Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - P49619 (DGKG_HUMAN)

Entry version 199 (25 May 2022)
Sequence version 3 (02 Nov 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Diacylglycerol kinase gamma

Gene

DGKG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity).

Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597).

Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The activity is calcium-dependent (By similarity). Requires phosphatidylserine for maximal activity (PubMed:8034597).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi188Calcium 1PROSITE-ProRule annotation1
Metal bindingi190Calcium 1PROSITE-ProRule annotation1
Metal bindingi192Calcium 1PROSITE-ProRule annotation1
Metal bindingi199Calcium 1PROSITE-ProRule annotation1
Metal bindingi233Calcium 2PROSITE-ProRule annotation1
Metal bindingi235Calcium 2PROSITE-ProRule annotation1
Metal bindingi237Calcium 2PROSITE-ProRule annotation1
Metal bindingi244Calcium 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri271 – 321Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri336 – 385Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.107, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49619

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114508, Effects of PIP2 hydrolysis

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P49619

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49619

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49619

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00230

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000923
SLP:000000938 [P49619-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.1071 Publication)
Short name:
DAG kinase gamma
Alternative name(s):
Diglyceride kinase gamma
Short name:
DGK-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGKG
Synonyms:DAGK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2853, DGKG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601854, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49619

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000058866

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1608

Open Targets

More...OpenTargetsi		ENSG00000058866

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27314

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49619, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075157

Drug and drug target database

More...DrugBanki		DB14001, alpha-Tocopherol succinate
DB00144, Phosphatidyl serine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DGKG

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033457

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002184591 – 791Diacylglycerol kinase gammaAdd BLAST791

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49619

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49619

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49619

PeptideAtlas

More...PeptideAtlasi		P49619

PRoteomics IDEntifications database

More...PRIDEi		P49619

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56029 [P49619-1]
56030 [P49619-2]
56031 [P49619-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49619

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49619

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000058866, Expressed in cerebellar hemisphere and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49619, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49619, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000058866, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107978, 24 interactors

Protein interaction database and analysis system

More...IntActi		P49619, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265022

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P49619

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49619, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P49619

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini175 – 210EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini220 – 255EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini430 – 564DAGKcPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni82 – 103DisorderedSequence analysisAdd BLAST22
Regioni117 – 154DisorderedSequence analysisAdd BLAST38
Regioni768 – 791DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 321Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri336 – 385Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1169, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156768

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003770_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49619

Identification of Orthologs from Complete Genome Data

More...OMAi		ALCKYTV

Database of Orthologous Groups

More...OrthoDBi		633642at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49619

TreeFam database of animal gene trees

More...TreeFami		TF313104

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 1 hit
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.238.110, 2 hits
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR046349, C1-like_sf
IPR029477, DAG_kinase_typeI_N
IPR037607, DGK
IPR038199, DGK_typeI_N_sf
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd

The PANTHER Classification System

More...PANTHERi		PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130, C1_1, 1 hit
PF14513, DAG_kinase_N, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111331, SSF111331, 1 hit
SSF47473, SSF47473, 2 hits
SSF57889, SSF57889, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50146, DAGK, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P49619-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEERWVSLT PEEFDQLQKY SEYSSKKIKD ALTEFNEGGS LKQYDPHEPI 
        60         70         80         90        100
SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRHETSDH PTEGASNSEA 
       110        120        130        140        150
NSADTNIQNA DNATKADEAC APDTESNMAE KQAPAEDQVA ATPLEPPVPR 
       160        170        180        190        200
SSSSESPVVY LKDVVCYLSL LETGRPQDKL EFMFRLYDSD ENGLLDQAEM 
       210        220        230        240        250
DCIVNQMLHI AQYLEWDPTE LRPILKEMLQ GMDYDRDGFV SLQEWVHGGM 
       260        270        280        290        300
TTIPLLVLLG MDDSGSKGDG RHAWTMKHFK KPTYCNFCHI MLMGVRKQGL 
       310        320        330        340        350
CCTYCKYTVH ERCVSRNIPG CVKTYSKAKR SGEVMQHAWV EGNSSVKCDR 
       360        370        380        390        400
CHKSIKCYQS VTARHCVWCR MTFHRKCELS TLCDGGELRD HILLPTSICP 
       410        420        430        440        450
ITRDRPGEKS DGCVSAKGEL VMQYKIIPTP GTHPLLVLVN PKSGGRQGER 
       460        470        480        490        500
ILRKFHYLLN PKQVFNLDNG GPTPGLNFFR DTPDFRVLAC GGDGTVGWIL 
       510        520        530        540        550
DCIDKANFAK HPPVAVLPLG TGNDLARCLR WGGGYEGGSL TKILKDIEQS 
       560        570        580        590        600
PLVMLDRWHL EVIPREEVEN GDQVPYSIMN NYFSIGVDAS IAHRFHVMRE 
       610        620        630        640        650
KHPEKFNSRM KNKLWYFEFG TSETFAATCK KLHDHIELEC DGVGVDLSNI 
       660        670        680        690        700
FLEGIAILNI PSMYGGTNLW GENKKNRAVI RESRKGVTDP KELKFCVQDL 
       710        720        730        740        750
SDQLLEVVGL EGAMEMGQIY TGLKSAGRRL AQCASVTIRT NKLLPMQVDG 
       760        770        780        790 
EPWMQPCCTI KITHKNQAPM MMGPPQKSSF FSLRRKSRSK D
Length:791
Mass (Da):89,124
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1382CF1B2CD7362
GO
Isoform 2 (identifier: P49619-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     451-475: Missing.

Note: May be inactive.Curated
Show »
Length:766
Mass (Da):86,303
Checksum:i1D3F8C78BD59219F
GO
Isoform 3 (identifier: P49619-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-372: Missing.

Show »
Length:752
Mass (Da):84,573
Checksum:i4B58648DC4E785ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0L0H7C0L0_HUMAN
Diacylglycerol kinase gamma
DGKG
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271R → G in BAA05132 (PubMed:8034597).Curated1
Sequence conflicti271R → G in AAC04686 (PubMed:10071200).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020259142T → S2 PublicationsCorresponds to variant dbSNP:rs1004588Ensembl.1
Natural variantiVAR_024430316R → K4 PublicationsCorresponds to variant dbSNP:rs2193587Ensembl.1
Natural variantiVAR_020260370R → W. Corresponds to variant dbSNP:rs3213770Ensembl.1
Natural variantiVAR_036119706E → K in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039922334 – 372Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_001267451 – 475Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D26135 mRNA Translation: BAA05132.1
AF020945 AF020944 Genomic DNA Translation: AAC04686.1
AK314192 mRNA Translation: BAG36871.1
AC007917 Genomic DNA No translation available.
AC112649 Genomic DNA No translation available.
BC089411 mRNA Translation: AAH89411.1
BC112363 mRNA Translation: AAI12364.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3274.1 [P49619-1]
CCDS43181.1 [P49619-3]
CCDS43182.1 [P49619-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A53691

NCBI Reference Sequences

More...RefSeqi		NP_001074213.1, NM_001080744.1 [P49619-2]
NP_001074214.1, NM_001080745.1 [P49619-3]
NP_001337.2, NM_001346.2 [P49619-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265022.8; ENSP00000265022.3; ENSG00000058866.15
ENST00000344484.8; ENSP00000339777.4; ENSG00000058866.15 [P49619-2]
ENST00000382164.8; ENSP00000371599.4; ENSG00000058866.15 [P49619-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1608

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1608

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000265022.8; ENSP00000265022.3; NM_001346.3; NP_001337.2

UCSC genome browser

More...UCSCi		uc003fqa.4, human [P49619-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26135 mRNA Translation: BAA05132.1
AF020945 AF020944 Genomic DNA Translation: AAC04686.1
AK314192 mRNA Translation: BAG36871.1
AC007917 Genomic DNA No translation available.
AC112649 Genomic DNA No translation available.
BC089411 mRNA Translation: AAH89411.1
BC112363 mRNA Translation: AAI12364.1
CCDSiCCDS3274.1 [P49619-1]
CCDS43181.1 [P49619-3]
CCDS43182.1 [P49619-2]
PIRiA53691
RefSeqiNP_001074213.1, NM_001080744.1 [P49619-2]
NP_001074214.1, NM_001080745.1 [P49619-3]
NP_001337.2, NM_001346.2 [P49619-1]

3D structure databases

AlphaFoldDBiP49619
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi107978, 24 interactors
IntActiP49619, 3 interactors
STRINGi9606.ENSP00000265022

Chemistry databases

BindingDBiP49619
ChEMBLiCHEMBL1075157
DrugBankiDB14001, alpha-Tocopherol succinate
DB00144, Phosphatidyl serine
SwissLipidsiSLP:000000923
SLP:000000938 [P49619-1]

PTM databases

iPTMnetiP49619
PhosphoSitePlusiP49619

Genetic variation databases

BioMutaiDGKG
DMDMi311033457

Proteomic databases

EPDiP49619
MassIVEiP49619
PaxDbiP49619
PeptideAtlasiP49619
PRIDEiP49619
ProteomicsDBi56029 [P49619-1]
56030 [P49619-2]
56031 [P49619-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34852, 126 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		1608

Genome annotation databases

EnsembliENST00000265022.8; ENSP00000265022.3; ENSG00000058866.15
ENST00000344484.8; ENSP00000339777.4; ENSG00000058866.15 [P49619-2]
ENST00000382164.8; ENSP00000371599.4; ENSG00000058866.15 [P49619-3]
GeneIDi1608
KEGGihsa:1608
MANE-SelectiENST00000265022.8; ENSP00000265022.3; NM_001346.3; NP_001337.2
UCSCiuc003fqa.4, human [P49619-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1608
DisGeNETi1608

GeneCards: human genes, protein and diseases

More...GeneCardsi		DGKG
HGNCiHGNC:2853, DGKG
HPAiENSG00000058866, Tissue enhanced (brain)
MIMi601854, gene
neXtProtiNX_P49619
OpenTargetsiENSG00000058866
PharmGKBiPA27314
VEuPathDBiHostDB:ENSG00000058866

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1169, Eukaryota
GeneTreeiENSGT00940000156768
HOGENOMiCLU_003770_1_0_1
InParanoidiP49619
OMAiALCKYTV
OrthoDBi633642at2759
PhylomeDBiP49619
TreeFamiTF313104

Enzyme and pathway databases

UniPathwayiUPA00230
BRENDAi2.7.1.107, 2681
PathwayCommonsiP49619
ReactomeiR-HSA-114508, Effects of PIP2 hydrolysis
SABIO-RKiP49619
SignaLinkiP49619
SIGNORiP49619

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1608, 11 hits in 1064 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DGKG, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DGKG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1608
PharosiP49619, Tbio

Protein Ontology

More...PROi		PR:P49619
RNActiP49619, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000058866, Expressed in cerebellar hemisphere and 133 other tissues
ExpressionAtlasiP49619, baseline and differential
GenevisibleiP49619, HS

Family and domain databases

CDDicd00029, C1, 1 hit
cd00051, EFh, 1 hit
Gene3Di1.10.238.110, 2 hits
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR046349, C1-like_sf
IPR029477, DAG_kinase_typeI_N
IPR037607, DGK
IPR038199, DGK_typeI_N_sf
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF14513, DAG_kinase_N, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00054, EFh, 2 hits
SUPFAMiSSF111331, SSF111331, 1 hit
SSF47473, SSF47473, 2 hits
SSF57889, SSF57889, 2 hits
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49619
Secondary accession number(s): B2RAH4, Q2M1H4, Q5FWG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: May 25, 2022
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again