STAR

Functionⁱ

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

Pathwayⁱ: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

GO - Molecular functionⁱ

cholesterol binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18403318
cholesterol transporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bile acid biosynthetic process Source: Ensembl
biphenyl metabolic process Source: Ensembl
brain development Source: Ensembl
C21-steroid hormone biosynthetic process Source: Reactome
cellular response to alkaloid Source: Ensembl
cellular response to antibiotic Source: Ensembl
cellular response to cadmium ion Source: Ensembl
cellular response to cAMP Source: Ensembl
cellular response to dexamethasone stimulus Source: Ensembl
cellular response to epinephrine stimulus Source: Ensembl
cellular response to fibroblast growth factor stimulus Source: Ensembl
cellular response to follicle-stimulating hormone stimulus Source: Ensembl
cellular response to glucose stimulus Source: Ensembl
cellular response to growth hormone stimulus Source: Ensembl
cellular response to insulin stimulus Source: Ensembl
cellular response to interferon-alpha Source: Ensembl
cellular response to interferon-gamma Source: Ensembl
cellular response to lipopolysaccharide Source: Ensembl
cellular response to luteinizing hormone stimulus Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
cholesterol metabolic process Source: UniProtKB-UniPathway
circadian sleep/wake cycle, REM sleep Source: Ensembl
dibenzo-p-dioxin metabolic process Source: Ensembl
diterpenoid metabolic process Source: Ensembl
estrogen biosynthetic process Source: Ensembl
glucocorticoid metabolic process Source: Ensembl
insecticide metabolic process Source: Ensembl
intracellular cholesterol transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
male gonad development Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
phenol-containing compound metabolic process Source: Ensembl
phthalate metabolic process Source: Ensembl
positive regulation of bile acid biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18403318
positive regulation of gene expression Source: Ensembl
positive regulation of neurogenesis Source: Ensembl
regulation of neuronal synaptic plasticity Source: Ensembl
regulation of steroid biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to activity Source: Ensembl
response to corticosterone Source: Ensembl
response to estrogen Source: Ensembl
response to ethanol Source: Ensembl
response to fungicide Source: Ensembl
response to herbicide Source: Ensembl
response to hydrogen peroxide Source: Ensembl
response to ionizing radiation Source: Ensembl
response to lead ion Source: Ensembl
response to leptin Source: Ensembl
response to nicotine Source: Ensembl
response to nutrient Source: Ensembl
steroid biosynthetic process
Source: ProtInc
Traceable author statementⁱ
- 7761400
testosterone biosynthetic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Steroidogenesis, Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196108 Pregnenolone biosynthesis
SIGNORⁱ	P49675
UniPathwayⁱ	UPA00296

Chemistry databases

SwissLipidsⁱ	SLP:000000714 SLP:000000716

SwissLipidsⁱ

SLP:000000714
SLP:000000716

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Steroidogenic acute regulatory protein, mitochondrial Short name: StAR Alternative name(s): START domain-containing protein 1 Short name: StARD1
Gene namesⁱ	Name:STAR Synonyms:STARD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147465.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11359 STAR
MIMⁱ	600617 gene
neXtProtⁱ	NX_P49675

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Adrenal hyperplasia 1 (AH1)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionThe most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014236	169	E → G in AH1; partial loss of activity. 1 Publication	1
Natural variantⁱVAR_014237	169	E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.	1
Natural variantⁱVAR_005627	182	R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.	1
Natural variantⁱVAR_014238	217	R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.	1
Natural variantⁱVAR_014239	218	A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.	1
Natural variantⁱVAR_014240	225	M → T in AH1. 1 Publication	1
Natural variantⁱVAR_014241	272	Missing in AH1; partial loss of activity. 1 Publication	1
Natural variantⁱVAR_014242	275	L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736Ensembl.	1

Keywords - Diseaseⁱ

Congenital adrenal hyperplasia, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6770
MalaCards human disease database More...MalaCardsⁱ	STAR
MIMⁱ	201710 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000147465
Orphanetⁱ	325524 Classic congenital lipoid adrenal hyperplasia due to STAR deficency 361 Familial glucocorticoid deficiency 325529 Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency
PharmGKBⁱ	PA36181

Polymorphism and mutation databases

BioMutaⁱ	STAR
DMDMⁱ	71152974

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 63	MitochondrionBy similarityAdd BLAST		63
ChainⁱPRO_0000033316	64 – 285	Steroidogenic acute regulatory protein, mitochondrialAdd BLAST		222

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	57	Phosphoserine; by PKA1 Publication		1
Modified residueⁱ	195	Phosphoserine; by PKA1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P49675
PaxDbⁱ	P49675
PeptideAtlas More...PeptideAtlasⁱ	P49675
PRIDEⁱ	P49675
ProteomicsDBⁱ	56046

PTM databases

iPTMnetⁱ	P49675
PhosphoSitePlusⁱ	P49675

Expressionⁱ

Tissue specificityⁱ

Expressed in gonads, adrenal cortex and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000147465 Expressed in 118 organ(s), highest expression level in metanephros
CleanExⁱ	HS_STAR
ExpressionAtlasⁱ	P49675 baseline and differential
Genevisibleⁱ	P49675 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB032598 HPA023644 HPA027318

HPAⁱ

CAB032598
HPA023644
HPA027318

Interactionⁱ

Subunit structureⁱ

May interact with TSPO.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
MAGEA11	G5E962	3	EBI-722932,EBI-11525615
MAGEA11	P43364	5	EBI-722932,EBI-739552
MAGEA11	P43364-2	3	EBI-722932,EBI-10178634

Protein-protein interaction databases

BioGridⁱ	112647, 5 interactors
IntActⁱ	P49675, 10 interactors
STRINGⁱ	9606.ENSP00000276449

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	70 – 91	Combined sources	22
Beta strandⁱ	97 – 101	Combined sources	5
Beta strandⁱ	107 – 112	Combined sources	6
Beta strandⁱ	114 – 116	Combined sources	3
Beta strandⁱ	118 – 128	Combined sources	11
Helixⁱ	130 – 137	Combined sources	8
Turnⁱ	138 – 140	Combined sources	3
Helixⁱ	141 – 143	Combined sources	3
Beta strandⁱ	152 – 159	Combined sources	8
Beta strandⁱ	161 – 171	Combined sources	11
Beta strandⁱ	182 – 192	Combined sources	11
Beta strandⁱ	197 – 199	Combined sources	3
Beta strandⁱ	215 – 217	Combined sources	3
Beta strandⁱ	224 – 230	Combined sources	7
Beta strandⁱ	233 – 243	Combined sources	11
Helixⁱ	253 – 274	Combined sources	22

Show more details

3D structure databases

ProteinModelPortalⁱ	P49675
SMRⁱ	P49675
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49675

EvolutionaryTraceⁱ

P49675

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	67 – 280	STARTPROSITE-ProRule annotationAdd BLAST		214

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3845 Eukaryota ENOG41100B5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155477
HOGENOMⁱ	HOG000142452
HOVERGENⁱ	HBG010529
InParanoidⁱ	P49675
KEGG Orthology (KO) More...KOⁱ	K16931
OMAⁱ	QQGEEAM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06RM
PhylomeDBⁱ	P49675
TreeFamⁱ	TF313869

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08905 START_STARD1-like, 1 hit
Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR029866 StAR IPR000799 StAR-like IPR023393 START-like_dom_sf IPR002913 START_lipid-bd_dom
PANTHERⁱ	PTHR12136:SF9 PTHR12136:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01852 START, 1 hit
PRINTSⁱ	PR00978 STARPROTEIN
SMARTⁱ	View protein in SMART SM00234 START, 1 hit
PROSITEⁱ	View protein in PROSITE PS50848 START, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P49675-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLATFKLCA GSSYRHMRNM KGLRQQAVMA ISQELNRRAL GGPTPSTWIN 
        60         70         80         90        100
QVRRRSSLLG SRLEETLYSD QELAYLQQGE EAMQKALGIL SNQEGWKKES 
       110        120        130        140        150
QQDNGDKVMS KVVPDVGKVF RLEVVVDQPM ERLYEELVER MEAMGEWNPN 
       160        170        180        190        200
VKEIKVLQKI GKDTFITHEL AAEAAGNLVG PRDFVSVRCA KRRGSTCVLA 
       210        220        230        240        250
GMATDFGNMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT WLLSIDLKGW 
       260        270        280 
LPKSIINQVL SQTQVDFANH LRKRLESHPA SEARC

Length:285

Mass (Da):31,914

Last modified:July 19, 2005 - v2

Checksum:ⁱ2683086C20DE88AB

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YB94	H0YB94_HUMAN	Steroidogenic acute regulatory prot... Steroidogenic acute regulatory protein, mitochondrial	STAR	249	Annotation score:
E5RH12	E5RH12_HUMAN	Steroidogenic acute regulatory prot... Steroidogenic acute regulatory protein, mitochondrial	STAR	48	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034520	121	R → W. Corresponds to variant dbSNP:rs34908868EnsemblClinVar.	1
Natural variantⁱVAR_014236	169	E → G in AH1; partial loss of activity. 1 Publication	1
Natural variantⁱVAR_014237	169	E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.	1
Natural variantⁱVAR_005627	182	R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.	1
Natural variantⁱVAR_005628	203	A → D3 PublicationsCorresponds to variant dbSNP:rs1042854Ensembl.	1
Natural variantⁱVAR_014238	217	R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.	1
Natural variantⁱVAR_014239	218	A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.	1
Natural variantⁱVAR_014240	225	M → T in AH1. 1 Publication	1
Natural variantⁱVAR_014241	272	Missing in AH1; partial loss of activity. 1 Publication	1
Natural variantⁱVAR_014242	275	L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17280 mRNA Translation: AAC50141.1 U29105 U29104 Genomic DNA Translation: AAC50234.1 S79669 mRNA Translation: AAB35726.1 AF035277 mRNA Translation: AAB88174.1 BC010550 mRNA Translation: AAH10550.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6102.1
PIRⁱ	I38248
NCBI Reference Sequences More...RefSeqⁱ	NP_000340.2, NM_000349.2
UniGeneⁱ	Hs.521535

Genome annotation databases

Ensemblⁱ	ENST00000276449; ENSP00000276449; ENSG00000147465
GeneIDⁱ	6770
KEGGⁱ	hsa:6770

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49675	Steroidogenic acute regulatory protein, mitochondrial		HUMAN		285	UniRef100_P49675
Steroidogenic acute regulatory protein, mitochondrial		PANTR		203

Protein	Similar proteins		Species	Score	Length	Source
P49675	Steroidogenic acute regulatory protein, mitochondrial		HORSE		285	UniRef90_P49675
Steroidogenic acute regulatory protein, mitochondrial		HUMAN		285
Steroidogenic acute regulatory protein, mitochondrial		PANTR		203
Steroidogenic acute regulatory protein, mitochondrial		AILME		287
Steroidogenic acute regulatory protein, mitochondrial		BALAS		285
+68

Protein	Similar proteins		Species	Score	Length	Source
P49675	Steroidogenic acute regulatory protein, mitochondrial		HORSE		285	UniRef50_P49675
Steroidogenic acute regulatory protein, mitochondrial		DANRE		285
Steroidogenic acute regulatory protein, mitochondrial		PIG		285
Steroidogenic acute regulatory protein, mitochondrial		SHEEP		285
Steroidogenic acute regulatory protein, mitochondrial		BOVIN		285
+184

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Steroidogenic acute regulatory protein entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17280 mRNA Translation: AAC50141.1 U29105 U29104 Genomic DNA Translation: AAC50234.1 S79669 mRNA Translation: AAB35726.1 AF035277 mRNA Translation: AAB88174.1 BC010550 mRNA Translation: AAH10550.1
CCDSⁱ	CCDS6102.1
PIRⁱ	I38248
RefSeqⁱ	NP_000340.2, NM_000349.2
UniGeneⁱ	Hs.521535

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IMG	model	-	A	67-280	[»]
	2I93	model	-	A	67-280	[»]
	3P0L	X-ray	3.40	A/B/C/D	66-284	[»]
	5OMA	X-ray	3.90	A/B/C/D	54-62	[»]
ProteinModelPortalⁱ	P49675
SMRⁱ	P49675
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112647, 5 interactors
IntActⁱ	P49675, 10 interactors
STRINGⁱ	9606.ENSP00000276449

Chemistry databases

SwissLipidsⁱ	SLP:000000714 SLP:000000716

SwissLipidsⁱ

SLP:000000714
SLP:000000716

PTM databases

iPTMnetⁱ	P49675
PhosphoSitePlusⁱ	P49675

Polymorphism and mutation databases

BioMutaⁱ	STAR
DMDMⁱ	71152974

Proteomic databases

EPDⁱ	P49675
PaxDbⁱ	P49675
PeptideAtlasⁱ	P49675
PRIDEⁱ	P49675
ProteomicsDBⁱ	56046

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000276449; ENSP00000276449; ENSG00000147465
GeneIDⁱ	6770
KEGGⁱ	hsa:6770

Organism-specific databases

CTDⁱ	6770
DisGeNETⁱ	6770
EuPathDBⁱ	HostDB:ENSG00000147465.11
GeneCardsⁱ	STAR
HGNCⁱ	HGNC:11359 STAR
HPAⁱ	CAB032598 HPA023644 HPA027318
MalaCardsⁱ	STAR
MIMⁱ	201710 phenotype 600617 gene
neXtProtⁱ	NX_P49675
OpenTargetsⁱ	ENSG00000147465
Orphanetⁱ	325524 Classic congenital lipoid adrenal hyperplasia due to STAR deficency 361 Familial glucocorticoid deficiency 325529 Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency
PharmGKBⁱ	PA36181
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3845 Eukaryota ENOG41100B5 LUCA
GeneTreeⁱ	ENSGT00940000155477
HOGENOMⁱ	HOG000142452
HOVERGENⁱ	HBG010529
InParanoidⁱ	P49675
KOⁱ	K16931
OMAⁱ	QQGEEAM
OrthoDBⁱ	EOG091G06RM
PhylomeDBⁱ	P49675
TreeFamⁱ	TF313869

Enzyme and pathway databases

UniPathwayⁱ	UPA00296
Reactomeⁱ	R-HSA-196108 Pregnenolone biosynthesis
SIGNORⁱ	P49675

Miscellaneous databases

ChiTaRSⁱ	STAR human
EvolutionaryTraceⁱ	P49675
GenomeRNAiⁱ	6770
Protein Ontology More...PROⁱ	PR:P49675
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147465 Expressed in 118 organ(s), highest expression level in metanephros
CleanExⁱ	HS_STAR
ExpressionAtlasⁱ	P49675 baseline and differential
Genevisibleⁱ	P49675 HS

Family and domain databases

CDDⁱ	cd08905 START_STARD1-like, 1 hit
Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR029866 StAR IPR000799 StAR-like IPR023393 START-like_dom_sf IPR002913 START_lipid-bd_dom
PANTHERⁱ	PTHR12136:SF9 PTHR12136:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF01852 START, 1 hit
PRINTSⁱ	PR00978 STARPROTEIN
SMARTⁱ	View protein in SMART SM00234 START, 1 hit
PROSITEⁱ	View protein in PROSITE PS50848 START, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STAR_HUMAN
Accessionⁱ	P49675Primary (citable) accession number: P49675 Secondary accession number(s): Q16396
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	July 19, 2005
	Last modified:	December 5, 2018
	This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P49675 (STAR_HUMAN)

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Steroidogenic acute regulatory protein, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cholesterol metabolism

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: cholesterol metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ