Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - P49675 (STAR_HUMAN)

Entry version 203 (23 Feb 2022)
Sequence version 2 (19 Jul 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Steroidogenic acute regulatory protein, mitochondrial

Gene

STAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Steroidogenesis, Transport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49675

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-196108, Pregnenolone biosynthesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49675

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49675

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00296

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000714
SLP:000000716

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Steroidogenic acute regulatory protein, mitochondrial
Short name:
StAR
Alternative name(s):
START domain-containing protein 1
Short name:
StARD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAR
Synonyms:STARD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11359, STAR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600617, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49675

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000147465

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Adrenal hyperplasia 1 (AH1)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionThe most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014236169E → G in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1254559989Ensembl.1
Natural variantiVAR_014237169E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.1
Natural variantiVAR_005627182R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.1
Natural variantiVAR_014238217R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.1
Natural variantiVAR_014239218A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.1
Natural variantiVAR_014240225M → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs1446362214Ensembl.1
Natural variantiVAR_014241272Missing in AH1; partial loss of activity. 1 Publication1
Natural variantiVAR_014242275L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736EnsemblClinVar.1

Keywords - Diseasei

Congenital adrenal hyperplasia, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		6770

MalaCards human disease database

More...MalaCardsi		STAR
MIMi201710, phenotype

Open Targets

More...OpenTargetsi		ENSG00000147465

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		325524, Classic congenital lipoid adrenal hyperplasia due to STAR deficency
361, Familial glucocorticoid deficiency
325529, Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36181

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49675, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STAR

Domain mapping of disease mutations (DMDM)

More...DMDMi		71152974

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 63MitochondrionBy similarityAdd BLAST63
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003331664 – 285Steroidogenic acute regulatory protein, mitochondrialAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57Phosphoserine; by PKA1 Publication1
Modified residuei195Phosphoserine; by PKA1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49675

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49675

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49675

PeptideAtlas

More...PeptideAtlasi		P49675

PRoteomics IDEntifications database

More...PRIDEi		P49675

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56046

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49675

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49675

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in gonads, adrenal cortex and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147465, Expressed in metanephros and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49675, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49675, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147465, Tissue enriched (adrenal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with TSPO.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112647, 11 interactors

Protein interaction database and analysis system

More...IntActi		P49675, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000276449

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49675, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49675

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P49675

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 280STARTPROSITE-ProRule annotationAdd BLAST214

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3845, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155477

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_093200_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49675

Identification of Orthologs from Complete Genome Data

More...OMAi		PGPSNWI

Database of Orthologous Groups

More...OrthoDBi		1437203at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49675

TreeFam database of animal gene trees

More...TreeFami		TF313869

Family and domain databases

Conserved Domains Database

More...CDDi		cd08905, START_STARD1-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029866, StAR
IPR000799, StAR-like
IPR023393, START-like_dom_sf
IPR002913, START_lipid-bd_dom

The PANTHER Classification System

More...PANTHERi		PTHR46489, PTHR46489, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01852, START, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00978, STARPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00234, START, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50848, START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P49675-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLATFKLCA GSSYRHMRNM KGLRQQAVMA ISQELNRRAL GGPTPSTWIN 
        60         70         80         90        100
QVRRRSSLLG SRLEETLYSD QELAYLQQGE EAMQKALGIL SNQEGWKKES 
       110        120        130        140        150
QQDNGDKVMS KVVPDVGKVF RLEVVVDQPM ERLYEELVER MEAMGEWNPN 
       160        170        180        190        200
VKEIKVLQKI GKDTFITHEL AAEAAGNLVG PRDFVSVRCA KRRGSTCVLA 
       210        220        230        240        250
GMATDFGNMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT WLLSIDLKGW 
       260        270        280 
LPKSIINQVL SQTQVDFANH LRKRLESHPA SEARC
Length:285
Mass (Da):31,914
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2683086C20DE88AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YB94H0YB94_HUMAN
START domain-containing protein 1
STAR
249Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH12E5RH12_HUMAN
Steroidogenic acute regulatory prot...
STAR
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034520121R → W. Corresponds to variant dbSNP:rs34908868EnsemblClinVar.1
Natural variantiVAR_014236169E → G in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1254559989Ensembl.1
Natural variantiVAR_014237169E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.1
Natural variantiVAR_005627182R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.1
Natural variantiVAR_005628203A → D3 PublicationsCorresponds to variant dbSNP:rs1042854Ensembl.1
Natural variantiVAR_014238217R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.1
Natural variantiVAR_014239218A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.1
Natural variantiVAR_014240225M → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs1446362214Ensembl.1
Natural variantiVAR_014241272Missing in AH1; partial loss of activity. 1 Publication1
Natural variantiVAR_014242275L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U17280 mRNA Translation: AAC50141.1
U29105 U29104 Genomic DNA Translation: AAC50234.1
S79669 mRNA Translation: AAB35726.1
AF035277 mRNA Translation: AAB88174.1
BC010550 mRNA Translation: AAH10550.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6102.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38248

NCBI Reference Sequences

More...RefSeqi		NP_000340.2, NM_000349.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000276449; ENSP00000276449; ENSG00000147465

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6770

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000276449.9; ENSP00000276449.3; NM_000349.3; NP_000340.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Steroidogenic acute regulatory protein entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17280 mRNA Translation: AAC50141.1
U29105 U29104 Genomic DNA Translation: AAC50234.1
S79669 mRNA Translation: AAB35726.1
AF035277 mRNA Translation: AAB88174.1
BC010550 mRNA Translation: AAH10550.1
CCDSiCCDS6102.1
PIRiI38248
RefSeqiNP_000340.2, NM_000349.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P0LX-ray3.40A/B/C/D66-284[»]
5OMAX-ray3.90A/B/C/D54-62[»]
6T5FX-ray2.63E/F/G/H192-200[»]
6T5HX-ray2.04A/B54-62[»]
SMRiP49675
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112647, 11 interactors
IntActiP49675, 11 interactors
STRINGi9606.ENSP00000276449

Chemistry databases

SwissLipidsiSLP:000000714
SLP:000000716

PTM databases

iPTMnetiP49675
PhosphoSitePlusiP49675

Genetic variation databases

BioMutaiSTAR
DMDMi71152974

Proteomic databases

EPDiP49675
MassIVEiP49675
PaxDbiP49675
PeptideAtlasiP49675
PRIDEiP49675
ProteomicsDBi56046

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23510, 326 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		6770

Genome annotation databases

EnsembliENST00000276449; ENSP00000276449; ENSG00000147465
GeneIDi6770
KEGGihsa:6770
MANE-SelectiENST00000276449.9; ENSP00000276449.3; NM_000349.3; NP_000340.2

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6770
DisGeNETi6770

GeneCards: human genes, protein and diseases

More...GeneCardsi		STAR
HGNCiHGNC:11359, STAR
HPAiENSG00000147465, Tissue enriched (adrenal)
MalaCardsiSTAR
MIMi201710, phenotype
600617, gene
neXtProtiNX_P49675
OpenTargetsiENSG00000147465
Orphaneti325524, Classic congenital lipoid adrenal hyperplasia due to STAR deficency
361, Familial glucocorticoid deficiency
325529, Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency
PharmGKBiPA36181
VEuPathDBiHostDB:ENSG00000147465

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3845, Eukaryota
GeneTreeiENSGT00940000155477
HOGENOMiCLU_093200_1_0_1
InParanoidiP49675
OMAiPGPSNWI
OrthoDBi1437203at2759
PhylomeDBiP49675
TreeFamiTF313869

Enzyme and pathway databases

UniPathwayiUPA00296
PathwayCommonsiP49675
ReactomeiR-HSA-196108, Pregnenolone biosynthesis
SignaLinkiP49675
SIGNORiP49675

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6770, 6 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STAR, human
EvolutionaryTraceiP49675

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6770
PharosiP49675, Tbio

Protein Ontology

More...PROi		PR:P49675
RNActiP49675, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147465, Expressed in metanephros and 133 other tissues
ExpressionAtlasiP49675, baseline and differential
GenevisibleiP49675, HS

Family and domain databases

CDDicd08905, START_STARD1-like, 1 hit
Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR029866, StAR
IPR000799, StAR-like
IPR023393, START-like_dom_sf
IPR002913, START_lipid-bd_dom
PANTHERiPTHR46489, PTHR46489, 1 hit
PfamiView protein in Pfam
PF01852, START, 1 hit
PRINTSiPR00978, STARPROTEIN
SMARTiView protein in SMART
SM00234, START, 1 hit
PROSITEiView protein in PROSITE
PS50848, START, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49675
Secondary accession number(s): Q16396
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 19, 2005
Last modified: February 23, 2022
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again