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Protein

P2X purinoceptor 3

Gene

P2rx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated cation channel (PubMed:7566120, PubMed:7566119). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172ATPBy similarity1
Binding sitei275ATPBy similarity1
Binding sitei299ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 65ATPBy similarity3
Nucleotide bindingi279 – 281ATPBy similarity3

GO - Molecular functioni

  • ATP binding Source: RGD
  • ATP-gated ion channel activity Source: GO_Central
  • extracellularly ATP-gated cation channel activity Source: UniProtKB
  • purinergic nucleotide receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 3
Short name:
P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620253 P2rx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicCuratedAdd BLAST20
Transmembranei21 – 43Helical; Name=1By similarityAdd BLAST23
Topological domaini44 – 322ExtracellularCuratedAdd BLAST279
Transmembranei323 – 341Helical; Name=2By similarityAdd BLAST19
Topological domaini342 – 397CytoplasmicCuratedAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4824
GuidetoPHARMACOLOGYi480

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615521 – 397P2X purinoceptor 3Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi107 ↔ 153By similarity
Disulfide bondi116 ↔ 137By similarity
Disulfide bondi122 ↔ 147By similarity
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi203 ↔ 213By similarity
Disulfide bondi247 ↔ 256By similarity
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49654
PRIDEiP49654

PTM databases

iPTMnetiP49654
PhosphoSitePlusiP49654

Expressioni

Tissue specificityi

Selectively expressed in sensory ganglia.1 Publication

Gene expression databases

BgeeiENSRNOG00000008552 Expressed in 9 organ(s), highest expression level in liver
ExpressionAtlasiP49654 baseline and differential
GenevisibleiP49654 RN

Interactioni

Subunit structurei

Homotrimer (By similarity). Functional P2XRs are organized as homomeric and heteromeric trimers (PubMed:7566120).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031629

Chemistry databases

BindingDBiP49654

Structurei

3D structure databases

ProteinModelPortaliP49654
SMRiP49654
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP49654
KOiK05217
OMAiGWCPAEI
OrthoDBiEOG091G0A2U
PhylomeDBiP49654

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003046 P2X3_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF8 PTHR10125:SF8, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01310 P2X3RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P49654-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRAV QLLIISYFVG WVFLHEKAYQ
60 70 80 90 100
VRDTAIESSV VTKVKGFGRY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE
110 120 130 140 150
NQMQGFCPEN EEKYRCVSDS QCGPERFPGG GILTGRCVNY SSVLRTCEIQ
160 170 180 190 200
GWCPTEVDTV EMPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTDKDI
210 220 230 240 250
KRCRFHPEKA PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD
260 270 280 290 300
KAWDQCIPKY SFTRLDGVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA
310 320 330 340 350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA
360 370 380 390
DHYKARKFEE VTETTLKGTA STNPVFASDQ ATVEKQSTDS GAYSIGH
Length:397
Mass (Da):44,392
Last modified:February 1, 1996 - v1
Checksum:iAA7ED5410F639D25
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9R1K3Q9R1K3_RAT
P2X purinoceptor
P2rx3 rCG_26470
373Annotation score:
Q66HM4Q66HM4_RAT
P2X purinoceptor
P2rx3
395Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96M → I in CAA62223 (PubMed:7566119).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91167 mRNA Translation: CAA62594.1
X90651 mRNA Translation: CAA62223.1
PIRiI58099
S60334
RefSeqiNP_001257550.1, NM_001270621.1
NP_112337.2, NM_031075.2
UniGeneiRn.10388

Genome annotation databases

EnsembliENSRNOT00000033427; ENSRNOP00000031629; ENSRNOG00000008552
GeneIDi81739
KEGGirno:81739
UCSCiRGD:620253 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91167 mRNA Translation: CAA62594.1
X90651 mRNA Translation: CAA62223.1
PIRiI58099
S60334
RefSeqiNP_001257550.1, NM_001270621.1
NP_112337.2, NM_031075.2
UniGeneiRn.10388

3D structure databases

ProteinModelPortaliP49654
SMRiP49654
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031629

Chemistry databases

BindingDBiP49654
ChEMBLiCHEMBL4824
GuidetoPHARMACOLOGYi480

PTM databases

iPTMnetiP49654
PhosphoSitePlusiP49654

Proteomic databases

PaxDbiP49654
PRIDEiP49654

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033427; ENSRNOP00000031629; ENSRNOG00000008552
GeneIDi81739
KEGGirno:81739
UCSCiRGD:620253 rat

Organism-specific databases

CTDi5024
RGDi620253 P2rx3

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP49654
KOiK05217
OMAiGWCPAEI
OrthoDBiEOG091G0A2U
PhylomeDBiP49654

Enzyme and pathway databases

ReactomeiR-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-418346 Platelet homeostasis

Miscellaneous databases

PROiPR:P49654

Gene expression databases

BgeeiENSRNOG00000008552 Expressed in 9 organ(s), highest expression level in liver
ExpressionAtlasiP49654 baseline and differential
GenevisibleiP49654 RN

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003046 P2X3_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF8 PTHR10125:SF8, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01310 P2X3RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX3_RAT
AccessioniPrimary (citable) accession number: P49654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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