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Protein

Prolactin-releasing peptide receptor

Gene

PRLHR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
SignaLinkiP49683

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-releasing peptide receptor
Short name:
PrRP receptor
Short name:
PrRPR
Alternative name(s):
G-protein coupled receptor 10
hGR3
Gene namesi
Name:PRLHR
Synonyms:GPR10, GR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119973.4
HGNCiHGNC:4464 PRLHR
MIMi600895 gene
neXtProtiNX_P49683

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
Transmembranei63 – 83Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini84 – 101CytoplasmicSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini123 – 126ExtracellularSequence analysis4
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 175CytoplasmicSequence analysisAdd BLAST28
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 225ExtracellularSequence analysisAdd BLAST29
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini247 – 276CytoplasmicSequence analysisAdd BLAST30
Transmembranei277 – 297Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini298 – 317ExtracellularSequence analysisAdd BLAST20
Transmembranei318 – 338Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini339 – 369CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi365 – 370Missing : Abolishes binding to GRIP1 and PICK1. 6
Mutagenesisi365T → A: No effect on binding to GRIP1. 1 Publication1
Mutagenesisi366V → A: No effect on binding to GRIP1. 1 Publication1
Mutagenesisi367S → A: Abolishes binding to GRIP1. 1 Publication1
Mutagenesisi368V → A: Abolishes binding to GRIP1. 1 Publication1
Mutagenesisi369V → A: No effect on binding to GRIP1. 1 Publication1
Mutagenesisi370I → A: Abolishes binding to GRIP1. 1 Publication1

Organism-specific databases

DisGeNETi2834
OpenTargetsiENSG00000119973
PharmGKBiPA28847

Chemistry databases

ChEMBLiCHEMBL1681611
GuidetoPHARMACOLOGYi337

Polymorphism and mutation databases

BioMutaiPRLHR
DMDMi311033415

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695241 – 370Prolactin-releasing peptide receptorAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 211PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49683
PeptideAtlasiP49683
PRIDEiP49683
ProteomicsDBi56050

PTM databases

iPTMnetiP49683
PhosphoSitePlusiP49683

Expressioni

Tissue specificityi

Only detected in the pituitary gland and in all cell types of pituitary adenomas.2 Publications

Inductioni

Repressed by bromocriptine, a dopamine agonist.1 Publication

Gene expression databases

BgeeiENSG00000119973 Expressed in 38 organ(s), highest expression level in pituitary gland
CleanExiHS_PRLHR
GenevisibleiP49683 HS

Organism-specific databases

HPAiHPA039361

Interactioni

Subunit structurei

Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GRIP1Q9Y3R02EBI-8009236,EBI-5349621

Protein-protein interaction databases

BioGridi109095, 3 interactors
IntActiP49683, 3 interactors
MINTiP49683
STRINGi9606.ENSP00000239032

Chemistry databases

BindingDBiP49683

Structurei

3D structure databases

ProteinModelPortaliP49683
SMRiP49683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni365 – 370Required for interaction with GRIP1, GRIP2 and PICK11 Publication6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000050229
HOVERGENiHBG101109
InParanoidiP49683
KOiK04314
OMAiPRKIAPH
OrthoDBiEOG091G0C2X
PhylomeDBiP49683
TreeFamiTF315303

Family and domain databases

CDDicd15394 7tmA_PrRP_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001402 Prolrel_pep_rcpt
PANTHERiPTHR44364 PTHR44364, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01018 PRPRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSTTRGPR VSDLFSGLPP AVTTPANQSA EASAGNGSVA GADAPAVTPF
60 70 80 90 100
QSLQLVHQLK GLIVLLYSVV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG
110 120 130 140 150
NLALSDVLMC TACVPLTLAY AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF
160 170 180 190 200
TLTTIAVDRY VVLVHPLRRR ISLRLSAYAV LAIWALSAVL ALPAAVHTYH
210 220 230 240 250
VELKPHDVRL CEEFWGSQER QRQLYAWGLL LVTYLLPLLV ILLSYVRVSV
260 270 280 290 300
KLRNRVVPGC VTQSQADWDR ARRRRTFCLL VVIVVVFAVC WLPLHVFNLL
310 320 330 340 350
RDLDPHAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKLL
360 370
VAWPRKIAPH GQNMTVSVVI
Length:370
Mass (Da):41,121
Last modified:November 2, 2010 - v3
Checksum:i47F71490A080C81F
GO

Sequence cautioni

The sequence AAC50504 differs from that shown. Reason: Frameshift at positions 168 and 175.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89R → P in AAC50504 (PubMed:8666380).Curated1
Sequence conflicti194A → P in AAC50504 (PubMed:8666380).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023948283I → V4 PublicationsCorresponds to variant dbSNP:rs1613448Ensembl.1
Natural variantiVAR_029746302D → G. Corresponds to variant dbSNP:rs8192523Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32672 Genomic DNA Translation: AAC50504.1 Frameshift.
AB015745 mRNA Translation: BAA31159.1
AB048946 Genomic DNA Translation: BAB83030.1
AL356865 Genomic DNA No translation available.
BC095539 mRNA Translation: AAH95539.1
BC101490 mRNA Translation: AAI01491.1
BC101492 mRNA Translation: AAI01493.1
CCDSiCCDS7606.1
RefSeqiNP_004239.1, NM_004248.2
UniGeneiHs.248119

Genome annotation databases

EnsembliENST00000239032; ENSP00000239032; ENSG00000119973
ENST00000636925; ENSP00000490073; ENSG00000119973
GeneIDi2834
KEGGihsa:2834
UCSCiuc001ldp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32672 Genomic DNA Translation: AAC50504.1 Frameshift.
AB015745 mRNA Translation: BAA31159.1
AB048946 Genomic DNA Translation: BAB83030.1
AL356865 Genomic DNA No translation available.
BC095539 mRNA Translation: AAH95539.1
BC101490 mRNA Translation: AAI01491.1
BC101492 mRNA Translation: AAI01493.1
CCDSiCCDS7606.1
RefSeqiNP_004239.1, NM_004248.2
UniGeneiHs.248119

3D structure databases

ProteinModelPortaliP49683
SMRiP49683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109095, 3 interactors
IntActiP49683, 3 interactors
MINTiP49683
STRINGi9606.ENSP00000239032

Chemistry databases

BindingDBiP49683
ChEMBLiCHEMBL1681611
GuidetoPHARMACOLOGYi337

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP49683
PhosphoSitePlusiP49683

Polymorphism and mutation databases

BioMutaiPRLHR
DMDMi311033415

Proteomic databases

PaxDbiP49683
PeptideAtlasiP49683
PRIDEiP49683
ProteomicsDBi56050

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239032; ENSP00000239032; ENSG00000119973
ENST00000636925; ENSP00000490073; ENSG00000119973
GeneIDi2834
KEGGihsa:2834
UCSCiuc001ldp.2 human

Organism-specific databases

CTDi2834
DisGeNETi2834
EuPathDBiHostDB:ENSG00000119973.4
GeneCardsiPRLHR
H-InvDBiHIX0170463
HGNCiHGNC:4464 PRLHR
HPAiHPA039361
MIMi600895 gene
neXtProtiNX_P49683
OpenTargetsiENSG00000119973
PharmGKBiPA28847
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000050229
HOVERGENiHBG101109
InParanoidiP49683
KOiK04314
OMAiPRKIAPH
OrthoDBiEOG091G0C2X
PhylomeDBiP49683
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
SignaLinkiP49683

Miscellaneous databases

GeneWikiiProlactin-releasing_peptide_receptor
GenomeRNAii2834
PROiPR:P49683
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119973 Expressed in 38 organ(s), highest expression level in pituitary gland
CleanExiHS_PRLHR
GenevisibleiP49683 HS

Family and domain databases

CDDicd15394 7tmA_PrRP_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001402 Prolrel_pep_rcpt
PANTHERiPTHR44364 PTHR44364, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01018 PRPRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRLHR_HUMAN
AccessioniPrimary (citable) accession number: P49683
Secondary accession number(s): O75194, Q502U8, Q5VXR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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