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Protein

Steroidogenic acute regulatory protein, mitochondrial

Gene

STAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • cholesterol transporter activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Steroidogenesis, Transport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196108 Pregnenolone biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49675

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00296

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000714
SLP:000000716

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Steroidogenic acute regulatory protein, mitochondrial
Short name:
StAR
Alternative name(s):
START domain-containing protein 1
Short name:
StARD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAR
Synonyms:STARD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147465.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11359 STAR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600617 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49675

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Adrenal hyperplasia 1 (AH1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThe most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
See also OMIM:201710
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014236169E → G in AH1; partial loss of activity. 1 Publication1
Natural variantiVAR_014237169E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.1
Natural variantiVAR_005627182R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.1
Natural variantiVAR_014238217R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.1
Natural variantiVAR_014239218A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.1
Natural variantiVAR_014240225M → T in AH1. 1 Publication1
Natural variantiVAR_014241272Missing in AH1; partial loss of activity. 1 Publication1
Natural variantiVAR_014242275L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736Ensembl.1

Keywords - Diseasei

Congenital adrenal hyperplasia, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6770

MalaCards human disease database

More...
MalaCardsi
STAR
MIMi201710 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000147465

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
325524 Classic congenital lipoid adrenal hyperplasia due to STAR deficency
361 Familial glucocorticoid deficiency
325529 Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36181

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STAR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152974

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 63MitochondrionBy similarityAdd BLAST63
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003331664 – 285Steroidogenic acute regulatory protein, mitochondrialAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57Phosphoserine; by PKA1 Publication1
Modified residuei195Phosphoserine; by PKA1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49675

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49675

PeptideAtlas

More...
PeptideAtlasi
P49675

PRoteomics IDEntifications database

More...
PRIDEi
P49675

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56046

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49675

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49675

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in gonads, adrenal cortex and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147465 Expressed in 118 organ(s), highest expression level in metanephros

CleanEx database of gene expression profiles

More...
CleanExi
HS_STAR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49675 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49675 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032598
HPA023644
HPA027318

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with TSPO.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112647, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P49675, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276449

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P49675

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49675

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49675

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 280STARTPROSITE-ProRule annotationAdd BLAST214

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3845 Eukaryota
ENOG41100B5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155477

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000142452

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG010529

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49675

KEGG Orthology (KO)

More...
KOi
K16931

Identification of Orthologs from Complete Genome Data

More...
OMAi
QQGEEAM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06RM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49675

TreeFam database of animal gene trees

More...
TreeFami
TF313869

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08905 START_STARD1-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029866 StAR
IPR000799 StAR-like
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12136:SF9 PTHR12136:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01852 START, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00978 STARPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00234 START, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50848 START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P49675-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLATFKLCA GSSYRHMRNM KGLRQQAVMA ISQELNRRAL GGPTPSTWIN
60 70 80 90 100
QVRRRSSLLG SRLEETLYSD QELAYLQQGE EAMQKALGIL SNQEGWKKES
110 120 130 140 150
QQDNGDKVMS KVVPDVGKVF RLEVVVDQPM ERLYEELVER MEAMGEWNPN
160 170 180 190 200
VKEIKVLQKI GKDTFITHEL AAEAAGNLVG PRDFVSVRCA KRRGSTCVLA
210 220 230 240 250
GMATDFGNMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT WLLSIDLKGW
260 270 280
LPKSIINQVL SQTQVDFANH LRKRLESHPA SEARC
Length:285
Mass (Da):31,914
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2683086C20DE88AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YB94H0YB94_HUMAN
Steroidogenic acute regulatory prot...
STAR
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH12E5RH12_HUMAN
Steroidogenic acute regulatory prot...
STAR
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034520121R → W. Corresponds to variant dbSNP:rs34908868EnsemblClinVar.1
Natural variantiVAR_014236169E → G in AH1; partial loss of activity. 1 Publication1
Natural variantiVAR_014237169E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.1
Natural variantiVAR_005627182R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.1
Natural variantiVAR_005628203A → D3 PublicationsCorresponds to variant dbSNP:rs1042854Ensembl.1
Natural variantiVAR_014238217R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.1
Natural variantiVAR_014239218A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.1
Natural variantiVAR_014240225M → T in AH1. 1 Publication1
Natural variantiVAR_014241272Missing in AH1; partial loss of activity. 1 Publication1
Natural variantiVAR_014242275L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U17280 mRNA Translation: AAC50141.1
U29105
, U29099, U29100, U29101, U29102, U29103, U29104 Genomic DNA Translation: AAC50234.1
S79669 mRNA Translation: AAB35726.1
AF035277 mRNA Translation: AAB88174.1
BC010550 mRNA Translation: AAH10550.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6102.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38248

NCBI Reference Sequences

More...
RefSeqi
NP_000340.2, NM_000349.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.521535

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276449; ENSP00000276449; ENSG00000147465

Database of genes from NCBI RefSeq genomes

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GeneIDi
6770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6770

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Steroidogenic acute regulatory protein entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17280 mRNA Translation: AAC50141.1
U29105
, U29099, U29100, U29101, U29102, U29103, U29104 Genomic DNA Translation: AAC50234.1
S79669 mRNA Translation: AAB35726.1
AF035277 mRNA Translation: AAB88174.1
BC010550 mRNA Translation: AAH10550.1
CCDSiCCDS6102.1
PIRiI38248
RefSeqiNP_000340.2, NM_000349.2
UniGeneiHs.521535

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IMGmodel-A67-280[»]
2I93model-A67-280[»]
3P0LX-ray3.40A/B/C/D66-284[»]
5OMAX-ray3.90A/B/C/D54-62[»]
ProteinModelPortaliP49675
SMRiP49675
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112647, 5 interactors
IntActiP49675, 10 interactors
STRINGi9606.ENSP00000276449

Chemistry databases

SwissLipidsiSLP:000000714
SLP:000000716

PTM databases

iPTMnetiP49675
PhosphoSitePlusiP49675

Polymorphism and mutation databases

BioMutaiSTAR
DMDMi71152974

Proteomic databases

EPDiP49675
PaxDbiP49675
PeptideAtlasiP49675
PRIDEiP49675
ProteomicsDBi56046

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276449; ENSP00000276449; ENSG00000147465
GeneIDi6770
KEGGihsa:6770

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6770
DisGeNETi6770
EuPathDBiHostDB:ENSG00000147465.11

GeneCards: human genes, protein and diseases

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GeneCardsi
STAR
HGNCiHGNC:11359 STAR
HPAiCAB032598
HPA023644
HPA027318
MalaCardsiSTAR
MIMi201710 phenotype
600617 gene
neXtProtiNX_P49675
OpenTargetsiENSG00000147465
Orphaneti325524 Classic congenital lipoid adrenal hyperplasia due to STAR deficency
361 Familial glucocorticoid deficiency
325529 Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency
PharmGKBiPA36181

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3845 Eukaryota
ENOG41100B5 LUCA
GeneTreeiENSGT00940000155477
HOGENOMiHOG000142452
HOVERGENiHBG010529
InParanoidiP49675
KOiK16931
OMAiQQGEEAM
OrthoDBiEOG091G06RM
PhylomeDBiP49675
TreeFamiTF313869

Enzyme and pathway databases

UniPathwayi
UPA00296

ReactomeiR-HSA-196108 Pregnenolone biosynthesis
SIGNORiP49675

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STAR human
EvolutionaryTraceiP49675

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6770

Protein Ontology

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PROi
PR:P49675

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147465 Expressed in 118 organ(s), highest expression level in metanephros
CleanExiHS_STAR
ExpressionAtlasiP49675 baseline and differential
GenevisibleiP49675 HS

Family and domain databases

CDDicd08905 START_STARD1-like, 1 hit
Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR029866 StAR
IPR000799 StAR-like
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PANTHERiPTHR12136:SF9 PTHR12136:SF9, 1 hit
PfamiView protein in Pfam
PF01852 START, 1 hit
PRINTSiPR00978 STARPROTEIN
SMARTiView protein in SMART
SM00234 START, 1 hit
PROSITEiView protein in PROSITE
PS50848 START, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49675
Secondary accession number(s): Q16396
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 19, 2005
Last modified: December 5, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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