Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 203 (07 Oct 2020)
Sequence version 2 (15 Jul 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Homeobox protein Hox-A1

Gene

HOXA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P49639

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49639

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-A1
Alternative name(s):
Homeobox protein Hox-1F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOXA1
Synonyms:HOX1F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105991.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5099, HOXA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142955, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49639

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Athabaskan brainstem dysgenesis syndrome (ABDS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by horizontal gaze palsy, sensorineural deafness, central hypoventilation, and developmental delay. Some patients had swallowing dysfunction, vocal cord paralysis, facial paresis, seizures, and cardiac outflow tract anomalies.
Related information in OMIM
Bosley-Salih-Alorainy syndrome (BSAS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by horizontal gaze abnormalities, deafness, facial weakness, vascular malformations of the internal carotid arteries and cardiac outflow trac. Some patients manifest mental retardation and autism spectrum disorder. Affected individuals do not suffer from central hypoventilation.
Related information in OMIM

Keywords - Diseasei

Autism spectrum disorder

Organism-specific databases

DisGeNET

More...
DisGeNETi
3198

MalaCards human disease database

More...
MalaCardsi
HOXA1
MIMi601536, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
69739, Athabaskan brainstem dysgenesis syndrome
69737, Bosley-Salih-Alorainy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29376

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49639, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HOXA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6166216

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002000301 – 335Homeobox protein Hox-A1Add BLAST335

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49639

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49639

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49639

PeptideAtlas

More...
PeptideAtlasi
P49639

PRoteomics IDEntifications database

More...
PRIDEi
P49639

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56033 [P49639-1]
56034 [P49639-2]
56035 [P49639-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49639

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105991, Expressed in embryo and 103 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49639, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105991, Tissue enhanced (urinary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with OGT (via TPR repeats domain); the interaction takes place mainly in the nucleus.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P49639
With#Exp.IntAct
ADAM12 - isoform 4 [O43184-4]3EBI-740785,EBI-12006944
ADAMTSL4 - isoform 3 [Q6UY14-3]10EBI-740785,EBI-10173507
AGXT [P21549]3EBI-740785,EBI-727098
ALG13 - isoform 4 [Q9NP73-4]3EBI-740785,EBI-10186621
ALPP [P05187]7EBI-740785,EBI-1211484
AMMECR1 - isoform 3 [Q9Y4X0-3]3EBI-740785,EBI-12823597
AMOT [A2BDD9]3EBI-740785,EBI-17286414
ANKS1A [Q49AR9]3EBI-740785,EBI-11954519
ARID5A [Q03989]3EBI-740785,EBI-948603
ARMC7 [Q9H6L4]3EBI-740785,EBI-742909
ATG9B - isoform 2 [Q674R7-2]3EBI-740785,EBI-12837280
ATP23 [Q9Y6H3]3EBI-740785,EBI-12811889
BAG4 [O95429]3EBI-740785,EBI-2949658
BAHD1 [Q8TBE0]3EBI-740785,EBI-742750
BATF2 [Q8N1L9]3EBI-740785,EBI-742695
BHLHB9 [Q6PI77]3EBI-740785,EBI-11519926
BLCAP [P62952]3EBI-740785,EBI-3895726
BLZF1 [Q9H2G9]6EBI-740785,EBI-2548012
BSCL2 [J3KQ12]6EBI-740785,EBI-11532900
BUD31 [P41223]3EBI-740785,EBI-3904603
C11orf1 [Q9H5F2]3EBI-740785,EBI-718615
CATSPER1 [Q8NEC5]3EBI-740785,EBI-744545
CCDC120 [Q96HB5]5EBI-740785,EBI-744556
CCN3 [P48745]3EBI-740785,EBI-3904822
CCN4 [O95388]5EBI-740785,EBI-1050638
CCN5 [O76076]3EBI-740785,EBI-2850068
CCNK - isoform 2 [O75909-2]5EBI-740785,EBI-12010594
CD164 [Q04900]3EBI-740785,EBI-2115896
CDPF1 [Q6NVV7]3EBI-740785,EBI-2802782
CERCAM [Q5T4B2]3EBI-740785,EBI-12261896
CFP [P27918]3EBI-740785,EBI-9038570
CHIC2 [Q9UKJ5]4EBI-740785,EBI-741528
CHRD [Q9H2X0]3EBI-740785,EBI-947551
CHRDL2 - isoform 2 [Q6WN34-2]3EBI-740785,EBI-12593838
CNFN [Q9BYD5]3EBI-740785,EBI-12819063
CNNM3 [Q8NE01]5EBI-740785,EBI-741032
COL8A1 [P27658]6EBI-740785,EBI-747133
CREB5 - isoform 3 [Q02930-3]5EBI-740785,EBI-10192698
CUTA - isoform C [O60888-3]3EBI-740785,EBI-10979071
CYHR1 - isoform 3 [Q6ZMK1-3]3EBI-740785,EBI-11997340
CYP21A2 [Q08AG9]5EBI-740785,EBI-14156412
CYSRT1 [A8MQ03]6EBI-740785,EBI-3867333
DOCK2 [Q92608]3EBI-740785,EBI-448771
DOCK3 [Q8IZD9]3EBI-740785,EBI-1752361
DOK3 - isoform 3 [Q7L591-3]3EBI-740785,EBI-10694655
DTX2 [Q86UW9]6EBI-740785,EBI-740376
DUSP10 [Q9Y6W6]5EBI-740785,EBI-3443946
EFEMP1 [Q12805]3EBI-740785,EBI-536772
EGFL7 [Q9UHF1]3EBI-740785,EBI-949532
ENKD1 [Q9H0I2]5EBI-740785,EBI-744099
EPDR1 [Q9UM22]3EBI-740785,EBI-946972
ESM1 [Q9NQ30]3EBI-740785,EBI-12260294
ESR2 - isoform 3 [Q92731-3]3EBI-740785,EBI-12259414
EVA1B [Q9NVM1]3EBI-740785,EBI-10314666
FAAP100 - isoform 3 [Q0VG06-3]3EBI-740785,EBI-10226932
FAM219B [Q5XKK7]3EBI-740785,EBI-12290965
FAM221A [A4D161]6EBI-740785,EBI-11960181
FBLN1 - isoform C [P23142-4]3EBI-740785,EBI-11956479
FHL3 [Q13643]3EBI-740785,EBI-741101
FHL5 [Q5TD97]3EBI-740785,EBI-750641
FOXH1 [O75593]3EBI-740785,EBI-1759806
FOXN1 [O15353]3EBI-740785,EBI-11319000
FRS3 [O43559]7EBI-740785,EBI-725515
FST [P19883]3EBI-740785,EBI-1571188
FUCA2 [Q9BTY2]3EBI-740785,EBI-9050116
GAS8 [O95995]3EBI-740785,EBI-1052570
GATA1 [P15976]3EBI-740785,EBI-3909284
GATA1 - isoform 2 [P15976-2]3EBI-740785,EBI-9090198
GCM2 [O75603]3EBI-740785,EBI-10188645
GDF15 [Q99988]3EBI-740785,EBI-2116863
GNE - isoform 2 [Q9Y223-2]5EBI-740785,EBI-11975289
GP9 [P14770]4EBI-740785,EBI-1754109
GPS2 [Q13227]3EBI-740785,EBI-713355
GRN [P28799]14EBI-740785,EBI-747754
GSTP1 [P09211]3EBI-740785,EBI-353467
GUCD1 - isoform 2 [Q96NT3-2]5EBI-740785,EBI-11978177
hCG_1987119 [A0A024R8L2]3EBI-740785,EBI-14103818
HEXB [P07686]3EBI-740785,EBI-7133736
HEXIM2 [Q96MH2]3EBI-740785,EBI-5460660
HEY2 [Q9UBP5]3EBI-740785,EBI-750630
itself6EBI-740785,EBI-740785
HOXB9 [P17482]3EBI-740785,EBI-745290
HR [O43593]3EBI-740785,EBI-2880706
HSD3B7 [Q9H2F3]3EBI-740785,EBI-3918847
ID3 [Q02535]3EBI-740785,EBI-1387094
IGFL1 [Q6UW32]3EBI-740785,EBI-3870426
IGFN1 - isoform 5 [Q86VF2-5]3EBI-740785,EBI-11955401
INCA1 [Q0VD86]3EBI-740785,EBI-6509505
INO80B [Q9C086]5EBI-740785,EBI-715611
IRX6 [P78412]3EBI-740785,EBI-12100506
ITGB4 - isoform Beta-4A [P16144-2]3EBI-740785,EBI-11051601
KCTD9 [Q7L273]5EBI-740785,EBI-4397613
KPRP [Q5T749]8EBI-740785,EBI-10981970
KRT31 [Q15323]7EBI-740785,EBI-948001
KRT33B [Q14525]3EBI-740785,EBI-1049638
KRT34 [O76011]3EBI-740785,EBI-1047093
KRT35 [Q92764]3EBI-740785,EBI-1058674
KRT37 [O76014]3EBI-740785,EBI-1045716
KRT38 [O76015]6EBI-740785,EBI-1047263
KRT40 [Q6A162]3EBI-740785,EBI-10171697
KRT81 [Q14533]5EBI-740785,EBI-739648
KRT82 [Q9NSB4]3EBI-740785,EBI-1045341
KRT83 [P78385]8EBI-740785,EBI-10221390
KRTAP1-1 [Q07627]3EBI-740785,EBI-11959885
KRTAP1-5 [Q9BYS1]5EBI-740785,EBI-11741292
KRTAP10-10 [P60014]3EBI-740785,EBI-11955579
KRTAP10-11 [P60412]9EBI-740785,EBI-10217483
KRTAP10-4 [P60372]3EBI-740785,EBI-10178153
KRTAP10-5 [P60370]6EBI-740785,EBI-10172150
KRTAP10-7 [P60409]5EBI-740785,EBI-10172290
KRTAP10-8 [P60410]9EBI-740785,EBI-10171774
KRTAP10-9 [P60411]8EBI-740785,EBI-10172052
KRTAP11-1 [Q8IUC1]5EBI-740785,EBI-1052037
KRTAP12-1 [P59990]13EBI-740785,EBI-10210845
KRTAP12-2 [P59991]3EBI-740785,EBI-10176379
KRTAP12-3 [P60328]6EBI-740785,EBI-11953334
KRTAP12-4 [P60329]10EBI-740785,EBI-10176396
KRTAP13-2 [Q52LG2]5EBI-740785,EBI-11953846
KRTAP13-3 [Q3SY46]3EBI-740785,EBI-10241252
KRTAP13-4 [Q3LI77]3EBI-740785,EBI-11953996
KRTAP15-1 [Q3LI76]7EBI-740785,EBI-11992140
KRTAP19-6 [Q3LI70]3EBI-740785,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-740785,EBI-10241353
KRTAP2-4 [Q9BYR9]3EBI-740785,EBI-14065470
KRTAP23-1 [A1A580]3EBI-740785,EBI-10171734
KRTAP26-1 [Q6PEX3]8EBI-740785,EBI-3957672
KRTAP3-2 [Q9BYR7]6EBI-740785,EBI-751260
KRTAP3-3 [Q9BYR6]3EBI-740785,EBI-3957694
KRTAP4-1 [A0A087WY89]3EBI-740785,EBI-11957260
KRTAP4-11 [Q9BYQ6]10EBI-740785,EBI-10302392
KRTAP4-12 [Q9BQ66]9EBI-740785,EBI-739863
KRTAP4-2 [Q9BYR5]10EBI-740785,EBI-10172511
KRTAP4-4 [Q9BYR3]5EBI-740785,EBI-11958132
KRTAP4-5 [Q9BYR2]7EBI-740785,EBI-11993254
KRTAP4-7 [Q9BYR0]3EBI-740785,EBI-10302547
KRTAP5-11 [Q6L8G4]5EBI-740785,EBI-11993296
KRTAP5-2 [Q701N4]5EBI-740785,EBI-11958178
KRTAP5-3 [Q6L8H2]5EBI-740785,EBI-11974251
KRTAP5-4 [Q6L8H1]8EBI-740785,EBI-11963072
KRTAP5-6 [Q6L8G9]9EBI-740785,EBI-10250562
KRTAP5-9 [P26371]12EBI-740785,EBI-3958099
KRTAP6-1 [Q3LI64]3EBI-740785,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-740785,EBI-11962084
KRTAP9-2 [Q9BYQ4]13EBI-740785,EBI-1044640
KRTAP9-3 [Q9BYQ3]8EBI-740785,EBI-1043191
KRTAP9-4 [Q9BYQ2]3EBI-740785,EBI-10185730
KRTAP9-8 [Q9BYQ0]8EBI-740785,EBI-11958364
LASP1 - isoform 2 [Q14847-2]3EBI-740785,EBI-9088686
LCE1A [Q5T7P2]6EBI-740785,EBI-11962058
LCE1B [Q5T7P3]13EBI-740785,EBI-10245913
LCE1C [Q5T751]3EBI-740785,EBI-12224199
LCE1D [Q5T752]5EBI-740785,EBI-11741311
LCE1F [Q5T754]6EBI-740785,EBI-11958008
LCE2A [Q5TA79]3EBI-740785,EBI-10246607
LCE2B [O14633]5EBI-740785,EBI-11478468
LCE2C [Q5TA81]8EBI-740785,EBI-11973993
LCE2D [Q5TA82]8EBI-740785,EBI-10246750
LCE3C [Q5T5A8]3EBI-740785,EBI-10245291
LCE3E [Q5T5B0]3EBI-740785,EBI-10245456
LCE4A [Q5TA78]9EBI-740785,EBI-10246358
LCE5A [Q5TCM9]8EBI-740785,EBI-11955689
LGALS13 [Q9UHV8]6EBI-740785,EBI-3957707
LGALS4 [P56470]3EBI-740785,EBI-720805
LMX1B - isoform 2 [O60663-2]3EBI-740785,EBI-10258690
LNX1 [Q8TBB1]3EBI-740785,EBI-739832
LONRF1 [Q17RB8]3EBI-740785,EBI-2341787
MACO1 [Q8N5G2]3EBI-740785,EBI-2683507
MAPKBP1 [O60336]5EBI-740785,EBI-947402
MDFI [Q99750]6EBI-740785,EBI-724076
MFAP2 [P55001]3EBI-740785,EBI-2462387
MKRN3 [Q13064]3EBI-740785,EBI-2340269
MYPOP [Q86VE0]3EBI-740785,EBI-2858213
N4BP2L2 [Q92802]3EBI-740785,EBI-2514973
NCK2 [O43639]3EBI-740785,EBI-713635
NECTIN2 - isoform Alpha [Q92692-2]3EBI-740785,EBI-6979889
NEDD9 - isoform 2 [Q14511-2]3EBI-740785,EBI-11746523
NEK6 - isoform 4 [Q9HC98-4]3EBI-740785,EBI-11750983
NELL2 - isoform 2 [Q99435-2]3EBI-740785,EBI-17754404
NFKBID [Q8NI38]3EBI-740785,EBI-10271199
NOTCH2NLA [Q7Z3S9]3EBI-740785,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-740785,EBI-22310682
NR1D2 [Q6NSM0]5EBI-740785,EBI-10250949
NTN4 [Q9HB63]5EBI-740785,EBI-743459
NXF1 [Q9UBU9]3EBI-740785,EBI-398874
ODF1 [Q14990]3EBI-740785,EBI-10234557
OIT3 [Q8WWZ8]5EBI-740785,EBI-10277776
P2RY6 [Q15077]5EBI-740785,EBI-10235794
PAX6 [P26367]3EBI-740785,EBI-747278
PBX2 [P40425]3EBI-740785,EBI-348489
PCSK5 - isoform PC6A [Q92824-2]5EBI-740785,EBI-11956269
PCYOX1 [Q9UHG3]3EBI-740785,EBI-2908417
PHETA1 - isoform 4 [Q8N4B1-4]3EBI-740785,EBI-14131832
PIN1 [Q13526]5EBI-740785,EBI-714158
PITX1 [P78337]5EBI-740785,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-740785,EBI-12138495
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-740785,EBI-12014286
PLLP [Q9Y342]3EBI-740785,EBI-3919291
PLSCR2 [Q9NRY7]3EBI-740785,EBI-3937430
PLSCR3 [Q9NRY6]5EBI-740785,EBI-750734
PLSCR4 [Q9NRQ2]5EBI-740785,EBI-769257
PPP1R32 - isoform 2 [Q7Z5V6-2]5EBI-740785,EBI-12000762
PRNP [P04156]4EBI-740785,EBI-977302
PROP1 [O75360]3EBI-740785,EBI-9027467
PSMB1 [P20618]3EBI-740785,EBI-372273
PTH1R [Q03431]3EBI-740785,EBI-2860297
PVR [P15151]3EBI-740785,EBI-3919694
QARS1 [P47897]3EBI-740785,EBI-347462
RALGDS - isoform 6 [Q12967-6]3EBI-740785,EBI-12005546
RBP3 [P10745]3EBI-740785,EBI-12806054
RBPMS [Q93062]3EBI-740785,EBI-740322
RGS17 [Q9UGC6]6EBI-740785,EBI-3918154
RGS19 [P49795]3EBI-740785,EBI-874907
RGS20 [O76081]5EBI-740785,EBI-1052678
RGS20 - isoform 5 [O76081-6]3EBI-740785,EBI-10178530
RNF208 [Q9H0X6]3EBI-740785,EBI-751555
RSPO2 - isoform 2 [Q6UXX9-2]3EBI-740785,EBI-12009390
RTN4R [Q9BZR6]3EBI-740785,EBI-5240240
SCT [P09683]3EBI-740785,EBI-12844598
SDCBP [O00560]6EBI-740785,EBI-727004
SIVA1 - isoform 2 [O15304-2]3EBI-740785,EBI-12372219
SLC15A3 [Q8IY34]3EBI-740785,EBI-12179023
SLC23A1 - isoform 3 [Q9UHI7-3]3EBI-740785,EBI-11998660
SLIT1 [O75093]3EBI-740785,EBI-947791
SLPI [P03973]3EBI-740785,EBI-355293
SNRPB - isoform SM-B [P14678-2]3EBI-740785,EBI-372475
SNRPC [P09234]5EBI-740785,EBI-766589
SPATA12 [Q7Z6I5]3EBI-740785,EBI-10696971
SPATA18 [Q8TC71]3EBI-740785,EBI-11334239
SPRY1 [O43609]8EBI-740785,EBI-3866665
SPRY3 [O43610]3EBI-740785,EBI-12290641
SPRY4 [Q9C004]3EBI-740785,EBI-354861
SSUH2 - isoform 2 [Q9Y2M2-2]5EBI-740785,EBI-12231891
STX11 [O75558]3EBI-740785,EBI-714135
SUV39H1 [O43463]2EBI-740785,EBI-349968
TBC1D10C [Q8IV04]6EBI-740785,EBI-10261452
TBX15 [Q96SF7]3EBI-740785,EBI-10191361
TCF19 [Q9Y242]3EBI-740785,EBI-7413767
TEKT4 [Q8WW24]3EBI-740785,EBI-750487
TEKT5 [Q96M29]3EBI-740785,EBI-10239812
TGFB1 [P01137]3EBI-740785,EBI-779636
TGM7 [Q96PF1]3EBI-740785,EBI-12029034
THAP7 [Q9BT49]3EBI-740785,EBI-741350
TLE5 - isoform 2 [Q08117-2]3EBI-740785,EBI-11741437
TNS2 [Q63HR2]3EBI-740785,EBI-949753
TRAF1 [Q13077]3EBI-740785,EBI-359224
TRAF2 [Q12933]3EBI-740785,EBI-355744
TRAF4 [Q9BUZ4]3EBI-740785,EBI-3650647
TRIM42 [Q8IWZ5]12EBI-740785,EBI-5235829
TRIM8 [Q9BZR9]3EBI-740785,EBI-2340370
TSPAN4 [O14817]3EBI-740785,EBI-8652667
UBL5 [Q9BZL1]3EBI-740785,EBI-607755
UNKL - isoform 5 [Q9H9P5-5]3EBI-740785,EBI-12817837
VASN [Q6EMK4]5EBI-740785,EBI-10249550
VWC2 [Q2TAL6]6EBI-740785,EBI-11957238
VWC2L [B2RUY7]3EBI-740785,EBI-11747707
WDR83 [Q9BRX9]3EBI-740785,EBI-7705033
WWOX - isoform 5 [Q9NZC7-5]3EBI-740785,EBI-12040603
YIPF3 [Q9GZM5]3EBI-740785,EBI-743787
ZBTB16 [Q05516]3EBI-740785,EBI-711925
ZIM2 [Q9NZV7]3EBI-740785,EBI-11962760
ZNF417 [Q8TAU3]5EBI-740785,EBI-740727
ZNF587 [Q96SQ5]5EBI-740785,EBI-6427977
ZNF688 [P0C7X2]3EBI-740785,EBI-4395732
ZNF774 [Q6NX45]3EBI-740785,EBI-10251462
ZNF837 [Q96EG3]5EBI-740785,EBI-11962574
ZNF843 [Q8N446]3EBI-740785,EBI-6428016
A0A384ME253EBI-740785,EBI-10211777
Q7Z7836EBI-740785,EBI-9088990
Hoxa1 [P09022] from Mus musculus.4EBI-740785,EBI-3957603

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109438, 298 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P49639

Protein interaction database and analysis system

More...
IntActi
P49639, 278 interactors

Molecular INTeraction database

More...
MINTi
P49639

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343246

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P49639, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49639

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 203Interaction with OGTBy similarityAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi204 – 209Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 74Poly-His10
Compositional biasi142 – 146Poly-His5
Compositional biasi314 – 317Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0489, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_058839_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49639

KEGG Orthology (KO)

More...
KOi
K09301

Database of Orthologous Groups

More...
OrthoDBi
1216870at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49639

TreeFam database of animal gene trees

More...
TreeFami
TF317730

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR020479, Homeobox_metazoa

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00024, HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P49639-1) [UniParc]FASTAAdd to basket
Also known as: 36 kDa

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNARMNSFL EYPILSSGDS GTCSARAYPS DHRITTFQSC AVSANSCGGD
60 70 80 90 100
DRFLVGRGVQ IGSPHHHHHH HHHHPQPATY QTSGNLGVSY SHSSCGPSYG
110 120 130 140 150
SQNFSAPYSP YALNQEADVS GGYPQCAPAV YSGNLSSPMV QHHHHHQGYA
160 170 180 190 200
GGAVGSPQYI HHSYGQEHQS LALATYNNSL SPLHASHQEA CRSPASETSS
210 220 230 240 250
PAQTFDWMKV KRNPPKTGKV GEYGYLGQPN AVRTNFTTKQ LTELEKEFHF
260 270 280 290 300
NKYLTRARRV EIAASLQLNE TQVKIWFQNR RMKQKKREKE GLLPISPATP
310 320 330
PGNDEKAEES SEKSSSSPCV PSPGSSTSDT LTTSH
Length:335
Mass (Da):36,641
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C3A2D0A59A4181C
GO
Isoform 1 (identifier: P49639-2) [UniParc]FASTAAdd to basket
Also known as: 14 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     119-137: VSGGYPQCAPAVYSGNLSS → PPRSLSLPRIGDIFSSADF
     138-335: Missing.

Note: Lacks the homeobox domain.Curated
Show »
Length:137
Mass (Da):14,816
Checksum:i9F0067A9E6AD51DE
GO
Isoform 2 (identifier: P49639-3) [UniParc]FASTAAdd to basket
Also known as: 24 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     219-227: KVGEYGYLG → QSCWLVDAP
     228-335: Missing.

Note: Lacks the homeobox domain.Curated
Show »
Length:227
Mass (Da):24,489
Checksum:i81A54EF51FB0F033
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y4R9A0A2R8Y4R9_HUMAN
Homeobox protein Hox-A1
HOXA1
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERT8E7ERT8_HUMAN
Homeobox protein Hox-A1
HOXA1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01030573H → R Frequent polymorphism in individuals of European or African origin. 2 PublicationsCorresponds to variant dbSNP:rs10951154Ensembl.1
Natural variantiVAR_030576189E → A. Corresponds to variant dbSNP:rs17500494EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002376119 – 137VSGGY…GNLSS → PPRSLSLPRIGDIFSSADF in isoform 1. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_002377138 – 335Missing in isoform 1. 1 PublicationAdd BLAST198
Alternative sequenceiVSP_002378219 – 227KVGEYGYLG → QSCWLVDAP in isoform 2. 1 Publication9
Alternative sequenceiVSP_002379228 – 335Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U10421 mRNA Translation: AAA86954.1
AK313514 mRNA Translation: BAG36294.1
AC004079 Genomic DNA Translation: AAS00374.1
CH236948 Genomic DNA Translation: EAL24228.1
CH471073 Genomic DNA Translation: EAW93861.1
BC032547 mRNA Translation: AAH32547.1
U37431 mRNA Translation: AAC50248.1
U37431 mRNA Translation: AAC50249.1
U37431 mRNA Translation: AAC50250.1
S79869 mRNA Translation: AAB35424.2
S79871 mRNA Translation: AAB35425.1
S79910 mRNA Translation: AAB35423.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5401.1 [P49639-1]
CCDS5402.2 [P49639-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
G01448

NCBI Reference Sequences

More...
RefSeqi
NP_005513.1, NM_005522.4
NP_705873.2, NM_153620.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343060; ENSP00000343246; ENSG00000105991

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3198

UCSC genome browser

More...
UCSCi
uc003sye.4, human [P49639-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10421 mRNA Translation: AAA86954.1
AK313514 mRNA Translation: BAG36294.1
AC004079 Genomic DNA Translation: AAS00374.1
CH236948 Genomic DNA Translation: EAL24228.1
CH471073 Genomic DNA Translation: EAW93861.1
BC032547 mRNA Translation: AAH32547.1
U37431 mRNA Translation: AAC50248.1
U37431 mRNA Translation: AAC50249.1
U37431 mRNA Translation: AAC50250.1
S79869 mRNA Translation: AAB35424.2
S79871 mRNA Translation: AAB35425.1
S79910 mRNA Translation: AAB35423.2
CCDSiCCDS5401.1 [P49639-1]
CCDS5402.2 [P49639-2]
PIRiG01448
RefSeqiNP_005513.1, NM_005522.4
NP_705873.2, NM_153620.2

3D structure databases

SMRiP49639
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109438, 298 interactors
ELMiP49639
IntActiP49639, 278 interactors
MINTiP49639
STRINGi9606.ENSP00000343246

PTM databases

iPTMnetiP49639
PhosphoSitePlusiP49639

Polymorphism and mutation databases

BioMutaiHOXA1
DMDMi6166216

Proteomic databases

jPOSTiP49639
MassIVEiP49639
PaxDbiP49639
PeptideAtlasiP49639
PRIDEiP49639
ProteomicsDBi56033 [P49639-1]
56034 [P49639-2]
56035 [P49639-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3198

Genome annotation databases

EnsembliENST00000343060; ENSP00000343246; ENSG00000105991
GeneIDi3198
KEGGihsa:3198
UCSCiuc003sye.4, human [P49639-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3198
DisGeNETi3198
EuPathDBiHostDB:ENSG00000105991.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HOXA1
HGNCiHGNC:5099, HOXA1
HPAiENSG00000105991, Tissue enhanced (urinary)
MalaCardsiHOXA1
MIMi142955, gene
601536, phenotype
neXtProtiNX_P49639
Orphaneti69739, Athabaskan brainstem dysgenesis syndrome
69737, Bosley-Salih-Alorainy syndrome
PharmGKBiPA29376

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0489, Eukaryota
HOGENOMiCLU_058839_1_1_1
InParanoidiP49639
KOiK09301
OrthoDBi1216870at2759
PhylomeDBiP49639
TreeFamiTF317730

Enzyme and pathway databases

PathwayCommonsiP49639
ReactomeiR-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP49639

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3198, 4 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HOXA1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Homeobox_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3198
PharosiP49639, Tbio

Protein Ontology

More...
PROi
PR:P49639
RNActiP49639, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105991, Expressed in embryo and 103 other tissues
GenevisibleiP49639, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR020479, Homeobox_metazoa
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PRINTSiPR00024, HOMEOBOX
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49639
Secondary accession number(s): A4D184, B2R8U7, O43363
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: October 7, 2020
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again