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Protein

G-protein coupled receptor 15

Gene

GPR15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

GO - Molecular functioni

  • coreceptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB
  • virus receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • T cell migration Source: Ensembl
  • viral entry into host cell Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 15
Alternative name(s):
Brother of Bonzo
Short name:
BoB
Gene namesi
Name:GPR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000154165.4
HGNCiHGNC:4469 GPR15
MIMi601166 gene
neXtProtiNX_P49685

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 69CytoplasmicSequence analysisAdd BLAST15
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 120ExtracellularSequence analysisAdd BLAST30
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 149CytoplasmicSequence analysis8
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 192ExtracellularSequence analysisAdd BLAST22
Transmembranei193 – 213Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini214 – 239CytoplasmicSequence analysisAdd BLAST26
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 284ExtracellularSequence analysisAdd BLAST24
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 360CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2838
OpenTargetsiENSG00000154165
PharmGKBiPA28858

Polymorphism and mutation databases

DMDMi1346170

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695311 – 360G-protein coupled receptor 15Add BLAST360

Proteomic databases

PaxDbiP49685
PeptideAtlasiP49685
PRIDEiP49685
ProteomicsDBi56051

PTM databases

iPTMnetiP49685
PhosphoSitePlusiP49685

Expressioni

Gene expression databases

BgeeiENSG00000154165
CleanExiHS_GPR15
ExpressionAtlasiP49685 baseline and differential
GenevisibleiP49685 HS

Organism-specific databases

HPAiHPA013775

Interactioni

Protein-protein interaction databases

BioGridi109098, 2 interactors
ELMiP49685
STRINGi9606.ENSP00000284311

Structurei

3D structure databases

ProteinModelPortaliP49685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJEK Eukaryota
ENOG410YCV2 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000077773
HOVERGENiHBG101112
InParanoidiP49685
KOiK08403
OMAiFLLTCMS
OrthoDBiEOG091G0AX0
PhylomeDBiP49685
TreeFamiTF330024

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG
60 70 80 90 100
NLVLMGALHF KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR
110 120 130 140 150
TGSFLCKGSS YMISVNMHCS VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA
160 170 180 190 200
YVVCASIWFI SCLLGLPTLL SRELTLIDDK PYCAEKKATP IKLIWSLVAL
210 220 230 240 250
IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI KIIFIVVAAF
260 270 280 290 300
LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF
310 320 330 340 350
IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF
360
ARRRKRSVSL
Length:360
Mass (Da):40,787
Last modified:February 1, 1996 - v1
Checksum:iF781F28B7E312390
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02007537P → S. Corresponds to variant dbSNP:rs2230344Ensembl.1
Natural variantiVAR_049391112M → V. Corresponds to variant dbSNP:rs35320046Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34806 Genomic DNA Translation: AAC50826.1
BC069437 mRNA Translation: AAH69437.1
BC101779 mRNA Translation: AAI01780.1
BC101781 mRNA Translation: AAI01782.1
CCDSiCCDS2931.1
PIRiG02064
RefSeqiNP_005281.1, NM_005290.3
UniGeneiHs.162987
Hs.563128

Genome annotation databases

EnsembliENST00000284311; ENSP00000284311; ENSG00000154165
GeneIDi2838
KEGGihsa:2838
UCSCiuc011bgy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGPR15_HUMAN
AccessioniPrimary (citable) accession number: P49685
Secondary accession number(s): Q3MIL4, Q6ISN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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