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Protein

Urotensin-2 receptor

Gene

Uts2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • urotensin II receptor activity Source: RGD

GO - Biological processi

  • negative regulation of blood pressure Source: RGD
  • negative regulation of glomerular filtration Source: RGD
  • negative regulation of renal sodium excretion Source: RGD
  • negative regulation of urine volume Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of circadian sleep/wake cycle, REM sleep Source: RGD
  • positive regulation of circadian sleep/wake cycle, wakefulness Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • response to drug Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2 receptor
Short name:
UR-2-R
Alternative name(s):
G-protein coupled receptor 14
G-protein coupled sensory epithelial neuropeptide-like receptor
Short name:
SENR
Urotensin II receptor
Short name:
UR-II-R
Gene namesi
Name:Uts2r
Synonyms:Gpr14, Senr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621884 Uts2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54ExtracellularSequence analysisAdd BLAST54
Transmembranei55 – 77Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini78 – 87CytoplasmicSequence analysis10
Transmembranei88 – 113Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini114 – 124ExtracellularSequence analysisAdd BLAST11
Transmembranei125 – 146Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini147 – 167CytoplasmicSequence analysisAdd BLAST21
Transmembranei168 – 186Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini187 – 209ExtracellularSequence analysisAdd BLAST23
Transmembranei210 – 232Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini233 – 258CytoplasmicSequence analysisAdd BLAST26
Transmembranei259 – 284Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini285 – 299ExtracellularSequence analysisAdd BLAST15
Transmembranei300 – 321Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini322 – 386CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4921
GuidetoPHARMACOLOGYi365

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701961 – 386Urotensin-2 receptorAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49684
PRIDEiP49684

PTM databases

PhosphoSitePlusiP49684

Expressioni

Tissue specificityi

Preferentially expressed in neural and sensory tissues.

Gene expression databases

BgeeiENSRNOG00000036669
GenevisibleiP49684 RN

Interactioni

Protein-protein interaction databases

BioGridi248616, 1 interactor
STRINGi10116.ENSRNOP00000051809

Chemistry databases

BindingDBiP49684

Structurei

3D structure databases

ProteinModelPortaliP49684
SMRiP49684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00670000098072
HOGENOMiHOG000060074
HOVERGENiHBG098595
InParanoidiP49684
KOiK04241
OMAiNQKVLYL
OrthoDBiEOG091G0DD6
PhylomeDBiP49684
TreeFamiTF334200

Family and domain databases

CDDicd14999 7tmA_UII-R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000670 Urot_II_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00647 UROTENSIN2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLESTTS FHMLTVSGST VTELPGDSNV SLNSSWSGPT DPSSLKDLVA
60 70 80 90 100
TGVIGAVLSA MGVVGMVGNV YTLVVMCRFL RASASMYVYV VNLALADLLY
110 120 130 140 150
LLSIPFIIAT YVTKDWHFGD VGCRVLFSLD FLTMHASIFT LTIMSSERYA
160 170 180 190 200
AVLRPLDTVQ RSKGYRKLLV LGTWLLALLL TLPMMLAIQL VRRGSKSLCL
210 220 230 240 250
PAWGPRAHRT YLTLLFGTSI VGPGLVIGLL YVRLARAYWL SQQASFKQTR
260 270 280 290 300
RLPNPRVLYL ILGIVLLFWA CFLPFWLWQL LAQYHEAMPL TPETARIVNY
310 320 330 340 350
LTTCLTYGNS CINPFLYTLL TKNYREYLRG RQRSLGSSCH SPGSPGSFLP
360 370 380
SRVHLQQDSG RSLSSSSQQA TETLMLSPVP RNGALL
Length:386
Mass (Da):42,707
Last modified:July 15, 1999 - v2
Checksum:iFA4E95CC6A4CA27C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti315F → L in AAC52593 (PubMed:8666380).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32673 Genomic DNA Translation: AAC52593.1
U23483 Genomic DNA Translation: AAA80111.1
AB012210 mRNA Translation: BAA25251.1
AB029611 mRNA Translation: BAA82357.1
PIRiI84612
RefSeqiNP_065412.1, NM_020537.1
UniGeneiRn.44230

Genome annotation databases

EnsembliENSRNOT00000054926; ENSRNOP00000051809; ENSRNOG00000036669
GeneIDi57305
KEGGirno:57305

Similar proteinsi

Entry informationi

Entry nameiUR2R_RAT
AccessioniPrimary (citable) accession number: P49684
Secondary accession number(s): P48041
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: October 25, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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