UniProtKB - P49619 (DGKG_HUMAN)
Diacylglycerol kinase gamma
DGKG
Functioni
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597).
Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity).
Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597).
Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity).
By similarity1 PublicationCatalytic activityi
- EC:2.7.1.1071 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
: glycerolipid metabolism Pathwayi
This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 188 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 190 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 192 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 199 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 233 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 235 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 237 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 244 | Calcium 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 271 – 321 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 336 – 385 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 50 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
- diacylglycerol kinase activity Source: UniProtKB
- lipid binding Source: BHF-UCL
- NAD+ kinase activity Source: InterPro
GO - Biological processi
- diacylglycerol metabolic process Source: UniProtKB
- glycerolipid metabolic process Source: BHF-UCL
- intracellular signal transduction Source: GO_Central
- lipid phosphorylation Source: UniProtKB
- negative regulation of protein kinase C signaling Source: UniProtKB
- neuron development Source: Ensembl
- phosphatidic acid biosynthetic process Source: UniProtKB
- platelet activation Source: Reactome
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
- regulation of dendrite development Source: Ensembl
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Lipid metabolism |
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.1.107, 2681 |
PathwayCommonsi | P49619 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis |
SABIO-RKi | P49619 |
SignaLinki | P49619 |
SIGNORi | P49619 |
UniPathwayi | UPA00230 |
Chemistry databases
SwissLipidsi | SLP:000000923 SLP:000000938 [P49619-1] |
Names & Taxonomyi
Protein namesi | Recommended name: Diacylglycerol kinase gamma (EC:2.7.1.1071 Publication)Short name: DAG kinase gamma Alternative name(s): Diglyceride kinase gamma Short name: DGK-gamma |
Gene namesi | Name:DGKG Synonyms:DAGK3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2853, DGKG |
MIMi | 601854, gene |
neXtProti | NX_P49619 |
VEuPathDBi | HostDB:ENSG00000058866 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoplasm and Cytosol
- cytosol 1 Publication
Other locations
- Membrane 1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1608 |
OpenTargetsi | ENSG00000058866 |
PharmGKBi | PA27314 |
Miscellaneous databases
Pharosi | P49619, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1075157 |
DrugBanki | DB14001, alpha-Tocopherol succinate DB00144, Phosphatidyl serine |
Genetic variation databases
BioMutai | DGKG |
DMDMi | 311033457 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218459 | 1 – 791 | Diacylglycerol kinase gammaAdd BLAST | 791 |
Proteomic databases
EPDi | P49619 |
MassIVEi | P49619 |
PaxDbi | P49619 |
PeptideAtlasi | P49619 |
PRIDEi | P49619 |
ProteomicsDBi | 56029 [P49619-1] 56030 [P49619-2] 56031 [P49619-3] |
PTM databases
iPTMneti | P49619 |
PhosphoSitePlusi | P49619 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000058866, Expressed in cerebellar hemisphere and 133 other tissues |
ExpressionAtlasi | P49619, baseline and differential |
Genevisiblei | P49619, HS |
Organism-specific databases
HPAi | ENSG00000058866, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107978, 24 interactors |
IntActi | P49619, 3 interactors |
STRINGi | 9606.ENSP00000265022 |
Chemistry databases
BindingDBi | P49619 |
Miscellaneous databases
RNActi | P49619, protein |
Structurei
3D structure databases
AlphaFoldDBi | P49619 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 175 – 210 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 220 – 255 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 430 – 564 | DAGKcPROSITE-ProRule annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 103 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 117 – 154 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 768 – 791 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 271 – 321 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 336 – 385 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1169, Eukaryota |
GeneTreei | ENSGT00940000156768 |
HOGENOMi | CLU_003770_1_0_1 |
InParanoidi | P49619 |
OMAi | ALCKYTV |
OrthoDBi | 633642at2759 |
PhylomeDBi | P49619 |
TreeFami | TF313104 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd00051, EFh, 1 hit |
Gene3Di | 1.10.238.110, 2 hits 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR046349, C1-like_sf IPR029477, DAG_kinase_typeI_N IPR037607, DGK IPR038199, DGK_typeI_N_sf IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF14513, DAG_kinase_N, 1 hit PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit SM00054, EFh, 2 hits |
SUPFAMi | SSF111331, SSF111331, 1 hit SSF47473, SSF47473, 2 hits SSF57889, SSF57889, 2 hits |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGEERWVSLT PEEFDQLQKY SEYSSKKIKD ALTEFNEGGS LKQYDPHEPI
60 70 80 90 100
SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRHETSDH PTEGASNSEA
110 120 130 140 150
NSADTNIQNA DNATKADEAC APDTESNMAE KQAPAEDQVA ATPLEPPVPR
160 170 180 190 200
SSSSESPVVY LKDVVCYLSL LETGRPQDKL EFMFRLYDSD ENGLLDQAEM
210 220 230 240 250
DCIVNQMLHI AQYLEWDPTE LRPILKEMLQ GMDYDRDGFV SLQEWVHGGM
260 270 280 290 300
TTIPLLVLLG MDDSGSKGDG RHAWTMKHFK KPTYCNFCHI MLMGVRKQGL
310 320 330 340 350
CCTYCKYTVH ERCVSRNIPG CVKTYSKAKR SGEVMQHAWV EGNSSVKCDR
360 370 380 390 400
CHKSIKCYQS VTARHCVWCR MTFHRKCELS TLCDGGELRD HILLPTSICP
410 420 430 440 450
ITRDRPGEKS DGCVSAKGEL VMQYKIIPTP GTHPLLVLVN PKSGGRQGER
460 470 480 490 500
ILRKFHYLLN PKQVFNLDNG GPTPGLNFFR DTPDFRVLAC GGDGTVGWIL
510 520 530 540 550
DCIDKANFAK HPPVAVLPLG TGNDLARCLR WGGGYEGGSL TKILKDIEQS
560 570 580 590 600
PLVMLDRWHL EVIPREEVEN GDQVPYSIMN NYFSIGVDAS IAHRFHVMRE
610 620 630 640 650
KHPEKFNSRM KNKLWYFEFG TSETFAATCK KLHDHIELEC DGVGVDLSNI
660 670 680 690 700
FLEGIAILNI PSMYGGTNLW GENKKNRAVI RESRKGVTDP KELKFCVQDL
710 720 730 740 750
SDQLLEVVGL EGAMEMGQIY TGLKSAGRRL AQCASVTIRT NKLLPMQVDG
760 770 780 790
EPWMQPCCTI KITHKNQAPM MMGPPQKSSF FSLRRKSRSK D
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C0L0 | H7C0L0_HUMAN | Diacylglycerol kinase gamma | DGKG | 154 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 271 | R → G in BAA05132 (PubMed:8034597).Curated | 1 | |
Sequence conflicti | 271 | R → G in AAC04686 (PubMed:10071200).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020259 | 142 | T → S2 PublicationsCorresponds to variant dbSNP:rs1004588Ensembl. | 1 | |
Natural variantiVAR_024430 | 316 | R → K4 PublicationsCorresponds to variant dbSNP:rs2193587Ensembl. | 1 | |
Natural variantiVAR_020260 | 370 | R → W. Corresponds to variant dbSNP:rs3213770Ensembl. | 1 | |
Natural variantiVAR_036119 | 706 | E → K in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039922 | 334 – 372 | Missing in isoform 3. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_001267 | 451 – 475 | Missing in isoform 2. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26135 mRNA Translation: BAA05132.1 AF020945 , AF020922, AF020923, AF020924, AF020925, AF020926, AF020927, AF020928, AF020929, AF020930, AF020931, AF020932, AF020933, AF020934, AF020935, AF020936, AF020937, AF020938, AF020939, AF020940, AF020941, AF020942, AF020943, AF020944 Genomic DNA Translation: AAC04686.1 AK314192 mRNA Translation: BAG36871.1 AC007917 Genomic DNA No translation available. AC112649 Genomic DNA No translation available. BC089411 mRNA Translation: AAH89411.1 BC112363 mRNA Translation: AAI12364.1 |
CCDSi | CCDS3274.1 [P49619-1] CCDS43181.1 [P49619-3] CCDS43182.1 [P49619-2] |
PIRi | A53691 |
RefSeqi | NP_001074213.1, NM_001080744.1 [P49619-2] NP_001074214.1, NM_001080745.1 [P49619-3] NP_001337.2, NM_001346.2 [P49619-1] |
Genome annotation databases
Ensembli | ENST00000265022.8; ENSP00000265022.3; ENSG00000058866.15 ENST00000344484.8; ENSP00000339777.4; ENSG00000058866.15 [P49619-2] ENST00000382164.8; ENSP00000371599.4; ENSG00000058866.15 [P49619-3] |
GeneIDi | 1608 |
KEGGi | hsa:1608 |
MANE-Selecti | ENST00000265022.8; ENSP00000265022.3; NM_001346.3; NP_001337.2 |
UCSCi | uc003fqa.4, human [P49619-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26135 mRNA Translation: BAA05132.1 AF020945 , AF020922, AF020923, AF020924, AF020925, AF020926, AF020927, AF020928, AF020929, AF020930, AF020931, AF020932, AF020933, AF020934, AF020935, AF020936, AF020937, AF020938, AF020939, AF020940, AF020941, AF020942, AF020943, AF020944 Genomic DNA Translation: AAC04686.1 AK314192 mRNA Translation: BAG36871.1 AC007917 Genomic DNA No translation available. AC112649 Genomic DNA No translation available. BC089411 mRNA Translation: AAH89411.1 BC112363 mRNA Translation: AAI12364.1 |
CCDSi | CCDS3274.1 [P49619-1] CCDS43181.1 [P49619-3] CCDS43182.1 [P49619-2] |
PIRi | A53691 |
RefSeqi | NP_001074213.1, NM_001080744.1 [P49619-2] NP_001074214.1, NM_001080745.1 [P49619-3] NP_001337.2, NM_001346.2 [P49619-1] |
3D structure databases
AlphaFoldDBi | P49619 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107978, 24 interactors |
IntActi | P49619, 3 interactors |
STRINGi | 9606.ENSP00000265022 |
Chemistry databases
BindingDBi | P49619 |
ChEMBLi | CHEMBL1075157 |
DrugBanki | DB14001, alpha-Tocopherol succinate DB00144, Phosphatidyl serine |
SwissLipidsi | SLP:000000923 SLP:000000938 [P49619-1] |
PTM databases
iPTMneti | P49619 |
PhosphoSitePlusi | P49619 |
Genetic variation databases
BioMutai | DGKG |
DMDMi | 311033457 |
Proteomic databases
EPDi | P49619 |
MassIVEi | P49619 |
PaxDbi | P49619 |
PeptideAtlasi | P49619 |
PRIDEi | P49619 |
ProteomicsDBi | 56029 [P49619-1] 56030 [P49619-2] 56031 [P49619-3] |
Protocols and materials databases
Antibodypediai | 34852, 126 antibodies from 18 providers |
DNASUi | 1608 |
Genome annotation databases
Ensembli | ENST00000265022.8; ENSP00000265022.3; ENSG00000058866.15 ENST00000344484.8; ENSP00000339777.4; ENSG00000058866.15 [P49619-2] ENST00000382164.8; ENSP00000371599.4; ENSG00000058866.15 [P49619-3] |
GeneIDi | 1608 |
KEGGi | hsa:1608 |
MANE-Selecti | ENST00000265022.8; ENSP00000265022.3; NM_001346.3; NP_001337.2 |
UCSCi | uc003fqa.4, human [P49619-1] |
Organism-specific databases
CTDi | 1608 |
DisGeNETi | 1608 |
GeneCardsi | DGKG |
HGNCi | HGNC:2853, DGKG |
HPAi | ENSG00000058866, Tissue enhanced (brain) |
MIMi | 601854, gene |
neXtProti | NX_P49619 |
OpenTargetsi | ENSG00000058866 |
PharmGKBi | PA27314 |
VEuPathDBi | HostDB:ENSG00000058866 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1169, Eukaryota |
GeneTreei | ENSGT00940000156768 |
HOGENOMi | CLU_003770_1_0_1 |
InParanoidi | P49619 |
OMAi | ALCKYTV |
OrthoDBi | 633642at2759 |
PhylomeDBi | P49619 |
TreeFami | TF313104 |
Enzyme and pathway databases
UniPathwayi | UPA00230 |
BRENDAi | 2.7.1.107, 2681 |
PathwayCommonsi | P49619 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis |
SABIO-RKi | P49619 |
SignaLinki | P49619 |
SIGNORi | P49619 |
Miscellaneous databases
BioGRID-ORCSi | 1608, 11 hits in 1064 CRISPR screens |
ChiTaRSi | DGKG, human |
GeneWikii | DGKG |
GenomeRNAii | 1608 |
Pharosi | P49619, Tbio |
PROi | PR:P49619 |
RNActi | P49619, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000058866, Expressed in cerebellar hemisphere and 133 other tissues |
ExpressionAtlasi | P49619, baseline and differential |
Genevisiblei | P49619, HS |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd00051, EFh, 1 hit |
Gene3Di | 1.10.238.110, 2 hits 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR046349, C1-like_sf IPR029477, DAG_kinase_typeI_N IPR037607, DGK IPR038199, DGK_typeI_N_sf IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF14513, DAG_kinase_N, 1 hit PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit SM00054, EFh, 2 hits |
SUPFAMi | SSF111331, SSF111331, 1 hit SSF47473, SSF47473, 2 hits SSF57889, SSF57889, 2 hits |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DGKG_HUMAN | |
Accessioni | P49619Primary (citable) accession number: P49619 Secondary accession number(s): B2RAH4, Q2M1H4, Q5FWG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | November 2, 2010 | |
Last modified: | May 25, 2022 | |
This is version 199 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families