P49698 baseline and differential
Genevisibleⁱ	P49698 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR039067 HNF4A IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24083:SF41 PTHR24083:SF41, 1 hit
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HNF4A_MOUSE
Accessionⁱ	P49698Primary (citable) accession number: P49698 Secondary accession number(s): A2A5I5 , A2ICH0, Q3UNX3, Q8CFY1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	May 29, 2007
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P49698 (HNF4A_MOUSE)

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Hepatocyte nuclear factor 4-alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ