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Protein

Alpha-tocopherol transfer protein

Gene

TTPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei190Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei192Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei217Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei221Phosphatidylinositol lipid headgroupBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8877627 Vitamin E

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-tocopherol transfer protein
Short name:
Alpha-TTP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTPA
Synonyms:TPP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137561.4

Human Gene Nomenclature Database

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HGNCi
HGNC:12404 TTPA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600415 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49638

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ataxia with isolated vitamin E deficiency (AVED)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by undetectable or markedly reduced plasma levels of vitamin E, spinocerebellar degeneration, ataxia, areflexia and proprioception loss.
See also OMIM:277460
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02238859R → W in AVED. 2 PublicationsCorresponds to variant dbSNP:rs397515522EnsemblClinVar.1
Natural variantiVAR_005668101H → Q in AVED. 2 PublicationsCorresponds to variant dbSNP:rs121917849EnsemblClinVar.1
Natural variantiVAR_022389120A → T in AVED. 2 PublicationsCorresponds to variant dbSNP:rs143010236EnsemblClinVar.1
Natural variantiVAR_022390141E → K in AVED. 2 PublicationsCorresponds to variant dbSNP:rs397515524EnsemblClinVar.1
Natural variantiVAR_007858192R → H in AVED. 2 PublicationsCorresponds to variant dbSNP:rs121917850EnsemblClinVar.1
Natural variantiVAR_022391221R → W in AVED. 2 PublicationsCorresponds to variant dbSNP:rs35916840EnsemblClinVar.1
Natural variantiVAR_022392246G → R in AVED; mild and slowly progressive form of the disease. 1 PublicationCorresponds to variant dbSNP:rs397515526EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7274

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
TTPA

MalaCards human disease database

More...
MalaCardsi
TTPA
MIMi277460 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137561

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
96 Ataxia with vitamin E deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37068

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3308919

Drug and drug target database

More...
DrugBanki
DB00163 Vitamin E

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTPA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1351322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002107641 – 278Alpha-tocopherol transfer proteinAdd BLAST278

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P49638

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P49638

PeptideAtlas

More...
PeptideAtlasi
P49638

PRoteomics IDEntifications database

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PRIDEi
P49638

ProteomicsDB human proteome resource

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ProteomicsDBi
56032

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P49638

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P49638

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137561 Expressed in 68 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_TPP1
HS_TTPA

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49638 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homotetramer. Phosphatidylinol 4,5-bisphosphate binding induces the formation of homotetramers. Phosphatidylinol 3,4-bisphosphate is less efficient in inducing tetramerization (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CMTM5Q96DZ93EBI-10210710,EBI-2548702

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113125, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P49638, 38 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260116

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1278
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P49638

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49638

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P49638

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 253CRAL-TRIOPROSITE-ProRule annotationAdd BLAST166

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1471 Eukaryota
ENOG410XRSQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159203

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231534

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018009

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49638

Identification of Orthologs from Complete Genome Data

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OMAi
RAECPEI

Database of Orthologous Groups

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OrthoDBi
EOG091G0KN0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49638

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00170 SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49638-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARSQPSA GPQLNALPDH SPLLQPGLAA LRRRAREAGV PLAPLPLTDS
60 70 80 90 100
FLLRFLRARD FDLDLAWRLL KNYYKWRAEC PEISADLHPR SIIGLLKAGY
110 120 130 140 150
HGVLRSRDPT GSKVLIYRIA HWDPKVFTAY DVFRVSLITS ELIVQEVETQ
160 170 180 190 200
RNGIKAIFDL EGWQFSHAFQ ITPSVAKKIA AVLTDSFPLK VRGIHLINEP
210 220 230 240 250
VIFHAVFSMI KPFLTEKIKE RIHMHGNNYK QSLLQHFPDI LPLEYGGEEF
260 270
SMEDICQEWT NFIMKSEDYL SSISESIQ
Length:278
Mass (Da):31,750
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64D1551CC155071E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271S → R in AAA64309 (PubMed:8602747).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02238859R → W in AVED. 2 PublicationsCorresponds to variant dbSNP:rs397515522EnsemblClinVar.1
Natural variantiVAR_005668101H → Q in AVED. 2 PublicationsCorresponds to variant dbSNP:rs121917849EnsemblClinVar.1
Natural variantiVAR_022389120A → T in AVED. 2 PublicationsCorresponds to variant dbSNP:rs143010236EnsemblClinVar.1
Natural variantiVAR_022390141E → K in AVED. 2 PublicationsCorresponds to variant dbSNP:rs397515524EnsemblClinVar.1
Natural variantiVAR_037973172T → S. Corresponds to variant dbSNP:rs34647756Ensembl.1
Natural variantiVAR_007858192R → H in AVED. 2 PublicationsCorresponds to variant dbSNP:rs121917850EnsemblClinVar.1
Natural variantiVAR_022391221R → W in AVED. 2 PublicationsCorresponds to variant dbSNP:rs35916840EnsemblClinVar.1
Natural variantiVAR_022392246G → R in AVED; mild and slowly progressive form of the disease. 1 PublicationCorresponds to variant dbSNP:rs397515526EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D49488 mRNA Translation: BAA08449.1
U21938 mRNA Translation: AAA64309.1
BC058000 mRNA Translation: AAH58000.1
AH006950 Genomic DNA Translation: AAC67490.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6178.1

Protein sequence database of the Protein Information Resource

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PIRi
S54352

NCBI Reference Sequences

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RefSeqi
NP_000361.1, NM_000370.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.69049

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260116; ENSP00000260116; ENSG00000137561

Database of genes from NCBI RefSeq genomes

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GeneIDi
7274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7274

UCSC genome browser

More...
UCSCi
uc003xux.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49488 mRNA Translation: BAA08449.1
U21938 mRNA Translation: AAA64309.1
BC058000 mRNA Translation: AAH58000.1
AH006950 Genomic DNA Translation: AAC67490.1
CCDSiCCDS6178.1
PIRiS54352
RefSeqiNP_000361.1, NM_000370.3
UniGeneiHs.69049

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OIPX-ray1.95A1-278[»]
1OIZX-ray1.88A/B1-278[»]
1R5LX-ray1.50A21-278[»]
5MUEX-ray2.40A48-275[»]
5MUGX-ray2.42A48-278[»]
ProteinModelPortaliP49638
SMRiP49638
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113125, 3 interactors
IntActiP49638, 38 interactors
STRINGi9606.ENSP00000260116

Chemistry databases

ChEMBLiCHEMBL3308919
DrugBankiDB00163 Vitamin E

PTM databases

iPTMnetiP49638
PhosphoSitePlusiP49638

Polymorphism and mutation databases

BioMutaiTTPA
DMDMi1351322

Proteomic databases

MaxQBiP49638
PaxDbiP49638
PeptideAtlasiP49638
PRIDEiP49638
ProteomicsDBi56032

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7274
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260116; ENSP00000260116; ENSG00000137561
GeneIDi7274
KEGGihsa:7274
UCSCiuc003xux.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7274
DisGeNETi7274
EuPathDBiHostDB:ENSG00000137561.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTPA
GeneReviewsiTTPA
HGNCiHGNC:12404 TTPA
MalaCardsiTTPA
MIMi277460 phenotype
600415 gene
neXtProtiNX_P49638
OpenTargetsiENSG00000137561
Orphaneti96 Ataxia with vitamin E deficiency
PharmGKBiPA37068

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00940000159203
HOGENOMiHOG000231534
HOVERGENiHBG018009
InParanoidiP49638
OMAiRAECPEI
OrthoDBiEOG091G0KN0
PhylomeDBiP49638

Enzyme and pathway databases

ReactomeiR-HSA-8877627 Vitamin E

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTPA human
EvolutionaryTraceiP49638

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Alpha-tocopherol_transfer_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7274

Protein Ontology

More...
PROi
PR:P49638

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137561 Expressed in 68 organ(s), highest expression level in liver
CleanExiHS_TPP1
HS_TTPA
GenevisibleiP49638 HS

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTPA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49638
Secondary accession number(s): Q71V64
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 5, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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