STAR

Functionⁱ

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.3 Publications

Catalytic activityⁱ

cholesterol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
(in) =
cholesterol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
(out)
2 Publications
Manual assertion based on experiment inⁱ
- Ref.1
  "Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13."
  Sugawara T., Holt J.A., Driscoll D., Strauss J.F. III, Lin D., Miller W.L., Patterson D., Clancy K.P., Hart I.M., Clark B.J., Stocco D.M.
  Proc. Natl. Acad. Sci. U.S.A. 92:4778-4782(1995) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-203, FUNCTION, CATALYTIC ACTIVITY.
- Ref.8
  "Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis."
  Lin D., Sugawara T., Strauss J.F. III, Clark B.J., Stocco D.M., Saenger P., Rogol A., Miller W.L.
  Science 267:1828-1831(1995) [PubMed] [Europe PMC] [Abstract]
  Cited for: CATALYTIC ACTIVITY, INVOLVEMENT IN AH1, FUNCTION.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
cholesterol(in)
zoom
=
cholesterol(out)
zoom

Pathwayⁱ: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

bile acid biosynthetic process Source: Ensembl
biphenyl metabolic process Source: Ensembl
brain development Source: Ensembl
C21-steroid hormone biosynthetic process Source: Reactome
cellular response to alkaloid Source: Ensembl
cellular response to antibiotic Source: Ensembl
cellular response to cadmium ion Source: Ensembl
cellular response to cAMP Source: Ensembl
cellular response to dexamethasone stimulus Source: Ensembl
cellular response to epinephrine stimulus Source: Ensembl
cellular response to fibroblast growth factor stimulus Source: Ensembl
cellular response to follicle-stimulating hormone stimulus Source: Ensembl
cellular response to glucose stimulus Source: Ensembl
cellular response to growth hormone stimulus Source: Ensembl
cellular response to insulin stimulus Source: Ensembl
cellular response to interferon-alpha Source: Ensembl
cellular response to interferon-gamma Source: Ensembl
cellular response to lipopolysaccharide Source: Ensembl
cellular response to luteinizing hormone stimulus Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
cholesterol metabolic process Source: UniProtKB-UniPathway
circadian sleep/wake cycle, REM sleep Source: Ensembl
dibenzo-p-dioxin metabolic process Source: Ensembl
diterpenoid metabolic process Source: Ensembl
estrogen biosynthetic process Source: Ensembl
glucocorticoid metabolic process Source: Ensembl
insecticide metabolic process Source: Ensembl
intracellular cholesterol transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
male gonad development Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
phenol-containing compound metabolic process Source: Ensembl
phthalate metabolic process Source: Ensembl
positive regulation of bile acid biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- "Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation."
  Rodriguez-Agudo D., Ren S., Wong E., Marques D., Redford K., Gil G., Hylemon P., Pandak W.M.
  J. Lipid Res. 49:1409-1419(2008) [PubMed] [Europe PMC] [Abstract]
positive regulation of gene expression Source: Ensembl
positive regulation of neurogenesis Source: Ensembl
regulation of neuronal synaptic plasticity Source: Ensembl
regulation of steroid biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
response to activity Source: Ensembl
response to corticosterone Source: Ensembl
response to drug Source: Ensembl
response to estrogen Source: Ensembl
response to ethanol Source: Ensembl
response to fungicide Source: Ensembl
response to herbicide Source: Ensembl
response to hydrogen peroxide Source: Ensembl
response to ionizing radiation Source: Ensembl
response to lead ion Source: Ensembl
response to leptin Source: Ensembl
response to nicotine Source: Ensembl
response to nutrient Source: Ensembl
steroid biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
testosterone biosynthetic process Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Steroidogenesis, Transport
Ligand	Lipid-binding

Enzyme and pathway databases

PathwayCommonsⁱ	P49675
Reactomeⁱ	R-HSA-196108, Pregnenolone biosynthesis
SIGNORⁱ	P49675
UniPathwayⁱ	UPA00296

Chemistry databases

SwissLipidsⁱ	SLP:000000714 SLP:000000716

SwissLipidsⁱ

SLP:000000714
SLP:000000716

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Steroidogenic acute regulatory protein, mitochondrial Short name: StAR Alternative name(s): START domain-containing protein 1 Short name: StARD1
Gene namesⁱ	Name:STAR Synonyms:STARD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11359, STAR
MIMⁱ	600617, gene
neXtProtⁱ	NX_P49675
VEuPathDBⁱ	HostDB:ENSG00000147465.11

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Adrenal hyperplasia 1 (AH1)4 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionThe most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014236	169	E → G in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1254559989Ensembl.	1
Natural variantⁱVAR_014237	169	E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.	1
Natural variantⁱVAR_005627	182	R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.	1
Natural variantⁱVAR_014238	217	R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.	1
Natural variantⁱVAR_014239	218	A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.	1
Natural variantⁱVAR_014240	225	M → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs1446362214Ensembl.	1
Natural variantⁱVAR_014241	272	Missing in AH1; partial loss of activity. 1 Publication	1
Natural variantⁱVAR_014242	275	L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736Ensembl.	1

Keywords - Diseaseⁱ

Congenital adrenal hyperplasia, Disease variant

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6770
MalaCards human disease database More...MalaCardsⁱ	STAR
MIMⁱ	201710, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000147465
Orphanetⁱ	325524, Classic congenital lipoid adrenal hyperplasia due to STAR deficency 361, Familial glucocorticoid deficiency 325529, Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency
PharmGKBⁱ	PA36181

Miscellaneous databases

Pharosⁱ	P49675, Tbio

Pharosⁱ

P49675, Tbio

Genetic variation databases

BioMutaⁱ	STAR
DMDMⁱ	71152974

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 63	MitochondrionBy similarityAdd BLAST		63
ChainⁱPRO_0000033316	64 – 285	Steroidogenic acute regulatory protein, mitochondrialAdd BLAST		222

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	57	Phosphoserine; by PKA1 Publication		1
Modified residueⁱ	195	Phosphoserine; by PKA1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P49675
MassIVEⁱ	P49675
PaxDbⁱ	P49675
PeptideAtlas More...PeptideAtlasⁱ	P49675
PRIDEⁱ	P49675
ProteomicsDBⁱ	56046

PTM databases

iPTMnetⁱ	P49675
PhosphoSitePlusⁱ	P49675

Expressionⁱ

Tissue specificityⁱ

Expressed in gonads, adrenal cortex and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000147465, Expressed in metanephros and 132 other tissues
ExpressionAtlasⁱ	P49675, baseline and differential
Genevisibleⁱ	P49675, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000147465, Group enriched (adrenal gland, ovary)

HPAⁱ

ENSG00000147465, Group enriched (adrenal gland, ovary)

Interactionⁱ

Subunit structureⁱ

May interact with TSPO.

By similarity

Binary interactionsⁱ

Hide details

P49675

With	#Exp.	IntAct
AGTRAP - isoform 2 [Q6RW13-2]	3	EBI-722932,EBI-11522760
CMTM4 - isoform 2 [Q8IZR5-2]	3	EBI-722932,EBI-17278014
DGAT2L6 [Q6ZPD8]	3	EBI-722932,EBI-12831978
HTT [P42858]	3	EBI-722932,EBI-466029
MAGEA11 [G5E962]	3	EBI-722932,EBI-11525615
MAGEA11 [P43364]	6	EBI-722932,EBI-739552
MAGEA11 - isoform 2 [P43364-2]	3	EBI-722932,EBI-10178634
RABEP1 [Q15276]	3	EBI-722932,EBI-447043
SMPD2 [O60906]	3	EBI-722932,EBI-12828299
STX8 [Q9UNK0]	3	EBI-722932,EBI-727240

Protein-protein interaction databases

BioGRIDⁱ	112647, 11 interactors
IntActⁱ	P49675, 11 interactors
STRINGⁱ	9606.ENSP00000276449

Miscellaneous databases

RNActⁱ	P49675, protein

RNActⁱ

P49675, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	70 – 91	Combined sources	22
Beta strandⁱ	97 – 101	Combined sources	5
Beta strandⁱ	107 – 112	Combined sources	6
Beta strandⁱ	114 – 116	Combined sources	3
Beta strandⁱ	118 – 128	Combined sources	11
Helixⁱ	130 – 137	Combined sources	8
Turnⁱ	138 – 140	Combined sources	3
Helixⁱ	141 – 143	Combined sources	3
Beta strandⁱ	152 – 159	Combined sources	8
Beta strandⁱ	161 – 171	Combined sources	11
Beta strandⁱ	182 – 192	Combined sources	11
Beta strandⁱ	197 – 199	Combined sources	3
Beta strandⁱ	215 – 217	Combined sources	3
Beta strandⁱ	224 – 230	Combined sources	7
Beta strandⁱ	233 – 243	Combined sources	11
Helixⁱ	253 – 274	Combined sources	22

Show more details

3D structure databases

SMRⁱ	P49675
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49675

EvolutionaryTraceⁱ

P49675

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	67 – 280	STARTPROSITE-ProRule annotationAdd BLAST		214

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3845, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155477
HOGENOMⁱ	CLU_093200_1_0_1
InParanoidⁱ	P49675
OMAⁱ	PGPSNWI
Database of Orthologous Groups More...OrthoDBⁱ	1437203at2759
PhylomeDBⁱ	P49675
TreeFamⁱ	TF313869

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08905, START_STARD1-like, 1 hit
Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR029866, StAR IPR000799, StAR-like IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom
PANTHERⁱ	PTHR46489, PTHR46489, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01852, START, 1 hit
PRINTSⁱ	PR00978, STARPROTEIN
SMARTⁱ	View protein in SMART SM00234, START, 1 hit
PROSITEⁱ	View protein in PROSITE PS50848, START, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P49675-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLATFKLCA GSSYRHMRNM KGLRQQAVMA ISQELNRRAL GGPTPSTWIN 
        60         70         80         90        100
QVRRRSSLLG SRLEETLYSD QELAYLQQGE EAMQKALGIL SNQEGWKKES 
       110        120        130        140        150
QQDNGDKVMS KVVPDVGKVF RLEVVVDQPM ERLYEELVER MEAMGEWNPN 
       160        170        180        190        200
VKEIKVLQKI GKDTFITHEL AAEAAGNLVG PRDFVSVRCA KRRGSTCVLA 
       210        220        230        240        250
GMATDFGNMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT WLLSIDLKGW 
       260        270        280 
LPKSIINQVL SQTQVDFANH LRKRLESHPA SEARC

Length:285

Mass (Da):31,914

Last modified:July 19, 2005 - v2

Checksum:ⁱ2683086C20DE88AB

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YB94	H0YB94_HUMAN	START domain-containing protein 1 START domain-containing protein 1 (Steroidogenic acute regulatory protein, mitochondrial)	STAR	249	Annotation score:
E5RH12	E5RH12_HUMAN	Steroidogenic acute regulatory prot... Steroidogenic acute regulatory protein, mitochondrial	STAR	48	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034520	121	R → W. Corresponds to variant dbSNP:rs34908868EnsemblClinVar.	1
Natural variantⁱVAR_014236	169	E → G in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1254559989Ensembl.	1
Natural variantⁱVAR_014237	169	E → K in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747169620EnsemblClinVar.	1
Natural variantⁱVAR_005627	182	R → L in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894086EnsemblClinVar.	1
Natural variantⁱVAR_005628	203	A → D3 PublicationsCorresponds to variant dbSNP:rs1042854Ensembl.	1
Natural variantⁱVAR_014238	217	R → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs137852689EnsemblClinVar.	1
Natural variantⁱVAR_014239	218	A → V in AH1; partial loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs137852690EnsemblClinVar.	1
Natural variantⁱVAR_014240	225	M → T in AH1. 1 PublicationCorresponds to variant dbSNP:rs1446362214Ensembl.	1
Natural variantⁱVAR_014241	272	Missing in AH1; partial loss of activity. 1 Publication	1
Natural variantⁱVAR_014242	275	L → P in AH1; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs762245736Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17280 mRNA Translation: AAC50141.1 U29105 U29104 Genomic DNA Translation: AAC50234.1 S79669 mRNA Translation: AAB35726.1 AF035277 mRNA Translation: AAB88174.1 BC010550 mRNA Translation: AAH10550.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6102.1
PIRⁱ	I38248
NCBI Reference Sequences More...RefSeqⁱ	NP_000340.2, NM_000349.2

Genome annotation databases

Ensemblⁱ	ENST00000276449; ENSP00000276449; ENSG00000147465
GeneIDⁱ	6770
KEGGⁱ	hsa:6770

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49675	Steroidogenic acute regulatory protein, mitochondrial		HUMAN		285	UniRef100_P49675
Steroidogenic acute regulatory protein, mitochondrial		PANTR		203
Steroid acute regulatory protein (Fragment)		HUMAN		28

Protein	Similar proteins		Species	Score	Length	Source
P49675	Steroidogenic acute regulatory protein, mitochondrial		HUMAN		285	UniRef90_P49675
Steroidogenic acute regulatory protein, mitochondrial		PANTR		203
Steroidogenic acute regulatory protein, mitochondrial		MACMU		285
Steroidogenic acute regulatory protein, mitochondrial		MACFA		285
START domain-containing protein 1		PANPA		230
+5

Protein	Similar proteins		Species	Score	Length	Source
P49675	Steroidogenic acute regulatory protein, mitochondrial		RAT		284	UniRef50_P97826
Steroidogenic acute regulatory protein, mitochondrial	)	MESAU		284
Steroidogenic acute regulatory protein, mitochondrial		MOUSE		284
Steroidogenic acute regulatory protein		XENLA		285
Steroidogenic acute regulatory protein, mitochondrial		ONCMY		287
+378

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Steroidogenic acute regulatory protein entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17280 mRNA Translation: AAC50141.1 U29105 U29104 Genomic DNA Translation: AAC50234.1 S79669 mRNA Translation: AAB35726.1 AF035277 mRNA Translation: AAB88174.1 BC010550 mRNA Translation: AAH10550.1
CCDSⁱ	CCDS6102.1
PIRⁱ	I38248
RefSeqⁱ	NP_000340.2, NM_000349.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IMG	model	-	A	67-280	[»]
	2I93	model	-	A	67-280	[»]
	3P0L	X-ray	3.40	A/B/C/D	66-284	[»]
	5OMA	X-ray	3.90	A/B/C/D	54-62	[»]
	6T5H	X-ray	2.04	A/B	54-62	[»]
SMRⁱ	P49675
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	112647, 11 interactors
IntActⁱ	P49675, 11 interactors
STRINGⁱ	9606.ENSP00000276449

Chemistry databases

SwissLipidsⁱ	SLP:000000714 SLP:000000716

SwissLipidsⁱ

SLP:000000714
SLP:000000716

PTM databases

iPTMnetⁱ	P49675
PhosphoSitePlusⁱ	P49675

Genetic variation databases

BioMutaⁱ	STAR
DMDMⁱ	71152974

Proteomic databases

EPDⁱ	P49675
MassIVEⁱ	P49675
PaxDbⁱ	P49675
PeptideAtlasⁱ	P49675
PRIDEⁱ	P49675
ProteomicsDBⁱ	56046

Protocols and materials databases

Antibodypediaⁱ	23510, 316 antibodies

Antibodypediaⁱ

23510, 316 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000276449; ENSP00000276449; ENSG00000147465
GeneIDⁱ	6770
KEGGⁱ	hsa:6770

Organism-specific databases

CTDⁱ	6770
DisGeNETⁱ	6770
GeneCardsⁱ	STAR
HGNCⁱ	HGNC:11359, STAR
HPAⁱ	ENSG00000147465, Group enriched (adrenal gland, ovary)
MalaCardsⁱ	STAR
MIMⁱ	201710, phenotype 600617, gene
neXtProtⁱ	NX_P49675
OpenTargetsⁱ	ENSG00000147465
Orphanetⁱ	325524, Classic congenital lipoid adrenal hyperplasia due to STAR deficency 361, Familial glucocorticoid deficiency 325529, Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency
PharmGKBⁱ	PA36181
VEuPathDBⁱ	HostDB:ENSG00000147465.11
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3845, Eukaryota
GeneTreeⁱ	ENSGT00940000155477
HOGENOMⁱ	CLU_093200_1_0_1
InParanoidⁱ	P49675
OMAⁱ	PGPSNWI
OrthoDBⁱ	1437203at2759
PhylomeDBⁱ	P49675
TreeFamⁱ	TF313869

Enzyme and pathway databases

UniPathwayⁱ	UPA00296
PathwayCommonsⁱ	P49675
Reactomeⁱ	R-HSA-196108, Pregnenolone biosynthesis
SIGNORⁱ	P49675

Miscellaneous databases

BioGRID-ORCSⁱ	6770, 4 hits in 992 CRISPR screens
ChiTaRSⁱ	STAR, human
EvolutionaryTraceⁱ	P49675
GenomeRNAiⁱ	6770
Pharosⁱ	P49675, Tbio
Protein Ontology More...PROⁱ	PR:P49675
RNActⁱ	P49675, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147465, Expressed in metanephros and 132 other tissues
ExpressionAtlasⁱ	P49675, baseline and differential
Genevisibleⁱ	P49675, HS

Family and domain databases

CDDⁱ	cd08905, START_STARD1-like, 1 hit
Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR029866, StAR IPR000799, StAR-like IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom
PANTHERⁱ	PTHR46489, PTHR46489, 1 hit
Pfamⁱ	View protein in Pfam PF01852, START, 1 hit
PRINTSⁱ	PR00978, STARPROTEIN
SMARTⁱ	View protein in SMART SM00234, START, 1 hit
PROSITEⁱ	View protein in PROSITE PS50848, START, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STAR_HUMAN
Accessionⁱ	P49675Primary (citable) accession number: P49675 Secondary accession number(s): Q16396
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	July 19, 2005
	Last modified:	April 7, 2021
	This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniRef

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Supporting data

UniProtKB - P49675 (STAR_HUMAN)

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Steroidogenic acute regulatory protein, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cholesterol metabolism

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P49675

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: cholesterol metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ