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Entry version 186 (08 May 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Nucleoporin NUP145

Gene

NUP145

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP145 is autocatalytically cleaved in vivo in 2 polypeptides which assume different functions in the NPC. NUP145N as one of the FG repeat nucleoporins participates in karyopherin interactions and contains part of the autocatalytic cleavage activity. NUP145C as part of the NUP84 complex is involved in nuclear poly(A)+ RNA and tRNA export. It is also required for normal NPC distribution (probably through interactions with MLP1 and MLP2) and NPC assembly, as well as for normal nuclear envelope organization.9 Publications

Miscellaneous

Present with 4630 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30592-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S59.002

Transport Classification Database

More...
TCDBi
1.I.1.1.1 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin NUP145 (EC:3.4.21.-)
Alternative name(s):
Nuclear pore protein NUP145
Cleaved into the following 2 chains:
Nucleoporin NUP145N
Short name:
N-NUP145
Nucleoporin NUP145C
Short name:
C-NUP145
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP145
Synonyms:RAT10
Ordered Locus Names:YGL092W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YGL092W

Saccharomyces Genome Database

More...
SGDi
S000003060 NUP145

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi604H → P: Loss of autocatalytic cleavage; when associated with L-608. 1 Publication1
Mutagenesisi605F → S: Loss of autocatalytic cleavage; when associated with R-608. 1 Publication1
Mutagenesisi606S → A: Loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi608W → L: Loss of autocatalytic cleavage; when associated with P-604. 1 Publication1
Mutagenesisi608W → R: Loss of autocatalytic cleavage; when associated with F-605. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000199271 – 605Nucleoporin NUP145NAdd BLAST605
ChainiPRO_0000019928606 – 1317Nucleoporin NUP145CAdd BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei273PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei751PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

NUP145 is autocatalytically cleaved in NUP145N and NUP145C.1 Publication

Keywords - PTMi

Autocatalytic cleavage, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49687

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P49687

PRoteomics IDEntifications database

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PRIDEi
P49687

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P49687

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P49687

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP145C is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1). NUP145N may bind homopolymeric RNA and interacts through its FG repeats with karyopherins. Interacts with MLP1 and MLP2.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33159, 275 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-824 Nuclear pore complex

Database of interacting proteins

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DIPi
DIP-2074N

Protein interaction database and analysis system

More...
IntActi
P49687, 21 interactors

Molecular INTeraction database

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MINTi
P49687

STRING: functional protein association networks

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STRINGi
4932.YGL092W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49687

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49687

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati12 – 13FG 12
Repeati39 – 42GLFG 14
Repeati79 – 80FG 22
Repeati89 – 92GLFG 24
Repeati106 – 107FG 32
Repeati136 – 139GLFG 34
Repeati154 – 157GLFG 44
Repeati168 – 171GLFG 54
Repeati181 – 184GLFG 64
Repeati193 – 196GLFG 7; approximate4
Repeati206 – 209GLFG 84
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini458 – 605Peptidase S59PROSITE-ProRule annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni398 – 523Required for autocatalytic cleavageAdd BLAST126
Regioni460 – 604Nucleoporin RNA-binding motif (NRM)Add BLAST145

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi369 – 385Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 145Asn-richAdd BLAST103
Compositional biasi140 – 145Poly-Asn6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin GLFG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113874

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49687

KEGG Orthology (KO)

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KOi
K18720

Identification of Orthologs from Complete Genome Data

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OMAi
PHKMQLM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1610.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025574 Nucleoporin_FG_rpt
IPR037665 Nucleoporin_S59-like
IPR037672 Nup145
IPR021967 Nup96
IPR007230 Peptidase_S59
IPR036903 Peptidase_S59_sf

The PANTHER Classification System

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PANTHERi
PTHR23198 PTHR23198, 1 hit
PTHR23198:SF13 PTHR23198:SF13, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04096 Nucleoporin2, 1 hit
PF13634 Nucleoporin_FG, 1 hit
PF12110 Nup96, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF82215 SSF82215, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51434 NUP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P49687-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNKSVNSGF TFGNQNTSTP TSTPAQPSSS LQFPQKSTGL FGNVNVNANT
60 70 80 90 100
STPSPSGGLF NANSNANSIS QQPANNSLFG NKPAQPSGGL FGATNNTTSK
110 120 130 140 150
SAGSLFGNNN ATANSTGSTG LFSGSNNIAS STQNGGLFGN SNNNNITSTT
160 170 180 190 200
QNGGLFGKPT TTPAGAGGLF GNSSSTNSTT GLFGSNNTQS STGIFGQKPG
210 220 230 240 250
ASTTGGLFGN NGASFPRSGE TTGTMSTNPY GINISNVPMA VADMPRSITS
260 270 280 290 300
SLSDVNGKSD AEPKPIENRR TYSFSSSVSG NAPLPLASQS SLVSRLSTRL
310 320 330 340 350
KATQKSTSPN EIFSPSYSKP WLNGAGSAPL VDDFFSSKMT SLAPNENSIF
360 370 380 390 400
PQNGFNFLSS QRADLTELRK LKIDSNRSAA KKLKLLSGTP AITKKHMQDE
410 420 430 440 450
QDSSENEPIA NADSVTNIDR KENRDNNLDN TYLNGKEQSN NLNKQDGENT
460 470 480 490 500
LQHEKSSSFG YWCSPSPEQL ERLSLKQLAA VSNFVIGRRG YGCITFQHDV
510 520 530 540 550
DLTAFTKSFR EELFGKIVIF RSSKTVEVYP DEATKPMIGH GLNVPAIITL
560 570 580 590 600
ENVYPVDKKT KKPMKDTTKF AEFQVFDRKL RSMREMNYIS YNPFGGTWTF
610 620 630 640 650
KVNHFSIWGL VNEEDAEIDE DDLSKQEDGG EQPLRKVRTL AQSKPSDKEV
660 670 680 690 700
ILKTDGTFGT LSGKDDSIVE EKAYEPDLSD ADFEGIEASP KLDVSKDWVE
710 720 730 740 750
QLILAGSSLR SVFATSKEFD GPCQNEIDLL FSECNDEIDN AKLIMKERRF
760 770 780 790 800
TASYTFAKFS TGSMLLTKDI VGKSGVSIKR LPTELQRKFL FDDVYLDKEI
810 820 830 840 850
EKVTIEARKS NPYPQISESS LLFKDALDYM EKTSSDYNLW KLSSILFDPV
860 870 880 890 900
SYPYKTDNDQ VKMALLKKER HCRLTSWIVS QIGPEIEEKI RNSSNEIEQI
910 920 930 940 950
FLYLLLNDVV RASKLAIESK NGHLSVLISY LGSNDPRIRD LAELQLQKWS
960 970 980 990 1000
TGGCSIDKNI SKIYKLLSGS PFEGLFSLKE LESEFSWLCL LNLTLCYGQI
1010 1020 1030 1040 1050
DEYSLESLVQ SHLDKFSLPY DDPIGVIFQL YAANENTEKL YKEVRQRTNA
1060 1070 1080 1090 1100
LDVQFCWYLI QTLRFNGTRV FSKETSDEAT FAFAAQLEFA QLHGHSLFVS
1110 1120 1130 1140 1150
CFLNDDKAAE DTIKRLVMRE ITLLRASTND HILNRLKIPS QLIFNAQALK
1160 1170 1180 1190 1200
DRYEGNYLSE VQNLLLGSSY DLAEMAIVTS LGPRLLLSNN PVQNNELKTL
1210 1220 1230 1240 1250
REILNEFPDS ERDKWSVSIN VFEVYLKLVL DNVETQETID SLISGMKIFY
1260 1270 1280 1290 1300
DQYKHCREVA ACCNVMSQEI VSKILEKNNP SIGDSKAKLL ELPLGQPEKA
1310
YLRGEFAQDL MKCTYKI
Length:1,317
Mass (Da):145,661
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59399D86BB553030
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti281 – 282NA → QR in CAA83584 (PubMed:8195299).Curated2
Sequence conflicti1142L → S in CAA83584 (PubMed:8195299).Curated1
Sequence conflicti1310 – 1316LMKCTYK → FEVYI (PubMed:8195299).Curated7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X76557 Genomic DNA Translation: CAA54057.1
Z32672 Genomic DNA Translation: CAA83584.1
Z72614 Genomic DNA Translation: CAA96798.1
BK006941 Genomic DNA Translation: DAA08014.1

Protein sequence database of the Protein Information Resource

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PIRi
A54831

NCBI Reference Sequences

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RefSeqi
NP_011423.1, NM_001180957.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL092W_mRNA; YGL092W_mRNA; YGL092W

Database of genes from NCBI RefSeq genomes

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GeneIDi
852788

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL092W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76557 Genomic DNA Translation: CAA54057.1
Z32672 Genomic DNA Translation: CAA83584.1
Z72614 Genomic DNA Translation: CAA96798.1
BK006941 Genomic DNA Translation: DAA08014.1
PIRiA54831
RefSeqiNP_011423.1, NM_001180957.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BG0X-ray3.15B/C/F/G731-1158[»]
3BG1X-ray3.00B/C/F/G731-1158[»]
3IKOX-ray3.20B/E/H731-1158[»]
3JROX-ray4.00A714-1160[»]
3JRPX-ray2.60A714-784[»]
3KEPX-ray1.82A/B442-605[»]
3KESX-ray2.10A/B442-605[»]
4XMMX-ray7.38B680-1317[»]
4XMNX-ray7.60B680-1317[»]
SMRiP49687
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33159, 275 interactors
ComplexPortaliCPX-824 Nuclear pore complex
DIPiDIP-2074N
IntActiP49687, 21 interactors
MINTiP49687
STRINGi4932.YGL092W

Protein family/group databases

MEROPSiS59.002
TCDBi1.I.1.1.1 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiP49687

Proteomic databases

MaxQBiP49687
PaxDbiP49687
PRIDEiP49687

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
852788
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL092W_mRNA; YGL092W_mRNA; YGL092W
GeneIDi852788
KEGGisce:YGL092W

Organism-specific databases

EuPathDBiFungiDB:YGL092W
SGDiS000003060 NUP145

Phylogenomic databases

HOGENOMiHOG000113874
InParanoidiP49687
KOiK18720
OMAiPHKMQLM

Enzyme and pathway databases

BioCyciYEAST:G3O-30592-MONOMER

Miscellaneous databases

EvolutionaryTraceiP49687
PMAP-CutDBiP49687

Protein Ontology

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PROi
PR:P49687

Family and domain databases

Gene3Di3.30.1610.10, 1 hit
InterProiView protein in InterPro
IPR025574 Nucleoporin_FG_rpt
IPR037665 Nucleoporin_S59-like
IPR037672 Nup145
IPR021967 Nup96
IPR007230 Peptidase_S59
IPR036903 Peptidase_S59_sf
PANTHERiPTHR23198 PTHR23198, 1 hit
PTHR23198:SF13 PTHR23198:SF13, 1 hit
PfamiView protein in Pfam
PF04096 Nucleoporin2, 1 hit
PF13634 Nucleoporin_FG, 1 hit
PF12110 Nup96, 1 hit
SUPFAMiSSF82215 SSF82215, 1 hit
PROSITEiView protein in PROSITE
PS51434 NUP_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU145_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49687
Secondary accession number(s): D6VU53
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 8, 2019
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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