UniProtKB - P49662 (CASP4_HUMAN)
Caspase-4
CASP4
Functioni
Catalytic activityi
- Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.2 Publications EC:3.4.22.57
Activity regulationi
Kineticsi
- KM=681 µM for synthetic peptide acetyl-YVAD-p-nitroanilide1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 210 | By similarity | 1 | |
Active sitei | 258 | 4 Publications | 1 |
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
- cysteine-type endopeptidase activity Source: UniProtKB
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: GO_Central
GO - Biological processi
- apoptotic process Source: ProtInc
- cellular response to amyloid-beta Source: ParkinsonsUK-UCL
- execution phase of apoptosis Source: GOC
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- positive regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- proteolysis Source: ProtInc
- regulation of apoptotic process Source: InterPro
- regulation of inflammatory response Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Immunity, Inflammatory response, Innate immunity, Necrosis |
Enzyme and pathway databases
BRENDAi | 3.4.22.57, 2681 |
PathwayCommonsi | P49662 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway |
SABIO-RKi | P49662 |
SIGNORi | P49662 |
Protein family/group databases
MEROPSi | C14.007 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase-41 Publication (EC:3.4.22.572 Publications)Short name: CASP-41 Publication Alternative name(s): ICE and Ced-3 homolog 21 Publication Short name: ICH-21 Publication ICE(rel)-II1 Publication Mih11 Publication Protease TX1 Publication Cleaved into the following 2 chains: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196954.12 |
HGNCi | HGNC:1505, CASP4 |
MIMi | 602664, gene |
neXtProti | NX_P49662 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Mitochondrion
- Mitochondrion 2 Publications
Cytosol
- cytosol 1 Publication
- Inflammasome 2 Publications
Extracellular region or secreted
- Secreted 1 Publication
Note: Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630).2 Publications
Cytosol
- AIM2 inflammasome complex Source: GO_Central
- cytosol Source: HPA
- IPAF inflammasome complex Source: GO_Central
- NLRP3 inflammasome complex Source: GO_Central
Endoplasmic reticulum
- endoplasmic reticulum Source: ParkinsonsUK-UCL
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: ParkinsonsUK-UCL
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Inflammasome, Membrane, Mitochondrion, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 258 | C → A: Loss of enzymatic activity. Loss of LPS-induced pyroptosis. No effect on the interaction with LPS. Decrease in cell death induced by TMEM214 overexpression. Does not support IL1B and IL18 secretion following UVB irradiation. 4 Publications | 1 | |
Mutagenesisi | 258 | C → S: Loss of autocatalysis. 1 Publication | 1 | |
Mutagenesisi | 267 | W → L or N: Abolished interaction with Gasdermin-D (GSDMD) and ability to mediate its cleavage. 1 Publication | 1 | |
Mutagenesisi | 270 | D → A: Abolished autoprocessing and ability to form a heterotetramer composed of Caspase-4 subunit p10 and Caspase-4 subunit p20, preventing ability to cleave GSDMD and induce pyroptosis. 1 Publication | 1 | |
Mutagenesisi | 291 | V → N: Abolished interaction with Gasdermin-D (GSDMD) and ability to mediate its cleavage. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 837 |
OpenTargetsi | ENSG00000196954 |
PharmGKBi | PA26088 |
Miscellaneous databases
Pharosi | P49662, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2226 |
DrugBanki | DB06255, Incadronic acid |
GuidetoPHARMACOLOGYi | 1620 |
Polymorphism and mutation databases
BioMutai | CASP4 |
DMDMi | 1352420 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
PropeptideiPRO_0000004596 | 1 – ?80 | Sequence analysisAdd BLAST | 80 | ||
ChainiPRO_0000004597 | ?81 – 270 | Caspase-4 subunit p101 PublicationAdd BLAST | 190 | ||
PropeptideiPRO_0000004598 | 271 – 289 | Sequence analysis1 PublicationAdd BLAST | 19 | ||
ChainiPRO_0000004599 | 290 – 377 | Caspase-4 subunit p201 PublicationAdd BLAST | 88 | ||
Isoform 2 (identifier: P49662-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 83 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: P49662-2) | |||||
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 289 – 290 | Cleavage; by autolysis1 Publication | 2 |
Keywords - PTMi
Acetylation, Phosphoprotein, ZymogenProteomic databases
EPDi | P49662 |
jPOSTi | P49662 |
MassIVEi | P49662 |
MaxQBi | P49662 |
PaxDbi | P49662 |
PeptideAtlasi | P49662 |
PRIDEi | P49662 |
ProteomicsDBi | 56043 [P49662-1] 56044 [P49662-2] |
PTM databases
iPTMneti | P49662 |
MetOSitei | P49662 |
PhosphoSitePlusi | P49662 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000196954, Expressed in monocyte and 206 other tissues |
ExpressionAtlasi | P49662, baseline and differential |
Genevisiblei | P49662, HS |
Organism-specific databases
HPAi | ENSG00000196954, Tissue enriched (blood) |
Interactioni
Subunit structurei
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit (PubMed:32109412). Upon direct LPS-binding, forms large homooligomers, resulting in its activation (By similarity). These oligomers are often referred to as 'non-canonical inflammasomes' (PubMed:25119034). In its precursor form, interacts with TMEM214; this interaction is required for association with the endoplasmic reticulum membrane (PubMed:23661706).
Interacts with CASP1 (PubMed:22246630).
Interacts with NOD2 (PubMed:18511561).
Interacts with SERPINB1; this interaction regulates CASP4 activity (PubMed:30692621).
By similarity6 PublicationsHeterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit.
1 PublicationHeterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit.
1 Publication(Microbial infection) Interacts with NleF protein from pathogenic E.coli; this interaction leads to enzyme inhibition.
1 PublicationGO - Molecular functioni
- CARD domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107287, 34 interactors |
DIPi | DIP-44806N |
IntActi | P49662, 6 interactors |
STRINGi | 9606.ENSP00000388566 |
Chemistry databases
BindingDBi | P49662 |
Miscellaneous databases
RNActi | P49662, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 91 | CARDPROSITE-ProRule annotationAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 59 | Required for LPS-bindingBy similarityAdd BLAST | 59 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000161497 |
HOGENOMi | CLU_036904_0_1_1 |
InParanoidi | P49662 |
OMAi | AHLNMEA |
OrthoDBi | 1327703at2759 |
PhylomeDBi | P49662 |
TreeFami | TF102023 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00114, CARD, 1 hit SM00115, CASc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEGNHRKKP LKVLESLGKD FLTGVLDNLV EQNVLNWKEE EKKKYYDAKT
60 70 80 90 100
EDKVRVMADS MQEKQRMAGQ MLLQTFFNID QISPNKKAHP NMEAGPPESG
110 120 130 140 150
ESTDALKLCP HEEFLRLCKE RAEEIYPIKE RNNRTRLALI ICNTEFDHLP
160 170 180 190 200
PRNGADFDIT GMKELLEGLD YSVDVEENLT ARDMESALRA FATRPEHKSS
210 220 230 240 250
DSTFLVLMSH GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP
260 270 280 290 300
KVIIVQACRG ANRGELWVRD SPASLEVASS QSSENLEEDA VYKTHVEKDF
310 320 330 340 350
IAFCSSTPHN VSWRDSTMGS IFITQLITCF QKYSWCCHLE EVFRKVQQSF
360 370
ETPRAKAQMP TIERLSMTRY FYLFPGN
The sequence of this isoform differs from the canonical sequence as follows:
88-116: AHPNMEAGPPESGESTDALKLCPHEEFLR → GDKLGHRGRNHNLCSAISCSSSEYGGWTT
117-377: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PMT1 | E9PMT1_HUMAN | Caspase-4 | CASP4 | 147 | Annotation score: | ||
H0YD34 | H0YD34_HUMAN | Caspase-4 | CASP4 | 72 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061081 | 47 | D → N. Corresponds to variant dbSNP:rs56226603EnsemblClinVar. | 1 | |
Natural variantiVAR_075654 | 134 | R → C1 PublicationCorresponds to variant dbSNP:rs181090259Ensembl. | 1 | |
Natural variantiVAR_061082 | 284 | E → D. Corresponds to variant dbSNP:rs55901059EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043495 | 1 – 56 | Missing in isoform 2. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_058177 | 88 – 116 | AHPNM…EEFLR → GDKLGHRGRNHNLCSAISCS SSEYGGWTT in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_058178 | 117 – 377 | Missing in isoform 3. 1 PublicationAdd BLAST | 261 | |
Alternative sequenceiVSP_058179 | 125 – 157 | IYPIK…NGADF → VLCYLYEIEKKEEISLLSFS APFLTALNDWGWG in isoform 5. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_058180 | 158 – 377 | Missing in isoform 5. 1 PublicationAdd BLAST | 220 | |
Alternative sequenceiVSP_058181 | 261 – 263 | ANR → GEC in isoform 4. 2 Publications | 3 | |
Alternative sequenceiVSP_058182 | 264 – 377 | Missing in isoform 4. 2 PublicationsAdd BLAST | 114 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48810 mRNA Translation: CAA88750.1 U28014 mRNA Translation: AAA75171.1 U25804 mRNA Translation: AAA86890.1 U28976 mRNA Translation: AAC99850.1 U28977 mRNA Translation: AAC99851.1 Frameshift. U28978 mRNA Translation: AAC99852.1 U28979 mRNA Translation: AAC99853.1 U28979 mRNA Translation: AAC99854.1 Sequence problems. AK057094 mRNA Translation: BAG51861.1 AK296081 mRNA Translation: BAG58837.1 AK304222 mRNA Translation: BAG65094.1 EF636667 Genomic DNA Translation: ABR09278.1 AP001153 Genomic DNA No translation available. AP002004 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67050.1 Sequence problems. CH471065 Genomic DNA Translation: EAW67051.1 CH471065 Genomic DNA Translation: EAW67052.1 BC017839 mRNA Translation: AAH17839.1 AL050391 mRNA Translation: CAB43686.2 |
CCDSi | CCDS41704.1 [P49662-2] CCDS8327.1 [P49662-1] |
PIRi | A57511 |
RefSeqi | NP_001216.1, NM_001225.3 [P49662-1] NP_150649.1, NM_033306.2 [P49662-2] XP_011541321.1, XM_011543019.1 XP_016873886.1, XM_017018397.1 |
Genome annotation databases
Ensembli | ENST00000393150; ENSP00000376857; ENSG00000196954 [P49662-2] ENST00000444739; ENSP00000388566; ENSG00000196954 [P49662-1] |
GeneIDi | 837 |
KEGGi | hsa:837 |
UCSCi | uc001pib.2, human [P49662-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48810 mRNA Translation: CAA88750.1 U28014 mRNA Translation: AAA75171.1 U25804 mRNA Translation: AAA86890.1 U28976 mRNA Translation: AAC99850.1 U28977 mRNA Translation: AAC99851.1 Frameshift. U28978 mRNA Translation: AAC99852.1 U28979 mRNA Translation: AAC99853.1 U28979 mRNA Translation: AAC99854.1 Sequence problems. AK057094 mRNA Translation: BAG51861.1 AK296081 mRNA Translation: BAG58837.1 AK304222 mRNA Translation: BAG65094.1 EF636667 Genomic DNA Translation: ABR09278.1 AP001153 Genomic DNA No translation available. AP002004 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67050.1 Sequence problems. CH471065 Genomic DNA Translation: EAW67051.1 CH471065 Genomic DNA Translation: EAW67052.1 BC017839 mRNA Translation: AAH17839.1 AL050391 mRNA Translation: CAB43686.2 |
CCDSi | CCDS41704.1 [P49662-2] CCDS8327.1 [P49662-1] |
PIRi | A57511 |
RefSeqi | NP_001216.1, NM_001225.3 [P49662-1] NP_150649.1, NM_033306.2 [P49662-2] XP_011541321.1, XM_011543019.1 XP_016873886.1, XM_017018397.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6KMZ | X-ray | 3.61 | A/B/C/D | 105-377 | [»] | |
6NRY | X-ray | 2.18 | A | 92-377 | [»] | |
SMRi | P49662 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107287, 34 interactors |
DIPi | DIP-44806N |
IntActi | P49662, 6 interactors |
STRINGi | 9606.ENSP00000388566 |
Chemistry databases
BindingDBi | P49662 |
ChEMBLi | CHEMBL2226 |
DrugBanki | DB06255, Incadronic acid |
GuidetoPHARMACOLOGYi | 1620 |
Protein family/group databases
MEROPSi | C14.007 |
PTM databases
iPTMneti | P49662 |
MetOSitei | P49662 |
PhosphoSitePlusi | P49662 |
Polymorphism and mutation databases
BioMutai | CASP4 |
DMDMi | 1352420 |
Proteomic databases
EPDi | P49662 |
jPOSTi | P49662 |
MassIVEi | P49662 |
MaxQBi | P49662 |
PaxDbi | P49662 |
PeptideAtlasi | P49662 |
PRIDEi | P49662 |
ProteomicsDBi | 56043 [P49662-1] 56044 [P49662-2] |
Protocols and materials databases
Antibodypediai | 18094, 704 antibodies |
DNASUi | 837 |
Genome annotation databases
Ensembli | ENST00000393150; ENSP00000376857; ENSG00000196954 [P49662-2] ENST00000444739; ENSP00000388566; ENSG00000196954 [P49662-1] |
GeneIDi | 837 |
KEGGi | hsa:837 |
UCSCi | uc001pib.2, human [P49662-1] |
Organism-specific databases
CTDi | 837 |
DisGeNETi | 837 |
EuPathDBi | HostDB:ENSG00000196954.12 |
GeneCardsi | CASP4 |
HGNCi | HGNC:1505, CASP4 |
HPAi | ENSG00000196954, Tissue enriched (blood) |
MIMi | 602664, gene |
neXtProti | NX_P49662 |
OpenTargetsi | ENSG00000196954 |
PharmGKBi | PA26088 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000161497 |
HOGENOMi | CLU_036904_0_1_1 |
InParanoidi | P49662 |
OMAi | AHLNMEA |
OrthoDBi | 1327703at2759 |
PhylomeDBi | P49662 |
TreeFami | TF102023 |
Enzyme and pathway databases
BRENDAi | 3.4.22.57, 2681 |
PathwayCommonsi | P49662 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway |
SABIO-RKi | P49662 |
SIGNORi | P49662 |
Miscellaneous databases
BioGRID-ORCSi | 837, 6 hits in 842 CRISPR screens |
ChiTaRSi | CASP4, human |
GenomeRNAii | 837 |
Pharosi | P49662, Tchem |
PROi | PR:P49662 |
RNActi | P49662, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196954, Expressed in monocyte and 206 other tissues |
ExpressionAtlasi | P49662, baseline and differential |
Genevisiblei | P49662, HS |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00114, CARD, 1 hit SM00115, CASc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CASP4_HUMAN | |
Accessioni | P49662Primary (citable) accession number: P49662 Secondary accession number(s): A2NHL8 Q9UG96 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries